IT8322486A0 - N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche. - Google Patents

N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche.

Info

Publication number
IT8322486A0
IT8322486A0 IT8322486A IT2248683A IT8322486A0 IT 8322486 A0 IT8322486 A0 IT 8322486A0 IT 8322486 A IT8322486 A IT 8322486A IT 2248683 A IT2248683 A IT 2248683A IT 8322486 A0 IT8322486 A0 IT 8322486A0
Authority
IT
Italy
Prior art keywords
bifenyl
carboxymethylcysteine
carboxylics
mucolytics
acetylcysteine
Prior art date
Application number
IT8322486A
Other languages
English (en)
Other versions
IT1206515B (it
Inventor
Guido Cerbai
Original Assignee
Guidotti & C Spa Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guidotti & C Spa Labor filed Critical Guidotti & C Spa Labor
Publication of IT8322486A0 publication Critical patent/IT8322486A0/it
Priority to IT8322486A priority Critical patent/IT1206515B/it
Priority to EP84109446A priority patent/EP0144519B1/en
Priority to ES534958A priority patent/ES534958A0/es
Priority to AT84109446T priority patent/ATE27699T1/de
Priority to FR8412526A priority patent/FR2550530B1/fr
Priority to DE8484109446T priority patent/DE3464134D1/de
Priority to KR1019840004727A priority patent/KR920000374B1/ko
Priority to JP59165747A priority patent/JPS6067458A/ja
Priority to BE0/213470A priority patent/BE900328A/fr
Application granted granted Critical
Publication of IT1206515B publication Critical patent/IT1206515B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT8322486A 1983-08-09 1983-08-09 N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche. IT1206515B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT8322486A IT1206515B (it) 1983-08-09 1983-08-09 N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
FR8412526A FR2550530B1 (fr) 1983-08-09 1984-08-08 Derives 2',4'-difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxyliques de la n-acetyl-cysteine et s-carboxymethyl-cysteine a activite anti-inflammatoire et mucolytique, leur procede de preparation et compositions pharmaceutiques correspondantes
ES534958A ES534958A0 (es) 1983-08-09 1984-08-08 Procedimiento de preparar derivados cisteinicos
AT84109446T ATE27699T1 (de) 1983-08-09 1984-08-08 2'.4'-difluor-4-hydroxy-(1,1' diphenyl)-3carboxyl-derivate von n-acetylcystein und von s- carboxymethylcystein mit entzuendungshemmender und mucolytischer wirkung, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen.
EP84109446A EP0144519B1 (en) 1983-08-09 1984-08-08 2',4'-difluoro-4-hydroxy-(1,1'-diphenyl)-3-carboxylic derivatives of n-acetylcysteine and of s-carboxymethylcysteine having anti-inflammatory and mucolytic activity, process for their preparation and related pharmaceutical compositions
DE8484109446T DE3464134D1 (en) 1983-08-09 1984-08-08 2',4'-difluoro-4-hydroxy-(1,1'-diphenyl)-3-carboxylic derivatives of n-acetylcysteine and of s-carboxymethylcysteine having anti-inflammatory and mucolytic activity, process for their preparation and related pharmaceutical compositions
KR1019840004727A KR920000374B1 (ko) 1983-08-09 1984-08-08 소염작용 및 점액 용해작용을 갖는 n-아세틸 시스테인 및 s-카르복시메틸시스테인의 2',4'-디플루오로-4-히드록시-(1,1'-디페닐)-3-카르복실산 유도체의 제조방법
JP59165747A JPS6067458A (ja) 1983-08-09 1984-08-09 Ｎ−アセチルシステイン及びｓ−カルボキシメチルシステインの２′，４′−ジフルオロ−４−ヒドロキシ−（１，１′−ジフエニル）−３−カルボキシル誘導体、及びそれを含む組成物
BE0/213470A BE900328A (fr) 1983-08-09 1984-08-09 Derives de la n-acetylcysteine et de la s-carboxymethylcysteine, leur preparation et compositions en contenant.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8322486A IT1206515B (it) 1983-08-09 1983-08-09 N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche.

Publications (2)

Publication Number Publication Date
IT8322486A0 true IT8322486A0 (it) 1983-08-09
IT1206515B IT1206515B (it) 1989-04-27

Family

ID=11196917

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8322486A IT1206515B (it) 1983-08-09 1983-08-09 N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche.

Country Status (9)

Country Link
EP (1) EP0144519B1 (it)
JP (1) JPS6067458A (it)
KR (1) KR920000374B1 (it)
AT (1) ATE27699T1 (it)
BE (1) BE900328A (it)
DE (1) DE3464134D1 (it)
ES (1) ES534958A0 (it)
FR (1) FR2550530B1 (it)
IT (1) IT1206515B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103251631A (zh) * 2008-05-13 2013-08-21 根梅迪卡治疗公司 用于治疗代谢性病症的水杨酸盐(酯)缀合物
BRPI1013878A2 (pt) * 2009-03-16 2016-04-05 Genmedica Therapeutics Sl método para tratar distúrbios metabólicos, e, composto
WO2010106083A1 (en) * 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Combination therapies for treating metabolic disorders
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
WO2013037984A1 (en) 2011-09-16 2013-03-21 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
BR112014006150A2 (pt) 2011-09-16 2017-04-04 Genmedica Therapeutics Sl combinação farmacêutica, e, métodos para tratar doença, síndrome ou condição, e para proteger beta-células pancreáticas

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2068398B2 (it) * 1969-10-07 1973-01-12 Rech Pharmac Scientif
BE794952A (fr) * 1972-02-03 1973-08-02 Bristol Myers Co N-acetyl-l-cysteinate d'ammonium et procede pour le preparer
IT1194117B (it) * 1981-11-20 1988-09-14 Isnardi Pietro & C Spa Derivati salicilici di n-acetilcisteina

Also Published As

Publication number Publication date
BE900328A (fr) 1984-12-03
DE3464134D1 (en) 1987-07-16
IT1206515B (it) 1989-04-27
KR920000374B1 (ko) 1992-01-13
EP0144519A1 (en) 1985-06-19
KR850001732A (ko) 1985-04-01
FR2550530B1 (fr) 1987-01-23
JPS6067458A (ja) 1985-04-17
ES8602640A1 (es) 1985-12-16
ATE27699T1 (de) 1987-06-15
EP0144519B1 (en) 1987-06-10
ES534958A0 (es) 1985-12-16
JPH051788B2 (it) 1993-01-11
FR2550530A1 (fr) 1985-02-15

Similar Documents

Publication Publication Date Title
NL300136I1 (nl) Farmacologisch actieve catecholderivaten en samenstellingen ervan.
KR870700608A (ko) 아미노-살리실산 유도체 및 제약 조성물
DE3583765D1 (de) Hydantoinderivate und diese enthaltende pharmazeutische zusammensetzungen.
IT8347605A0 (it) Uree e tiouree sostituite aventi attivita' antiaterosclerotica, procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
IT8322486A0 (it) N-acetilcisteina ederivati 2',4's-carbossimetilcisteina ad-difluoro-4-idrossi-(1,1'-bifenil)attivita' antinfiammatoria, 3-carbossilici della mucolitica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
IT8423896A0 (it) Diacilderivati della glicerilfosforilcolina ad attivita' terapeutica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
IT8026233A0 (it) Derivato della n-acetil-cisteina ad attivita' terapeutica, procedimento per la sua preparazione e relative composizioni farmaceutiche.
NO871190L (no) Fremgangsmaate for fremstilling av farmakologisk aktive substituerte anilider.
IT8103423A0 (it) Derivati di alcandioli conattivita' ipolipidemizzante, metodi per la loro preparazione e composizioni farmaceutiche che licontengono
IT8123546A0 (it) Composto ad attivita' antiulcera, procedimento per la sua preparazione e composizioni farmaceutiche relative
NO167801C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,2'-bi-1h-imidazolderivater.
DE3577656D1 (de) Pharmazeutische zusammensetzungen von ceftazidim.
IT8648217A0 (it) L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono
IT8721958A0 (it) Derivato di taurina, sua preparazione e composizioni farmaceutiche relative
IT1167746B (it) Nitroimidazoli ad attivita' tricomonacida, procedimento per la loro preparazione e relative composizioni farmaceutiche
IT1196494B (it) Derivati dell'acito cef-3-em-4-carbossilico,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
KR900700471A (ko) 신규의 2,3-티오모르폴린디온-2-옥심유도체, 이들을 함유하는 약제학적 조성물 및 제법
FI904673A0 (fi) 2,6-dioksopiperidiinijohdannaisten valmistus
IT8720271A0 (it) Nuovi derivati dell'ergolene, composizioni farmaceutiche che licontengono e procedimento per lapreparazione dei medesimi.
IT8420355A0 (it) Derivato del p-aminofenolo conattivita'mucosecretolitica-fluidificante e antipiretica, procedimento per lasua preparazione e sue composizioni farmaceutiche.
IT8321358A0 (it) Derivati ad attivita' terapeutica della s-carbossimetilcisteina, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
ES8705847A1 (es) Procedimiento para preparar nuevos derivados de n-(2-hidro- xialquil)-aminoacidos
IT8620135A0 (it) Procedimento per la preparazione di derivati della eburnamenina e composizioni farmaceutiche che licontengono.
IT8520150A0 (it) Nuovi derivati ad attivita'terapeutica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
IT8520515A0 (it) Composizioni di farmaci eprocedimento per la loro preparazione.