DE69433564D1 - Verbindungen die kolorektale krebszellen spezifisch binden und verfahren für ihre herstellung - Google Patents
Verbindungen die kolorektale krebszellen spezifisch binden und verfahren für ihre herstellungInfo
- Publication number
- DE69433564D1 DE69433564D1 DE69433564T DE69433564T DE69433564D1 DE 69433564 D1 DE69433564 D1 DE 69433564D1 DE 69433564 T DE69433564 T DE 69433564T DE 69433564 T DE69433564 T DE 69433564T DE 69433564 D1 DE69433564 D1 DE 69433564D1
- Authority
- DE
- Germany
- Prior art keywords
- disclosed
- colorectal cancer
- pct
- cancer cells
- receptor binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57446—Specifically defined cancers of stomach or intestine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- G01N2333/245—Escherichia (G)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Optics & Photonics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US305056 | 1981-09-24 | ||
US08/141,892 US5518888A (en) | 1993-10-26 | 1993-10-26 | ST receptor binding compounds and methods of using the same |
US141892 | 1993-10-26 | ||
US08/305,056 US5601990A (en) | 1994-09-13 | 1994-09-13 | Methods of diagnosing colorectal tumors and metastasis thereof |
PCT/US1994/012232 WO1995011694A1 (en) | 1993-10-26 | 1994-10-26 | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69433564D1 true DE69433564D1 (de) | 2004-03-25 |
DE69433564T2 DE69433564T2 (de) | 2004-12-23 |
Family
ID=26839545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433564T Expired - Lifetime DE69433564T2 (de) | 1993-10-26 | 1994-10-26 | Verbindungen, die kolorektale Krebszellen spezifisch binden, und Verfahren zu ihrer Verwendung |
Country Status (10)
Country | Link |
---|---|
US (1) | US6060037A (de) |
EP (1) | EP0734264B1 (de) |
JP (2) | JP4194113B2 (de) |
AT (1) | ATE259648T1 (de) |
AU (1) | AU681920B2 (de) |
CA (1) | CA2174928C (de) |
DE (1) | DE69433564T2 (de) |
ES (1) | ES2216004T3 (de) |
NO (1) | NO318980B1 (de) |
WO (1) | WO1995011694A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5912171A (en) * | 1993-10-20 | 1999-06-15 | Oregon Health Science University | Amino acid transporters and uses |
US5658782A (en) * | 1993-10-20 | 1997-08-19 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A Non-Profit Organization | Amino acid transporters and uses |
US7097839B1 (en) * | 1993-10-26 | 2006-08-29 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
US5879656A (en) * | 1993-10-26 | 1999-03-09 | Thomas Jefferson University | Methods of treating metastatic colorectal cancer with ST receptor binding compounds |
WO1997042220A1 (en) | 1996-05-03 | 1997-11-13 | Thomas Jefferson University | Metastatic colorectal cancer vaccine |
WO1997042506A1 (en) | 1996-05-03 | 1997-11-13 | Thomas Jefferson University | Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof |
US6106804A (en) * | 1997-06-13 | 2000-08-22 | The University Of New Mexico | Arsenic-72 labeled compounds for tissue specific medical imaging |
US6120995A (en) * | 1997-08-07 | 2000-09-19 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
US7135333B1 (en) | 1997-08-07 | 2006-11-14 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
AU9452198A (en) * | 1997-10-15 | 1999-05-17 | Nycomed Imaging As | Complexing agents and targeting immunoreagents |
DE69834420T2 (de) * | 1997-10-21 | 2007-04-19 | The Regents Of The University Of California, Oakland | Zielsequenzen für synthetische moleküle und verfahren für deren verwendung |
AU2530199A (en) * | 1998-02-06 | 1999-08-23 | Nycomed Imaging As | Targeting immunoreagents useful in therapeutic and diagnostic compositions and methods |
US6962779B1 (en) | 1998-10-02 | 2005-11-08 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating gastrointestinal cancers |
