BG61231B1 - A method for isolating factor viii - Google Patents

A method for isolating factor viii Download PDF

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Publication number
BG61231B1
BG61231B1 BG96316A BG9631692A BG61231B1 BG 61231 B1 BG61231 B1 BG 61231B1 BG 96316 A BG96316 A BG 96316A BG 9631692 A BG9631692 A BG 9631692A BG 61231 B1 BG61231 B1 BG 61231B1
Authority
BG
Bulgaria
Prior art keywords
factor viii
plasma
volume
gel filtration
gel
Prior art date
Application number
BG96316A
Other languages
Bulgarian (bg)
English (en)
Inventor
Per Kaersgaard
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of BG61231B1 publication Critical patent/BG61231B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Networks Using Active Elements (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Cephalosporin Compounds (AREA)
  • Amplifiers (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Separation By Low-Temperature Treatments (AREA)
BG96316A 1989-11-09 1992-05-08 A method for isolating factor viii BG61231B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii
PCT/DK1990/000279 WO1991007438A1 (en) 1989-11-09 1990-11-05 A method for isolating factor viii

Publications (1)

Publication Number Publication Date
BG61231B1 true BG61231B1 (en) 1997-03-31

Family

ID=8144000

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96316A BG61231B1 (en) 1989-11-09 1992-05-08 A method for isolating factor viii

Country Status (26)

Country Link
US (1) US5245014A (da)
EP (1) EP0524172B1 (da)
JP (1) JP2509407B2 (da)
CN (1) CN1044121C (da)
AT (1) ATE118508T1 (da)
AU (1) AU631471B2 (da)
BG (1) BG61231B1 (da)
CA (1) CA2073012C (da)
CZ (1) CZ537190A3 (da)
DE (1) DE69017050T2 (da)
DK (1) DK162233C (da)
ES (1) ES2068404T3 (da)
FI (1) FI103510B (da)
HU (1) HU214905B (da)
IE (1) IE66836B1 (da)
IL (1) IL96277A (da)
NO (1) NO180741C (da)
NZ (1) NZ236004A (da)
PL (1) PL164894B1 (da)
PT (1) PT95830B (da)
RU (1) RU2055593C1 (da)
SK (1) SK278640B6 (da)
UA (1) UA29421C2 (da)
WO (1) WO1991007438A1 (da)
YU (1) YU47524B (da)
ZA (1) ZA908599B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0399321T3 (da) * 1989-05-24 1993-08-09 Miles Inc Gelfiltrering af varmebehandlet faktor VIII
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6290527B1 (en) * 1998-07-03 2001-09-18 Nippon Telegraph And Telephone Corp. Nippon telegraph and telephone corporation
DK2130554T3 (da) 1999-02-22 2012-12-03 Univ Connecticut Albuminfrie faktor VIII-præparater
JP2002348300A (ja) * 1999-04-12 2002-12-04 Fujimori Kogyo Co Ltd 血液凝固第ｖｉｉｉ因子および血液凝固第ｖｉｉｉ因子／フォン・ビルブラント因子複合体の精製方法
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
SI1750733T1 (sl) 2004-05-03 2014-03-31 Emory University POSTOPEK DAJANJA PRAĹ IÄŚJEGA fVIII BREZ DOMENE B
WO2006021584A2 (en) * 2004-08-27 2006-03-02 Novo Nordisk Health Care Ag Purification of factor xiii polypeptides from biological materials
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
EP2385825B1 (en) * 2008-11-07 2018-10-10 University of Connecticut Factor viii formulations
ES2740825T3 (es) * 2010-03-30 2020-02-06 Octapharma Ag Un procedimiento de purificación de proteínas dependientes de vitamina K
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
EP2635297B1 (en) 2010-11-05 2019-02-27 Baxalta GmbH A new variant of antihemophilic factor viii having increased specific activity
JP6088435B2 (ja) 2010-12-15 2017-03-01 バクスアルタ ゲーエムベーハー 導電率グラディエントを用いる溶出液収集
CN103506080A (zh) * 2012-06-19 2014-01-15 汪志友 一种用于分离纯化凝血因子viii的介质及其制备方法
BR112015006634B1 (pt) 2012-09-28 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Método e kit para avaliação de reação de coagulação sanguínea
US9663553B2 (en) * 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
US4675385A (en) * 1985-03-27 1987-06-23 Alpha Therapeutic Corporation Isolation of human plasma procoagulant protein factor VIII from biological factors
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
EP0321835B1 (en) * 1987-12-21 1994-09-28 Miles Inc. Gel filteration of factor VIII
WO1989009784A1 (en) * 1988-04-08 1989-10-19 Commonwealth Serum Laboratories Commission Production of heat-stable factor viii concentrate
DK0399321T3 (da) * 1989-05-24 1993-08-09 Miles Inc Gelfiltrering af varmebehandlet faktor VIII

Also Published As

Publication number Publication date
DK562189A (da) 1991-05-10
AU631471B2 (en) 1992-11-26
DE69017050T2 (de) 1995-06-14
FI922105A0 (fi) 1992-05-08
YU210590A (sh) 1993-05-28
CN1044121C (zh) 1999-07-14
ES2068404T3 (es) 1995-04-16
FI103510B1 (fi) 1999-07-15
DE69017050D1 (de) 1995-03-23
NO921839L (no) 1992-07-08
PL164894B1 (pl) 1994-10-31
CA2073012A1 (en) 1991-05-10
CN1051732A (zh) 1991-05-29
NO180741C (no) 1997-06-11
DK562189D0 (da) 1989-11-09
CA2073012C (en) 1996-03-19
EP0524172A1 (en) 1993-01-27
IE66836B1 (en) 1996-02-07
DK162233B (da) 1991-09-30
IE904022A1 (en) 1991-05-22
UA29421C2 (uk) 2000-11-15
FI103510B (fi) 1999-07-15
FI922105A (fi) 1992-05-08
HU214905B (hu) 1998-07-28
JP2509407B2 (ja) 1996-06-19
SK537190A3 (en) 1997-12-10
NZ236004A (en) 1991-11-26
AU6747090A (en) 1991-06-13
WO1991007438A1 (en) 1991-05-30
IL96277A (en) 1995-07-31
IL96277A0 (en) 1991-08-16
ATE118508T1 (de) 1995-03-15
HUT60511A (en) 1992-09-28
DK162233C (da) 1992-03-16
EP0524172B1 (en) 1995-02-15
PT95830B (pt) 1997-11-28
CZ537190A3 (cs) 1998-05-13
PT95830A (pt) 1991-09-30
US5245014A (en) 1993-09-14
JPH05501557A (ja) 1993-03-25
RU2055593C1 (ru) 1996-03-10
PL287703A1 (en) 1991-12-02
ZA908599B (en) 1991-07-31
NO921839D0 (no) 1992-05-08
HU9201551D0 (en) 1992-08-28
SK278640B6 (en) 1997-12-10
YU47524B (sh) 1995-10-03
NO180741B (no) 1997-03-03

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