BR9808079A - Uso de ressonância nuclear magnética unidimensional para identificar ligantes para biomoléculas alvos - Google Patents

Uso de ressonância nuclear magnética unidimensional para identificar ligantes para biomoléculas alvos

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Publication number
BR9808079A
BR9808079A BR9808079-2A BR9808079A BR9808079A BR 9808079 A BR9808079 A BR 9808079A BR 9808079 A BR9808079 A BR 9808079A BR 9808079 A BR9808079 A BR 9808079A
Authority
BR
Brazil
Prior art keywords
magnetic resonance
nuclear magnetic
target molecule
dimensional nuclear
target biomolecules
Prior art date
Application number
BR9808079-2A
Other languages
English (en)
Inventor
Stephen W Fesik
Philip J Hajduk
Edward T Olejniczac
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25291882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9808079(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BR9808079A publication Critical patent/BR9808079A/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/087—Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
    • G01V3/00—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation
    • G01V3/14—Electric or magnetic prospecting or detecting; Measuring magnetic field characteristics of the earth, e.g. declination, deviation operating with electron or nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Environmental & Geological Engineering (AREA)
  • Geology (AREA)
  • Remote Sensing (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"USO DE RESSONâNCIA NUCLEAR MAGNéTICA UNIDIMENSIONAL PARA IDENTIFICAR LIGANTES PARA BIOMOLéCULAS ALVOS". A presente invenção provê um processo para identificação de compostos que se ligam a uma molécula alvo específica. O processo compreende as etapas de: a) geração de um primeiro espectro de próton filtrado - difusão ou T~ 2~ de um ou uma mistura de compostos químicos; b) exposição de um ou uma mistura de compostos químicos à molécula alvo; c) geração de um segundo espectro de próton filtrado - difusão ou T~ 2~ de um ou mais mistura de compostos químicos que foi exposta à molécula alvo na etapa (b); e d) comparação do primeiro e segundo espectros de próton filtrado - difusão ou T~ 2~ para determinar diferenças entre o dito primeiro e segundo espectros, as diferenças identificando a presença de um ou mais compostos que são ligantes que ligaram-se à molécula alvo.
BR9808079-2A 1997-04-18 1998-04-17 Uso de ressonância nuclear magnética unidimensional para identificar ligantes para biomoléculas alvos BR9808079A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/844,124 US6043024A (en) 1997-04-18 1997-04-18 Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
PCT/US1998/007907 WO1998048264A1 (en) 1997-04-18 1998-04-17 Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules

Publications (1)

Publication Number Publication Date
BR9808079A true BR9808079A (pt) 2000-03-08

Family

ID=25291882

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808079-2A BR9808079A (pt) 1997-04-18 1998-04-17 Uso de ressonância nuclear magnética unidimensional para identificar ligantes para biomoléculas alvos

Country Status (29)

Country Link
US (1) US6043024A (pt)
EP (1) EP0975954B2 (pt)
JP (1) JP2002507277A (pt)
KR (1) KR100542420B1 (pt)
CN (1) CN1225648C (pt)
AR (1) AR004651A1 (pt)
AT (1) ATE259061T1 (pt)
AU (1) AU7138098A (pt)
BG (1) BG64326B1 (pt)
BR (1) BR9808079A (pt)
CA (1) CA2286795C (pt)
CO (1) CO5060446A1 (pt)
CZ (1) CZ297275B6 (pt)
DE (1) DE69821475T3 (pt)
DK (1) DK0975954T4 (pt)
ES (1) ES2215296T5 (pt)
HK (1) HK1027158A1 (pt)
HU (1) HU228433B1 (pt)
IL (1) IL131726A0 (pt)
NO (1) NO995078L (pt)
NZ (1) NZ337126A (pt)
PL (1) PL194184B1 (pt)
PT (1) PT975954E (pt)
SI (1) SI0975954T1 (pt)
SK (1) SK285411B6 (pt)
TR (1) TR199902167T2 (pt)
TW (1) TW574502B (pt)
WO (1) WO1998048264A1 (pt)
ZA (1) ZA982919B (pt)

