YU210590A - Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi - Google Patents

Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi

Info

Publication number
YU210590A
YU210590A YU210590A YU210590A YU210590A YU 210590 A YU210590 A YU 210590A YU 210590 A YU210590 A YU 210590A YU 210590 A YU210590 A YU 210590A YU 210590 A YU210590 A YU 210590A
Authority
YU
Yugoslavia
Prior art keywords
factor viii
blood plasma
idolation
procedure
plasma proteins
Prior art date
Application number
YU210590A
Other languages
English (en)
Other versions
YU47524B (sh
Inventor
P. Kaersgaard
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Priority to SI9012105A priority Critical patent/SI9012105A/sl
Priority to HRP-2105/90A priority patent/HRP930277A2/hr
Publication of YU210590A publication Critical patent/YU210590A/sh
Publication of YU47524B publication Critical patent/YU47524B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Amplifiers (AREA)
  • Networks Using Active Elements (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Postupak za izolovanje biološki aktivnih jedinjenja, odnosno, za izolovanje faktora VIII, u obliku kompleksa Faktora VIII: C i vWF iz drugih proteina u krvnoj plazmi, u kojem je plazma podvrgnuta gel filtraciji pod uslovima grupne separacije, upotrebom visokog punjenja i velike protočne brzine, pri čemu ej gel hemijski i imunološki inertan za Faktor VIII za vreme gel filtracije, daje frakciju koja sadrži Faktor VIII u veoma visokom prinosu i uvek bez drugih proteina.
YU210590A 1989-11-09 1990-11-07 Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi YU47524B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9012105A SI9012105A (sl) 1989-11-09 1990-11-07 Postopek za izoliranje biološko aktivnih spoji
HRP-2105/90A HRP930277A2 (en) 1989-11-09 1993-03-08 A method for isolating biologically active compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii

Publications (2)

Publication Number Publication Date
YU210590A true YU210590A (sh) 1993-05-28
YU47524B YU47524B (sh) 1995-10-03

Family

ID=8144000

Family Applications (1)

Application Number Title Priority Date Filing Date
YU210590A YU47524B (sh) 1989-11-09 1990-11-07 Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi

Country Status (26)

Country Link
US (1) US5245014A (sh)
EP (1) EP0524172B1 (sh)
JP (1) JP2509407B2 (sh)
CN (1) CN1044121C (sh)
AT (1) ATE118508T1 (sh)
AU (1) AU631471B2 (sh)
BG (1) BG61231B1 (sh)
CA (1) CA2073012C (sh)
CZ (1) CZ537190A3 (sh)
DE (1) DE69017050T2 (sh)
DK (1) DK162233C (sh)
ES (1) ES2068404T3 (sh)
FI (1) FI103510B1 (sh)
HU (1) HU214905B (sh)
IE (1) IE66836B1 (sh)
IL (1) IL96277A (sh)
NO (1) NO180741C (sh)
NZ (1) NZ236004A (sh)
PL (1) PL164894B1 (sh)
PT (1) PT95830B (sh)
RU (1) RU2055593C1 (sh)
SK (1) SK278640B6 (sh)
UA (1) UA29421C2 (sh)
WO (1) WO1991007438A1 (sh)
YU (1) YU47524B (sh)
ZA (1) ZA908599B (sh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE90875T1 (de) * 1989-05-24 1993-07-15 Miles Inc Gelfiltration von waermebehandeltem faktor viii.
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6290527B1 (en) * 1998-07-03 2001-09-18 Nippon Telegraph And Telephone Corp. Nippon telegraph and telephone corporation
EP1820516B1 (en) * 1999-02-22 2013-07-24 University of Connecticut Novel albumin-free factor VIII formulations
JP2002348300A (ja) * 1999-04-12 2002-12-04 Fujimori Kogyo Co Ltd 血液凝固第ｖｉｉｉ因子および血液凝固第ｖｉｉｉ因子／フォン・ビルブラント因子複合体の精製方法
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
JP2007536230A (ja) 2004-05-03 2007-12-13 エモリー ユニバーシティ ブタＢドメイン欠損ｆＶＩＩＩの投与方法
EP1784415A2 (en) * 2004-08-27 2007-05-16 Novo Nordisk Health Care AG Purification of factor xiii polypeptides from biological materials
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
CA2742328C (en) 2008-11-07 2019-02-26 Baxter International Inc. Factor viii formulations
MX2012011066A (es) * 2010-03-30 2012-10-10 Octapharma Ag Proceso para purificar proteinas dependientes de vitamina k tal como el factor ix de coagulacion.
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
EP2635297B1 (en) 2010-11-05 2019-02-27 Baxalta GmbH A new variant of antihemophilic factor viii having increased specific activity
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
CN103506080A (zh) * 2012-06-19 2014-01-15 汪志友 一种用于分离纯化凝血因子viii的介质及其制备方法
KR102134305B1 (ko) * 2012-09-28 2020-07-15 추가이 세이야쿠 가부시키가이샤 혈액응고반응의 평가방법
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
US4675385A (en) * 1985-03-27 1987-06-23 Alpha Therapeutic Corporation Isolation of human plasma procoagulant protein factor VIII from biological factors
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
ATE112287T1 (de) * 1987-12-21 1994-10-15 Miles Inc Faktor viii- gelfiltration.
WO1989009784A1 (en) * 1988-04-08 1989-10-19 Commonwealth Serum Laboratories Commission Production of heat-stable factor viii concentrate
ATE90875T1 (de) * 1989-05-24 1993-07-15 Miles Inc Gelfiltration von waermebehandeltem faktor viii.

