DK169894B1 - Fremgangsmåde til fremstilling af en tumornecrosefaktor ud fra en blanding med andre proteiner, human tumornecrosefaktor og præparater omfattende denne - Google Patents
Fremgangsmåde til fremstilling af en tumornecrosefaktor ud fra en blanding med andre proteiner, human tumornecrosefaktor og præparater omfattende denne Download PDFInfo
- Publication number
- DK169894B1 DK169894B1 DK305885A DK305885A DK169894B1 DK 169894 B1 DK169894 B1 DK 169894B1 DK 305885 A DK305885 A DK 305885A DK 305885 A DK305885 A DK 305885A DK 169894 B1 DK169894 B1 DK 169894B1
- Authority
- DK
- Denmark
- Prior art keywords
- tumor necrosis
- necrosis factor
- dna
- cells
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C07K14/5255—Lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62795984A | 1984-07-05 | 1984-07-05 | |
US62806084A | 1984-07-05 | 1984-07-05 | |
US62805984A | 1984-07-05 | 1984-07-05 | |
US62805984 | 1984-07-05 | ||
US62795984 | 1984-07-05 | ||
US62806084 | 1984-07-05 | ||
US67715684A | 1984-12-03 | 1984-12-03 | |
US67745484A | 1984-12-03 | 1984-12-03 | |
US67715684 | 1984-12-03 | ||
US67725784 | 1984-12-03 | ||
US67745484 | 1984-12-03 | ||
US06/677,257 US4650674A (en) | 1984-07-05 | 1984-12-03 | Synergistic cytotoxic composition |
Publications (3)
Publication Number | Publication Date |
---|---|
DK305885D0 DK305885D0 (da) | 1985-07-04 |
DK305885A DK305885A (da) | 1986-03-14 |
DK169894B1 true DK169894B1 (da) | 1995-03-27 |
Family
ID=27560190
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK305885A DK169894B1 (da) | 1984-07-05 | 1985-07-04 | Fremgangsmåde til fremstilling af en tumornecrosefaktor ud fra en blanding med andre proteiner, human tumornecrosefaktor og præparater omfattende denne |
DK075694A DK171418B1 (da) | 1984-07-05 | 1994-06-24 | Tumornecrosefaktorderivater, DNA som koder derfor, replikerbare udtrykkelsesvektorer indeholdende DNA'en, værtsceller transformeret dermed og en fremgangsmåde til fremstilling af tumornecrosefaktorderivaterne samt præparater omfattende tumornecrosefaktorderivaterne |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK075694A DK171418B1 (da) | 1984-07-05 | 1994-06-24 | Tumornecrosefaktorderivater, DNA som koder derfor, replikerbare udtrykkelsesvektorer indeholdende DNA'en, værtsceller transformeret dermed og en fremgangsmåde til fremstilling af tumornecrosefaktorderivaterne samt præparater omfattende tumornecrosefaktorderivaterne |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0168214B1 (ja) |
JP (4) | JP2557341B2 (ja) |
AT (1) | ATE113295T1 (ja) |
AU (1) | AU599571B2 (ja) |
BG (1) | BG60250B1 (ja) |
CZ (1) | CZ283149B6 (ja) |
DE (2) | DE19975064I2 (ja) |
DK (2) | DK169894B1 (ja) |
FI (2) | FI95472C (ja) |
GR (1) | GR851626B (ja) |
HU (1) | HU209153B (ja) |
IE (1) | IE65426B1 (ja) |
IL (2) | IL75717A (ja) |
LU (1) | LU90456I2 (ja) |
NL (1) | NL990033I2 (ja) |
NO (1) | NO852673L (ja) |
NZ (1) | NZ212632A (ja) |
PL (1) | PL155778B1 (ja) |
SK (1) | SK506785A3 (ja) |
YU (1) | YU47968B (ja) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1265444A (en) * | 1983-06-27 | 1990-02-06 | Lloyd J. Old | Effect of human tumor necrosis factor and human interferon on human cancer cells and methods |
