PT831837E - Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe - Google Patents

Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe

Info

Publication number
PT831837E
PT831837E PT96919096T PT96919096T PT831837E PT 831837 E PT831837 E PT 831837E PT 96919096 T PT96919096 T PT 96919096T PT 96919096 T PT96919096 T PT 96919096T PT 831837 E PT831837 E PT 831837E
Authority
PT
Portugal
Prior art keywords
compounds
eschalamine
utilization
manufacture
medicinal product
Prior art date
Application number
PT96919096T
Other languages
English (en)
Inventor
Michael Zasloff
Original Assignee
Genaera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaera Corp filed Critical Genaera Corp
Publication of PT831837E publication Critical patent/PT831837E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
PT96919096T 1995-06-07 1996-06-07 Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe PT831837E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/474,799 US5792635A (en) 1995-06-07 1995-06-07 Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine

Publications (1)

Publication Number Publication Date
PT831837E true PT831837E (pt) 2003-09-30

Family

ID=23884982

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96919096T PT831837E (pt) 1995-06-07 1996-06-07 Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe

Country Status (12)

Country Link
US (1) US5792635A (pt)
EP (1) EP0831837B1 (pt)
JP (1) JP4077512B2 (pt)
AT (1) ATE238800T1 (pt)
AU (1) AU712436B2 (pt)
CA (1) CA2223908C (pt)
DE (1) DE69627853T2 (pt)
DK (1) DK0831837T3 (pt)
ES (1) ES2201187T3 (pt)
PT (1) PT831837E (pt)
WO (1) WO1996040151A1 (pt)
ZA (1) ZA964819B (pt)

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DE19960204A1 (de) * 1999-12-14 2001-06-28 Aventis Pharma Gmbh Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
AU2001253427B2 (en) 2000-04-12 2007-02-08 Genaera Corporation A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
US20050130948A1 (en) * 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives
CN102727501A (zh) * 2002-03-27 2012-10-17 菲特法姆股份有限公司 皂角苷配基及其衍生物的用途
CA2814247C (en) 2005-04-25 2016-01-19 Genaera Corporation Polymorphic and amorphous salt forms of squalamine dilactate
CA2650027A1 (en) * 2006-04-21 2007-11-01 Genaera Corporation Induction of weight loss and the selective inhibition of ptp1b
EP2188299B1 (en) * 2007-09-06 2017-10-25 Ohr Pharmaceutical, Inc. Compounds for treating diabetes
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives
US8729058B2 (en) 2009-10-27 2014-05-20 Michael Zasloff Methods and compositions for treating and preventing viral infections
WO2011066260A2 (en) * 2009-11-25 2011-06-03 Michael Zasloff Formulations comprising aminosterols
PT2838907T (pt) * 2012-04-20 2019-08-05 Ohr Pharmaceutical Inc Aminoesteróides para o tratamento de uma doença associada a ptp1b
DK3461834T3 (da) * 2013-03-13 2021-08-23 Sage Therapeutics Inc Neuroaktive steroider
US10040817B2 (en) 2013-10-03 2018-08-07 Enterin Laboratories, Inc. Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same
MD3319612T2 (ro) 2015-07-06 2021-10-31 Sage Therapeutics Inc Oxisteroli și metode de utilizare a acestora
JP7112331B2 (ja) 2016-04-01 2022-08-03 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびその使用方法
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PT3519422T (pt) 2016-09-30 2022-12-05 Sage Therapeutics Inc Oxisteróis substituídos em c7 e métodos como moduladores nmda
IL266093B2 (en) 2016-10-18 2024-02-01 Sage Therapeutics Inc Oxysterols and methods of using them
US11083735B2 (en) 2017-09-08 2021-08-10 Enterin, Inc. Methods for treating sleep disorders, sleep disturbances, and related symptoms using aminosterol compositions

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Also Published As

Publication number Publication date
JPH11506775A (ja) 1999-06-15
US5792635A (en) 1998-08-11
WO1996040151A1 (en) 1996-12-19
AU6152896A (en) 1996-12-30
ZA964819B (en) 1998-02-09
DK0831837T3 (da) 2003-08-25
CA2223908A1 (en) 1996-12-19
ES2201187T3 (es) 2004-03-16
JP4077512B2 (ja) 2008-04-16
DE69627853T2 (de) 2004-02-19
DE69627853D1 (de) 2003-06-05
ATE238800T1 (de) 2003-05-15
AU712436B2 (en) 1999-11-04
EP0831837A1 (en) 1998-04-01
EP0831837B1 (en) 2003-05-02
CA2223908C (en) 2007-02-20

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