DE60141156D1 - Neue pyrazolderivate und diese enthaltende mittel gegen diabetes - Google Patents

Neue pyrazolderivate und diese enthaltende mittel gegen diabetes

Info

Publication number
DE60141156D1
DE60141156D1 DE60141156T DE60141156T DE60141156D1 DE 60141156 D1 DE60141156 D1 DE 60141156D1 DE 60141156 T DE60141156 T DE 60141156T DE 60141156 T DE60141156 T DE 60141156T DE 60141156 D1 DE60141156 D1 DE 60141156D1
Authority
DE
Germany
Prior art keywords
group
lower alkyl
perfluoro
alkyl group
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60141156T
Other languages
English (en)
Inventor
K Ohsumi
T Umemura
H Matsueda
T Hatanaka
A Onuki
K Maezono
Yoko Kageyama
N Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of DE60141156D1 publication Critical patent/DE60141156D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE60141156T 2000-11-02 2001-10-31 Neue pyrazolderivate und diese enthaltende mittel gegen diabetes Expired - Lifetime DE60141156D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000335851 2000-11-02
JP2001131264 2001-04-27
PCT/JP2001/009555 WO2002036602A1 (fr) 2000-11-02 2001-10-31 Nouveaux derives du pyrazole et remedes au diabete contenant ces derniers

Publications (1)

Publication Number Publication Date
DE60141156D1 true DE60141156D1 (de) 2010-03-11

Family

ID=26603344

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60141156T Expired - Lifetime DE60141156D1 (de) 2000-11-02 2001-10-31 Neue pyrazolderivate und diese enthaltende mittel gegen diabetes

Country Status (8)

Country Link
US (6) US6815428B2 (de)
EP (2) EP1338603B1 (de)
JP (1) JP3915116B2 (de)
AT (1) ATE455785T1 (de)
AU (1) AU2002210990A1 (de)
DE (1) DE60141156D1 (de)
ES (1) ES2337127T3 (de)
WO (1) WO2002036602A1 (de)

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CN1238363C (zh) 2000-12-28 2006-01-25 橘生药品工业株式会社 吡喃葡糖氧基吡唑衍生物及其在药物中的应用
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WO2002088157A1 (fr) * 2001-04-27 2002-11-07 Ajinomoto Co., Inc. Derives pyrazolyl-o-glycoside n-substitues et medicament contre le diabete en contenant
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WO2003090783A1 (fr) * 2002-04-26 2003-11-06 Ajinomoto Co., Inc. Agent preventif/remede pour diabete
US7956041B2 (en) 2002-04-26 2011-06-07 Ajinomoto Co., Inc. Prophylactic and therapeutic agent of diabetes mellitus
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JPWO2004089967A1 (ja) * 2003-04-01 2006-07-06 大正製薬株式会社 ヘテロアリール５−チオ−β−Ｄ−グルコピラノシド誘導体及びそれを含有する糖尿病治療薬
US7439232B2 (en) 2003-04-01 2008-10-21 Taisho Pharmaceutical Co., Ltd. Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
ATE384526T1 (de) * 2003-04-14 2008-02-15 Inst For Pharm Discovery Inc N-(((((1,3-thiazol-2- yl)amino)carbonyl)phenyl)sulphonyl)phenylalanin derivate und verwandte verbindungen zur behandlung von diabetes
ES2377741T3 (es) * 2003-06-20 2012-03-30 Kissei Pharmaceutical Co., Ltd. Derivados de pirazol, composición farmacológica que los contiene e intermedios de producción de los mismos
EP1651658B2 (de) 2003-08-01 2020-08-12 Mitsubishi Tanabe Pharma Corporation Neue verbindungen mit inhibierender aktivität gegenüber natriumabhängigen glukosetransporter
US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
US7375090B2 (en) 2003-08-26 2008-05-20 Boehringer Ingelheim International Gmbh Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof
DE502004008951D1 (de) * 2003-08-26 2009-03-19 Boehringer Ingelheim Pharma Glucopyranosyloxy-pyrazole, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
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CA2588963C (en) * 2004-11-18 2013-06-25 Kissei Pharmaceutical Co., Ltd. 1-substituted-3-.beta.-d-glucopyranosylated nitrogenous hetero-cyclic compounds and medicines containing the same
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UY30082A1 (es) 2006-01-11 2007-08-31 Boehringer Ingelheim Int Forma cristalina de 1-(1-metiletil)-4`-((2-fluoro-4-metoxifenil)metil)-5`- metil-1h-pirazol-3`-o-b-d-glucopiranosido, un metodo para su preparacion y el uso de la misma para preparar medicamentos
US7834050B2 (en) 2006-03-29 2010-11-16 Duke University Small molecule insulin mimetics absent quinones
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DE102006028862A1 (de) 2006-06-23 2007-12-27 Merck Patent Gmbh 3-Amino-imidazo[1,2-a]pyridinderivate
US20080020987A1 (en) * 2006-07-20 2008-01-24 Waldemar Pfrengle Processes for preparing pyrazole-O-glycoside derivatives and novel intermediates of said processes
UY30730A1 (es) 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
WO2008070692A2 (en) 2006-12-06 2008-06-12 Smithkline Beecham Corporation Bicyclic compounds and use as antidiabetics
DE102007008420A1 (de) 2007-02-21 2008-08-28 Merck Patent Gmbh Benzimidazolderivate
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PL2488515T3 (pl) 2009-10-14 2017-07-31 Janssen Pharmaceutica Nv Sposób wytwarzania związków użytecznych jako inhibitory sglt2
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WO2011070592A2 (en) 2009-12-09 2011-06-16 Panacea Biotec Ltd. Novel sugar derivatives
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
EP2774619B1 (de) 2013-03-04 2016-05-18 BioActive Food GmbH Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen
EP2944311A1 (de) 2014-05-16 2015-11-18 BioActive Food GmbH Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
US11078502B2 (en) 2017-02-17 2021-08-03 Hyasynth Biologicals Inc. Method and cell line for production of polyketides in yeast
EA202190226A1 (ru) 2018-07-19 2021-06-16 Астразенека Аб СПОСОБЫ ЛЕЧЕНИЯ HFpEF С ИСПОЛЬЗОВАНИЕМ ДАПАГЛИФЛОЗИНА И СОДЕРЖАЩИХ ЕГО КОМПОЗИЦИЙ
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TW202220672A (zh) 2020-07-27 2022-06-01 瑞典商阿斯特捷利康公司 用達格列淨治療慢性腎臟病之方法
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WO2023144722A1 (en) 2022-01-26 2023-08-03 Astrazeneca Ab Dapagliflozin for use in the treatment of prediabetes or reducing the risk of developing type 2 diabetes

