BG106451A - Глюкопиранозилоксипиразолови производни, лекарствени състави, които ги съдържат и междинни съединения за тяхното получаване - Google Patents

Глюкопиранозилоксипиразолови производни, лекарствени състави, които ги съдържат и междинни съединения за тяхното получаване

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Publication number
BG106451A
BG106451A BG06451A BG10645102A BG106451A BG 106451 A BG106451 A BG 106451A BG 06451 A BG06451 A BG 06451A BG 10645102 A BG10645102 A BG 10645102A BG 106451 A BG106451 A BG 106451A
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Bulgaria
Prior art keywords
lower alkyl
intermediates
production
same
compositions containing
Prior art date
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BG06451A
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English (en)
Other versions
BG65388B1 (bg
Inventor
Hideki Fujikura
Toshihiro Nishimura
Kenji Katsuno
Masahiro Hiratochi
Akira Iyobe
Minoru Fujioka
Masayuki Isaji
Original Assignee
Kissei Pharmaceutical Co., Ltd.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17153879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG106451(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kissei Pharmaceutical Co., Ltd. filed Critical Kissei Pharmaceutical Co., Ltd.
Publication of BG106451A publication Critical patent/BG106451A/bg
Publication of BG65388B1 publication Critical patent/BG65388B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретението се отнася до глюкопиранозилоксипиразолови производни или техни фармацевтично приемливи соли, проявяващи инхибиторна активност върху човешки SGLT2 и приложими като средства за профилактика или лечение на диабет, диабетни усложнения или затлъстяване. Изобретението се отнася също до фармацевтични състави, които включват посочените производни, както и до техните междинни съединения. Производните са представени с обща формула@@в която R1 означава водороден атом или нисша алкилна група;един от Q1 и T1 представлява група от формулата@@докато другият е нисша алкилна група или хало(нисша алкилна) група; R2 е водороден атом, нисша алкилна група, нисша алкоксигрупа, нисша алкилтиогрупа,хало(нисша алкилна) група или халогенен атом.
BG106451A 1999-08-31 2002-02-27 Глюкопиранозилоксипиразолови производни, лекарствени състави, които ги съдържат, и междинни съединения за тяхното получаване BG65388B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP24680099 1999-08-31

Publications (2)

Publication Number Publication Date
BG106451A true BG106451A (bg) 2002-09-30
BG65388B1 BG65388B1 (bg) 2008-05-30

Family

ID=17153879

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106451A BG65388B1 (bg) 1999-08-31 2002-02-27 Глюкопиранозилоксипиразолови производни, лекарствени състави, които ги съдържат, и междинни съединения за тяхното получаване

Country Status (29)

Country Link
US (4) US6972283B2 (bg)
EP (1) EP1213296B1 (bg)
JP (1) JP3989730B2 (bg)
KR (1) KR100591585B1 (bg)
CN (1) CN1145635C (bg)
AT (1) ATE264337T1 (bg)
AU (1) AU782330B2 (bg)
BG (1) BG65388B1 (bg)
BR (1) BRPI0013667B8 (bg)
CA (1) CA2382480C (bg)
CZ (1) CZ303372B6 (bg)
DE (1) DE60009929T2 (bg)
DK (1) DK1213296T3 (bg)
ES (1) ES2216937T3 (bg)
HK (1) HK1050369A1 (bg)
HU (1) HU229581B1 (bg)
IL (2) IL148384A0 (bg)
MX (1) MXPA02002271A (bg)
NO (1) NO322703B1 (bg)
NZ (1) NZ517439A (bg)
PL (1) PL203124B1 (bg)
PT (1) PT1213296E (bg)
RU (1) RU2232767C2 (bg)
SK (1) SK286600B6 (bg)
TR (1) TR200201082T2 (bg)
TW (1) TW579378B (bg)
UA (1) UA71994C2 (bg)
WO (1) WO2001016147A1 (bg)
ZA (1) ZA200201991B (bg)

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