FR2805994A1 (fr) * | 2000-03-10 | 2001-09-14 | Agronomique Inst Nat Rech | Methode de detection de la guanylyl cyclase-c et son utilisation pour le diagnostic des tumeurs colorectales metastatiques |
EP1268854A4 (de) | 2000-03-27 | 2003-05-02 | Univ Jefferson | Markerdetektion mit hoher spezifität |
US20050287638A1 (en) * | 2000-04-25 | 2005-12-29 | Weigel Paul H | Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same |
AU2001255688A1 (en) * | 2000-04-25 | 2001-11-07 | The Board Of Regents Of The University Of Oklahoma | Identification and uses of a hyaluronan receptor |
US20030104987A1 (en) * | 2001-04-25 | 2003-06-05 | Weigel Paul H. | Methods of using the hyaluronan receptor for endocytosis |
US7829276B2 (en) | 2000-09-18 | 2010-11-09 | Thomas Jefferson University | Methods of using CRCA-1 as a stomach and esophageal cancer marker |
GB0105224D0 (en) | 2001-03-02 | 2001-04-18 | Nycomed Amersham Plc | Improved peptide-chelate conjugates |
DK1379224T4 (da) | 2001-03-29 | 2013-12-02 | Synergy Pharmaceuticals Inc | Guanylat-cyklase-receptoragonister til behandling af vævsbetændelse og karcinogenese |
US20030232013A1 (en) * | 2002-02-22 | 2003-12-18 | Gary Sieckman | Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides |
US7371727B2 (en) * | 2003-01-28 | 2008-05-13 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US7304036B2 (en) | 2003-01-28 | 2007-12-04 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US20060281682A1 (en) * | 2003-01-28 | 2006-12-14 | Currie Mark G | Methods and compositions for the treatment of gastrointestinal disorders |
EP1594517B1 (de) * | 2003-01-28 | 2007-06-20 | Microbia, Inc. | Zusammensetzungen zur behandlung von gastrointestinalen störungen |
US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EP1599165A4 (de) * | 2003-02-10 | 2010-09-08 | Univ Jefferson | Die benutzung von gcc-liganden |
US7494979B2 (en) * | 2003-06-13 | 2009-02-24 | Ironwood Pharmaceuticals, Inc. | Method for treating congestive heart failure and other disorders |
EP1644021B1 (de) * | 2003-06-13 | 2012-08-22 | Ironwood Pharmaceuticals, Inc. | Verfahren und zusammensetzungen zur behandlung von gastrointestinalen störungen |
GB0403856D0 (en) * | 2004-02-20 | 2004-03-24 | Algeta As | Composition |
ES2451496T3 (es) | 2004-06-25 | 2014-03-27 | Thomas Jefferson University | Ligandos de guanilato ciclasa C |
US20090253634A1 (en) * | 2005-08-19 | 2009-10-08 | Microbia, Inc. | Methods and Compositions for the Treatment of Gastrointestinal Disorders |
CA2652677A1 (en) * | 2006-02-24 | 2007-09-07 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US8207295B2 (en) * | 2008-06-04 | 2012-06-26 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) * | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2328910B1 (de) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
AU2009270833B2 (en) * | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US20100221329A1 (en) | 2008-12-03 | 2010-09-02 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase c agonists and methods of use |
EP2401394B1 (de) | 2009-02-25 | 2013-11-27 | Diagnocure Inc. | Verfahren für den nachweis von metastasen eines magendarmtumors |
NZ623607A (en) | 2009-10-23 | 2016-07-29 | Millennium Pharm Inc | Anti-gcc antibody molecules and related compositions and methods |
NZ599751A (en) | 2009-11-09 | 2014-08-29 | Ironwood Pharmaceuticals Inc | Treatments for gastrointestinal disorders |
RU2012128509A (ru) | 2009-12-07 | 2014-01-20 | Айронвуд Фармасьютикалз, Инк. | Способы лечения заболеваний желудочно-кишечного тракта |
JP5610125B2 (ja) * | 2010-02-22 | 2014-10-22 | 国立大学法人 長崎大学 | 癌転移の検出方法および検出用キット |
EP2605786A4 (de) * | 2010-06-09 | 2014-03-12 | Combimab Inc | Therapeutische peptide |
EP2621509A4 (de) | 2010-09-15 | 2016-08-03 | Synergy Pharmaceuticals Inc | Formulierungen von guanylatcyclase-c-agonisten und anwendungsverfahren |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
WO2012155114A1 (en) | 2011-05-11 | 2012-11-15 | Ironwood Pharmaceuticals, Inc. | Peptides derived from uroguanylin and their use in gastrointestinal disorders |
US9650417B2 (en) | 2011-05-11 | 2017-05-16 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
WO2012170804A1 (en) | 2011-06-08 | 2012-12-13 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
WO2012170766A1 (en) | 2011-06-08 | 2012-12-13 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
ES2402014B1 (es) | 2011-09-07 | 2014-02-27 | Consejo Superior De Investigaciones Científicas (Csic) | Peptido secretado por lactobacillus plantarum con función inmunomoduladora |
MX362020B (es) | 2012-04-27 | 2019-01-04 | Millennium Pharm Inc | Moleculas de anticuerpo anti-gcc y uso de las mismas para probar la susceptibilidad a la terapia dirigida a gcc. |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
JP2014158468A (ja) * | 2014-03-05 | 2014-09-04 | Clinical Genomics Pty Ltd | 検出方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4584268A (en) * | 1981-10-13 | 1986-04-22 | Ceriani Roberto Luis | Method and compositions for carcinoma diagnosis |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US5160723A (en) * | 1985-04-19 | 1992-11-03 | Sloan-Kettering Institute For Cancer Research | Method of imaging colorectal carcinoma lesion and composition for use therein |
US5075216A (en) * | 1988-09-23 | 1991-12-24 | Cetus Corporation | Methods for dna sequencing with thermus aquaticus dna polymerase |
US5237051A (en) * | 1990-12-06 | 1993-08-17 | Vanderbilt University | Purified enterotoxin receptor protein |
US5237015A (en) * | 1991-11-04 | 1993-08-17 | Polysar Rubber Corporation | Core-shell polymer for use in tire treads |
US5601990A (en) * | 1994-09-13 | 1997-02-11 | Thomas Jefferson University | Methods of diagnosing colorectal tumors and metastasis thereof |
US5879656A (en) * | 1993-10-26 | 1999-03-09 | Thomas Jefferson University | Methods of treating metastatic colorectal cancer with ST receptor binding compounds |
US5518888A (en) * | 1993-10-26 | 1996-05-21 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
-
1994
- 1994-10-26 WO PCT/US1994/012232 patent/WO1995011694A1/en active IP Right Grant
- 1994-10-26 US US08/635,930 patent/US6060037A/en not_active Expired - Lifetime
- 1994-10-26 JP JP51278195A patent/JP4194113B2/ja not_active Expired - Fee Related
- 1994-10-26 DE DE69433564T patent/DE69433564T2/de not_active Expired - Lifetime
- 1994-10-26 AT AT95900421T patent/ATE259648T1/de active
- 1994-10-26 ES ES95900421T patent/ES2216004T3/es not_active Expired - Lifetime
- 1994-10-26 EP EP95900421A patent/EP0734264B1/de not_active Expired - Lifetime
- 1994-10-26 CA CA2174928A patent/CA2174928C/en not_active Expired - Lifetime
- 1994-10-26 AU AU81249/94A patent/AU681920B2/en not_active Expired
-
1996
- 1996-04-26 NO NO19961706A patent/NO318980B1/no unknown
-
2006
- 2006-04-25 JP JP2006120753A patent/JP4684940B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6060037A (en) | 2000-05-09 |
ES2216004T3 (es) | 2004-10-16 |
NO961706L (no) | 1996-06-20 |
JP2006246895A (ja) | 2006-09-21 |
DE69433564T2 (de) | 2004-12-23 |
AU8124994A (en) | 1995-05-22 |
EP0734264A4 (de) | 1999-04-21 |
CA2174928A1 (en) | 1995-05-04 |
NO318980B1 (no) | 2005-05-30 |
AU681920B2 (en) | 1997-09-11 |
NO961706D0 (no) | 1996-04-26 |
ATE259648T1 (de) | 2004-03-15 |
EP0734264A1 (de) | 1996-10-02 |
CA2174928C (en) | 2011-08-16 |
JPH09506340A (ja) | 1997-06-24 |
EP0734264B1 (de) | 2004-02-18 |
JP4194113B2 (ja) | 2008-12-10 |
JP4684940B2 (ja) | 2011-05-18 |
WO1995011694A1 (en) | 1995-05-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |