JPH11506775A - 医薬品の製造のためのスクアラミンの使用 - Google Patents
医薬品の製造のためのスクアラミンの使用Info
- Publication number
- JPH11506775A JPH11506775A JP9501397A JP50139797A JPH11506775A JP H11506775 A JPH11506775 A JP H11506775A JP 9501397 A JP9501397 A JP 9501397A JP 50139797 A JP50139797 A JP 50139797A JP H11506775 A JPH11506775 A JP H11506775A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- squalamine
- cells
- mmol
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- UIRKNQLZZXALBI-UHFFFAOYSA-N Squalamine Natural products OC1CC2CC(NCCCNCCCCN)CCC2(C)C2C1C1CCC(C(C)CCC(C(C)C)OS(O)(=O)=O)C1(C)CC2 UIRKNQLZZXALBI-UHFFFAOYSA-N 0.000 title claims description 143
- 229950001248 squalamine Drugs 0.000 title claims description 143
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- 150000001875 compounds Chemical class 0.000 abstract description 465
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract description 14
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- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 description 14
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- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 14
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- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Inorganic materials [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- MNWBNISUBARLIT-UHFFFAOYSA-N sodium cyanide Chemical compound [Na+].N#[C-] MNWBNISUBARLIT-UHFFFAOYSA-N 0.000 description 1
- NASFKTWZWDYFER-UHFFFAOYSA-N sodium;hydrate Chemical group O.[Na] NASFKTWZWDYFER-UHFFFAOYSA-N 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 210000003699 striated muscle Anatomy 0.000 description 1
- 238000012799 strong cation exchange Methods 0.000 description 1
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000019635 sulfation Effects 0.000 description 1
- 238000005670 sulfation reaction Methods 0.000 description 1
- RVEZZJVBDQCTEF-UHFFFAOYSA-N sulfenic acid Chemical compound SO RVEZZJVBDQCTEF-UHFFFAOYSA-N 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- AGIUPQUTLBAVDK-UHFFFAOYSA-N tert-butyl n-(3-aminopropyl)-n-[4-[(2-methylpropan-2-yl)oxycarbonylamino]butyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCCN(CCCN)C(=O)OC(C)(C)C AGIUPQUTLBAVDK-UHFFFAOYSA-N 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 230000003614 tolerogenic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 230000007998 vessel formation Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.スクアラミンまたはその薬学的に許容される塩を有効量投与することを含 む、NHE3を阻害する方法。 2.NHE3が特異的に阻害される、請求項1記載の方法。 3.NHE3が病理学的過程で発現される、請求項1記載の方法。 4.スクアラミンまたはその薬学的に許容される塩を有効量投与することを含 む、内皮細胞の増殖を阻害する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/474,799 US5792635A (en) | 1995-06-07 | 1995-06-07 | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
US08/474,799 | 1995-06-07 | ||
PCT/US1996/008954 WO1996040151A1 (en) | 1995-06-07 | 1996-06-07 | Use of squalamine for the manufacture of a medicament for inhibiting nhe |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11506775A true JPH11506775A (ja) | 1999-06-15 |
JP4077512B2 JP4077512B2 (ja) | 2008-04-16 |
Family
ID=23884982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50139797A Expired - Fee Related JP4077512B2 (ja) | 1995-06-07 | 1996-06-07 | 医薬品の製造のためのスクアラミンの使用 |
Country Status (12)
Country | Link |
---|---|
US (1) | US5792635A (ja) |
