DK0831837T3 - Anvendelse af squalamin i fremstilling af et medikament til inhibering af NHE - Google Patents

Anvendelse af squalamin i fremstilling af et medikament til inhibering af NHE

Info

Publication number
DK0831837T3
DK0831837T3 DK96919096T DK96919096T DK0831837T3 DK 0831837 T3 DK0831837 T3 DK 0831837T3 DK 96919096 T DK96919096 T DK 96919096T DK 96919096 T DK96919096 T DK 96919096T DK 0831837 T3 DK0831837 T3 DK 0831837T3
Authority
DK
Denmark
Prior art keywords
compounds
inhibitors
nhe
squalamine
medicament
Prior art date
Application number
DK96919096T
Other languages
English (en)
Inventor
Michael Zasloff
Original Assignee
Genaera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaera Corp filed Critical Genaera Corp
Application granted granted Critical
Publication of DK0831837T3 publication Critical patent/DK0831837T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DK96919096T 1995-06-07 1996-06-07 Anvendelse af squalamin i fremstilling af et medikament til inhibering af NHE DK0831837T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,799 US5792635A (en) 1995-06-07 1995-06-07 Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
PCT/US1996/008954 WO1996040151A1 (en) 1995-06-07 1996-06-07 Use of squalamine for the manufacture of a medicament for inhibiting nhe

Publications (1)

Publication Number Publication Date
DK0831837T3 true DK0831837T3 (da) 2003-08-25

Family

ID=23884982

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96919096T DK0831837T3 (da) 1995-06-07 1996-06-07 Anvendelse af squalamin i fremstilling af et medikament til inhibering af NHE

Country Status (12)

Country Link
US (1) US5792635A (da)
EP (1) EP0831837B1 (da)
JP (1) JP4077512B2 (da)
AT (1) ATE238800T1 (da)
AU (1) AU712436B2 (da)
CA (1) CA2223908C (da)
DE (1) DE69627853T2 (da)
DK (1) DK0831837T3 (da)
ES (1) ES2201187T3 (da)
PT (1) PT831837E (da)
WO (1) WO1996040151A1 (da)
ZA (1) ZA964819B (da)

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EP2051716A1 (en) * 2006-04-21 2009-04-29 Genaera Corporation Induction of weight loss and the selective inhibition of ptp1b
TW200927755A (en) * 2007-09-06 2009-07-01 Genaera Corp A method for treating diabetes
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives
US8729058B2 (en) 2009-10-27 2014-05-20 Michael Zasloff Methods and compositions for treating and preventing viral infections
US8623416B2 (en) * 2009-11-25 2014-01-07 Michael Zasloff Formulations comprising aminosterols
PL2838907T3 (pl) * 2012-04-20 2019-12-31 Ohr Pharmaceutical, Inc. Aminosteroidy do leczenia choroby związanej z PTP1B
JP6255082B2 (ja) * 2013-03-13 2017-12-27 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイドおよびその使用方法
US10040817B2 (en) * 2013-10-03 2018-08-07 Enterin Laboratories, Inc. Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same
KR20180026742A (ko) 2015-07-06 2018-03-13 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
BR112018070123A2 (pt) 2016-04-01 2019-02-05 Sage Therapeutics Inc oxiesterós e métodos de uso dos mesmos
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MA46351A (fr) 2016-09-30 2021-06-02 Sage Therapeutics Inc Oxystérols substitués en c7 et procédés en tant que modulateurs nmda
CN115181153A (zh) 2016-10-18 2022-10-14 萨奇治疗股份有限公司 氧甾醇及其使用方法
MA50094A (fr) 2017-09-08 2020-07-15 Enterin Inc Méthodes de traitement des troubles du sommeil, des perturbations du sommeil et de symptômes associés à l'aide de compositions d'aminostérol

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Also Published As

Publication number Publication date
AU712436B2 (en) 1999-11-04
DE69627853D1 (de) 2003-06-05
DE69627853T2 (de) 2004-02-19
JP4077512B2 (ja) 2008-04-16
US5792635A (en) 1998-08-11
ES2201187T3 (es) 2004-03-16
AU6152896A (en) 1996-12-30
ATE238800T1 (de) 2003-05-15
PT831837E (pt) 2003-09-30
EP0831837B1 (en) 2003-05-02
ZA964819B (en) 1998-02-09
CA2223908A1 (en) 1996-12-19
EP0831837A1 (en) 1998-04-01
WO1996040151A1 (en) 1996-12-19
CA2223908C (en) 2007-02-20
JPH11506775A (ja) 1999-06-15

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