BG60250B2 - Метод за получаване на тумор некрозис фактор - Google Patents

Метод за получаване на тумор некрозис фактор Download PDF

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Publication number
BG60250B2
BG60250B2 BG70958A BG7095885A BG60250B2 BG 60250 B2 BG60250 B2 BG 60250B2 BG 70958 A BG70958 A BG 70958A BG 7095885 A BG7095885 A BG 7095885A BG 60250 B2 BG60250 B2 BG 60250B2
Authority
BG
Bulgaria
Prior art keywords
necrosis factor
tumor necrosis
dna
tumor
cells
Prior art date
Application number
BG70958A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG60250B1 (bg
Inventor
Bharat Aggarwal
David Goeddel
Sang Lee
Glenn Nedwin
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/677,257 external-priority patent/US4650674A/en
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of BG60250B2 publication Critical patent/BG60250B2/bg
Publication of BG60250B1 publication Critical patent/BG60250B1/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • C07K14/5255Lymphotoxin [LT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
BG070958A 1984-07-05 1985-07-04 Метод за получаване на тумор некрозис фактор BG60250B1 (bg)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US62795984A 1984-07-05 1984-07-05
US62806084A 1984-07-05 1984-07-05
US62805984A 1984-07-05 1984-07-05
US67715684A 1984-12-03 1984-12-03
US67745484A 1984-12-03 1984-12-03
US06/677,257 US4650674A (en) 1984-07-05 1984-12-03 Synergistic cytotoxic composition

Publications (2)

Publication Number Publication Date
BG60250B2 true BG60250B2 (bg) 1994-03-24
BG60250B1 BG60250B1 (bg) 1994-03-24

Family

ID=27560190

Family Applications (1)

Application Number Title Priority Date Filing Date
BG070958A BG60250B1 (bg) 1984-07-05 1985-07-04 Метод за получаване на тумор некрозис фактор

Country Status (20)

Country Link
EP (1) EP0168214B1 (ja)
JP (4) JP2557341B2 (ja)
AT (1) ATE113295T1 (ja)
AU (1) AU599571B2 (ja)
BG (1) BG60250B1 (ja)
CZ (1) CZ283149B6 (ja)
DE (2) DE19975064I2 (ja)
DK (2) DK169894B1 (ja)
FI (2) FI95472C (ja)
GR (1) GR851626B (ja)
HU (1) HU209153B (ja)
IE (1) IE65426B1 (ja)
IL (2) IL75717A (ja)
LU (1) LU90456I2 (ja)
NL (1) NL990033I2 (ja)
NO (1) NO852673L (ja)
NZ (1) NZ212632A (ja)
PL (1) PL155778B1 (ja)
SK (1) SK506785A3 (ja)
YU (1) YU47968B (ja)

