BG50834A3 - Метод за получаване на 3-ацил-2-оксиндол-1-карбоксамиди - Google Patents

Метод за получаване на 3-ацил-2-оксиндол-1-карбоксамиди

Info

Publication number
BG50834A3
BG50834A3 BG090022A BG9002289A BG50834A3 BG 50834 A3 BG50834 A3 BG 50834A3 BG 090022 A BG090022 A BG 090022A BG 9002289 A BG9002289 A BG 9002289A BG 50834 A3 BG50834 A3 BG 50834A3
Authority
BG
Bulgaria
Prior art keywords
oxindole
carboxamides
acyl
preparation
general formula
Prior art date
Application number
BG090022A
Other languages
English (en)
Inventor
Thomas Crawford
Lawrence Reiter
Original Assignee
Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware filed Critical Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Publication of BG50834A3 publication Critical patent/BG50834A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Методът намира приложение за получаване на противовъзпалителни средства от нестероиден тип с обща формула
BG090022A 1988-10-18 1989-10-16 Метод за получаване на 3-ацил-2-оксиндол-1-карбоксамиди BG50834A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1988/003658 WO1990004393A1 (en) 1988-10-18 1988-10-18 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Publications (1)

Publication Number Publication Date
BG50834A3 true BG50834A3 (bg) 1992-11-16

Family

ID=22208957

Family Applications (1)

Application Number Title Priority Date Filing Date
BG090022A BG50834A3 (bg) 1988-10-18 1989-10-16 Метод за получаване на 3-ацил-2-оксиндол-1-карбоксамиди

Country Status (33)

Country Link
US (1) US5118703A (bg)
JP (1) JPH07597B2 (bg)
KR (1) KR910007237B1 (bg)
CN (1) CN1022241C (bg)
AP (1) AP118A (bg)
AR (1) AR246519A1 (bg)
AT (1) ATE125794T1 (bg)
AU (1) AU606819B2 (bg)
BG (1) BG50834A3 (bg)
CA (1) CA1339558C (bg)
CZ (1) CZ278983B6 (bg)
DD (1) DD285604A5 (bg)
DK (1) DK514989A (bg)
EG (1) EG19887A (bg)
FI (1) FI95253C (bg)
HU (1) HU208421B (bg)
IE (1) IE66586B1 (bg)
IL (1) IL91960A (bg)
IS (1) IS1598B (bg)
MA (1) MA21657A1 (bg)
MX (1) MX18021A (bg)
MY (1) MY104238A (bg)
NO (1) NO178027C (bg)
NZ (1) NZ231044A (bg)
OA (1) OA09140A (bg)
PH (1) PH27554A (bg)
PL (2) PL163112B1 (bg)
PT (1) PT92000B (bg)
RO (1) RO109195B1 (bg)
RU (1) RU2036905C1 (bg)
SK (1) SK590689A3 (bg)
WO (1) WO1990004393A1 (bg)
YU (1) YU48070B (bg)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides
BR9307503A (pt) * 1992-11-23 1999-06-29 Pfizer Síntese regiosseletiva da ácido 4-cloro-2 tiofenocarboxícilo
US5270331A (en) * 1993-01-26 1993-12-14 Pfizer, Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
JP2709530B2 (ja) * 1993-02-09 1998-02-04 ファイザー・インク． 抗炎症薬としてのオキシンドール１−［ｎ−（アルコキシカルボニル）］カルボキサミド類および１−（ｎ−カルボキサミド）カルボキサミド類
US5449788A (en) * 1994-01-28 1995-09-12 Catalytica, Inc. Process for preparing 2-oxindole-1-carboxamides
CN1094819C (zh) * 1997-04-30 2002-11-27 大兴株式会社 环状坯料之制造装置
EP0984012A3 (en) * 1998-08-31 2001-01-10 Pfizer Products Inc. Nitric oxide releasing oxindole prodrugs with analgesic and anti-inflammatory properties
EP1223809A4 (en) * 1999-10-26 2004-03-03 Univ Texas Southwestern Med Ct METHODS OF TREATING HAIR LOSS COMPRISING THE ADMINISTRATION OF AN INDOLIN COMPOUND

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE558210A (bg) * 1956-06-08
US3564009A (en) * 1966-01-13 1971-02-16 Sumitomo Chemical Co Process for producing 1-acylindole derivatives
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3923996A (en) * 1972-07-31 1975-12-02 Sandoz Ag 3-Substituted-oxindoles in compositions and methods of treating obesity
IE53102B1 (en) * 1981-05-12 1988-06-22 Ici Plc Pharmaceutical spiro-succinimide derivatives
EP0076606B1 (en) * 1981-10-06 1986-02-05 Imperial Chemical Industries Plc Biochemical process
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
RO105052B1 (en) * 1987-02-02 1994-12-01 Pfizer Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide
EP0365194B1 (en) * 1988-10-18 1995-08-02 Pfizer Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides

Also Published As

Publication number Publication date
MA21657A1 (fr) 1990-07-01
KR910007237B1 (ko) 1991-09-24
SK278175B6 (en) 1996-03-06
CZ590689A3 (en) 1994-04-13
CZ278983B6 (en) 1994-11-16
AP118A (en) 1991-02-22
MX18021A (es) 1993-11-01
JPH02149559A (ja) 1990-06-08
AP8900141A0 (en) 1989-10-31
FI911855A0 (fi) 1991-04-17
SK590689A3 (en) 1996-03-06
CA1339558C (en) 1997-11-25
NO911512D0 (no) 1991-04-17
IL91960A0 (en) 1990-07-12
NZ231044A (en) 1990-12-21
YU200589A (en) 1991-02-28
FI95253B (fi) 1995-09-29
HUT58052A (en) 1992-01-28
KR900006285A (ko) 1990-05-07
AR246519A1 (es) 1994-08-31
ATE125794T1 (de) 1995-08-15
NO911512L (no) 1991-06-12
IE66586B1 (en) 1996-01-24
PT92000A (pt) 1990-04-30
DK514989D0 (da) 1989-10-17
DK514989A (da) 1990-04-19
RU2036905C1 (ru) 1995-06-09
WO1990004393A1 (en) 1990-05-03
NO178027C (no) 1996-01-10
YU48070B (sh) 1997-01-08
OA09140A (fr) 1991-10-31
AU4295689A (en) 1990-04-26
CN1022241C (zh) 1993-09-29
PL162316B1 (pl) 1993-09-30
IL91960A (en) 1994-04-12
FI95253C (fi) 1996-01-10
PL163112B1 (pl) 1994-02-28
HU208421B (en) 1993-10-28
IS3509A7 (is) 1990-04-19
US5118703A (en) 1992-06-02
IS1598B (is) 1996-05-20
AU606819B2 (en) 1991-02-14
EG19887A (en) 1996-03-31
IE893332L (en) 1990-04-18
JPH07597B2 (ja) 1995-01-11
PH27554A (en) 1993-08-18
HU886740D0 (en) 1991-07-29
DD285604A5 (de) 1990-12-19
NO178027B (no) 1995-10-02
PT92000B (pt) 1995-06-30
CN1041938A (zh) 1990-05-09
RO109195B1 (ro) 1994-12-30
MY104238A (en) 1994-02-28

Similar Documents

Publication Publication Date Title
BG49825A3 (bg) Метод за получаване на 10-дихидро-10-деоксо- 11-азаеритронолиди а
ES553821A0 (es) Un procedimiento para la preparacion de nuevas azetidinonas sustituidas.
FI90976C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten indolijohdannaisten ja niiden happoadditiosuolojen valmistamiseksi
DK588486D0 (da) Anvendelse af en forbindelse til behandling af hypoxi
FI850654L (fi) Menetelmä terapeuttisesti käyttökelpoisten pleuromutilinijohdannaisten valmistamiseksi
FI874459A (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten piperidiinijohdannaisten valmistamiseksi
NO874699D0 (no) Fremgangsmaate for frenstilling av nye substituerte cefalosporin-sulfoner.
ES555646A0 (es) Un procedimiento para producir derivados de 4-0-sulfonil-uracilo
ES2054715T3 (es) Nuevos derivados de naftaleno y productos farmaceuticos antialergicos y antiinflamatorios.
BG44204A3 (bg) Метод за получаване на 2-оксииндолови производни
BG50834A3 (bg) Метод за получаване на 3-ацил-2-оксиндол-1-карбоксамиди
GR1000316B (el) Μεθοδος για την παρασκευη μιας ενωσης με γαστρικη ανασταλτικη δραση.
FI893003A (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
ES2038176T3 (es) Un procedimiento para la preparacion de derivados del naftaleno.
FR2355822A1 (fr) Derives d'esters de l'acide indolacetique. utiles comme anti-inflammatoires et analgesiques
FI861821A (fi) Nytt foerfarande foer optisk separation av racemiska blandningar av -naftylpropionsyror
DK45486A (da) Anti-inflammatorisk praeparat
ES2045197T3 (es) N-substituidos-n-nitroso-aminoacetonitrilos, procedimiento para su fabricacion y utilizacion.
FI863471A (fi) Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi
GR1000887B (el) Νεα παραγωγα σπιροφουρανης.
ES547599A0 (es) Un procedimiento para preparar nuevos derivados de ciano-2- bencimidazol
BE850653A (fr) Nouvel inhibiteur de glyco-hydrolases et sa preparation par culture d'un streptomyces
ES2046528T3 (es) Derivados heterotetraciclicos de lactamas, proceso para su preparacion y composiciones farmaceuticas a base de los mismos.
FI92396B (fi) Uusi menetelmä valmistaa metyleenidioksifenantreeniyhdisteitä
IT1091113B (it) Composizioni terapeutiche a base di n-acil-derivati di acido clavulanico e procedimento per produrle