BG103856A - Използване на едномерен ядреномагнитен резонанс за идентифициране на лиганди с таргет биомолекули - Google Patents

Използване на едномерен ядреномагнитен резонанс за идентифициране на лиганди с таргет биомолекули

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Publication number
BG103856A
BG103856A BG103856A BG10385699A BG103856A BG 103856 A BG103856 A BG 103856A BG 103856 A BG103856 A BG 103856A BG 10385699 A BG10385699 A BG 10385699A BG 103856 A BG103856 A BG 103856A
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Bulgaria
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application
magnetic resonance
nuclear magnetic
dimensional nuclear
biomolecular targets
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BG103856A
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English (en)
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BG64326B1 (bg
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Stephen FESIK
Philip HAJDUK
Edward OLEJNICZAK
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Abbott Laboratories
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25291882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG103856(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of BG103856A publication Critical patent/BG103856A/bg
Publication of BG64326B1 publication Critical patent/BG64326B1/bg

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/087—Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
    • G01V3/00—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation
    • G01V3/14—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation operating with electron or nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Geology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Remote Sensing (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Изобретението се отнася до метод за идентифициране на съединения, които се свързват със специфична мишена молекула. Той включва следните етапи: а) получаване на първи Т2- или дифузионен филтриран протонен спектър на едно или на смес от химични съединения; b) подлагане на едно или на смес от химичнисъединения на въздействието на мишена молекула; с) получаване на втори Т2- или дифузионен филтриранпротонен спектър на едно или на смес от химични съединения, които са подложени на въздействието на молекула мишена в етап (b), и d) сравняване на първия и втория Т2- или на дифузионните филтрирани протонни спектри, за да се определят разликите между първия и втория спектър, като разликите идентифицират присъствието на едно или повече съединения, които са лиганди, свързали се с мишената молекула.
BG103856A 1997-04-18 1999-11-04 Използване на едномерен ядреномагнитен резонанс за идентифициране на лиганди с таргет биомолекули BG64326B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/844,124 US6043024A (en) 1997-04-18 1997-04-18 Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
PCT/US1998/007907 WO1998048264A1 (en) 1997-04-18 1998-04-17 Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules

Publications (2)

Publication Number Publication Date
BG103856A true BG103856A (bg) 2000-07-31
BG64326B1 BG64326B1 (bg) 2004-09-30

Family

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Family Applications (1)

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BG103856A BG64326B1 (bg) 1997-04-18 1999-11-04 Използване на едномерен ядреномагнитен резонанс за идентифициране на лиганди с таргет биомолекули

Country Status (29)

Country Link
US (1) US6043024A (bg)
EP (1) EP0975954B2 (bg)
JP (1) JP2002507277A (bg)
KR (1) KR100542420B1 (bg)
CN (1) CN1225648C (bg)
AR (1) AR004651A1 (bg)
AT (1) ATE259061T1 (bg)
AU (1) AU7138098A (bg)
BG (1) BG64326B1 (bg)
BR (1) BR9808079A (bg)
CA (1) CA2286795C (bg)
CO (1) CO5060446A1 (bg)
CZ (1) CZ297275B6 (bg)
DE (1) DE69821475T3 (bg)
DK (1) DK0975954T4 (bg)
ES (1) ES2215296T5 (bg)
HK (1) HK1027158A1 (bg)
HU (1) HU228433B1 (bg)
IL (1) IL131726A0 (bg)
NO (1) NO995078L (bg)
NZ (1) NZ337126A (bg)
PL (1) PL194184B1 (bg)
PT (1) PT975954E (bg)
SI (1) SI0975954T1 (bg)
SK (1) SK285411B6 (bg)
TR (1) TR199902167T2 (bg)
TW (1) TW574502B (bg)
WO (1) WO1998048264A1 (bg)
ZA (1) ZA982919B (bg)

