ATE256120T1 - Reagentien für cyp2d fluoreszenztest - Google Patents
Reagentien für cyp2d fluoreszenztestInfo
- Publication number
- ATE256120T1 ATE256120T1 AT99933887T AT99933887T ATE256120T1 AT E256120 T1 ATE256120 T1 AT E256120T1 AT 99933887 T AT99933887 T AT 99933887T AT 99933887 T AT99933887 T AT 99933887T AT E256120 T1 ATE256120 T1 AT E256120T1
- Authority
- AT
- Austria
- Prior art keywords
- cyp2d
- reagents
- cyp2d6
- enzyme activity
- fluorescence test
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9299598P | 1998-07-16 | 1998-07-16 | |
PCT/US1999/015659 WO2000004008A1 (en) | 1998-07-16 | 1999-07-12 | Novel cyp2d fluorescent assay reagents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE256120T1 true ATE256120T1 (de) | 2003-12-15 |
Family
ID=22236180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99933887T ATE256120T1 (de) | 1998-07-16 | 1999-07-12 | Reagentien für cyp2d fluoreszenztest |
Country Status (7)
Country | Link |
---|---|
US (1) | US6130342A (de) |
EP (1) | EP1095032B1 (de) |
AT (1) | ATE256120T1 (de) |
DE (1) | DE69913533T2 (de) |
DK (1) | DK1095032T3 (de) |
ES (1) | ES2211123T3 (de) |
WO (1) | WO2000004008A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143492A (en) * | 1998-12-14 | 2000-11-07 | Aurora Biosciences Corporation | Optical molecular sensors for cytochrome P450 activity |
US6420130B1 (en) | 1998-12-14 | 2002-07-16 | Aurora Biosciences Corporation | Optical molecular sensors for cytochrome P450 activity |
ES2199605T3 (es) * | 1998-12-14 | 2004-02-16 | Vertex Pharmaceuticals (San Diego) Llc | Indicadores moleculares opticos de actividad del citocromo p450. |
US6514687B1 (en) | 1998-12-14 | 2003-02-04 | Vertex Pharmaceuticals (San Diego), Llc | Optical molecular sensors for cytochrome P450 activity |
US6420131B1 (en) | 1999-08-19 | 2002-07-16 | Gentest Corporation | Use of fluorescein aryl ethers in high throughput cytochrome P450 inhibition assays |
US6207404B1 (en) * | 1999-09-30 | 2001-03-27 | Gentest Corporation | Coumarin-based CYP3A fluorescent assay reagents |
WO2002004660A2 (en) * | 2000-07-12 | 2002-01-17 | Wyeth | Method for testing for inhibition of drug-metabolizing cytochrome p450 isozymes |
US20040096874A1 (en) * | 2002-04-11 | 2004-05-20 | Third Wave Technologies, Inc. | Characterization of CYP 2D6 genotypes |
US7232663B2 (en) * | 2005-07-13 | 2007-06-19 | The University Of Wyoming | Assays employing novel substrates for measuring P450-mediated N-dealkylation |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1210883B (de) * | 1961-11-09 | 1966-02-17 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von Derivaten des 7-Oxycumarins |
FR1451667A (fr) * | 1964-10-17 | 1966-01-07 | Cassella Farbwerke Mainkur Ag | Nouvelles 3-aminoalkyl-4-alkyl-coumarines et leur préparation |
US3515721A (en) * | 1967-06-26 | 1970-06-02 | Cassella Farbwerke Mainkur Ag | 3-tertiary-aminoethyl-4-methyl or phenyl-7-ethoxycarbonylmethoxy - halo or mononitro coumarins and congeners |
IT1088554B (it) * | 1977-11-17 | 1985-06-10 | F I D I A Spa | Procedimento sellettivo per la preparazione di derivati della 7-indrossi cumarina |
GB2211500B (en) * | 1987-10-26 | 1991-03-06 | Medical Res Council | 7-alkoxy-3-cyanocoumarins and their use as substrates in fluorometric assays for enzymes |
CS275270B2 (en) * | 1988-08-19 | 1992-02-19 | Univ Komenskeho | Method of substituted 3-/n,n-dimethylamino/-6-x-7-y-8-z-2h-1-benzopyran-2-one compounds production |
DE3834861A1 (de) * | 1988-10-13 | 1990-04-19 | Basf Ag | Arylalkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel |
US5247099A (en) * | 1989-08-17 | 1993-09-21 | Abbott Laboratories | Process for synthesis of 7-hydroxy coumarins having substitutions in the 4-position |
IT1247476B (it) * | 1991-06-14 | 1994-12-17 | Fidia Spa | Derivati della cumarina. |
US5851785A (en) * | 1992-02-04 | 1998-12-22 | Kyowa Medex Co., Ltd. | Method of quantitative determination of substances using coumarin derivatives |
WO1993015219A1 (en) * | 1992-02-04 | 1993-08-05 | Kyowa Medex Co., Ltd. | Method of quantitative determination of substance with coumarin derivative |
US5830912A (en) * | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
-
1999
- 1999-07-12 DE DE69913533T patent/DE69913533T2/de not_active Expired - Lifetime
- 1999-07-12 US US09/352,576 patent/US6130342A/en not_active Expired - Lifetime
- 1999-07-12 AT AT99933887T patent/ATE256120T1/de active
- 1999-07-12 ES ES99933887T patent/ES2211123T3/es not_active Expired - Lifetime
- 1999-07-12 WO PCT/US1999/015659 patent/WO2000004008A1/en active IP Right Grant
- 1999-07-12 DK DK99933887T patent/DK1095032T3/da active
- 1999-07-12 EP EP99933887A patent/EP1095032B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69913533T2 (de) | 2004-11-11 |
US6130342A (en) | 2000-10-10 |
DK1095032T3 (da) | 2004-03-29 |
EP1095032B1 (de) | 2003-12-10 |
WO2000004008A1 (en) | 2000-01-27 |
DE69913533D1 (de) | 2004-01-22 |
ES2211123T3 (es) | 2004-07-01 |
EP1095032A1 (de) | 2001-05-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
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