BG50834A3 - Метод за получаване на 3-ацил-2-оксиндол-1-карбоксамиди - Google Patents
Метод за получаване на 3-ацил-2-оксиндол-1-карбоксамидиInfo
- Publication number
- BG50834A3 BG50834A3 BG090022A BG9002289A BG50834A3 BG 50834 A3 BG50834 A3 BG 50834A3 BG 090022 A BG090022 A BG 090022A BG 9002289 A BG9002289 A BG 9002289A BG 50834 A3 BG50834 A3 BG 50834A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- oxindole
- carboxamides
- acyl
- preparation
- general formula
- Prior art date
Links
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Методът намира приложение за получаване на противовъзпалителни средства от нестероиден тип с обща формула
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1988/003658 WO1990004393A1 (en) | 1988-10-18 | 1988-10-18 | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
Publications (1)
Publication Number | Publication Date |
---|---|
BG50834A3 true BG50834A3 (bg) | 1992-11-16 |
Family
ID=22208957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG090022A BG50834A3 (bg) | 1988-10-18 | 1989-10-16 | Метод за получаване на 3-ацил-2-оксиндол-1-карбоксамиди |
Country Status (33)
Country | Link |
---|---|
US (1) | US5118703A (bg) |
JP (1) | JPH07597B2 (bg) |
KR (1) | KR910007237B1 (bg) |
CN (1) | CN1022241C (bg) |
AP (1) | AP118A (bg) |
AR (1) | AR246519A1 (bg) |
AT (1) | ATE125794T1 (bg) |
AU (1) | AU606819B2 (bg) |
BG (1) | BG50834A3 (bg) |
CA (1) | CA1339558C (bg) |
CZ (1) | CZ278983B6 (bg) |
DD (1) | DD285604A5 (bg) |
DK (1) | DK514989A (bg) |
EG (1) | EG19887A (bg) |
FI (1) | FI95253C (bg) |
HU (1) | HU208421B (bg) |
IE (1) | IE66586B1 (bg) |
IL (1) | IL91960A (bg) |
IS (1) | IS1598B (bg) |
MA (1) | MA21657A1 (bg) |
MX (1) | MX18021A (bg) |
MY (1) | MY104238A (bg) |
NO (1) | NO178027C (bg) |
NZ (1) | NZ231044A (bg) |
OA (1) | OA09140A (bg) |
PH (1) | PH27554A (bg) |
PL (2) | PL163112B1 (bg) |
PT (1) | PT92000B (bg) |
RO (1) | RO109195B1 (bg) |
RU (1) | RU2036905C1 (bg) |
SK (1) | SK590689A3 (bg) |
WO (1) | WO1990004393A1 (bg) |
YU (1) | YU48070B (bg) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
BR9307503A (pt) * | 1992-11-23 | 1999-06-29 | Pfizer | Síntese regiosseletiva da ácido 4-cloro-2 tiofenocarboxícilo |
US5270331A (en) * | 1993-01-26 | 1993-12-14 | Pfizer, Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
JP2709530B2 (ja) * | 1993-02-09 | 1998-02-04 | ファイザー・インク. | 抗炎症薬としてのオキシンドール1−[n−(アルコキシカルボニル)]カルボキサミド類および1−(n−カルボキサミド)カルボキサミド類 |
US5449788A (en) * | 1994-01-28 | 1995-09-12 | Catalytica, Inc. | Process for preparing 2-oxindole-1-carboxamides |
CN1094819C (zh) * | 1997-04-30 | 2002-11-27 | 大兴株式会社 | 环状坯料之制造装置 |
EP0984012A3 (en) * | 1998-08-31 | 2001-01-10 | Pfizer Products Inc. | Nitric oxide releasing oxindole prodrugs with analgesic and anti-inflammatory properties |
EP1223809A4 (en) * | 1999-10-26 | 2004-03-03 | Univ Texas Southwestern Med Ct | METHODS OF TREATING HAIR LOSS COMPRISING THE ADMINISTRATION OF AN INDOLIN COMPOUND |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE558210A (bg) * | 1956-06-08 | |||
US3564009A (en) * | 1966-01-13 | 1971-02-16 | Sumitomo Chemical Co | Process for producing 1-acylindole derivatives |
BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
US3923996A (en) * | 1972-07-31 | 1975-12-02 | Sandoz Ag | 3-Substituted-oxindoles in compositions and methods of treating obesity |
IE53102B1 (en) * | 1981-05-12 | 1988-06-22 | Ici Plc | Pharmaceutical spiro-succinimide derivatives |
EP0076606B1 (en) * | 1981-10-06 | 1986-02-05 | Imperial Chemical Industries Plc | Biochemical process |
US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
US4752609A (en) * | 1985-06-20 | 1988-06-21 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
RO105052B1 (en) * | 1987-02-02 | 1994-12-01 | Pfizer | Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide |
EP0365194B1 (en) * | 1988-10-18 | 1995-08-02 | Pfizer Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
-
1988
- 1988-10-18 WO PCT/US1988/003658 patent/WO1990004393A1/en active IP Right Grant
- 1988-10-18 HU HU886740A patent/HU208421B/hu not_active IP Right Cessation
- 1988-10-18 US US07/675,883 patent/US5118703A/en not_active Expired - Lifetime
- 1988-10-18 SK SK5906-89A patent/SK590689A3/sk unknown
- 1988-10-18 RO RO147347A patent/RO109195B1/ro unknown
- 1988-10-18 MX MX1802188A patent/MX18021A/es unknown
-
1989
- 1989-09-20 IS IS3509A patent/IS1598B/is unknown
- 1989-09-28 CA CA000614317A patent/CA1339558C/en not_active Expired - Fee Related
- 1989-10-04 PH PH39329A patent/PH27554A/en unknown
- 1989-10-09 AT AT89310319T patent/ATE125794T1/de active
- 1989-10-12 IL IL9196089A patent/IL91960A/xx not_active IP Right Cessation
- 1989-10-16 YU YU200589A patent/YU48070B/sh unknown
- 1989-10-16 MY MYPI89001415A patent/MY104238A/en unknown
- 1989-10-16 BG BG090022A patent/BG50834A3/bg unknown
- 1989-10-16 AP APAP/P/1989/000141A patent/AP118A/en active
- 1989-10-16 PT PT92000A patent/PT92000B/pt not_active IP Right Cessation
- 1989-10-17 CN CN89107943A patent/CN1022241C/zh not_active Expired - Fee Related
- 1989-10-17 OA OA59665A patent/OA09140A/xx unknown
- 1989-10-17 AU AU42956/89A patent/AU606819B2/en not_active Ceased
- 1989-10-17 NZ NZ231044A patent/NZ231044A/en unknown
- 1989-10-17 JP JP1270174A patent/JPH07597B2/ja not_active Expired - Lifetime
- 1989-10-17 IE IE333289A patent/IE66586B1/en not_active IP Right Cessation
- 1989-10-17 KR KR1019890014914A patent/KR910007237B1/ko not_active IP Right Cessation
- 1989-10-17 PL PL89296831A patent/PL163112B1/pl unknown
- 1989-10-17 MA MA21909A patent/MA21657A1/fr unknown
- 1989-10-17 PL PL89281871A patent/PL162316B1/pl unknown
- 1989-10-17 DD DD89333653A patent/DD285604A5/de not_active IP Right Cessation
- 1989-10-17 AR AR89315179A patent/AR246519A1/es active
- 1989-10-17 DK DK514989A patent/DK514989A/da not_active Application Discontinuation
- 1989-10-18 EG EG49689A patent/EG19887A/xx active
- 1989-10-18 CZ CS895906A patent/CZ278983B6/cs not_active IP Right Cessation
-
1991
- 1991-04-17 FI FI911855A patent/FI95253C/fi not_active IP Right Cessation
- 1991-04-17 NO NO911512A patent/NO178027C/no unknown
- 1991-04-17 RU SU914895525A patent/RU2036905C1/ru active
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