IN2015KN00265A - - Google Patents

Info

Publication number
IN2015KN00265A
IN2015KN00265A IN265KON2015A IN2015KN00265A IN 2015KN00265 A IN2015KN00265 A IN 2015KN00265A IN 265KON2015 A IN265KON2015 A IN 265KON2015A IN 2015KN00265 A IN2015KN00265 A IN 2015KN00265A
Authority
IN
India
Prior art keywords
compounds
hif
activity
stability
increasing
Prior art date
Application number
Inventor
Michael D Thompson
Jung Min Park
Michael P Arend
Original Assignee
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fibrogen Inc filed Critical Fibrogen Inc
Publication of IN2015KN00265A publication Critical patent/IN2015KN00265A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)

Abstract

The present invention relates to methods for making isoquinoline compounds and the intermediate compounds achieved thereby. Such compounds can be used to prepare compounds and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
IN265KON2015 2012-07-16 2013-07-15 IN2015KN00265A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261672191P 2012-07-16 2012-07-16
PCT/US2013/050538 WO2014014834A1 (en) 2012-07-16 2013-07-15 Process for making isoquinoline compounds

Publications (1)

Publication Number Publication Date
IN2015KN00265A true IN2015KN00265A (en) 2015-06-12

Family

ID=48857024

Family Applications (1)

Application Number Title Priority Date Filing Date
IN265KON2015 IN2015KN00265A (en) 2012-07-16 2013-07-15

Country Status (21)