Also Published As

Publication number Publication date
EP0524172B1 (en) 1995-02-15
NO180741C (no) 1997-06-11
FI103510B (fi) 1999-07-15
IL96277A0 (en) 1991-08-16
BG61231B1 (en) 1997-03-31
NZ236004A (en) 1991-11-26
DK162233C (da) 1992-03-16
HU214905B (hu) 1998-07-28
WO1991007438A1 (en) 1991-05-30
DK162233B (da) 1991-09-30
SK537190A3 (en) 1997-12-10
FI922105A0 (fi) 1992-05-08
PT95830A (pt) 1991-09-30
DE69017050D1 (de) 1995-03-23
PL287703A1 (en) 1991-12-02
JPH05501557A (ja) 1993-03-25
ATE118508T1 (de) 1995-03-15
HU9201551D0 (en) 1992-08-28
NO921839L (no) 1992-07-08
FI922105A (fi) 1992-05-08
CN1051732A (zh) 1991-05-29
FI103510B1 (fi) 1999-07-15
CZ537190A3 (cs) 1998-05-13
AU631471B2 (en) 1992-11-26
RU2055593C1 (ru) 1996-03-10
CA2073012A1 (en) 1991-05-10
HUT60511A (en) 1992-09-28
NO180741B (no) 1997-03-03
CA2073012C (en) 1996-03-19
EP0524172A1 (en) 1993-01-27
DK562189A (da) 1991-05-10
CN1044121C (zh) 1999-07-14
PT95830B (pt) 1997-11-28
PL164894B1 (pl) 1994-10-31
ZA908599B (en) 1991-07-31
DE69017050T2 (de) 1995-06-14
NO921839D0 (no) 1992-05-08
AU6747090A (en) 1991-06-13
SK278640B6 (en) 1997-12-10
US5245014A (en) 1993-09-14
IE904022A1 (en) 1991-05-22
DK562189D0 (da) 1989-11-09
YU47524B (sh) 1995-10-03
ES2068404T3 (es) 1995-04-16
IL96277A (en) 1995-07-31
JP2509407B2 (ja) 1996-06-19
UA29421C2 (uk) 2000-11-15
IE66836B1 (en) 1996-02-07

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