YU210590A - Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi - Google Patents

Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi

Info

Publication number
YU210590A
YU210590A YU210590A YU210590A YU210590A YU 210590 A YU210590 A YU 210590A YU 210590 A YU210590 A YU 210590A YU 210590 A YU210590 A YU 210590A YU 210590 A YU210590 A YU 210590A
Authority
YU
Yugoslavia
Prior art keywords
factor viii
blood plasma
idolation
procedure
plasma proteins
Prior art date
Application number
YU210590A
Other languages
English (en)
Other versions
YU47524B (sh
Inventor
P. Kaersgaard
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Priority to SI9012105A priority Critical patent/SI9012105A/sl
Priority to HRP-2105/90A priority patent/HRP930277A2/hr
Publication of YU210590A publication Critical patent/YU210590A/sh
Publication of YU47524B publication Critical patent/YU47524B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Amplifiers (AREA)
  • Networks Using Active Elements (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Postupak za izolovanje biološki aktivnih jedinjenja, odnosno, za izolovanje faktora VIII, u obliku kompleksa Faktora VIII: C i vWF iz drugih proteina u krvnoj plazmi, u kojem je plazma podvrgnuta gel filtraciji pod uslovima grupne separacije, upotrebom visokog punjenja i velike protočne brzine, pri čemu ej gel hemijski i imunološki inertan za Faktor VIII za vreme gel filtracije, daje frakciju koja sadrži Faktor VIII u veoma visokom prinosu i uvek bez drugih proteina.
YU210590A 1989-11-09 1990-11-07 Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi YU47524B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9012105A SI9012105A (sl) 1989-11-09 1990-11-07 Postopek za izoliranje biološko aktivnih spoji
HRP-2105/90A HRP930277A2 (en) 1989-11-09 1993-03-08 A method for isolating biologically active compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii

Publications (2)

Publication Number Publication Date
YU210590A true YU210590A (sh) 1993-05-28
YU47524B YU47524B (sh) 1995-10-03

Family

ID=8144000

Family Applications (1)

Application Number Title Priority Date Filing Date
YU210590A YU47524B (sh) 1989-11-09 1990-11-07 Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi

Country Status (26)

Country Link
US (1) US5245014A (sh)
EP (1) EP0524172B1 (sh)
JP (1) JP2509407B2 (sh)
CN (1) CN1044121C (sh)
AT (1) ATE118508T1 (sh)
AU (1) AU631471B2 (sh)
BG (1) BG61231B1 (sh)
CA (1) CA2073012C (sh)
CZ (1) CZ537190A3 (sh)
DE (1) DE69017050T2 (sh)
DK (1) DK162233C (sh)
ES (1) ES2068404T3 (sh)
FI (1) FI103510B (sh)
HU (1) HU214905B (sh)
IE (1) IE66836B1 (sh)
IL (1) IL96277A (sh)
NO (1) NO180741C (sh)
NZ (1) NZ236004A (sh)
PL (1) PL164894B1 (sh)
PT (1) PT95830B (sh)
RU (1) RU2055593C1 (sh)
SK (1) SK278640B6 (sh)
UA (1) UA29421C2 (sh)
WO (1) WO1991007438A1 (sh)
YU (1) YU47524B (sh)
ZA (1) ZA908599B (sh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042138T3 (es) * 1989-05-24 1993-12-01 Miles Inc. Filtracion en gel del factor viii tratado termicamente.
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6290527B1 (en) * 1998-07-03 2001-09-18 Nippon Telegraph And Telephone Corp. Nippon telegraph and telephone corporation
RU2244556C2 (ru) 1999-02-22 2005-01-20 Юниверсити Оф Коннектикут Новые не содержащие альбумин составы фактора viii
JP2002348300A (ja) * 1999-04-12 2002-12-04 Fujimori Kogyo Co Ltd 血液凝固第ｖｉｉｉ因子および血液凝固第ｖｉｉｉ因子／フォン・ビルブラント因子複合体の精製方法
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
EP1750733B1 (en) 2004-05-03 2013-12-11 Emory University METHOD OF ADMINISTERING PORCINE B-DOMAINLESS fVIII
CN101010333B (zh) * 2004-08-27 2013-08-14 诺和诺德医疗保健公司 从生物材料中纯化凝血因子xⅲ多肽
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
JP5779780B2 (ja) 2008-11-07 2015-09-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 第ｖｉｉｉ因子製剤
JP5876868B2 (ja) * 2010-03-30 2016-03-02 オクタファルマ・アーゲー 第ｉｘ凝固因子などのビタミンｋ依存性タンパク質の精製方法
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
SG10201509149VA (en) 2010-11-05 2015-12-30 Baxter Int A new variant of antihemophilic factor viii having increased specific activity
US9488625B2 (en) 2010-12-15 2016-11-08 Baxalta GmbH Purification of factor VIII using a conductivity gradient
CN103506080A (zh) * 2012-06-19 2014-01-15 汪志友 一种用于分离纯化凝血因子viii的介质及其制备方法
TWI609083B (zh) 2012-09-28 2017-12-21 Chugai Pharmaceutical Co Ltd Blood coagulation reaction assessment method
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
US4675385A (en) * 1985-03-27 1987-06-23 Alpha Therapeutic Corporation Isolation of human plasma procoagulant protein factor VIII from biological factors
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
DE3851696T2 (de) * 1987-12-21 1995-02-23 Miles Inc Faktor VIII- Gelfiltration.
WO1989009784A1 (en) * 1988-04-08 1989-10-19 Commonwealth Serum Laboratories Commission Production of heat-stable factor viii concentrate
ES2042138T3 (es) * 1989-05-24 1993-12-01 Miles Inc. Filtracion en gel del factor viii tratado termicamente.