Country Link
US (2) US9340511B2 (en)
EP (2) EP2872487B1 (en)
JP (1) JP6196671B2 (en)
KR (1) KR102145272B1 (en)
CN (2) CN106083719B (en)
AU (1) AU2013290437B2 (en)
BR (1) BR112015001106B1 (en)
CA (1) CA2879238C (en)
DK (1) DK2872487T3 (en)
ES (1) ES2631655T3 (en)
HU (2) HUE034409T2 (en)
IL (1) IL236625B (en)
IN (1) IN2015KN00265A (en)
MX (1) MX350922B (en)
MY (1) MY171483A (en)
NZ (1) NZ704660A (en)
PL (1) PL2872487T3 (en)
PT (1) PT2872487T (en)
SG (1) SG11201500234YA (en)
WO (1) WO2014014834A1 (en)
ZA (1) ZA201500664B (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2528232C (en) 2003-06-06 2010-05-25 Fibrogen, Inc. Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
WO2010056767A1 (en) 2008-11-14 2010-05-20 Fibrogen, Inc. Thiochromene derivatives as hip hydroxylase inhibitors
EP2872488B1 (en) * 2012-07-16 2018-08-22 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
HUE034409T2 (en) 2012-07-16 2018-02-28 Fibrogen Inc Process for making isoquinoline compounds
EP3708154A1 (en) 2013-06-06 2020-09-16 Fibrogen, Inc. Pharmaceutical formulations of a hif hydroxylase inhibitor
CN103694172A (en) * 2013-12-26 2014-04-02 辽宁亿灵科创生物医药科技有限公司 Derivative of aza-aryl compound
AU2015311333B2 (en) 2014-09-02 2017-11-16 Sunshine Lake Pharma Co., Ltd. Quinolinone compound and use thereof
WO2016045125A1 (en) * 2014-09-28 2016-03-31 Merck Sharp & Dohme Corp. Inhibitors of hif prolyl hydroxylase
CN104447547B (en) * 2014-11-10 2017-04-19 苏州康润医药有限公司 Synthesis method of 4-aminoisoquinoline-8-methyl formate
CN106146490B (en) * 2015-03-27 2018-10-23 沈阳三生制药有限责任公司 5- hydroxyl -1,7- naphthyridine compounds, preparation method and its pharmaceutical applications replaced by aryloxy group or heteroaryloxy
CN104892509B (en) * 2015-06-04 2018-03-09 苏州明锐医药科技有限公司 Nuo get Si Ta preparation method
CN106187888A (en) * 2016-07-18 2016-12-07 江苏德源药业股份有限公司 FG 4592 monocrystalline and preparation method thereof
CN106478503A (en) * 2016-09-29 2017-03-08 上海勋和医药科技有限公司 The preparation method of Roxadustat intermediate
CZ2016627A3 (en) 2016-10-07 2018-04-18 Zentiva, K.S. A method of preparing (7-phenoxy-4-hydroxy-1-methyl-isoquinoline-3-carbonyl)glycine (roxadustate) and its intermediates based on the simultaneous opening of the oxazole ring, ether cleavage and imine formation
CN107954931B (en) * 2016-10-17 2021-06-22 上海医药集团青岛国风药业股份有限公司 Preparation method of nodispat
WO2018140186A1 (en) 2017-01-28 2018-08-02 Kingchem Life Science Llc A process for preparing 5-phenoxy-1(3h)isobenzofuranone
JP2021504440A (en) * 2017-12-01 2021-02-15 ドクター レディズ ラボラトリーズ リミテッド Method for preparing Lokidustat and its intermediates
CN109956870A (en) 2017-12-14 2019-07-02 南京卡文迪许生物工程技术有限公司 A kind of Luo Shasi his synthetic method and its midbody compound
CN110218184B (en) * 2018-03-01 2022-09-27 广东东阳光药业有限公司 Nodesserts eutectic and preparation method thereof
WO2019174631A1 (en) * 2018-03-16 2019-09-19 上海医药集团股份有限公司 Method for preparing norstat
CN110526813B (en) * 2018-05-24 2022-06-28 杭州科巢生物科技有限公司 Process for producing isoquinoline compounds and intermediates thereof
CN112166105B (en) 2018-06-05 2022-03-04 沈阳化工大学 Trifluoroethyl sulfide (sulfoxide) substituted benzene compound and application thereof
AU2019375983A1 (en) 2018-11-09 2021-06-10 Vivace Therapeutics, Inc. Bicyclic compounds
CN109776415B (en) * 2019-03-07 2020-11-17 福建南方制药股份有限公司 Preparation method of Roxadustat intermediate
CN114072207B (en) 2019-04-16 2024-03-29 维瓦斯治疗公司 Bicyclic compounds
RU2709493C1 (en) * 2019-08-01 2019-12-18 Марат Феликсович Фазылов Method of producing roxadustat
EP4010318A1 (en) 2019-08-07 2022-06-15 Teva Pharmaceuticals International GmbH Processes for the preparation of roxadustat and intermediates thereof
CN112441975B (en) * 2019-09-03 2023-10-31 西藏嘉信景天药业有限公司 Preparation method of important intermediate of roflumilast
CN112679431B (en) * 2019-10-18 2023-05-05 上海迪赛诺化学制药有限公司 Method for preparing isoquinolinones compound
US20230112619A1 (en) * 2019-10-18 2023-04-13 Shanghai Desano Chemical Pharmaceutical Co., Ltd. Method for preparing isoquinolinone compounds
CN112679430B (en) * 2019-10-18 2023-05-05 上海迪赛诺化学制药有限公司 Method for preparing isoquinolinones compound
CN113444042A (en) * 2020-03-27 2021-09-28 南京海润医药有限公司 Preparation method of Rosxastat
WO2021214785A1 (en) 2020-04-21 2021-10-28 Mylan Laboratories Limited Improved process for the preparation of roxadustat
CN111533691A (en) * 2020-06-08 2020-08-14 重庆三圣实业股份有限公司 Preparation method of Rosxastat
CN114539149A (en) * 2020-06-19 2022-05-27 济川(上海)医学科技有限公司 Compound containing isoquinoline ring, preparation method and application thereof
CN112409258A (en) * 2020-11-20 2021-02-26 杭州科巢生物科技有限公司 Preparation method of Rosxastat
CN114644589A (en) * 2020-12-17 2022-06-21 鲁南制药集团股份有限公司 Preparation method of compound N- [ (4-hydroxy-1-methyl-3-isoquinolyl) carbonyl ] -glycine
US20230101768A1 (en) * 2021-08-13 2023-03-30 The Board Of Regents Of The University Of Texas System Method to treat manganese toxicity and manganese-induced parkinsonism in humans
CN115124467A (en) * 2022-07-11 2022-09-30 天津力生制药股份有限公司 Preparation method of key intermediate of roxasistat

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036964A (en) 1973-10-11 1977-07-19 Beecham Group Limited Isocarbostyril-3-carboxylic acid derivatives for the prophylaxis of asthma, hayfever and rhinitis
US3989704A (en) 1973-10-30 1976-11-02 Sandoz, Inc. 3-Substituted-4-aryl isoquinolines
DE2818423A1 (en) 1978-04-27 1979-11-08 Hoechst Ag NEW ISOCHINOLINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
DE3233424A1 (en) 1982-09-09 1984-03-15 Hoechst Ag, 6230 Frankfurt ISOCHINOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE
US4558006A (en) 1983-02-04 1985-12-10 Kirin-Amgen, Inc. A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin
US4559403A (en) 1983-05-19 1985-12-17 Hoffmann-La Roche Inc. Substituted isoquinolines
US4584379A (en) 1985-01-22 1986-04-22 Merrell Dow Pharmaceuticals Inc. Isoquinoline thromboxane synthetase inhibitors
US4667016A (en) 1985-06-20 1987-05-19 Kirin-Amgen, Inc. Erythropoietin purification
US4822800A (en) 1986-06-09 1989-04-18 Ortho Pharmaceutical Corporation Isoquinolinol compounds having cardiotonic and phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
US4966906A (en) 1987-11-27 1990-10-30 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-isoquinolinecarboxamides
US4952588A (en) 1987-11-27 1990-08-28 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinoline-and 1-aryl-3-isoquinoline-carboxamides
ATE149485T1 (en) 1993-11-02 1997-03-15 Hoechst Ag SUBSTITUTED HETEROCYCLIC CARBOXYLIC AMIDE ESTERS, THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS
ES2101421T3 (en) 1993-11-02 1997-07-01 Hoechst Ag SUBSTITUTED HETERO-CYCLIC CARBOXYLIC ACID AMIDES, THEIR PREPARATION AND THEIR USE AS MEDICINES.
TW406076B (en) 1993-12-30 2000-09-21 Hoechst Ag Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals
WO1996018616A1 (en) 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
IL135495A (en) 1995-09-28 2002-12-01 Hoechst Ag Intermediate compounds for the preparation of substituted quinoline-2-carboxylic acid amides
WO1998023608A1 (en) 1996-11-27 1998-06-04 Dupont Pharmaceuticals Company Novel integrin receptor antagonists
DE19746287A1 (en) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituted isoquinoline-2-carboxylic acid amides, their preparation and their use as medicaments
FR2779963A1 (en) 1998-06-22 1999-12-24 Centre Nat Rech Scient New composition useful for treat cancer, comprises compound with affinity for mitochondrial benzodiazepine receptors and agent to induce apoptosis
IT1302677B1 (en) 1998-10-15 2000-09-29 Zambon Spa BENZAZINIC DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
IT1320162B1 (en) 2000-02-09 2003-11-18 Rotta Research Lab DERIVATIVES OF THYROSIN WITH ANTI LEUKOTRIENIC ACTIVITY, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE.
FI20002044A0 (en) 2000-09-15 2000-09-15 Orion Yhtymae Oyj Naphthalene derivatives which inhibit Comt enzymes
DE10110750A1 (en) 2001-03-07 2002-09-12 Bayer Ag Novel aminodicarboxylic acid derivatives with pharmaceutical properties
US6855510B2 (en) 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
AU2002241154A1 (en) 2001-03-21 2002-10-03 Isis Innovation Ltd. Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase
GB0107901D0 (en) * 2001-03-29 2001-05-23 Cyclacel Ltd Anti-cancer compounds
US6777425B2 (en) 2001-06-13 2004-08-17 Genesoft Pharmaceuticals, Inc. Isoquinoline compounds having antiinfective activity
AU2002312371A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Aryl-benzimidazole compounds having antiinfective activity
US6762318B2 (en) 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
US8318703B2 (en) 2001-12-06 2012-11-27 Fibrogen, Inc. Methods for improving kidney function
CN100522946C (en) 2001-12-06 2009-08-05 法布罗根股份有限公司 Stabilization of hypoxia inducible factor (HIF) alpha
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) * 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
GB0229581D0 (en) * 2002-12-19 2003-01-22 Cyclacel Ltd Use
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
US20060251638A1 (en) 2003-06-06 2006-11-09 Volkmar Guenzler-Pukall Cytoprotection through the use of hif hydroxylase inhibitors
CA2528232C (en) 2003-06-06 2010-05-25 Fibrogen, Inc. Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
US20060173046A1 (en) 2003-07-15 2006-08-03 Bell Ian M Hydroxypyridine cgrp receptor antagonists
US20070042937A1 (en) 2003-08-01 2007-02-22 Fibrogen, Inc. Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
US7208601B2 (en) 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
JP2007501844A (en) 2003-08-08 2007-02-01 トランス　テック　ファーマ，インコーポレイテッド Aryl and heteroaryl compounds, compositions and methods of use
AU2005250412B2 (en) 2004-05-28 2009-09-17 Fibrogen, Inc. HIF prolyl hydroxylase activity assay
AP2007004047A0 (en) * 2005-01-20 2007-06-30 Pfizer Ltd Substituted triazole derivatives as oxtocin antagonists
US8703795B2 (en) 2005-03-02 2014-04-22 Fibrogen, Inc. Thienopyridine compounds, and methods of use thereof
CN101849943A (en) 2005-06-06 2010-10-06 菲布罗根公司 Use the improved treatment for anemia of HIF alpha stabilizers
MX2007016160A (en) 2005-06-15 2008-03-07 Fibrogen Inc Use of hif 1alfa modulators for treatment of cancer.
CA2837984C (en) * 2005-11-28 2021-11-16 Commvault Systems, Inc. Systems and methods for classifying and transferring information in a storage network
EP2044028B1 (en) 2006-01-27 2012-05-16 Fibrogen, Inc. Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
AU2007218051A1 (en) 2006-02-16 2007-08-30 Fibrogen, Inc. Compounds and methods for treatment of stroke
WO2007115315A2 (en) 2006-04-04 2007-10-11 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as hif modulators
US20070293575A1 (en) 2006-06-15 2007-12-20 Fibrogen, Inc. Compounds and methods for treatment of cancer-related anemia
US7713986B2 (en) 2006-06-15 2010-05-11 Fibrogen, Inc. Compounds and methods for treatment of chemotherapy-induced anemia
US8269008B2 (en) 2007-12-03 2012-09-18 Fibrogen, Inc. Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions
US8952160B2 (en) 2008-01-11 2015-02-10 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity
WO2009100250A1 (en) 2008-02-05 2009-08-13 Fibrogen, Inc. Chromene derivatives and use thereof as hif hydroxylase activity inhibitors
US8217043B2 (en) 2008-08-20 2012-07-10 Fibrogen, Inc. Compounds and methods for their use
WO2010056767A1 (en) 2008-11-14 2010-05-20 Fibrogen, Inc. Thiochromene derivatives as hip hydroxylase inhibitors
CN103429239A (en) 2011-01-13 2013-12-04 菲布罗根有限公司 Methods for increasing reticulocyte hemoglobin content
WO2012106472A1 (en) 2011-02-02 2012-08-09 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor (hif) hydroxylase
KR102029951B1 (en) * 2011-07-22 2019-11-08 베이징 베타 파머수티컬 컴퍼니 리미티드 Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof
AU2013229922B2 (en) 2012-03-09 2017-09-28 Fibrogen, Inc. 4 -hydroxy- isoquinoline compounds as HIF hydroxylase inhibitors
EP2872488B1 (en) 2012-07-16 2018-08-22 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
HUE034409T2 (en) 2012-07-16 2018-02-28 Fibrogen Inc Process for making isoquinoline compounds
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
AU2014209319B2 (en) 2013-01-24 2018-04-19 Fibrogen, Inc. Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
EP3708154A1 (en) 2013-06-06 2020-09-16 Fibrogen, Inc. Pharmaceutical formulations of a hif hydroxylase inhibitor

