CN102507627B - 一种高通量筛选药物的核磁共振方法 - Google Patents
一种高通量筛选药物的核磁共振方法 Download PDFInfo
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- CN102507627B CN102507627B CN201110358670.7A CN201110358670A CN102507627B CN 102507627 B CN102507627 B CN 102507627B CN 201110358670 A CN201110358670 A CN 201110358670A CN 102507627 B CN102507627 B CN 102507627B
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Families Citing this family (11)
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CN104849298B (zh) * | 2015-05-26 | 2017-10-31 | 衢州普林千叶电子科技有限公司 | 一种用于核磁分析的样品检测分析仪和方法 |
CN106018454A (zh) * | 2016-05-16 | 2016-10-12 | 山东省分析测试中心 | 一种基于氢核磁共振快速测定奥贝胆酸纯度的方法 |
CN105954310A (zh) * | 2016-05-16 | 2016-09-21 | 山东省分析测试中心 | 一种基于氢核磁共振快速测定盐酸林可霉素原料药纯度的方法 |
CN106198594B (zh) * | 2016-06-20 | 2018-07-27 | 中国科学院长春应用化学研究所 | 一种聚合物分子量的表征方法 |
CN108072684B (zh) * | 2016-11-11 | 2020-06-16 | 中国科学院广州生物医药与健康研究院 | 法尼醇x受体的新配体及其筛选方法和应用 |
TWI722535B (zh) * | 2018-08-21 | 2021-03-21 | 美商美國禮來大藥廠 | 測定蛋白質或肽濃度的方法及其用途 |
CN109709129A (zh) * | 2019-02-13 | 2019-05-03 | 李秀利 | 一种高通量筛选药物的磁共振成像方法 |
CN110376235B (zh) * | 2019-07-18 | 2020-09-15 | 浙江大学 | 基于核磁共振技术的三尖杉宁碱的空间相关谱测试方法 |
CN110638451B (zh) * | 2019-08-21 | 2023-04-07 | 福建中医药大学 | 一种电针启动时间的计算方法及装置 |
JP7111310B2 (ja) * | 2019-12-11 | 2022-08-02 | 日本電子株式会社 | 核磁気共鳴測定方法及び装置 |
CN114177316A (zh) * | 2020-11-09 | 2022-03-15 | 深圳鼎邦生物科技有限公司 | 氘气在核磁成像和核磁检测中的应用 |
Citations (2)
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CN1252868A (zh) * | 1997-04-18 | 2000-05-10 | 艾博特公司 | 一维核磁共振用于鉴定靶生物分子配体的用途 |
CN1668757A (zh) * | 2002-06-05 | 2005-09-14 | 法玛西雅厄普约翰有限责任公司 | 氟核磁共振用于高通量筛选的用途 |
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AU2002359332A1 (en) * | 2001-10-30 | 2003-05-12 | Vertex Pharmaceuticals Incorporated | Noe-nmr based methods for the identifycation of compounds which can bind to membrane receptors |
US20040132102A1 (en) * | 2002-10-29 | 2004-07-08 | Maurizio Pellecchia | Use of selective labeling to detect and characterize molecular interactions by nuclear magnetic resonance spectroscopy |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1252868A (zh) * | 1997-04-18 | 2000-05-10 | 艾博特公司 | 一维核磁共振用于鉴定靶生物分子配体的用途 |
CN1668757A (zh) * | 2002-06-05 | 2005-09-14 | 法玛西雅厄普约翰有限责任公司 | 氟核磁共振用于高通量筛选的用途 |
Non-Patent Citations (4)
Title |
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姚念环等.核磁共振技术(NMR)在组合化学中的应用.《化学进展》.2004,第16卷(第05期),696-707. |
核磁共振技术(NMR)在组合化学中的应用;姚念环等;《化学进展》;20040924;第16卷(第05期);696-707 * |
郑枫等.高通量药物筛选现代检测技术研究进展.《中国科学:化学》.2010,第40卷(第06期),599-610. |
高通量药物筛选现代检测技术研究进展;郑枫等;《中国科学:化学》;20101231;第40卷(第06期);599-610 * |
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Effective date of registration: 20210218 Address after: 430071 Xiao Hong, Wuchang District, Wuhan District, Hubei, Shanxi, 30 Patentee after: Institute of precision measurement science and technology innovation, Chinese Academy of Sciences Address before: 430071 Xiao Hong, Wuchang District, Wuhan District, Hubei, Shanxi, 30 Patentee before: WUHAN INSTITUTE OF PHYSICS AND MATHEMATICS, CHINESE ACADEMY OF SCIENCES |
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Application publication date: 20120620 Assignee: Wuhan Lianying Life Science Instrument Co.,Ltd. Assignor: Institute of precision measurement science and technology innovation, Chinese Academy of Sciences Contract record no.: X2021980001566 Denomination of invention: A high throughput NMR method for drug screening Granted publication date: 20141001 License type: Common License Record date: 20210310 |