BG49941A3 - Метод за получаване на рекомбинантен колонии стимулиращ фактор-1 - Google Patents

Метод за получаване на рекомбинантен колонии стимулиращ фактор-1

Info

Publication number
BG49941A3
BG49941A3 BG076601A BG7660186A BG49941A3 BG 49941 A3 BG49941 A3 BG 49941A3 BG 076601 A BG076601 A BG 076601A BG 7660186 A BG7660186 A BG 7660186A BG 49941 A3 BG49941 A3 BG 49941A3
Authority
BG
Bulgaria
Prior art keywords
colonniade
recombinated
preparing
stimulating factor
eukaryotic
Prior art date
Application number
BG076601A
Other languages
English (en)
Inventor
Ernest Kawasaki
Janelle Noble Arsdell
Peter Ralph
Mary Warren
Martha Ladner
Alice Wang
Mazie Coyne
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of BG49941A3 publication Critical patent/BG49941A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Методът намира приложение в експерименталната клинична практика. Той създава възможност за използване на различн и контролни системи и вектори, позволяващи експресия в еукариотни и прокариотни гостоприемници. Методът се осъществява чрез култивиране на рекомбинантни клеткигостоприемници, трансформирани с репликативен клониращ вектор, който кодира човешки или муринов сsf-1 полипептид.5 претенции
BG076601A 1985-02-05 1986-10-01 Метод за получаване на рекомбинантен колонии стимулиращ фактор-1 BG49941A3 (bg)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US69835985A 1985-02-05 1985-02-05
US72883485A 1985-04-30 1985-04-30
US74492485A 1985-06-14 1985-06-14
US75681485A 1985-07-18 1985-07-18
US82106886A 1986-01-21 1986-01-21
PCT/US1986/000238 WO1986004607A1 (en) 1985-02-05 1986-02-03 Recombinant colony stimulating factor-1

Publications (1)

Publication Number Publication Date
BG49941A3 true BG49941A3 (bg) 1992-03-16

Family

ID=27542097

Family Applications (1)

Application Number Title Priority Date Filing Date
BG076601A BG49941A3 (bg) 1985-02-05 1986-10-01 Метод за получаване на рекомбинантен колонии стимулиращ фактор-1

Country Status (11)