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US6344330B1 (en) 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
JP2002534687A (ja) * 1998-12-30 2002-10-15 アメルシャム・パブリック・リミテッド・カンパニー 過分極を使用したｎｍｒ分光学アッセイ
US6333149B1 (en) 1999-06-04 2001-12-25 Triad Biotechnology, Inc. NMR-solve method for rapid identification of bi-ligand drug candidates
CA2383559A1 (en) * 1999-08-23 2001-03-01 Polaris Pharmaceuticals, Inc. Inhibitors of binding between proteins and macromolecular ligands
US6677160B1 (en) 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
US6764858B2 (en) 1999-09-29 2004-07-20 Pharmacia & Upjohn Company Methods for creating a compound library
AU2001251502A1 (en) * 2000-04-17 2001-10-30 Pharmacia And Upjohn Company Nuclear magnetic resonance methods for identifying sites in papillomavirus e2 protein
US7146277B2 (en) * 2000-06-13 2006-12-05 James H. Prestegard NMR assisted design of high affinity ligands for structurally uncharacterized proteins
US20030165431A1 (en) * 2000-07-13 2003-09-04 The Regents Of The University Of California Method for detecting macromolecular conformational change and binding information
US7061237B2 (en) * 2000-07-13 2006-06-13 The Regents Of The University Of California Remote NMR/MRI detection of laser polarized gases
DK1320387T3 (da) * 2000-09-13 2012-07-16 Glaxosmithkline Llc Farmaceutiske sammensætninger til vedvarende afgivelse af peptider
JP5129424B2 (ja) * 2000-09-27 2013-01-30 ユニヴェルシテイト レイデン リガンドの発見または薬物スクリーニング手段としてのｎｍｒ利用法
WO2002050538A2 (en) * 2000-12-21 2002-06-27 Triad Therapeutics, Inc. Sea-trosy and related methods
GB0031566D0 (en) * 2000-12-22 2001-02-07 Mets Ometrix Methods for spectral analysis and their applications
US20030092027A1 (en) * 2001-06-01 2003-05-15 Luciano Mueller Nuclear magnetic resonance method for identifying ligands to target compounds
US20040259092A1 (en) * 2001-08-27 2004-12-23 Carmen Barske Nogo receptor homologues and their use
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KR100888805B1 (ko) * 2002-06-14 2009-03-16 크리스탈지노믹스(주) 특정 아미노산이 표지된 단백질과 1ｄ ｎｍｒ 기법을이용하여 단백질의 활성 부위에 결합하는 화합물을검색하는 방법
KR100901309B1 (ko) * 2002-06-15 2009-06-09 크리스탈지노믹스(주) 단백질의 활성 부위에 결합하는 화합물을 선별하는 방법
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
CA2466792A1 (en) * 2003-05-16 2004-11-16 Affinium Pharmaceuticals, Inc. Evaluation of spectra
US7595170B2 (en) * 2004-08-05 2009-09-29 Modrovich Ivan E Apparatus and method for measuring concentrations of molecules through a barrier
US8933209B2 (en) 2006-04-26 2015-01-13 Abbvie Inc. Dep2 and its uses in major depressive disorder and other related disorders
US20070256148A1 (en) * 2006-04-26 2007-11-01 Katz David A DEP2 and its uses in major depressive disorder and other related disorders
FR2954830A1 (fr) * 2009-12-31 2011-07-01 Nmrtec Methode d'analyse comparative par resonance magnetique nucleaire
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Also Published As

Publication number Publication date
PL336299A1 (en) 2000-06-19
JP2002507277A (ja) 2002-03-05
ES2215296T5 (es) 2009-07-06
CN1225648C (zh) 2005-11-02
HUP0003956A2 (en) 2001-03-28
EP0975954A1 (en) 2000-02-02
WO1998048264A1 (en) 1998-10-29
EP0975954B2 (en) 2009-03-18
HUP0003956A3 (en) 2002-04-29
TW574502B (en) 2004-02-01
CZ9903683A3 (cs) 2001-02-14
CN1252868A (zh) 2000-05-10
BR9808079A (pt) 2000-03-08
DE69821475T3 (de) 2009-07-23
ES2215296T3 (es) 2004-10-01
DK0975954T4 (da) 2009-05-18
KR20010006454A (ko) 2001-01-26
ZA982919B (en) 1998-10-12
BG64326B1 (bg) 2004-09-30
DK0975954T3 (da) 2004-06-07
DE69821475T2 (de) 2004-11-25
KR100542420B1 (ko) 2006-01-11
CA2286795C (en) 2010-06-29
AU7138098A (en) 1998-11-13
EP0975954B1 (en) 2004-02-04
HK1027158A1 (en) 2001-01-05
NO995078D0 (no) 1999-10-18
PL194184B1 (pl) 2007-05-31
CO5060446A1 (es) 2001-07-30
ATE259061T1 (de) 2004-02-15
SI0975954T1 (en) 2004-08-31
HU228433B1 (en) 2013-03-28
CA2286795A1 (en) 1998-10-29
US6043024A (en) 2000-03-28
NO995078L (no) 1999-12-06
NZ337126A (en) 2001-05-25
SK141699A3 (en) 2000-06-12
DE69821475D1 (de) 2004-03-11
PT975954E (pt) 2004-06-30
AR004651A1 (es) 1999-03-10
CZ297275B6 (cs) 2006-10-11
SK285411B6 (sk) 2007-01-04
IL131726A0 (en) 2001-03-19
TR199902167T2 (xx) 2000-07-21

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