BG62210B1 - Имидазодиазепини,метод за получаването им и тяхното използване - Google Patents
Имидазодиазепини,метод за получаването им и тяхното използване Download PDFInfo
- Publication number
- BG62210B1 BG62210B1 BG99505A BG9950595A BG62210B1 BG 62210 B1 BG62210 B1 BG 62210B1 BG 99505 A BG99505 A BG 99505A BG 9950595 A BG9950595 A BG 9950595A BG 62210 B1 BG62210 B1 BG 62210B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- mmol
- dihydro
- imidazo
- oxadiazol
- methylene chloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH78394 | 1994-03-16 | ||
| CH1095 | 1995-01-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG99505A BG99505A (en) | 1996-01-31 |
| BG62210B1 true BG62210B1 (bg) | 1999-05-31 |
Family
ID=25683249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG99505A BG62210B1 (bg) | 1994-03-16 | 1995-03-16 | Имидазодиазепини,метод за получаването им и тяхното използване |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5665718A (sk) |
| EP (1) | EP0672666B1 (sk) |
| JP (1) | JP2690282B2 (sk) |
| KR (1) | KR100214800B1 (sk) |
| CN (1) | CN1036995C (sk) |
| AT (1) | ATE203536T1 (sk) |
| AU (1) | AU679608B2 (sk) |
| BG (1) | BG62210B1 (sk) |
| CA (1) | CA2143246C (sk) |
| CZ (1) | CZ288594B6 (sk) |
| DE (1) | DE59509432D1 (sk) |
| DK (1) | DK0672666T3 (sk) |
| ES (1) | ES2160646T3 (sk) |
| FI (1) | FI112487B (sk) |
| GR (1) | GR3037019T3 (sk) |
| HU (1) | HU219987B (sk) |
| IL (1) | IL112955A (sk) |
| IS (1) | IS4273A (sk) |
| LV (1) | LV11327B (sk) |
| MA (1) | MA23479A1 (sk) |
| NO (1) | NO303731B1 (sk) |
| NZ (1) | NZ270685A (sk) |
| PH (1) | PH31443A (sk) |
| PT (1) | PT672666E (sk) |
| RO (1) | RO117698B1 (sk) |
| RU (1) | RU2139873C1 (sk) |
| SK (1) | SK33995A3 (sk) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW349100B (en) * | 1994-11-11 | 1999-01-01 | Hoffmann La Roche | Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines |
| US5905176A (en) * | 1998-08-28 | 1999-05-18 | Eastman Chemical Company | Process for the production of cyclobutyl halides |
| EP1178990B1 (en) * | 1999-05-12 | 2003-01-29 | F. Hoffmann-La Roche Ag | Imidazodiazepine derivative |
| US7160880B1 (en) * | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
| US20060065608A1 (en) * | 2004-09-29 | 2006-03-30 | Choate Chris E | Process and apparatus for generating useful biomass from organic waste streams |
| US8338614B2 (en) * | 2005-01-19 | 2012-12-25 | Merck, Sharp & Dohme Corp. | Tertiary carbinamines having substituted heterocycles which are active as β-secretase inhibitors for the treatment of alzheimer's disease |
| CN101106994A (zh) * | 2005-01-19 | 2008-01-16 | 默克公司 | 用于治疗阿尔茨海默氏病的氨基甲基β-分泌酶抑制剂 |
| AU2006276998A1 (en) * | 2005-05-16 | 2007-02-15 | Wisys Technology Foundation, Inc. | Gabaergic agents to treat memory deficits |
| KR20150081370A (ko) * | 2006-07-10 | 2015-07-13 | 파이온 유케이 리미티드 | 속효형 벤조디아제핀 염 및 이의 중합체 형태 |
| GB0613693D0 (en) * | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| WO2009024324A2 (en) * | 2007-08-20 | 2009-02-26 | Evotec Neurosciences Gmbh | Treatment of sleep disorders |
| US20090054412A1 (en) * | 2007-08-20 | 2009-02-26 | John Alan Kemp | Treatment of Sleep Disorders |
| KR101589314B1 (ko) | 2007-08-20 | 2016-01-28 | 에보텍 인터내셔널 게엠베하 | 수면 장애의 치료 |
| RU2503681C2 (ru) * | 2008-09-30 | 2014-01-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Новое конденсированное производное аминодигидротиазина |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| MX368854B (es) | 2012-05-22 | 2019-10-18 | Paion Uk Ltd | Composiciones que comprenden benzodiazepinas de acción corta. |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
| ES2788848T3 (es) | 2013-09-06 | 2020-10-23 | Aurigene Discovery Tech Ltd | Derivados de 1,2,4-oxadiazol como inmunomoduladores |
| JP2018507894A (ja) * | 2015-03-10 | 2018-03-22 | オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ | 免疫調節剤としての３−置換−１，２，４−オキサジアゾールおよびチアジアゾール化合物 |
| CU24509B1 (es) * | 2015-03-10 | 2021-05-12 | Aurigene Discovery Tech Ltd | Compuestos de 1,2,4-oxadiazol y tiadiazol como inmunomoduladores |
| KR20180131617A (ko) | 2016-04-14 | 2018-12-10 | 파이온 유케이 리미티드 | 경구 흡입 및 비 벤조디아제핀 |
| WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
| EA202090536A1 (ru) | 2017-10-11 | 2020-07-22 | Ориджен Дискавери Текнолоджис Лимитед | Кристаллические формы 3-замещенного 1,2,4-оксадиазола |
| EA202090746A1 (ru) | 2017-11-03 | 2020-08-17 | Ориджен Дискавери Текнолоджис Лимитед | Двойные ингибиторы путей tim-3 и pd-1 |
| WO2019087092A1 (en) | 2017-11-06 | 2019-05-09 | Aurigene Discovery Technologies Limited | Conjoint therapies for immunomodulation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK151808C (da) * | 1982-11-16 | 1988-06-20 | Ferrosan As | Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater |
| DE3587913D1 (de) * | 1984-01-19 | 1994-10-06 | Hoffmann La Roche | Imidazodiazepin-Derivate. |
| AU587802B2 (en) * | 1985-03-08 | 1989-08-31 | Ferrosan A/S | Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds |
| DK476885D0 (da) * | 1985-10-17 | 1985-10-17 | Ferrosan As | Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf |
| US4622320A (en) * | 1985-05-17 | 1986-11-11 | As Ferrosan | Oxadiazolylimidazobenzodiazepine, compositions, and method |
| DK174086D0 (da) * | 1986-04-16 | 1986-04-16 | Ferrosan As | Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme |
| US4939139A (en) * | 1989-07-26 | 1990-07-03 | Merck & Co., Inc. | 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine |
| US4904654A (en) * | 1989-07-26 | 1990-02-27 | Merck & Co., Inc. | 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine |
-
1995
- 1995-02-23 CA CA002143246A patent/CA2143246C/en not_active Expired - Lifetime
- 1995-03-03 AT AT95103028T patent/ATE203536T1/de active
- 1995-03-03 ES ES95103028T patent/ES2160646T3/es not_active Expired - Lifetime
- 1995-03-03 DK DK95103028T patent/DK0672666T3/da active
- 1995-03-03 DE DE59509432T patent/DE59509432D1/de not_active Expired - Lifetime
- 1995-03-03 PT PT95103028T patent/PT672666E/pt unknown
- 1995-03-03 EP EP95103028A patent/EP0672666B1/de not_active Expired - Lifetime
- 1995-03-10 PH PH50110A patent/PH31443A/en unknown
- 1995-03-10 NZ NZ270685A patent/NZ270685A/en not_active IP Right Cessation
- 1995-03-10 AU AU14760/95A patent/AU679608B2/en not_active Expired
- 1995-03-10 IL IL112955A patent/IL112955A/en not_active IP Right Cessation
- 1995-03-13 HU HU9500743A patent/HU219987B/hu not_active IP Right Cessation
- 1995-03-14 RU RU95103921A patent/RU2139873C1/ru active
- 1995-03-15 NO NO950999A patent/NO303731B1/no not_active IP Right Cessation
- 1995-03-15 SK SK339-95A patent/SK33995A3/sk unknown
- 1995-03-15 IS IS4273A patent/IS4273A/is unknown
- 1995-03-15 CZ CZ1995663A patent/CZ288594B6/cs not_active IP Right Cessation
- 1995-03-15 CN CN95102481A patent/CN1036995C/zh not_active Expired - Lifetime
- 1995-03-15 MA MA23807A patent/MA23479A1/fr unknown
- 1995-03-15 LV LVP-95-59A patent/LV11327B/lv unknown
- 1995-03-15 RO RO95-00534A patent/RO117698B1/ro unknown
- 1995-03-16 JP JP7057227A patent/JP2690282B2/ja not_active Expired - Lifetime
- 1995-03-16 BG BG99505A patent/BG62210B1/bg unknown
- 1995-03-16 KR KR1019950005414A patent/KR100214800B1/ko not_active IP Right Cessation
- 1995-03-16 FI FI951251A patent/FI112487B/fi not_active IP Right Cessation
-
1996
- 1996-01-16 US US08/586,439 patent/US5665718A/en not_active Expired - Lifetime
-
2001
- 2001-10-25 GR GR20010401890T patent/GR3037019T3/el unknown
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