Country Link
US (1) US5470569A (bg)
EP (1) EP0209601B1 (bg)
JP (2) JP2561255B2 (bg)
AU (2) AU594045B2 (bg)
BG (1) BG49941A3 (bg)
DE (1) DE3689391T2 (bg)
DK (1) DK172843B1 (bg)
FI (1) FI100972B (bg)
IL (1) IL77789A (bg)
NO (1) NO179109C (bg)
WO (1) WO1986004607A1 (bg)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156300A (en) * 1985-02-05 2000-12-05 Chiron Corporation Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof
US5837229A (en) * 1985-02-05 1998-11-17 Chiron Corporation Uses of recombinant colony stimulating factor-1
US6146851A (en) * 1985-02-05 2000-11-14 Chiron Corporation DNA encoding NV2 (long form) and carboxy truncated fragments thereof
US5792450A (en) * 1985-02-05 1998-08-11 Chiron Corporation Purified human CSF-1
US5422105A (en) * 1985-02-05 1995-06-06 Cetus Oncology Corporation Use of recombinant colony stimulating factor 1
US5104650A (en) * 1985-02-05 1992-04-14 Cetus Corporation Uses of recombinant colony stimulating factor-1
US5556620A (en) * 1985-02-05 1996-09-17 Cetus Oncology Corporation Use of recombinant colony stimulating factor-1 to enhance wound healing
WO1986004607A1 (en) * 1985-02-05 1986-08-14 Cetus Corporation Recombinant colony stimulating factor-1
US5573930A (en) 1985-02-05 1996-11-12 Cetus Oncology Corporation DNA encoding various forms of colony stimulating factor-1
JP2579981B2 (ja) * 1986-05-06 1997-02-12 ジェネティックス・インスチチュート・インコーポレーテッド Ｍ―ｃｓｆの生産方法
AU7410987A (en) * 1986-06-12 1988-01-07 Immunex Corp. Polypeptides devoid of hydrophobic amino acids
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子
US5650297A (en) * 1986-09-17 1997-07-22 Otsuka Pharmaceutical Co., Ltd. DNA encoding human colony-stimulating factors
HU215241B (hu) * 1986-10-24 1998-11-30 Cetus Corp. Eljárás telepstimuláló faktor-1 új formáinak előállítására, valamint az eljárásban alkalmazható expressziós kazetta, vektor és rekombináns gazdasejtek előállítására
AU8313187A (en) * 1986-12-31 1988-07-07 Cetus Corporation Pharmaceutical composition of colony stimulating factor-i and granulocyte colony stimulating factor
CA1339757C (en) 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
AU625807B2 (en) * 1987-09-22 1992-07-16 Novartis Vaccines And Diagnostics, Inc. Uses of recombinant colony stimulating factor-1
JP2791418B2 (ja) 1987-12-02 1998-08-27 株式会社ミドリ十字 異種蛋白質の製造方法、組換えｄｎａ、形質転換体
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
DK54589A (da) * 1988-02-08 1989-08-09 Otsuka Pharma Co Ltd Humane kolonistmulerende faktorer
WO1989010407A1 (en) * 1988-04-29 1989-11-02 Genetics Institute, Inc. Homogeneous dimeric m-csf and storage stable formulations thereof
US5888495A (en) * 1988-05-23 1999-03-30 Genetics Institute, Inc. Method of producing storage stable M-CSF lyophilizates
US5171675A (en) * 1988-07-28 1992-12-15 Cerretti Douglas P Macrophage colony stimulating factor-γ
DE69022606T2 (de) * 1989-02-28 1996-05-02 Morinaga Milk Industry Co Ltd Menschlichen Monozyt-Makrophagen-Koloniestimulierungsfaktor enthaltende Zusammensetzung.
US5288487A (en) * 1989-02-28 1994-02-22 Morinaga Milk Industry Co., Ltd. Human monocyte-macrophage-CSF preparations
JPH02225418A (ja) * 1989-02-28 1990-09-07 Morinaga Milk Ind Co Ltd 抗悪性腫瘍剤
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
WO1999024582A1 (en) * 1997-11-07 1999-05-20 Dalhousie University Novel reovirus-derived proteins, nucleic acids encoding same, and uses therefor
US7108852B2 (en) * 2000-03-20 2006-09-19 Warner-Lambert Company Llc Methods of treating inflammation using antibodies to M-CSF
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
US20070099239A1 (en) * 2005-06-24 2007-05-03 Raymond Tabibiazar Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6030291B2 (ja) * 1978-03-20 1985-07-16 森永乳業株式会社 人顆粒球の分化増殖を促進するｈｇｉ糖蛋白質、ｈｇｉ糖蛋白質の製造法及びｈｇｉ糖蛋白質を含有する白血球減少症治療剤
US4230697A (en) * 1978-07-03 1980-10-28 Morinaga Milk Industry Co. Ltd. Virus-inactivated HGI-glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same
US4342828A (en) * 1979-07-20 1982-08-03 Morinaga Milk Industry Co., Ltd. Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
JPS5758629A (en) * 1980-09-25 1982-04-08 Morinaga Milk Ind Co Ltd Separating and purifying method of colonization stimulating factor and callicrein in human urine
JPS6030654B2 (ja) * 1980-12-31 1985-07-17 株式会社林原生物化学研究所 ヒトコロニ−刺激因子の製造方法
US4438032A (en) 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
US4432895A (en) * 1982-11-24 1984-02-21 Hoffmann-La Roche Inc. Monomeric interferons
US4485017A (en) * 1982-12-22 1984-11-27 Cetus Corporation Isolation of human interferon by immunosorbent and high performance liquid chromatography
JPS59137417A (ja) * 1983-01-28 1984-08-07 Morinaga Milk Ind Co Ltd 人尿由来コロニ−形成刺激因子及びカリクレインの製造法
US4504586A (en) * 1983-02-03 1985-03-12 Amgen Hybridoma tumor cell lines and their monoclonal antibodies to human colony stimulating factor subclass number 1
JPS6041615A (ja) * 1983-08-12 1985-03-05 Green Cross Corp:The コロニ−形成刺激因子の製造方法
US4658018A (en) * 1984-03-13 1987-04-14 Immunex Corporation Process for producing homogeneous colony stimulating factor
JPS61227526A (ja) * 1984-07-25 1986-10-09 Chugai Pharmaceut Co Ltd 新規なコロニー刺激因子
WO1986004587A1 (en) * 1985-02-05 1986-08-14 Cetus Corporation Purification of native colony stimulating factor-1
WO1986004607A1 (en) * 1985-02-05 1986-08-14 Cetus Corporation Recombinant colony stimulating factor-1
JPS629323A (ja) * 1985-07-08 1987-01-17 Seiko Epson Corp 液晶素子の駆動方法
JPH0764742B2 (ja) * 1985-11-27 1995-07-12 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド Ａｉｄｓ型疾患治療用組成物
JP2579981B2 (ja) * 1986-05-06 1997-02-12 ジェネティックス・インスチチュート・インコーポレーテッド Ｍ―ｃｓｆの生産方法
US4879227A (en) * 1986-05-06 1989-11-07 Genetics Institute, Inc. Production of a recombinant human colony stimulating factor
US4868119A (en) * 1986-12-11 1989-09-19 Genetics Institute, Inc. Hematopoietic growth factors
AU7410987A (en) * 1986-06-12 1988-01-07 Immunex Corp. Polypeptides devoid of hydrophobic amino acids
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子
US5171675A (en) * 1988-07-28 1992-12-15 Cerretti Douglas P Macrophage colony stimulating factor-γ

Also Published As

Publication number Publication date
IL77789A (en) 1992-03-29
NO179109B (no) 1996-04-29
NO179109C (no) 1996-08-07
AU5013090A (en) 1990-11-01
AU626639B2 (en) 1992-08-06
JPH07163391A (ja) 1995-06-27
FI864016A (fi) 1986-10-03
JP2561255B2 (ja) 1996-12-04
AU594045B2 (en) 1990-03-01
DE3689391D1 (de) 1994-01-27
WO1986004607A1 (en) 1986-08-14
US5470569A (en) 1995-11-28
NO863952D0 (no) 1986-10-03
DE3689391T2 (de) 1994-06-30
FI864016A0 (fi) 1986-10-03
FI100972B (fi) 1998-03-31
EP0209601B1 (en) 1993-12-15
NO863952L (no) 1986-10-03
DK474686D0 (da) 1986-10-03
DK172843B1 (da) 1999-08-09
DK474686A (da) 1986-12-05
JPS62501607A (ja) 1987-07-02
AU5517386A (en) 1986-08-26
JP2553829B2 (ja) 1996-11-13
EP0209601A1 (en) 1987-01-28

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