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CA1265444A (en) * 1983-06-27 1990-02-06 Lloyd J. Old Effect of human tumor necrosis factor and human interferon on human cancer cells and methods
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US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
EP0216786B1 (en) * 1984-12-21 1992-03-18 Biogen, Inc. Purification, production and use of tumor necrosis factors
JPS61155330A (ja) * 1984-12-28 1986-07-15 Denichi Mizuno 蛋白質標品
JPS6248634A (ja) * 1985-07-23 1987-03-03 Mochida Pharmaceut Co Ltd 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物
US4870163A (en) * 1985-08-29 1989-09-26 New York Blood Center, Inc. Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4828830A (en) * 1986-01-24 1989-05-09 Genentech, Inc. Method and composition for prophylaxis and treatment of viral infections
NZ219027A (en) * 1986-01-24 1989-09-27 Genentech Inc Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin
ATE116367T1 (de) * 1986-02-04 1995-01-15 Den Ichi Mizuno Für antitumor-polypeptide kodierende dns, die polypeptide und diese polypeptide enthaltenden antitumor-wirkstoffe.
US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
PT85076B (pt) * 1986-06-16 1990-07-31 Genentech Inc Metodo para o tratamento de doencas infecciosas pela administracao de factor de necrose tumoral-alfa
ATE107362T1 (de) * 1986-06-20 1994-07-15 Dainippon Pharmaceutical Co Polypeptid-mutanten des menschlichen tnf und für diese mutanten codierende dns.
JPH0817712B2 (ja) * 1986-06-20 1996-02-28 大日本製薬株式会社 新規ヒトtnfポリペプチド変異体
US4857314A (en) * 1986-07-18 1989-08-15 Health Research , Inc. C-reactive proteins in treatment of animal and human cancers
CA1340698C (en) * 1986-07-25 1999-08-10 Kabushiki Kaisha Hayashibara Seibutsu Kaguku Kenkyujo Preparation and uses of interferon-gamma
DD263234A5 (de) * 1986-07-31 1988-12-28 Genentech,Inc.,Us Verfahren zur herstellung von arzneimitteln zur behandlung oder vorbeugung von retroviralen infektionen
US5002876A (en) * 1986-09-22 1991-03-26 Phillips Petroleum Company Yeast production of human tumor necrosis factor
US4777242A (en) * 1986-10-10 1988-10-11 Phillips Petroleum Company Purification of recombinant tumor necrosis factor
AU1346488A (en) * 1987-02-26 1988-09-26 Cetus Corporation Arginine-depleted human tumor necrosis factor
US4894225A (en) * 1987-03-02 1990-01-16 Cetus Corporation Combination therapy using antitumor immunotoxins with tumor necrosis factor
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
DE3837012A1 (de) * 1988-01-15 1989-07-27 Knoll Ag Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217325B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene for tumour necrosis factor alpha.
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
ES2097766T3 (es) 1989-08-16 1997-04-16 Chiron Corp Composiciones para la inhibicion de la formacion de hormonas proteicas y sus usos.
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
SG46398A1 (en) * 1990-03-12 1998-02-20 Peptide Technology Ltd Neutrophil stimulating peptides
IL97779A (en) * 1990-04-10 2000-01-31 Genentech Inc Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
CA2055168A1 (en) * 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins
WO1994018325A1 (en) * 1993-02-03 1994-08-18 N.V. Innogenetics S.A. Tnf-alpha muteins and a process for preparing them
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인
CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
EP0749494A1 (en) 1994-03-07 1996-12-27 Chiron Corporation Compositions for the inhibition of tnf formation and uses thereof
US5747023A (en) * 1994-07-01 1998-05-05 Genentech, Inc. Cancer therapy using lymphotoxin
IL120979A0 (en) * 1997-06-02 1997-11-20 Interpharm Lab Ltd Glycosylated TNF
US9821010B2 (en) 2013-02-07 2017-11-21 The General Hospital Corporation Methods for expansion or depletion of T-regulatory cells

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CH65623A (de) * 1913-08-02 1914-07-01 Siemens Ag Zeitrelais mit Wechselstrommotor und dessen Drehmoment entgegenwirkender Feder
NO163060C (no) * 1981-03-13 1990-03-28 Damon Biotech Inc Fremgangsmaate for fremstilling av substanser som dannes av levende celler som produserer interferoner eller antistoffer.
JPS5821621A (ja) * 1981-07-31 1983-02-08 Hayashibara Biochem Lab Inc ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤
CA1265444A (en) * 1983-06-27 1990-02-06 Lloyd J. Old Effect of human tumor necrosis factor and human interferon on human cancer cells and methods
JPS60226816A (ja) * 1984-11-16 1985-11-12 Asahi Chem Ind Co Ltd 抗腫瘍活性をもつヒト由来蛋白質
JPH0695939B2 (ja) * 1983-12-02 1994-11-30 大日本製薬株式会社 ウサギ癌壊死因子をコ−ドするクロ−ン化dνa
JPS60221092A (ja) * 1984-04-18 1985-11-05 Asahi Chem Ind Co Ltd 新規生理活性ポリペプチドのdna
DE3472793D1 (en) * 1983-12-26 1988-08-25 Asahi Chemical Ind A novel physiologically active polypeptide
JPS60137292A (ja) * 1983-12-26 1985-07-20 Asahi Chem Ind Co Ltd 新規生理活性ポリペプチドの遺伝情報を有するポリデオキシリボ核酸、該ポリデオキシリボ核酸を含む複製可能な組換dνa、該複製可能な組換dνaで形質転換された微生物または細胞、新規生理活性ポリペプチド及びその製造方法
JPS60166696A (ja) * 1984-02-08 1985-08-29 Asahi Chem Ind Co Ltd 新規生理活性ポリペプチドのdνa
EP0155549B1 (en) * 1984-03-06 1991-03-20 Dainippon Pharmaceutical Co., Ltd. Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
JPS60185799A (ja) * 1984-03-06 1985-09-21 Dainippon Pharmaceut Co Ltd ヒト癌壊死因子
JPS60232097A (ja) * 1984-04-23 1985-11-18 Dainippon Pharmaceut Co Ltd ヒト癌壊死因子ポリペプチドの製造法
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
DE3421731A1 (de) * 1984-06-12 1985-12-12 Boehringer Ingelheim International GmbH, 6507 Ingelheim Humaner-tumor-nekrose-faktor
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
JP2515975B2 (ja) * 1985-02-26 1996-07-10 大日本製薬株式会社 抗腫瘍作用を有するポリペプチド

Also Published As

Publication number Publication date
EP0168214A3 (en) 1987-12-16
FI943750A0 (fi) 1994-08-15
IL75717A0 (en) 1985-11-29
PL155778B1 (pl) 1992-01-31
DE3587939T2 (de) 1995-04-27
LU90456I2 (fr) 1999-12-06
PL254399A1 (en) 1986-06-17
GR851626B (ja) 1985-11-26
FI98217B (fi) 1997-01-31
DK169894B1 (da) 1995-03-27
NZ212632A (en) 1991-05-28
NL990033I1 (nl) 1999-12-01
HUT38125A (en) 1986-04-28
FI852626L (fi) 1986-01-06
CZ506785A3 (en) 1997-07-16
FI95472B (fi) 1995-10-31
DE19975064I2 (de) 2005-11-03
JPH07291997A (ja) 1995-11-07
JP2614989B2 (ja) 1997-05-28
SK279897B6 (sk) 1999-05-07
DK75694A (da) 1994-06-24
JPS6140221A (ja) 1986-02-26
YU113285A (en) 1991-04-30
JPH083061A (ja) 1996-01-09
FI98217C (fi) 1997-05-12
EP0168214B1 (en) 1994-10-26
DK171418B1 (da) 1996-10-21
IL105271A (en) 1995-07-31
BG60250B1 (bg) 1994-03-24
AU599571B2 (en) 1990-07-26
CZ283149B6 (cs) 1998-01-14
IE851691L (en) 1986-01-05
SK506785A3 (en) 1999-05-07
EP0168214A2 (en) 1986-01-15
DE19975064I1 (de) 2005-09-29
DK305885A (da) 1986-03-14
IE65426B1 (en) 1995-11-01
NL990033I2 (nl) 2000-11-01
FI943750A (fi) 1994-08-15
FI852626A0 (fi) 1985-07-03
FI95472C (fi) 1996-02-12
JP2557341B2 (ja) 1996-11-27
ATE113295T1 (de) 1994-11-15
AU4465285A (en) 1986-01-09
JPH0928387A (ja) 1997-02-04
IL75717A (en) 1994-11-28
DE3587939D1 (de) 1994-12-01
HU209153B (en) 1994-03-28
YU47968B (sh) 1996-08-13
DK305885D0 (da) 1985-07-04
NO852673L (no) 1986-01-06

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