BG106998A - АНТИ-EGFRvIII SCFVS С ПОДОБРЕНА ЦИТОТОКСИЧНОСТ И ДОБИВ, ИМУНОТОКСИНИ НА БАЗАТА НА THEREON И МЕТОДИ ЗА ТЯХНОТО ПРИЛОЖЕНИЕ - Google Patents

АНТИ-EGFRvIII SCFVS С ПОДОБРЕНА ЦИТОТОКСИЧНОСТ И ДОБИВ, ИМУНОТОКСИНИ НА БАЗАТА НА THEREON И МЕТОДИ ЗА ТЯХНОТО ПРИЛОЖЕНИЕ Download PDF

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Publication number
BG106998A
BG106998A BG106998A BG10699802A BG106998A BG 106998 A BG106998 A BG 106998A BG 106998 A BG106998 A BG 106998A BG 10699802 A BG10699802 A BG 10699802A BG 106998 A BG106998 A BG 106998A
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BG
Bulgaria
Prior art keywords
polypeptide
amino acid
antibody
cdr3
variable region
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BG106998A
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Bulgarian (bg)
English (en)
Inventor
Ira Pastan
Richard Beers
Partha Chowdhury
Darell Bigner
Original Assignee
THE GOVERNMEMT OF THE UNITED STATES as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH-ANDHUMAN
Duke University
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Application filed by THE GOVERNMEMT OF THE UNITED STATES as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH-ANDHUMAN, Duke University filed Critical THE GOVERNMEMT OF THE UNITED STATES as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH-ANDHUMAN
Publication of BG106998A publication Critical patent/BG106998A/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BG106998A 2000-02-25 2002-08-14 АНТИ-EGFRvIII SCFVS С ПОДОБРЕНА ЦИТОТОКСИЧНОСТ И ДОБИВ, ИМУНОТОКСИНИ НА БАЗАТА НА THEREON И МЕТОДИ ЗА ТЯХНОТО ПРИЛОЖЕНИЕ BG106998A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18503900P 2000-02-25 2000-02-25
PCT/US2001/005923 WO2001062931A2 (fr) 2000-02-25 2001-02-23 SCFV ANTI-EGFRvIII POSSEDANT UNE CYTOTOXICITE ET UN RENDEMENT AMELIORES, IMMUNOTOXINES A BASE DE CES SCFV ET PROCEDE D'UTILISATION ASSOCIE

Publications (1)

Publication Number Publication Date
BG106998A true BG106998A (bg) 2003-07-31

Family

ID=22679306

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106998A BG106998A (bg) 2000-02-25 2002-08-14 АНТИ-EGFRvIII SCFVS С ПОДОБРЕНА ЦИТОТОКСИЧНОСТ И ДОБИВ, ИМУНОТОКСИНИ НА БАЗАТА НА THEREON И МЕТОДИ ЗА ТЯХНОТО ПРИЛОЖЕНИЕ

Country Status (22)

Country Link
US (1) US7129332B2 (fr)
EP (1) EP1266009B1 (fr)
JP (1) JP2003523771A (fr)
KR (1) KR100812658B1 (fr)
CN (1) CN1427891A (fr)
AT (1) ATE419354T1 (fr)
AU (2) AU2001239857B9 (fr)
BG (1) BG106998A (fr)
BR (1) BR0108646A (fr)
CA (1) CA2400868C (fr)
DE (1) DE60137202D1 (fr)
HR (1) HRP20020769A2 (fr)
HU (1) HUP0204142A3 (fr)
MX (1) MXPA02008178A (fr)
NO (1) NO20024034L (fr)
NZ (1) NZ520622A (fr)
PL (1) PL357448A1 (fr)
RU (1) RU2317999C2 (fr)
SK (1) SK12232002A3 (fr)
UA (1) UA77157C2 (fr)
WO (1) WO2001062931A2 (fr)
YU (1) YU63302A (fr)

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