ES2068404T3 - Un metodo para aislar el factor viii. - Google Patents

Un metodo para aislar el factor viii.

Info

Publication number
ES2068404T3
ES2068404T3 ES90917201T ES90917201T ES2068404T3 ES 2068404 T3 ES2068404 T3 ES 2068404T3 ES 90917201 T ES90917201 T ES 90917201T ES 90917201 T ES90917201 T ES 90917201T ES 2068404 T3 ES2068404 T3 ES 2068404T3
Authority
ES
Spain
Prior art keywords
factor viii
isolating
proteins
plasma
practically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90917201T
Other languages
English (en)
Inventor
Per Kaersgaard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2068404T3 publication Critical patent/ES2068404T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Amplifiers (AREA)
  • Networks Using Active Elements (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE PRESENTA UN METODO PARA AISLAR EL FACTOR VIII DE OTRAS PROTEINAS DISUELTAS EN EL PLASMA SANGUINEO, EN DONDE EL PLASMA SE SOMETE A UNA FILTRACION EN GEL BAJO CONDICIONES DE SEPARACION DEL GRUPO CON LO QUE SE OBTIENE UNA FRACCION QUE CONTIENE EL FACTOR VIII EN UN RENDIMIENTO MUY ELEVADO Y PRACTICAMENTE SIN OTRAS PROTEINAS.
ES90917201T 1989-11-09 1990-11-05 Un metodo para aislar el factor viii. Expired - Lifetime ES2068404T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii

Publications (1)

Publication Number Publication Date
ES2068404T3 true ES2068404T3 (es) 1995-04-16

Family

ID=8144000

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90917201T Expired - Lifetime ES2068404T3 (es) 1989-11-09 1990-11-05 Un metodo para aislar el factor viii.

Country Status (26)

Country Link
US (1) US5245014A (es)
EP (1) EP0524172B1 (es)
JP (1) JP2509407B2 (es)
CN (1) CN1044121C (es)
AT (1) ATE118508T1 (es)
AU (1) AU631471B2 (es)
BG (1) BG61231B1 (es)
CA (1) CA2073012C (es)
CZ (1) CZ537190A3 (es)
DE (1) DE69017050T2 (es)
DK (1) DK162233C (es)
ES (1) ES2068404T3 (es)
FI (1) FI103510B (es)
HU (1) HU214905B (es)
IE (1) IE66836B1 (es)
IL (1) IL96277A (es)
NO (1) NO180741C (es)
NZ (1) NZ236004A (es)
PL (1) PL164894B1 (es)
PT (1) PT95830B (es)
RU (1) RU2055593C1 (es)
SK (1) SK278640B6 (es)
UA (1) UA29421C2 (es)
WO (1) WO1991007438A1 (es)
YU (1) YU47524B (es)
ZA (1) ZA908599B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0399321T3 (da) * 1989-05-24 1993-08-09 Miles Inc Gelfiltrering af varmebehandlet faktor VIII
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6290527B1 (en) * 1998-07-03 2001-09-18 Nippon Telegraph And Telephone Corp. Nippon telegraph and telephone corporation
DE60035260T2 (de) 1999-02-22 2007-10-18 The University Of Connecticut, Farmington Neue albuminfreie faktor viii formulierungen
JP2002348300A (ja) * 1999-04-12 2002-12-04 Fujimori Kogyo Co Ltd 血液凝固第ｖｉｉｉ因子および血液凝固第ｖｉｉｉ因子／フォン・ビルブラント因子複合体の精製方法
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
SI1750733T1 (sl) 2004-05-03 2014-03-31 Emory University POSTOPEK DAJANJA PRAĹ IÄŚJEGA fVIII BREZ DOMENE B
JP2008510476A (ja) * 2004-08-27 2008-04-10 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 生物学的材料からのｘｉｉｉ因子ポリペプチドの精製
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations
AU2011234521B2 (en) * 2010-03-30 2015-04-23 Octapharma Ag A process for purifying Vitamin K dependent proteins such as coagulation factor IX
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
KR101948337B1 (ko) 2010-11-05 2019-02-14 박스알타 인코퍼레이티드 증가된 특이 활성도를 갖는 항혈우병 인자 ｖｉｉｉ의 신규 변이체
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
CN103506080A (zh) * 2012-06-19 2014-01-15 汪志友 一种用于分离纯化凝血因子viii的介质及其制备方法
CA2886326C (en) 2012-09-28 2021-11-02 Chugai Seiyaku Kabushiki Kaisha Method for evaluating blood coagulation reaction
US9663553B2 (en) * 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
US4675385A (en) * 1985-03-27 1987-06-23 Alpha Therapeutic Corporation Isolation of human plasma procoagulant protein factor VIII from biological factors
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
DE3851696T2 (de) * 1987-12-21 1995-02-23 Miles Inc Faktor VIII- Gelfiltration.
WO1989009784A1 (en) * 1988-04-08 1989-10-19 Commonwealth Serum Laboratories Commission Production of heat-stable factor viii concentrate
DK0399321T3 (da) * 1989-05-24 1993-08-09 Miles Inc Gelfiltrering af varmebehandlet faktor VIII

Also Published As

Publication number Publication date
PT95830B (pt) 1997-11-28
CN1051732A (zh) 1991-05-29
SK537190A3 (en) 1997-12-10
PT95830A (pt) 1991-09-30
CZ537190A3 (cs) 1998-05-13
NO921839D0 (no) 1992-05-08
SK278640B6 (en) 1997-12-10
IE904022A1 (en) 1991-05-22
DK162233B (da) 1991-09-30
PL164894B1 (pl) 1994-10-31
AU6747090A (en) 1991-06-13
WO1991007438A1 (en) 1991-05-30
BG61231B1 (en) 1997-03-31
CA2073012A1 (en) 1991-05-10
NO180741C (no) 1997-06-11
NO180741B (no) 1997-03-03
UA29421C2 (uk) 2000-11-15
ATE118508T1 (de) 1995-03-15
HUT60511A (en) 1992-09-28
NO921839L (no) 1992-07-08
HU9201551D0 (en) 1992-08-28
CA2073012C (en) 1996-03-19
EP0524172A1 (en) 1993-01-27
HU214905B (hu) 1998-07-28
DK562189A (da) 1991-05-10
AU631471B2 (en) 1992-11-26
RU2055593C1 (ru) 1996-03-10
ZA908599B (en) 1991-07-31
JP2509407B2 (ja) 1996-06-19
PL287703A1 (en) 1991-12-02
CN1044121C (zh) 1999-07-14
FI103510B1 (fi) 1999-07-15
DK162233C (da) 1992-03-16
DK562189D0 (da) 1989-11-09
JPH05501557A (ja) 1993-03-25
YU210590A (sh) 1993-05-28
YU47524B (sh) 1995-10-03
FI922105A (fi) 1992-05-08
DE69017050D1 (de) 1995-03-23
IE66836B1 (en) 1996-02-07
BG96316A (bg) 1993-12-24
FI922105A0 (fi) 1992-05-08
EP0524172B1 (en) 1995-02-15
IL96277A0 (en) 1991-08-16
FI103510B (fi) 1999-07-15
DE69017050T2 (de) 1995-06-14
IL96277A (en) 1995-07-31
US5245014A (en) 1993-09-14
NZ236004A (en) 1991-11-26

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