ATE116367T1 - Für antitumor-polypeptide kodierende dns, die polypeptide und diese polypeptide enthaltenden antitumor-wirkstoffe. - Google Patents

Für antitumor-polypeptide kodierende dns, die polypeptide und diese polypeptide enthaltenden antitumor-wirkstoffe.

Info

Publication number
ATE116367T1
ATE116367T1 AT87400261T AT87400261T ATE116367T1 AT E116367 T1 ATE116367 T1 AT E116367T1 AT 87400261 T AT87400261 T AT 87400261T AT 87400261 T AT87400261 T AT 87400261T AT E116367 T1 ATE116367 T1 AT E116367T1
Authority
AT
Austria
Prior art keywords
leu
ala
gln
glu
gly
Prior art date
Application number
AT87400261T
Other languages
English (en)
Inventor
Den Ichi Mizuno
Gen-Ichiro Soma
Original Assignee
Den Ichi Mizuno
Soma Genichiro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61169522A external-priority patent/JP2544114B2/ja
Application filed by Den Ichi Mizuno, Soma Genichiro filed Critical Den Ichi Mizuno
Application granted granted Critical
Publication of ATE116367T1 publication Critical patent/ATE116367T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT87400261T 1986-02-04 1987-02-04 Für antitumor-polypeptide kodierende dns, die polypeptide und diese polypeptide enthaltenden antitumor-wirkstoffe. ATE116367T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2130286 1986-02-04
JP2422086 1986-02-07
JP61169522A JP2544114B2 (ja) 1985-11-15 1986-07-17 新規ｄｎａ及びそれを含有する新規プラスミド

Publications (1)

Publication Number Publication Date
ATE116367T1 true ATE116367T1 (de) 1995-01-15

Family

ID=27283374

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87400261T ATE116367T1 (de) 1986-02-04 1987-02-04 Für antitumor-polypeptide kodierende dns, die polypeptide und diese polypeptide enthaltenden antitumor-wirkstoffe.

Country Status (5)

Country Link
US (1) US5081021A (de)
EP (1) EP0247906B1 (de)
AT (1) ATE116367T1 (de)
CA (1) CA1340998C (de)
DE (1) DE3750915T2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006625A2 (en) * 1987-02-26 1988-09-07 Cetus Corporation Arginine-depleted human tumor necrosis factor
US6569679B1 (en) 1988-03-21 2003-05-27 Chiron Corporation Producer cell that generates adenoviral vectors encoding a cytokine and a conditionally lethal gene
US5716826A (en) * 1988-03-21 1998-02-10 Chiron Viagene, Inc. Recombinant retroviruses
US6133029A (en) * 1988-03-21 2000-10-17 Chiron Corporation Replication defective viral vectors for infecting human cells
US6241982B1 (en) 1988-03-21 2001-06-05 Chiron Corporation Method for treating brain cancer with a conditionally lethal gene
JP2828988B2 (ja) * 1988-04-03 1998-11-25 源一郎 杣 新規ｄｎａとその生産方法、それを有する新規プラスミド、新規ポリペプチドとその生産方法、及び該ポリペプチドからなる新規抗腫瘍剤
DE3841755A1 (de) * 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
DE3841763A1 (de) * 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide
ATE199398T1 (de) * 1989-10-24 2001-03-15 Chiron Corp Sekretion vom mit gamma-interferon signalpeptid gebundenen humänen protein
DK53291D0 (da) * 1991-03-25 1991-03-25 Carlbiotech Ltd As Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser
CA2158936C (en) 1993-11-18 2012-02-21 Jack R. Barber Compositions and methods for utilizing conditionally lethal genes
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
CN1049663C (zh) * 1994-09-01 2000-02-23 中国科学院上海生物工程研究中心 突变的人肿瘤坏死因子
US20070172449A1 (en) * 2000-03-02 2007-07-26 Xencor, Inc. TNF-alpha VARIANT FORMULATIONS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
US7687461B2 (en) * 2000-03-02 2010-03-30 Xencor, Inc. Treatment of TNF-α related disorders with TNF-α variant proteins
US7056695B2 (en) 2000-03-02 2006-06-06 Xencor TNF-α variants
US7662367B2 (en) * 2000-03-02 2010-02-16 Xencor, Inc. Pharmaceutical compositions for the treatment of TNF-α related disorders
US7101974B2 (en) 2000-03-02 2006-09-05 Xencor TNF-αvariants
US7244823B2 (en) * 2000-03-02 2007-07-17 Xencor TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
US7446174B2 (en) 2001-03-02 2008-11-04 Xencor, Inc. Protein based TNF-α variants for the treatment of TNF-α related disorders
WO2004050683A2 (en) * 2002-12-02 2004-06-17 Abgenix, Inc. Antibodies directed to tumor necrosis factor and uses thereof
US7964470B2 (en) * 2006-03-01 2011-06-21 Taiwan Semiconductor Manufacturing Company, Ltd. Flexible processing method for metal-insulator-metal capacitor formation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769326A (en) * 1980-02-29 1988-09-06 The Regents Of The University Of California Expression linkers
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
EP0155549B1 (de) * 1984-03-06 1991-03-20 Dainippon Pharmaceutical Co., Ltd. DNS den menschlichen Tumornekrosisfaktor kodierend und das menschliche Tumornekronisfaktor-Polypeptid
GR851626B (de) * 1984-07-05 1985-11-26 Genentech Inc
US4677063A (en) * 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US4677069A (en) * 1984-12-18 1987-06-30 Cornell Research Foundation, Inc. Clam derived proteinases
DE3585690D1 (de) * 1984-12-21 1992-04-23 Biogen Inc Reinigung, herstellung und verwendung von tumor-nekrosisfaktoren.
EP0205038A1 (de) * 1985-05-29 1986-12-17 Suntory Limited Polypeptid, Verfahren zu dessen Herstellung, Mikroorganismus und pharmazeutische Verwendung
JPS6248634A (ja) * 1985-07-23 1987-03-03 Mochida Pharmaceut Co Ltd 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物
JPH064675B2 (ja) * 1985-07-29 1994-01-19 伝一 水野 抗腫瘍性ポリペプチド
JPH0698004B2 (ja) * 1985-09-30 1994-12-07 サントリー株式会社 Ｔｎｆ発現用新規プラスミド
JPS6293233A (ja) * 1985-10-18 1987-04-28 Denichi Mizuno Ｄｎａ及びそれを有する微生物を用いる抗腫瘍性ポリペプチドの製造法
DE3750056T2 (de) * 1986-06-20 1995-04-06 Dainippon Pharmaceutical Co Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.

Also Published As

Publication number Publication date
EP0247906A2 (de) 1987-12-02
DE3750915T2 (de) 1995-08-24
EP0247906A3 (en) 1988-12-07
CA1340998C (en) 2000-05-23
DE3750915D1 (de) 1995-02-09
US5081021A (en) 1992-01-14
EP0247906B1 (de) 1994-12-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee