UA29421C2 - Спосіб виділення фактора vііі з інших білків в плазмі крові - Google Patents

Спосіб виділення фактора vііі з інших білків в плазмі крові

Info

Publication number
UA29421C2
UA29421C2 UA94020494A UA94020494A UA29421C2 UA 29421 C2 UA29421 C2 UA 29421C2 UA 94020494 A UA94020494 A UA 94020494A UA 94020494 A UA94020494 A UA 94020494A UA 29421 C2 UA29421 C2 UA 29421C2
Authority
UA
Ukraine
Prior art keywords
proteins
blood plasma
factor viii
isolating
isolating factor
Prior art date
Application number
UA94020494A
Other languages
English (en)
Russian (ru)
Inventor
Пер КЕРСГААРД
Original Assignee
Ново-Нордіск А/с
Ново-Нордиск А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ново-Нордіск А/с, Ново-Нордиск А/С filed Critical Ново-Нордіск А/с
Publication of UA29421C2 publication Critical patent/UA29421C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Amplifiers (AREA)
  • Networks Using Active Elements (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Separation By Low-Temperature Treatments (AREA)

Abstract

Винахід стосуєься способу виділення біологічних сполук з рідких складових організму з використанням гель-фільтрації на першій стадії виділення. Спосіб полягає в тому, що виділена плазма або разморожена свіжозаморожена плазма крові піддається груповому розділенню способом гель-фільтрації при використанні великого навантаження і високої швидкості потоку.
UA94020494A 1989-11-09 1990-11-05 Спосіб виділення фактора vііі з інших білків в плазмі крові UA29421C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii
PCT/DK1990/000279 WO1991007438A1 (en) 1989-11-09 1990-11-05 A method for isolating factor viii

Publications (1)

Publication Number Publication Date
UA29421C2 true UA29421C2 (uk) 2000-11-15

Family

ID=8144000

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94020494A UA29421C2 (uk) 1989-11-09 1990-11-05 Спосіб виділення фактора vііі з інших білків в плазмі крові

Country Status (26)

Country Link
US (1) US5245014A (uk)
EP (1) EP0524172B1 (uk)
JP (1) JP2509407B2 (uk)
CN (1) CN1044121C (uk)
AT (1) ATE118508T1 (uk)
AU (1) AU631471B2 (uk)
BG (1) BG61231B1 (uk)
CA (1) CA2073012C (uk)
CZ (1) CZ537190A3 (uk)
DE (1) DE69017050T2 (uk)
DK (1) DK162233C (uk)
ES (1) ES2068404T3 (uk)
FI (1) FI103510B (uk)
HU (1) HU214905B (uk)
IE (1) IE66836B1 (uk)
IL (1) IL96277A (uk)
NO (1) NO180741C (uk)
NZ (1) NZ236004A (uk)
PL (1) PL164894B1 (uk)
PT (1) PT95830B (uk)
RU (1) RU2055593C1 (uk)
SK (1) SK278640B6 (uk)
UA (1) UA29421C2 (uk)
WO (1) WO1991007438A1 (uk)
YU (1) YU47524B (uk)
ZA (1) ZA908599B (uk)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042138T3 (es) * 1989-05-24 1993-12-01 Miles Inc. Filtracion en gel del factor viii tratado termicamente.
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6290527B1 (en) * 1998-07-03 2001-09-18 Nippon Telegraph And Telephone Corp. Nippon telegraph and telephone corporation
RU2244556C2 (ru) 1999-02-22 2005-01-20 Юниверсити Оф Коннектикут Новые не содержащие альбумин составы фактора viii
JP2002348300A (ja) * 1999-04-12 2002-12-04 Fujimori Kogyo Co Ltd 血液凝固第ｖｉｉｉ因子および血液凝固第ｖｉｉｉ因子／フォン・ビルブラント因子複合体の精製方法
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
EP1750733B1 (en) 2004-05-03 2013-12-11 Emory University METHOD OF ADMINISTERING PORCINE B-DOMAINLESS fVIII
CN101010333B (zh) * 2004-08-27 2013-08-14 诺和诺德医疗保健公司 从生物材料中纯化凝血因子xⅲ多肽
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
JP5779780B2 (ja) 2008-11-07 2015-09-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 第ｖｉｉｉ因子製剤
JP5876868B2 (ja) * 2010-03-30 2016-03-02 オクタファルマ・アーゲー 第ｉｘ凝固因子などのビタミンｋ依存性タンパク質の精製方法
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
SG10201509149VA (en) 2010-11-05 2015-12-30 Baxter Int A new variant of antihemophilic factor viii having increased specific activity
US9488625B2 (en) 2010-12-15 2016-11-08 Baxalta GmbH Purification of factor VIII using a conductivity gradient
CN103506080A (zh) * 2012-06-19 2014-01-15 汪志友 一种用于分离纯化凝血因子viii的介质及其制备方法
TWI609083B (zh) 2012-09-28 2017-12-21 Chugai Pharmaceutical Co Ltd Blood coagulation reaction assessment method
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
US4675385A (en) * 1985-03-27 1987-06-23 Alpha Therapeutic Corporation Isolation of human plasma procoagulant protein factor VIII from biological factors
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
DE3851696T2 (de) * 1987-12-21 1995-02-23 Miles Inc Faktor VIII- Gelfiltration.
WO1989009784A1 (en) * 1988-04-08 1989-10-19 Commonwealth Serum Laboratories Commission Production of heat-stable factor viii concentrate
ES2042138T3 (es) * 1989-05-24 1993-12-01 Miles Inc. Filtracion en gel del factor viii tratado termicamente.

