IL179441A - Method of measuring the activity of egln enzyme and of identifying an agent that modulates activity of said enzyme - Google Patents

Method of measuring the activity of egln enzyme and of identifying an agent that modulates activity of said enzyme

Info

Publication number
IL179441A
IL179441A IL179441A IL17944106A IL179441A IL 179441 A IL179441 A IL 179441A IL 179441 A IL179441 A IL 179441A IL 17944106 A IL17944106 A IL 17944106A IL 179441 A IL179441 A IL 179441A
Authority
IL
Israel
Prior art keywords
activity
enzyme
measuring
identifying
egln
Prior art date
Application number
IL179441A
Other versions
IL179441A0 (en
Original Assignee
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fibrogen Inc filed Critical Fibrogen Inc
Publication of IL179441A0 publication Critical patent/IL179441A0/en
Publication of IL179441A publication Critical patent/IL179441A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides methods for measuring EGLN activity. The invention also provides novel peptides for use in the methods, and use of the methods to identify agents which modulate EGLN activity.
IL179441A 2004-05-28 2006-11-21 Method of measuring the activity of egln enzyme and of identifying an agent that modulates activity of said enzyme IL179441A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57532404P 2004-05-28 2004-05-28
PCT/US2005/018577 WO2005118836A2 (en) 2004-05-28 2005-05-26 Hif prolyl hydroxylase activity assay

Publications (2)

Publication Number Publication Date
IL179441A0 IL179441A0 (en) 2007-05-15
IL179441A true IL179441A (en) 2010-12-30

Family

ID=34979114

Family Applications (1)

Application Number Title Priority Date Filing Date
IL179441A IL179441A (en) 2004-05-28 2006-11-21 Method of measuring the activity of egln enzyme and of identifying an agent that modulates activity of said enzyme

Country Status (13)

Country Link
US (1) US20080113383A1 (en)
EP (1) EP1766047B1 (en)
JP (1) JP2008500834A (en)
AT (1) ATE443775T1 (en)
AU (1) AU2005250412B2 (en)
CA (1) CA2567619A1 (en)
DE (1) DE602005016800D1 (en)
ES (1) ES2332798T3 (en)
HK (1) HK1102197A1 (en)
IL (1) IL179441A (en)
NZ (1) NZ551632A (en)
WO (1) WO2005118836A2 (en)
ZA (1) ZA200610164B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7928120B2 (en) 2006-01-27 2011-04-19 Fibrogen, Inc. Cyanoisoquinoline compounds and methods of use thereof
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
CN101460497A (en) 2006-04-04 2009-06-17 菲布罗根有限公司 Pyrrolo- and thiazolo-pyridine compounds as HIF modulators
EP3026044B8 (en) 2006-06-26 2018-12-19 Akebia Therapeutics, Inc. Prolyl hydroxylase inhibitors and methods of use
EP2496084B1 (en) 2009-11-06 2015-06-10 Aerpio Therapeutics Inc. Compositions and methods for treating colitis
EP2670750B1 (en) 2011-02-02 2016-09-14 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
NO2686520T3 (en) 2011-06-06 2018-03-17
CA2837560C (en) 2011-06-06 2017-02-14 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
CN104470899B (en) 2012-03-09 2017-12-26 菲布罗根有限公司 The 4 isoquinolinol compounds as HIF hydroxylase inhibitors
IN2015KN00265A (en) 2012-07-16 2015-06-12 Fibrogen Inc
CN107501177B (en) 2012-07-16 2018-12-07 菲布罗根有限公司 The crystal habit of prolyl hydroxylase inhibitors
CN114404414A (en) 2013-06-13 2022-04-29 阿克比治疗有限公司 Compositions and methods for treating anemia
US10150734B2 (en) 2015-01-23 2018-12-11 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
BR112017021097B1 (en) 2015-04-01 2024-01-02 Akebia Therapeutics, Inc ORAL DOSAGE FORMULATION AND ITS USE
TW202406895A (en) 2018-05-09 2024-02-16 美商阿克比治療有限公司 Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
CN114577945B (en) * 2022-03-10 2023-06-02 中国科学院兰州化学物理研究所 Micelle electric chromatography method for screening prolyl hydroxylase 2 inhibitor from traditional Chinese medicine extract

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040146964A1 (en) * 2001-03-21 2004-07-29 Maxwell Patrick Henry Assays, methods and means
ES2414706T3 (en) * 2001-12-06 2013-07-22 Fibrogen, Inc. Methods to increase endogenous erythropoietin

Also Published As

Publication number Publication date
HK1102197A1 (en) 2007-11-09
EP1766047A2 (en) 2007-03-28
AU2005250412B2 (en) 2009-09-17
US20080113383A1 (en) 2008-05-15
CA2567619A1 (en) 2005-12-15
IL179441A0 (en) 2007-05-15
NZ551632A (en) 2009-09-25
ATE443775T1 (en) 2009-10-15
WO2005118836A3 (en) 2006-04-06
JP2008500834A (en) 2008-01-17
WO2005118836A2 (en) 2005-12-15
ZA200610164B (en) 2008-02-27
DE602005016800D1 (en) 2009-11-05
ES2332798T3 (en) 2010-02-12
AU2005250412A1 (en) 2005-12-15
EP1766047B1 (en) 2009-09-23

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Legal Events

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