ATE118508T1 - Verfahren zur isolierung von faktor viii. - Google Patents

Verfahren zur isolierung von faktor viii.

Info

Publication number
ATE118508T1
ATE118508T1 AT90917201T AT90917201T ATE118508T1 AT E118508 T1 ATE118508 T1 AT E118508T1 AT 90917201 T AT90917201 T AT 90917201T AT 90917201 T AT90917201 T AT 90917201T AT E118508 T1 ATE118508 T1 AT E118508T1
Authority
AT
Austria
Prior art keywords
factor viii
isolation
proteins
plasma
subjected
Prior art date
Application number
AT90917201T
Other languages
English (en)
Inventor
Per Kaersgaard
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE118508T1 publication Critical patent/ATE118508T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Amplifiers (AREA)
  • Networks Using Active Elements (AREA)
  • Housing For Livestock And Birds (AREA)
  • Cephalosporin Compounds (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT90917201T 1989-11-09 1990-11-05 Verfahren zur isolierung von faktor viii. ATE118508T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii

Publications (1)

Publication Number Publication Date
ATE118508T1 true ATE118508T1 (de) 1995-03-15

Family

ID=8144000

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90917201T ATE118508T1 (de) 1989-11-09 1990-11-05 Verfahren zur isolierung von faktor viii.

Country Status (26)

Country Link
US (1) US5245014A (de)
EP (1) EP0524172B1 (de)
JP (1) JP2509407B2 (de)
CN (1) CN1044121C (de)
AT (1) ATE118508T1 (de)
AU (1) AU631471B2 (de)
BG (1) BG61231B1 (de)
CA (1) CA2073012C (de)
CZ (1) CZ537190A3 (de)
DE (1) DE69017050T2 (de)
DK (1) DK162233C (de)
ES (1) ES2068404T3 (de)
FI (1) FI103510B1 (de)
HU (1) HU214905B (de)
IE (1) IE66836B1 (de)
IL (1) IL96277A (de)
NO (1) NO180741C (de)
NZ (1) NZ236004A (de)
PL (1) PL164894B1 (de)
PT (1) PT95830B (de)
RU (1) RU2055593C1 (de)
SK (1) SK537190A3 (de)
UA (1) UA29421C2 (de)
WO (1) WO1991007438A1 (de)
YU (1) YU47524B (de)
ZA (1) ZA908599B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042138T3 (es) * 1989-05-24 1993-12-01 Miles Inc. Filtracion en gel del factor viii tratado termicamente.
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6290527B1 (en) * 1998-07-03 2001-09-18 Nippon Telegraph And Telephone Corp. Nippon telegraph and telephone corporation
US6586573B1 (en) 1999-02-22 2003-07-01 Baxter International Inc. Albumin-free Factor VIII formulations
JP2002348300A (ja) * 1999-04-12 2002-12-04 Fujimori Kogyo Co Ltd 血液凝固第ｖｉｉｉ因子および血液凝固第ｖｉｉｉ因子／フォン・ビルブラント因子複合体の精製方法
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
ES2449044T3 (es) 2004-05-03 2014-03-18 Emory University Procedimiento de administración de fVIII sin dominio B porcino
CN101010333B (zh) * 2004-08-27 2013-08-14 诺和诺德医疗保健公司 从生物材料中纯化凝血因子xⅲ多肽
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
AU2009313325B2 (en) * 2008-11-07 2014-05-01 Takeda Pharmaceutical Company Limited Factor VIII formulations
BR112012024550B1 (pt) * 2010-03-30 2020-12-08 Octapharma Ag processo de produção de uma proteína dependente de vitamina k livre de príons em uma sequência de purificação que emprega cromatografia
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
KR101948337B1 (ko) 2010-11-05 2019-02-14 박스알타 인코퍼레이티드 증가된 특이 활성도를 갖는 항혈우병 인자 ｖｉｉｉ의 신규 변이체
CA2821711C (en) 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient
CN103506080A (zh) * 2012-06-19 2014-01-15 汪志友 一种用于分离纯化凝血因子viii的介质及其制备方法
CA2886326C (en) * 2012-09-28 2021-11-02 Chugai Seiyaku Kabushiki Kaisha Method for evaluating blood coagulation reaction
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
US4675385A (en) * 1985-03-27 1987-06-23 Alpha Therapeutic Corporation Isolation of human plasma procoagulant protein factor VIII from biological factors
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
ATE112287T1 (de) * 1987-12-21 1994-10-15 Miles Inc Faktor viii- gelfiltration.
WO1989009784A1 (en) * 1988-04-08 1989-10-19 Commonwealth Serum Laboratories Commission Production of heat-stable factor viii concentrate
ES2042138T3 (es) * 1989-05-24 1993-12-01 Miles Inc. Filtracion en gel del factor viii tratado termicamente.

Also Published As

Publication number Publication date
HUT60511A (en) 1992-09-28
ZA908599B (en) 1991-07-31
DK162233B (da) 1991-09-30
WO1991007438A1 (en) 1991-05-30
FI103510B (fi) 1999-07-15
FI103510B1 (fi) 1999-07-15
IE904022A1 (en) 1991-05-22
IL96277A0 (en) 1991-08-16
DK562189A (da) 1991-05-10
DE69017050T2 (de) 1995-06-14
ES2068404T3 (es) 1995-04-16
NO180741C (no) 1997-06-11
EP0524172B1 (de) 1995-02-15
PT95830B (pt) 1997-11-28
CA2073012A1 (en) 1991-05-10
HU9201551D0 (en) 1992-08-28
NO180741B (no) 1997-03-03
YU47524B (sh) 1995-10-03
DK162233C (da) 1992-03-16
HU214905B (hu) 1998-07-28
CN1044121C (zh) 1999-07-14
CN1051732A (zh) 1991-05-29
DE69017050D1 (de) 1995-03-23
NO921839L (no) 1992-07-08
JP2509407B2 (ja) 1996-06-19
DK562189D0 (da) 1989-11-09
NO921839D0 (no) 1992-05-08
BG96316A (bg) 1993-12-24
SK278640B6 (en) 1997-12-10
PL287703A1 (en) 1991-12-02
FI922105A0 (fi) 1992-05-08
SK537190A3 (en) 1997-12-10
US5245014A (en) 1993-09-14
BG61231B1 (en) 1997-03-31
AU6747090A (en) 1991-06-13
IE66836B1 (en) 1996-02-07
CZ537190A3 (cs) 1998-05-13
PL164894B1 (pl) 1994-10-31
JPH05501557A (ja) 1993-03-25
UA29421C2 (uk) 2000-11-15
YU210590A (sh) 1993-05-28
RU2055593C1 (ru) 1996-03-10
PT95830A (pt) 1991-09-30
CA2073012C (en) 1996-03-19
EP0524172A1 (de) 1993-01-27
AU631471B2 (en) 1992-11-26
NZ236004A (en) 1991-11-26
FI922105A (fi) 1992-05-08
IL96277A (en) 1995-07-31

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Legal Events

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REN Ceased due to non-payment of the annual fee