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US20030143757A1 (en) * 1997-06-13 2003-07-31 Jonathan Moore Methods for identifying drug cores
US6111066A (en) 1997-09-02 2000-08-29 Martek Biosciences Corporation Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains
US6344330B1 (en) 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
JP2002534687A (ja) * 1998-12-30 2002-10-15 アメルシャム・パブリック・リミテッド・カンパニー 過分極を使用したｎｍｒ分光学アッセイ
US6333149B1 (en) 1999-06-04 2001-12-25 Triad Biotechnology, Inc. NMR-solve method for rapid identification of bi-ligand drug candidates
JP2003522325A (ja) * 1999-08-23 2003-07-22 ポラリス ファーマシューティカルズ，インコーポレイテッド タンパク質と巨大分子リガンドとの結合阻害剤
US6764858B2 (en) 1999-09-29 2004-07-20 Pharmacia & Upjohn Company Methods for creating a compound library
US6677160B1 (en) 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
AU2001251502A1 (en) * 2000-04-17 2001-10-30 Pharmacia And Upjohn Company Nuclear magnetic resonance methods for identifying sites in papillomavirus e2 protein
US7146277B2 (en) * 2000-06-13 2006-12-05 James H. Prestegard NMR assisted design of high affinity ligands for structurally uncharacterized proteins
US7061237B2 (en) * 2000-07-13 2006-06-13 The Regents Of The University Of California Remote NMR/MRI detection of laser polarized gases
US20030165431A1 (en) * 2000-07-13 2003-09-04 The Regents Of The University Of California Method for detecting macromolecular conformational change and binding information
US7037889B2 (en) * 2000-09-13 2006-05-02 Praecis Pharmaceuticals Inc. Pharmaceutical compositions for sustained drug delivery
WO2002027309A1 (en) * 2000-09-27 2002-04-04 Universiteit Leiden Method for applying nmr for ligand discovery or as a drug screening tool
CA2432924A1 (en) * 2000-12-21 2002-06-27 Triad Therapeutics, Inc. Sea-trosy and related methods
GB0031566D0 (en) * 2000-12-22 2001-02-07 Mets Ometrix Methods for spectral analysis and their applications
US20030092027A1 (en) * 2001-06-01 2003-05-15 Luciano Mueller Nuclear magnetic resonance method for identifying ligands to target compounds
EP1423427A2 (en) * 2001-08-27 2004-06-02 Novartis AG Nogo receptor homologues and their use
US7653490B2 (en) 2001-09-10 2010-01-26 Triad Liquidating Company LLC Nuclear magnetic resonance assembly of chemical entities
JP2005519584A (ja) * 2001-10-22 2005-07-07 ノバルティス アクチエンゲゼルシャフト Ｎｏｇｏレセプターホモログおよびそれらの使用
US7037660B2 (en) * 2001-11-06 2006-05-02 Message Pharmaceuticals Methods for detecting and quantifying binding and inhibition of binding of species to nucleic acids
KR100888805B1 (ko) * 2002-06-14 2009-03-16 크리스탈지노믹스(주) 특정 아미노산이 표지된 단백질과 1ｄ ｎｍｒ 기법을이용하여 단백질의 활성 부위에 결합하는 화합물을검색하는 방법
KR100901309B1 (ko) * 2002-06-15 2009-06-09 크리스탈지노믹스(주) 단백질의 활성 부위에 결합하는 화합물을 선별하는 방법
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
CA2466792A1 (en) * 2003-05-16 2004-11-16 Affinium Pharmaceuticals, Inc. Evaluation of spectra
US7595170B2 (en) * 2004-08-05 2009-09-29 Modrovich Ivan E Apparatus and method for measuring concentrations of molecules through a barrier
US8933209B2 (en) 2006-04-26 2015-01-13 Abbvie Inc. Dep2 and its uses in major depressive disorder and other related disorders
US20070256148A1 (en) * 2006-04-26 2007-11-01 Katz David A DEP2 and its uses in major depressive disorder and other related disorders
FR2954830A1 (fr) * 2009-12-31 2011-07-01 Nmrtec Methode d'analyse comparative par resonance magnetique nucleaire
PL2764351T3 (pl) * 2011-09-29 2019-05-31 Seattle Genetics Inc Oznaczanie nienaruszonej masy związków środków sprzężonych z białkami
CN102507627B (zh) * 2011-11-14 2014-10-01 中国科学院武汉物理与数学研究所 一种高通量筛选药物的核磁共振方法
US9678185B2 (en) 2013-03-15 2017-06-13 Pepsico, Inc. Method and apparatus for measuring physico-chemical properties using a nuclear magnetic resonance spectrometer
CN104198517B (zh) * 2014-09-23 2017-02-08 中国科学院昆明植物研究所 联合使用不同核的一维核磁共振混合物定量方法
CN104897826B (zh) * 2015-06-16 2016-06-22 广西师范大学 一种用于细胞原位检测小分子化合物与靶蛋白相互作用的方法
CN107328804B (zh) * 2017-07-21 2019-02-05 中国科学院山西煤炭化学研究所 一种甘油加氢反应混合物的核磁共振检测方法

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Also Published As

Publication number Publication date
CZ297275B6 (cs) 2006-10-11
CN1225648C (zh) 2005-11-02
JP2002507277A (ja) 2002-03-05
PL194184B1 (pl) 2007-05-31
BG64326B1 (bg) 2004-09-30
TR199902167T2 (xx) 2000-07-21
WO1998048264A1 (en) 1998-10-29
CZ9903683A3 (cs) 2001-02-14
NO995078L (no) 1999-12-06
TW574502B (en) 2004-02-01
CA2286795C (en) 2010-06-29
CA2286795A1 (en) 1998-10-29
HUP0003956A2 (en) 2001-03-28
DE69821475T3 (de) 2009-07-23
NO995078D0 (no) 1999-10-18
ES2215296T5 (es) 2009-07-06
BG103856A (en) 2000-07-31
DE69821475D1 (de) 2004-03-11
KR20010006454A (ko) 2001-01-26
AU7138098A (en) 1998-11-13
EP0975954B1 (en) 2004-02-04
KR100542420B1 (ko) 2006-01-11
DE69821475T2 (de) 2004-11-25
CN1252868A (zh) 2000-05-10
DK0975954T3 (da) 2004-06-07
CO5060446A1 (es) 2001-07-30
AR004651A1 (es) 1999-03-10
PT975954E (pt) 2004-06-30
EP0975954A1 (en) 2000-02-02
SK141699A3 (en) 2000-06-12
NZ337126A (en) 2001-05-25
EP0975954B2 (en) 2009-03-18
HUP0003956A3 (en) 2002-04-29
DK0975954T4 (da) 2009-05-18
PL336299A1 (en) 2000-06-19
ES2215296T3 (es) 2004-10-01
ATE259061T1 (de) 2004-02-15
HU228433B1 (en) 2013-03-28
SI0975954T1 (en) 2004-08-31
US6043024A (en) 2000-03-28
ZA982919B (en) 1998-10-12
HK1027158A1 (en) 2001-01-05
IL131726A0 (en) 2001-03-19
SK285411B6 (sk) 2007-01-04

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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