Also Published As

Publication number Publication date
AU6747090A (en) 1991-06-13
UA29421C2 (uk) 2000-11-15
JP2509407B2 (ja) 1996-06-19
FI103510B1 (fi) 1999-07-15
CA2073012A1 (en) 1991-05-10
JPH05501557A (ja) 1993-03-25
CZ537190A3 (cs) 1998-05-13
PL287703A1 (en) 1991-12-02
AU631471B2 (en) 1992-11-26
SK537190A3 (en) 1997-12-10
BG61231B1 (en) 1997-03-31
HU9201551D0 (en) 1992-08-28
CN1044121C (zh) 1999-07-14
DK162233C (da) 1992-03-16
PT95830B (pt) 1997-11-28
ZA908599B (en) 1991-07-31
YU47524B (sh) 1995-10-03
HUT60511A (en) 1992-09-28
SK278640B6 (en) 1997-12-10
RU2055593C1 (ru) 1996-03-10
IE66836B1 (en) 1996-02-07
DK162233B (da) 1991-09-30
FI103510B (fi) 1999-07-15
IL96277A0 (en) 1991-08-16
EP0524172B1 (en) 1995-02-15
US5245014A (en) 1993-09-14
HU214905B (hu) 1998-07-28
DK562189A (da) 1991-05-10
FI922105A0 (fi) 1992-05-08
NO921839L (no) 1992-07-08
NO180741B (no) 1997-03-03
NO180741C (no) 1997-06-11
WO1991007438A1 (en) 1991-05-30
PT95830A (pt) 1991-09-30
IE904022A1 (en) 1991-05-22
DE69017050T2 (de) 1995-06-14
DE69017050D1 (de) 1995-03-23
BG96316A (bg) 1993-12-24
NZ236004A (en) 1991-11-26
IL96277A (en) 1995-07-31
ES2068404T3 (es) 1995-04-16
NO921839D0 (no) 1992-05-08
CA2073012C (en) 1996-03-19
EP0524172A1 (en) 1993-01-27
ATE118508T1 (de) 1995-03-15
FI922105A (fi) 1992-05-08
DK562189D0 (da) 1989-11-09
PL164894B1 (pl) 1994-10-31
CN1051732A (zh) 1991-05-29

Similar Documents

Publication Publication Date Title
YU210590A (sh) Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi
ATE20073T1 (de) Homogenes human-interleukin-2 und verfahren zu seiner herstellung.
PT85849A (en) Process for the preparation of novel lymphokine related peptides
NO174105C (no) Analogifremgangsmåte for fremstilling av antikoagulerende peptider
ES2000030A6 (es) Metodo de purificar factor sanguineo viii:c
HUT63063A (en) Process for producing antibodies against cd44 cell surface glycoprotein and immunosuppressant pharmaceutical compositions comprising same
PT76831B (en) Process for preparing teichomycin a2 pure single factors 1,2,3,4 and 5 and of pharmaceutical compositions containing the same
KR880000765B1 (en) Process for the preparation of polypetide
HUT52792A (en) Process for production of liquid cathalizator-component, process for production of ethilen alpha olefin copolimers by cathalizator-system containing cathalizator-component
ES8304583A1 (es) Procedimiento para preparar un compuesto de halocarbonilbis (triorganofosforo) rodio.
ATE1856T1 (de) Peptide mit ubiquitin-aehnlicher aktivitaet, verfahren zu ihrer herstellung, sie enthaltende therapeutische zusammensetzungen und ihrer anwendung.
FI883589A (fi) Menetelmä tyydyttämättömien aminohappoyhdisteiden valmistamiseksi
PL242097A1 (en) Process for preparing novel derivatives of cyclic peptides a-21978 c
ES8305702A1 (es) Un procedimiento para la preparacion de hexapeptido ciclico.
DE68916181D1 (de) Verfahren zur Herstellung von Polyglycidylethern.
ZA833137B (en) Dextro-rotatory isomers of derivatives of 1-aza bicyclo (2,2,2) octane,process for their preparation and medicaments containing them
HUT46341A (en) Process for producing pharmaceutical compositions containing peptide derivatives as active components
PT73587A (en) Process for preparing novel peptides
AU550973B2 (en) Process for preparing b-hydroxy amino acid
PL242099A1 (en) Process for preparing novel derivatives of a-21978c cyclic peptides
FI873548A0 (fi) Menetelmä oktreotidiä sisältävän farmaseuttisen koostumuksen valmistamiseksi
PL237590A1 (en) Process for preparing novel,optically active derivatives of s-1-phenylethylamine
PL237058A1 (en) Process for preparing 9/11-dehydroderivatives of steroidseries of pregnane from 11 alpha,21-dihydroxyderivatives
PH17296A (en) Process for preparation of optically active n-mercaptoalkanyl amino acid
GB8729410D0 (en) Method for production of lymphokine activated killer(lak)cells & lak cells so produced