Also Published As

Publication number Publication date
AU6747090A (en) 1991-06-13
YU210590A (sh) 1993-05-28
JP2509407B2 (ja) 1996-06-19
FI103510B1 (fi) 1999-07-15
CA2073012A1 (en) 1991-05-10
JPH05501557A (ja) 1993-03-25
CZ537190A3 (cs) 1998-05-13
PL287703A1 (en) 1991-12-02
AU631471B2 (en) 1992-11-26
SK537190A3 (en) 1997-12-10
BG61231B1 (en) 1997-03-31
HU9201551D0 (en) 1992-08-28
CN1044121C (zh) 1999-07-14
DK162233C (da) 1992-03-16
PT95830B (pt) 1997-11-28
ZA908599B (en) 1991-07-31
YU47524B (sh) 1995-10-03
HUT60511A (en) 1992-09-28
SK278640B6 (en) 1997-12-10
RU2055593C1 (ru) 1996-03-10
IE66836B1 (en) 1996-02-07
DK162233B (da) 1991-09-30
FI103510B (fi) 1999-07-15
IL96277A0 (en) 1991-08-16
EP0524172B1 (en) 1995-02-15
US5245014A (en) 1993-09-14
HU214905B (hu) 1998-07-28
DK562189A (da) 1991-05-10
FI922105A0 (fi) 1992-05-08
NO921839L (no) 1992-07-08
NO180741B (no) 1997-03-03
NO180741C (no) 1997-06-11
WO1991007438A1 (en) 1991-05-30
PT95830A (pt) 1991-09-30
IE904022A1 (en) 1991-05-22
DE69017050T2 (de) 1995-06-14
DE69017050D1 (de) 1995-03-23
BG96316A (bg) 1993-12-24
NZ236004A (en) 1991-11-26
IL96277A (en) 1995-07-31
ES2068404T3 (es) 1995-04-16
NO921839D0 (no) 1992-05-08
CA2073012C (en) 1996-03-19
EP0524172A1 (en) 1993-01-27
ATE118508T1 (de) 1995-03-15
FI922105A (fi) 1992-05-08
DK562189D0 (da) 1989-11-09
PL164894B1 (pl) 1994-10-31
CN1051732A (zh) 1991-05-29

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