EP (1) | EP0831837B1 (ja) |
JP (1) | JP4077512B2 (ja) |
AT (1) | ATE238800T1 (ja) |
AU (1) | AU712436B2 (ja) |
CA (1) | CA2223908C (ja) |
DE (1) | DE69627853T2 (ja) |
DK (1) | DK0831837T3 (ja) |
ES (1) | ES2201187T3 (ja) |
PT (1) | PT831837E (ja) |
WO (1) | WO1996040151A1 (ja) |
ZA (1) | ZA964819B (ja) |
Cited By (5)
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JP2001505207A (ja) * | 1996-12-06 | 2001-04-17 | マガイニン ファーマシューティカルズ インコーポレーテッド | アミノステロール、ビタミンd類似体および他の化合物の製造に有用な24−ヒドロキシル化された化合物の立体選択的合成 |
JP2002515035A (ja) * | 1996-05-17 | 2002-05-21 | ジェネーラ・コーポレーション | アミノステロール化合物の治療学的使用 |
JP2015514781A (ja) * | 2012-04-20 | 2015-05-21 | オーエイチアール・ファーマシューティカル・インコーポレイテッドOhr Pharmaceutical,Inc. | Ptp1b関連疾患の処置のためのアミノステロイド化合物 |
JP2017519775A (ja) * | 2014-06-23 | 2017-07-20 | ザスロフ,マイケル | 腸の腸内分泌系を関連疾患又は病状の処置のために刺激する方法及び組成物 |
JP2021152086A (ja) * | 2013-03-13 | 2021-09-30 | セージ セラピューティクス, インコーポレイテッド | 神経刺激性ステロイドおよびその使用方法 |
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US6143738A (en) * | 1995-06-07 | 2000-11-07 | Magainin Pharmaceuticals, Inc. | Therapeutic uses for an aminosterol compound |
US5847172A (en) * | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
JP2000510460A (ja) * | 1996-04-26 | 2000-08-15 | マゲイニン・ファーマシューティカルズ・インコーポレーテッド | スクアラミンを他の抗癌剤と併用する上皮性悪性腫瘍の治療 |
US6596712B2 (en) | 1996-04-26 | 2003-07-22 | Genaera Corporation | Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities |
US7410959B1 (en) * | 2000-07-13 | 2008-08-12 | Genaera Corporation | Therapeutic uses for aminosterol compounds |
AU5194998A (en) * | 1996-11-01 | 1998-05-29 | Magainin Pharmaceuticals, Inc. | Certain aminosterol compounds and uses therefor |
GB9923076D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
TR200002774T2 (tr) * | 1998-03-26 | 2001-06-21 | Phytopharm Plc | Alzheimer hastalığının tedavisi için steroit sapogenler ve bunların türevleri |
DE19849722A1 (de) * | 1998-10-28 | 2000-05-04 | Aventis Pharma Gmbh | Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB9923077D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
AU784795B2 (en) | 1999-12-09 | 2006-06-22 | Genaera Corporation | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
DE19960204A1 (de) * | 1999-12-14 | 2001-06-28 | Aventis Pharma Gmbh | Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
CA2406847C (en) | 2000-04-12 | 2009-11-17 | Genaera Corporation | Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols |
GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
US20050130948A1 (en) * | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
CN102727501A (zh) * | 2002-03-27 | 2012-10-17 | 菲特法姆股份有限公司 | 皂角苷配基及其衍生物的用途 |
CA2606077C (en) | 2005-04-25 | 2013-07-09 | Genaera Corporation | Polymorphic and amorphous salt forms of squalamine dilactate |
JP2009534391A (ja) * | 2006-04-21 | 2009-09-24 | ジェネーラ・コーポレーション | 体重減少の誘発およびptp1bの選択的阻害 |
CA2697744C (en) * | 2007-09-06 | 2016-06-14 | Genaera Corporation | A method for treating diabetes |
US20120088737A2 (en) * | 2009-10-02 | 2012-04-12 | Ajinomoto Co., Inc | Novel acyl guanidine derivatives |
US8729058B2 (en) | 2009-10-27 | 2014-05-20 | Michael Zasloff | Methods and compositions for treating and preventing viral infections |
WO2011066260A2 (en) * | 2009-11-25 | 2011-06-03 | Michael Zasloff | Formulations comprising aminosterols |
CN108135911B (zh) | 2015-07-06 | 2021-06-25 | 萨奇治疗股份有限公司 | 氧甾醇及其使用方法 |
ES2921010T3 (es) | 2016-04-01 | 2022-08-16 | Sage Therapeutics Inc | Oxisteroles y procedimientos de uso de los mismos |
WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
US11149056B2 (en) | 2016-09-30 | 2021-10-19 | Sage Therapeutics, Inc. | C7 substituted oxysterols and methods of use thereof |
US11149054B2 (en) | 2016-10-18 | 2021-10-19 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
MA50094A (fr) | 2017-09-08 | 2020-07-15 | Enterin Inc | Méthodes de traitement des troubles du sommeil, des perturbations du sommeil et de symptômes associés à l'aide de compositions d'aminostérol |
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JP2002515019A (ja) * | 1995-06-07 | 2002-05-21 | マガイニン ファーマシューティカルズ インク. | ナトリウム/プロトン交換体(nhe)の阻害剤として有用なアミノステロール化合物、同阻害剤を使用する薬学的方法および組成物、ならびに化合物のnhe阻害効果を評価する方法 |
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-
1995
- 1995-06-07 US US08/474,799 patent/US5792635A/en not_active Expired - Fee Related
-
1996
- 1996-06-07 DK DK96919096T patent/DK0831837T3/da active
- 1996-06-07 DE DE69627853T patent/DE69627853T2/de not_active Expired - Fee Related
- 1996-06-07 JP JP50139797A patent/JP4077512B2/ja not_active Expired - Fee Related
- 1996-06-07 ZA ZA9604819A patent/ZA964819B/xx unknown
- 1996-06-07 AU AU61528/96A patent/AU712436B2/en not_active Ceased
- 1996-06-07 EP EP96919096A patent/EP0831837B1/en not_active Expired - Lifetime
- 1996-06-07 PT PT96919096T patent/PT831837E/pt unknown
- 1996-06-07 WO PCT/US1996/008954 patent/WO1996040151A1/en active IP Right Grant
- 1996-06-07 ES ES96919096T patent/ES2201187T3/es not_active Expired - Lifetime
- 1996-06-07 CA CA002223908A patent/CA2223908C/en not_active Expired - Lifetime
- 1996-06-07 AT AT96919096T patent/ATE238800T1/de not_active IP Right Cessation
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US5192756A (en) * | 1992-03-18 | 1993-03-09 | The Children's Hospital Of Pennsylvania | Aminosterol antibiotic |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2002515035A (ja) * | 1996-05-17 | 2002-05-21 | ジェネーラ・コーポレーション | アミノステロール化合物の治療学的使用 |
JP2001505207A (ja) * | 1996-12-06 | 2001-04-17 | マガイニン ファーマシューティカルズ インコーポレーテッド | アミノステロール、ビタミンd類似体および他の化合物の製造に有用な24−ヒドロキシル化された化合物の立体選択的合成 |
JP2015514781A (ja) * | 2012-04-20 | 2015-05-21 | オーエイチアール・ファーマシューティカル・インコーポレイテッドOhr Pharmaceutical,Inc. | Ptp1b関連疾患の処置のためのアミノステロイド化合物 |
JP2021152086A (ja) * | 2013-03-13 | 2021-09-30 | セージ セラピューティクス, インコーポレイテッド | 神経刺激性ステロイドおよびその使用方法 |
JP2017519775A (ja) * | 2014-06-23 | 2017-07-20 | ザスロフ,マイケル | 腸の腸内分泌系を関連疾患又は病状の処置のために刺激する方法及び組成物 |
JP2020097587A (ja) * | 2014-06-23 | 2020-06-25 | ザスロフ,マイケル | 腸の腸内分泌系を関連疾患又は病状の処置のために刺激する方法及び組成物 |
Also Published As
Publication number | Publication date |
---|---|
CA2223908A1 (en) | 1996-12-19 |
WO1996040151A1 (en) | 1996-12-19 |
AU6152896A (en) | 1996-12-30 |
CA2223908C (en) | 2007-02-20 |
AU712436B2 (en) | 1999-11-04 |
PT831837E (pt) | 2003-09-30 |
US5792635A (en) | 1998-08-11 |
EP0831837A1 (en) | 1998-04-01 |
DE69627853T2 (de) | 2004-02-19 |
DE69627853D1 (de) | 2003-06-05 |
DK0831837T3 (da) | 2003-08-25 |
ZA964819B (en) | 1998-02-09 |
JP4077512B2 (ja) | 2008-04-16 |
ATE238800T1 (de) | 2003-05-15 |
ES2201187T3 (es) | 2004-03-16 |
EP0831837B1 (en) | 2003-05-02 |
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