US5288852A (en) * | 1984-03-06 | 1994-02-22 | Dainippon Pharmaceutical Co., Ltd. | Human tumor necrosis factor polypeptides |
EP0155549B1 (en) * | 1984-03-06 | 1991-03-20 | Dainippon Pharmaceutical Co., Ltd. | Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide |
US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
JP2675294B2 (ja) * | 1984-10-15 | 1997-11-12 | カイロン コーポレイション | ヒト腫瘍壊死因子 |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
IL73883A (en) * | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
EP0216786B1 (en) * | 1984-12-21 | 1992-03-18 | Biogen, Inc. | Purification, production and use of tumor necrosis factors |
JPS61155330A (ja) * | 1984-12-28 | 1986-07-15 | Denichi Mizuno | 蛋白質標品 |
JPS6248634A (ja) * | 1985-07-23 | 1987-03-03 | Mochida Pharmaceut Co Ltd | 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物 |
US4870163A (en) * | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
US4677197A (en) * | 1985-10-30 | 1987-06-30 | Cetus Corporation | Purification method for tumor necrosis factor |
US4894439A (en) * | 1986-05-22 | 1990-01-16 | Cetus Corporation | N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes |
US4828830A (en) * | 1986-01-24 | 1989-05-09 | Genentech, Inc. | Method and composition for prophylaxis and treatment of viral infections |
NZ219027A (en) * | 1986-01-24 | 1989-09-27 | Genentech Inc | Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin |
ATE116367T1 (de) * | 1986-02-04 | 1995-01-15 | Den Ichi Mizuno | Für antitumor-polypeptide kodierende dns, die polypeptide und diese polypeptide enthaltenden antitumor-wirkstoffe. |
US4863727A (en) * | 1986-04-09 | 1989-09-05 | Cetus Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
PT85076B (pt) * | 1986-06-16 | 1990-07-31 | Genentech Inc | Metodo para o tratamento de doencas infecciosas pela administracao de factor de necrose tumoral-alfa |
ATE107362T1 (de) * | 1986-06-20 | 1994-07-15 | Dainippon Pharmaceutical Co | Polypeptid-mutanten des menschlichen tnf und für diese mutanten codierende dns. |
JPH0817712B2 (ja) * | 1986-06-20 | 1996-02-28 | 大日本製薬株式会社 | 新規ヒトtnfポリペプチド変異体 |
US4857314A (en) * | 1986-07-18 | 1989-08-15 | Health Research , Inc. | C-reactive proteins in treatment of animal and human cancers |
CA1340698C (en) * | 1986-07-25 | 1999-08-10 | Kabushiki Kaisha Hayashibara Seibutsu Kaguku Kenkyujo | Preparation and uses of interferon-gamma |
DD263234A5 (de) * | 1986-07-31 | 1988-12-28 | Genentech,Inc.,Us | Verfahren zur herstellung von arzneimitteln zur behandlung oder vorbeugung von retroviralen infektionen |
US5002876A (en) * | 1986-09-22 | 1991-03-26 | Phillips Petroleum Company | Yeast production of human tumor necrosis factor |
US4777242A (en) * | 1986-10-10 | 1988-10-11 | Phillips Petroleum Company | Purification of recombinant tumor necrosis factor |
AU1346488A (en) * | 1987-02-26 | 1988-09-26 | Cetus Corporation | Arginine-depleted human tumor necrosis factor |
US4894225A (en) * | 1987-03-02 | 1990-01-16 | Cetus Corporation | Combination therapy using antitumor immunotoxins with tumor necrosis factor |
JPS6463395A (en) * | 1987-05-04 | 1989-03-09 | Oncogen | Oncostatin m and novel composition having antitumor activity |
DE3837012A1 (de) * | 1988-01-15 | 1989-07-27 | Knoll Ag | Verwendung von tnf und lt zur herstellung von arzneimitteln |
GB2217325B (en) * | 1988-04-08 | 1991-11-20 | British Bio Technology | Synthetic gene for tumour necrosis factor alpha. |
DE3843534A1 (de) * | 1988-12-23 | 1990-07-12 | Basf Ag | Neue tnf-polypeptide |
US6586222B1 (en) | 1989-08-16 | 2003-07-01 | Chiron Corporation | Recombinant PR-3 and compositions thereof |
US5843693A (en) * | 1989-08-16 | 1998-12-01 | Chiron Corporation | Assay method for screening for inhibitors of proTNF conversion |
ES2097766T3 (es) | 1989-08-16 | 1997-04-16 | Chiron Corp | Composiciones para la inhibicion de la formacion de hormonas proteicas y sus usos. |
US5998378A (en) * | 1989-08-16 | 1999-12-07 | Chiron Corporation | Compositions for the inhibition of TNF hormone formation and uses thereof |
US5370870A (en) * | 1989-10-06 | 1994-12-06 | Genentech, Inc. | Method for protection against reactive oxygen species |
US5200176A (en) * | 1989-10-06 | 1993-04-06 | Genentech, Inc. | Method for protection of ischemic tissues using tumor nerosis factor |
SG46398A1 (en) * | 1990-03-12 | 1998-02-20 | Peptide Technology Ltd | Neutrophil stimulating peptides |
IL97779A (en) * | 1990-04-10 | 2000-01-31 | Genentech Inc | Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof |
CA2055168A1 (en) * | 1990-11-21 | 1992-05-22 | Walter Fiers | Tnf-muteins |
WO1994018325A1 (en) * | 1993-02-03 | 1994-08-18 | N.V. Innogenetics S.A. | Tnf-alpha muteins and a process for preparing them |
KR970005042B1 (ko) * | 1993-02-09 | 1997-04-11 | 한일합성섬유공업 주식회사 | 종양괴사인자-알파 뮤테인 |
CA2119089A1 (en) * | 1993-03-29 | 1994-09-30 | David Banner | Tumor necrosis factor muteins |
EP0749494A1 (en) | 1994-03-07 | 1996-12-27 | Chiron Corporation | Compositions for the inhibition of tnf formation and uses thereof |
US5747023A (en) * | 1994-07-01 | 1998-05-05 | Genentech, Inc. | Cancer therapy using lymphotoxin |
IL120979A0 (en) * | 1997-06-02 | 1997-11-20 | Interpharm Lab Ltd | Glycosylated TNF |
US9821010B2 (en) | 2013-02-07 | 2017-11-21 | The General Hospital Corporation | Methods for expansion or depletion of T-regulatory cells |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH65623A (de) * | 1913-08-02 | 1914-07-01 | Siemens Ag | Zeitrelais mit Wechselstrommotor und dessen Drehmoment entgegenwirkender Feder |
NO163060C (no) * | 1981-03-13 | 1990-03-28 | Damon Biotech Inc | Fremgangsmaate for fremstilling av substanser som dannes av levende celler som produserer interferoner eller antistoffer. |
JPS5821621A (ja) * | 1981-07-31 | 1983-02-08 | Hayashibara Biochem Lab Inc | ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤 |
CA1265444A (en) * | 1983-06-27 | 1990-02-06 | Lloyd J. Old | Effect of human tumor necrosis factor and human interferon on human cancer cells and methods |
JPS60226816A (ja) * | 1984-11-16 | 1985-11-12 | Asahi Chem Ind Co Ltd | 抗腫瘍活性をもつヒト由来蛋白質 |
JPH0695939B2 (ja) * | 1983-12-02 | 1994-11-30 | 大日本製薬株式会社 | ウサギ癌壊死因子をコ−ドするクロ−ン化dνa |
JPS60221092A (ja) * | 1984-04-18 | 1985-11-05 | Asahi Chem Ind Co Ltd | 新規生理活性ポリペプチドのdna |
DE3472793D1 (en) * | 1983-12-26 | 1988-08-25 | Asahi Chemical Ind | A novel physiologically active polypeptide |
JPS60137292A (ja) * | 1983-12-26 | 1985-07-20 | Asahi Chem Ind Co Ltd | 新規生理活性ポリペプチドの遺伝情報を有するポリデオキシリボ核酸、該ポリデオキシリボ核酸を含む複製可能な組換dνa、該複製可能な組換dνaで形質転換された微生物または細胞、新規生理活性ポリペプチド及びその製造方法 |
JPS60166696A (ja) * | 1984-02-08 | 1985-08-29 | Asahi Chem Ind Co Ltd | 新規生理活性ポリペプチドのdνa |
EP0155549B1 (en) * | 1984-03-06 | 1991-03-20 | Dainippon Pharmaceutical Co., Ltd. | Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide |
JPS60185799A (ja) * | 1984-03-06 | 1985-09-21 | Dainippon Pharmaceut Co Ltd | ヒト癌壊死因子 |
JPS60232097A (ja) * | 1984-04-23 | 1985-11-18 | Dainippon Pharmaceut Co Ltd | ヒト癌壊死因子ポリペプチドの製造法 |
US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
DE3421731A1 (de) * | 1984-06-12 | 1985-12-12 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Humaner-tumor-nekrose-faktor |
JP2675294B2 (ja) * | 1984-10-15 | 1997-11-12 | カイロン コーポレイション | ヒト腫瘍壊死因子 |
JP2515975B2 (ja) * | 1985-02-26 | 1996-07-10 | 大日本製薬株式会社 | 抗腫瘍作用を有するポリペプチド |
-
1985
- 1985-07-02 GR GR851626A patent/GR851626B/el unknown
- 1985-07-03 FI FI852626A patent/FI95472C/fi not_active IP Right Cessation
- 1985-07-03 IL IL7571785A patent/IL75717A/en not_active IP Right Cessation
- 1985-07-03 DE DE1999175064 patent/DE19975064I2/de active Active
- 1985-07-03 NO NO852673A patent/NO852673L/no unknown
- 1985-07-03 EP EP85304758A patent/EP0168214B1/en not_active Expired - Lifetime
- 1985-07-03 IL IL10527185A patent/IL105271A/en not_active IP Right Cessation
- 1985-07-03 AT AT85304758T patent/ATE113295T1/de not_active IP Right Cessation
- 1985-07-03 NZ NZ212632A patent/NZ212632A/xx unknown
- 1985-07-03 DE DE3587939T patent/DE3587939T2/de not_active Expired - Lifetime
- 1985-07-04 DK DK305885A patent/DK169894B1/da not_active IP Right Cessation
- 1985-07-04 IE IE169185A patent/IE65426B1/en not_active IP Right Cessation
- 1985-07-04 AU AU44652/85A patent/AU599571B2/en not_active Expired
- 1985-07-04 BG BG070958A patent/BG60250B1/bg unknown
- 1985-07-04 HU HU852602A patent/HU209153B/hu unknown
- 1985-07-05 SK SK5067-85A patent/SK506785A3/sk not_active IP Right Cessation
- 1985-07-05 PL PL85254399A patent/PL155778B1/pl unknown
- 1985-07-05 CZ CS855067A patent/CZ283149B6/cs not_active IP Right Cessation
- 1985-07-05 JP JP60149075A patent/JP2557341B2/ja not_active Expired - Lifetime
- 1985-07-08 YU YU113285A patent/YU47968B/sh unknown
-
1994
- 1994-06-24 DK DK075694A patent/DK171418B1/da not_active IP Right Cessation
- 1994-08-15 FI FI943750A patent/FI98217C/fi not_active IP Right Cessation
-
1995
- 1995-01-19 JP JP7006453A patent/JP2614989B2/ja not_active Expired - Lifetime
- 1995-01-19 JP JP7006437A patent/JPH07291997A/ja active Pending
-
1996
- 1996-07-23 JP JP8193520A patent/JPH0928387A/ja active Pending
-
1999
- 1999-10-06 LU LU90456C patent/LU90456I2/fr unknown
- 1999-10-12 NL NL990033C patent/NL990033I2/nl unknown
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US4650674A (en) | Synergistic cytotoxic composition | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
CTFF | Application for supplementary protection certificate (spc) filed |
Free format text: CA 1999 00024, 19991011, EXPIRES: 20100704 |
|
PUP | Patent expired |