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ATE216704T1 (de) 1996-12-26 2002-05-15 Tanabe Seiyaku Co Propiophenonderivate und verfahren zu ihrer herstellung
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ES2337127T3 (es) * 2000-11-02 2010-04-21 Ajinomoto Co., Inc. Nuevos derivados de pirazol y remedios contra la diabetes que los contienen.
CN1238363C (zh) 2000-12-28 2006-01-25 橘生药品工业株式会社 吡喃葡糖氧基吡唑衍生物及其在药物中的应用
WO2002068439A1 (fr) 2001-02-26 2002-09-06 Kissei Pharmaceutical Co., Ltd. Derives de glycopyranosyloxypyrazole et utilisation medicinale de ceux-ci
WO2002088157A1 (fr) 2001-04-27 2002-11-07 Ajinomoto Co., Inc. Derives pyrazolyl-o-glycoside n-substitues et medicament contre le diabete en contenant
JP4115105B2 (ja) 2001-07-02 2008-07-09 協和醗酵工業株式会社 ピラゾール誘導体
US7956041B2 (en) 2002-04-26 2011-06-07 Ajinomoto Co., Inc. Prophylactic and therapeutic agent of diabetes mellitus

Also Published As

Publication number Publication date
ATE455785T1 (de) 2010-02-15
US20070270479A1 (en) 2007-11-22
EP1338603A4 (de) 2007-03-28
US7256209B2 (en) 2007-08-14
JPWO2002036602A1 (ja) 2004-03-11
AU2002210990A1 (en) 2002-05-15
WO2002036602A1 (fr) 2002-05-10
ES2337127T3 (es) 2010-04-21
US20060058244A1 (en) 2006-03-16
US7645787B2 (en) 2010-01-12
US20100063124A1 (en) 2010-03-11
US6815428B2 (en) 2004-11-09
EP1338603A1 (de) 2003-08-27
US20050043249A1 (en) 2005-02-24
US20040006025A1 (en) 2004-01-08
US7247616B2 (en) 2007-07-24
JP3915116B2 (ja) 2007-05-16
EP2163555A1 (de) 2010-03-17
US20070099979A1 (en) 2007-05-03
EP1338603B1 (de) 2010-01-20
US7015201B2 (en) 2006-03-21

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