BG104288A - 6,9-мостови производни на еритромицина - Google Patents

6,9-мостови производни на еритромицина Download PDF

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Publication number
BG104288A
BG104288A BG104288A BG10428800A BG104288A BG 104288 A BG104288 A BG 104288A BG 104288 A BG104288 A BG 104288A BG 10428800 A BG10428800 A BG 10428800A BG 104288 A BG104288 A BG 104288A
Authority
BG
Bulgaria
Prior art keywords
compound
formula
group
hydroxy
protecting group
Prior art date
Application number
BG104288A
Other languages
Bulgarian (bg)
English (en)
Inventor
Yat S. Or
Richard R. Clark
Daniel T. Chu
Jacob J. Plattner
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of BG104288A publication Critical patent/BG104288A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
BG104288A 1997-09-08 2000-03-30 6,9-мостови производни на еритромицина BG104288A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/925,582 US5780605A (en) 1997-09-08 1997-09-08 6,9-bridged erythromycin derivatives
PCT/US1998/018225 WO1999012947A1 (en) 1997-09-08 1998-09-01 6,9-bridged erythromycin derivatives

Publications (1)

Publication Number Publication Date
BG104288A true BG104288A (bg) 2001-01-31

Family

ID=25451953

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104288A BG104288A (bg) 1997-09-08 2000-03-30 6,9-мостови производни на еритромицина

Country Status (24)

Country Link
US (1) US5780605A (da)
EP (1) EP1015467B1 (da)
JP (1) JP2001515915A (da)
KR (1) KR20010023756A (da)
CN (1) CN1269803A (da)
AR (1) AR015434A1 (da)
AT (1) ATE257484T1 (da)
AU (1) AU9216298A (da)
BG (1) BG104288A (da)
BR (1) BR9812148A (da)
CA (1) CA2301643A1 (da)
CO (1) CO4970722A1 (da)
DE (1) DE69821009T2 (da)
DK (1) DK1015467T3 (da)
ES (1) ES2213915T3 (da)
HU (1) HUP0003571A2 (da)
IL (1) IL134220A0 (da)
NO (1) NO20001169L (da)
PL (1) PL339137A1 (da)
PT (1) PT1015467E (da)
SK (1) SK3032000A3 (da)
TR (1) TR200000620T2 (da)
WO (1) WO1999012947A1 (da)
ZA (1) ZA987688B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7464097B2 (en) * 2002-08-16 2008-12-09 Sap Ag Managing data integrity using a filter condition
TW200420573A (en) * 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
WO2004078770A1 (en) * 2003-03-05 2004-09-16 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using the same
US20070149463A1 (en) * 2003-10-30 2007-06-28 Oyelere Adegboyega K Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
US7265094B2 (en) * 2004-01-09 2007-09-04 Enanta Pharmaceuticals, Inc. 9N-substituted 6-11 bicyclic erythromycin derivatives
WO2005080408A1 (en) * 2004-01-23 2005-09-01 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
JP2008540432A (ja) * 2005-05-04 2008-11-20 エナンタ ファーマシューティカルズ インコーポレイテッド ６−１１橋かけオキシムエリスロマイシン誘導体
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
WO2009039177A1 (en) * 2007-09-17 2009-03-26 Enanta Pharmaceuticals, Inc. 6, 11-bicycloides: bridged biaryl macrolide derivatives
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6248696A (ja) * 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
ES2115760T3 (es) * 1992-01-21 1998-07-01 Abbott Lab Derivados de 4''-desoxieritromicina.
DE69301916T2 (de) * 1992-04-22 1996-08-08 Taisho Pharmaceutical Co Ltd 5-0-desosaminylerythronolid a derivate
MY113693A (en) * 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5712253A (en) * 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B

Also Published As

Publication number Publication date
ATE257484T1 (de) 2004-01-15
DK1015467T3 (da) 2004-05-03
DE69821009D1 (de) 2004-02-12
PL339137A1 (en) 2000-12-04
DE69821009T2 (de) 2004-11-18
TR200000620T2 (tr) 2000-09-21
HUP0003571A2 (hu) 2001-02-28
NO20001169L (no) 2000-04-05
EP1015467A1 (en) 2000-07-05
AR015434A1 (es) 2001-05-02
ZA987688B (en) 1999-02-24
WO1999012947A1 (en) 1999-03-18
KR20010023756A (ko) 2001-03-26
ES2213915T3 (es) 2004-09-01
AU9216298A (en) 1999-03-29
CA2301643A1 (en) 1999-03-18
NO20001169D0 (no) 2000-03-07
PT1015467E (pt) 2004-05-31
IL134220A0 (en) 2001-04-30
JP2001515915A (ja) 2001-09-25
EP1015467B1 (en) 2004-01-07
CO4970722A1 (es) 2000-11-07
SK3032000A3 (en) 2000-07-11
BR9812148A (pt) 2000-07-18
US5780605A (en) 1998-07-14
CN1269803A (zh) 2000-10-11

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