Also Published As

Publication number Publication date
EP2872487B1 (en) 2017-04-26
HUE034409T2 (en) 2018-02-28
SG11201500234YA (en) 2015-02-27
US9708269B2 (en) 2017-07-18
WO2014014834A1 (en) 2014-01-23
CA2879238C (en) 2021-08-10
JP6196671B2 (en) 2017-09-13
PL2872487T3 (en) 2017-09-29
NZ704660A (en) 2017-10-27
PT2872487T (en) 2017-05-15
US9340511B2 (en) 2016-05-17
EP3219706A1 (en) 2017-09-20
EP2872487A1 (en) 2015-05-20
DK2872487T3 (en) 2017-06-06
CA2879238A1 (en) 2014-01-23
MX350922B (en) 2017-09-25
MX2015000505A (en) 2015-07-17
US20150175550A1 (en) 2015-06-25
ES2631655T3 (en) 2017-09-01
BR112015001106B1 (en) 2021-11-09
CN106083719B (en) 2019-10-18
IL236625A0 (en) 2015-02-26
ZA201500664B (en) 2017-08-30
KR20150058147A (en) 2015-05-28
CN103435546A (en) 2013-12-11
JP2015524409A (en) 2015-08-24
CN106083719A (en) 2016-11-09
KR102145272B1 (en) 2020-08-18
HUS2200030I1 (en) 2022-07-28
AU2013290437A1 (en) 2015-02-19
CN103435546B (en) 2016-08-10
BR112015001106A2 (en) 2017-06-27
US20160194285A1 (en) 2016-07-07
MY171483A (en) 2019-10-15
AU2013290437B2 (en) 2017-11-02
IL236625B (en) 2019-01-31

Similar Documents

Publication Publication Date Title
IN2015KN00265A (en)
WO2017064566A3 (en) Inducible modification of a cell genome
MX355428B (en) Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]- acetic acid.
WO2014100764A3 (en) Methods of inhibiting prmt5
MX360499B (en) Microbial strains, compositions, and methods for increasing available phosphate for plants.
PH12015502141A1 (en) Substituted xanthines and methods of use thereof
JO3773B1 (en) P2x7 modulators
MY195343A (en) A Novel Phtalazinone Derivatives and Manufacturing Process Thereof
WO2010056767A8 (en) Thiochromene derivatives as hif hydroxylase inhibitors
AU2015287674B2 (en) Topical antiviral compositions and methods of using the same
MX2020001756A (en) Benzoquinolone inhibitors of vmat2.
CA2902795C (en) Glycopyrrolate salts
EA201590887A1 (en) COMPOSITION
WO2014086982A3 (en) Stable metal compounds, their compositions and methods of their use
IN2015DN02793A (en)
MX347882B (en) Improved process for preparing (3e,7e)-homofarnesol.
NZ706838A (en) Use of p3 of bacteriophage fusion proteins as amyloid binding agents
AU2018253594A1 (en) Dihydroxyphenyl neurotransmitter compounds, compositions and methods
MX2014006337A (en) Use of p3 of bacteriophage as amyloid binding agents.
MX2012010127A (en) Derivatives of aminoindanes, their preparation and their application in therapeutics.
WO2014097318A3 (en) Agents for eliminating tumour-initiating cells
MX2011013878A (en) Substituted 4-hydroxypyrimidine-5-carboxamides.
MX2015016603A (en) Corticosteroid compositions.
IN2014DN10135A (en)
EA201492280A1 (en) STABLE PEXIGANANE COMPOSITION