AR024540A1 - Uso de resonancia magnetica nuclear 13 c para detectar la union con moleculas blanco - Google Patents

Uso de resonancia magnetica nuclear 13 c para detectar la union con moleculas blanco

Info

Publication number
AR024540A1
AR024540A1 ARP000101598A ARP000101598A AR024540A1 AR 024540 A1 AR024540 A1 AR 024540A1 AR P000101598 A ARP000101598 A AR P000101598A AR P000101598 A ARP000101598 A AR P000101598A AR 024540 A1 AR024540 A1 AR 024540A1
Authority
AR
Argentina
Prior art keywords
methods
white
union
detect
enriched
Prior art date
Application number
ARP000101598A
Other languages
English (en)
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR024540A1 publication Critical patent/AR024540A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027—Cleaning the internal surfaces; Removal of blockages
    • B08B9/04—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes
    • B08B9/053—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved along the pipes by a fluid, e.g. by fluid pressure or by suction
    • B08B9/055—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved along the pipes by a fluid, e.g. by fluid pressure or by suction the cleaning devices conforming to, or being conformable to, substantially the same cross-section of the pipes, e.g. pigs or moles
    • B08B9/0553—Cylindrically shaped pigs
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B37/00—Methods or apparatus for cleaning boreholes or wells
    • E21B37/02—Scrapers specially adapted therefor
    • E21B37/04—Scrapers specially adapted therefor operated by fluid pressure, e.g. free-piston scrapers
    • E21B37/045—Free-piston scrapers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4633—Sequences for multi-dimensional NMR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mining & Mineral Resources (AREA)
  • Fluid Mechanics (AREA)
  • Geology (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Environmental & Geological Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se brindan métodos para detectar la union de un ligando putativo con una molécula banco enriquecida con 13C, métodos para rastrear compuestos que se unana una molécula blanco enriquecida con 13C, métodos para calcular la constante de disociacion de un compuesto ligando que se une con una molécula blancoenriquecida con 13C y métodos utilizados en la determinacion de los aminoácidos específicos de una molécula blanco enriquecida con 13C por medio de la unionde un ligando, como así también los compuestos identificados por estos métodos de rastreo.
ARP000101598A 1999-04-09 2000-04-07 Uso de resonancia magnetica nuclear 13 c para detectar la union con moleculas blanco AR024540A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/288,924 US20010004528A1 (en) 1995-11-14 1999-04-09 Use of 13c nuclear magnetic resonance to detect binding to target molecules

Publications (1)

Publication Number Publication Date
AR024540A1 true AR024540A1 (es) 2002-10-16

Family

ID=23109248

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000101598A AR024540A1 (es) 1999-04-09 2000-04-07 Uso de resonancia magnetica nuclear 13 c para detectar la union con moleculas blanco

Country Status (18)

Country Link
US (2) US20010004528A1 (es)
EP (1) EP1169648B1 (es)
JP (1) JP4723094B2 (es)
AR (1) AR024540A1 (es)
AT (1) ATE327510T1 (es)
AU (1) AU776165B2 (es)
CA (1) CA2365385C (es)
CO (1) CO5241342A1 (es)
CY (1) CY1107474T1 (es)
DE (1) DE60028196T2 (es)
DK (1) DK1169648T3 (es)
ES (1) ES2264930T3 (es)
HK (1) HK1044817B (es)
IL (1) IL145135A (es)
MX (1) MXPA01010180A (es)
PT (1) PT1169648E (es)
TW (1) TWI223710B (es)
WO (1) WO2000062074A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10139465A1 (de) * 2001-08-10 2003-02-20 Bayer Cropscience Ag Selektive Herbizide auf Basis von substituierten, cayclischen Ketoenolen und Safenern
DE10160177A1 (de) * 2001-12-07 2003-06-26 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden die an ein drug target binden mittels 1H,1H-Kernresonanzspektroskopie
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
DE10221158A1 (de) * 2002-05-13 2004-02-19 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden, die an ein drug target binden, mittels heteronuklearer Kernresonanzspektroskopie
KR100901309B1 (ko) * 2002-06-15 2009-06-09 크리스탈지노믹스(주) 단백질의 활성 부위에 결합하는 화합물을 선별하는 방법
US20040132102A1 (en) * 2002-10-29 2004-07-08 Maurizio Pellecchia Use of selective labeling to detect and characterize molecular interactions by nuclear magnetic resonance spectroscopy
NO20025738D0 (no) 2002-11-29 2002-11-29 Amersham Health As Metode
JPWO2006082963A1 (ja) * 2005-02-07 2008-06-26 三菱化学株式会社 標的分子とリガンドあるいはリガンド候補化合物との結合検出方法
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
WO2012129347A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0856067A4 (en) * 1995-10-19 2005-09-21 Smithkline Beecham Corp BINARY CODING METHOD FOR USE IN COMBINATION CHEMISTRY
US5698401A (en) * 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
DK0870197T4 (da) * 1995-11-14 2007-02-26 Abbott Lab Anvendelse af nuclear magnetisk resonans til design af ligander rettet mod biomolekyler

Also Published As

Publication number Publication date
US20010004528A1 (en) 2001-06-21
TWI223710B (en) 2004-11-11
ATE327510T1 (de) 2006-06-15
IL145135A (en) 2007-06-17
CO5241342A1 (es) 2003-01-31
CY1107474T1 (el) 2012-12-19
IL145135A0 (en) 2002-06-30
US20020037529A1 (en) 2002-03-28
WO2000062074A1 (en) 2000-10-19
AU3907700A (en) 2000-11-14
DK1169648T3 (da) 2006-09-11
JP2004510952A (ja) 2004-04-08
EP1169648A1 (en) 2002-01-09
MXPA01010180A (es) 2002-10-23
WO2000062074A8 (en) 2003-10-23
CA2365385C (en) 2009-11-03
JP4723094B2 (ja) 2011-07-13
ES2264930T3 (es) 2007-02-01
HK1044817A1 (en) 2002-11-01
HK1044817B (zh) 2006-12-22
DE60028196T2 (de) 2007-03-29
EP1169648B1 (en) 2006-05-24
PT1169648E (pt) 2006-09-29
DE60028196D1 (de) 2006-06-29
AU776165B2 (en) 2004-08-26
CA2365385A1 (en) 2000-10-19

Similar Documents

Publication Publication Date Title
CY1121151T1 (el) Αντισωματα ως προς opgl
ES2505144T3 (es) Agentes de unión selectivos antagonistas de proteína de unión de osteoprotegerina
AR024540A1 (es) Uso de resonancia magnetica nuclear 13 c para detectar la union con moleculas blanco
CY1112101T1 (el) Νευροτροφικοι παραγοντες
EA200200427A1 (ru) Рецептор april (bcma) и его применения
GB0106953D0 (en) Neufofibrillary labels
PT1315520E (pt) Utilizacao de anticorpos trifuncionais biespecificos e triespecificos para tratamento de ascites malignas
MY139767A (en) Antibodies that bind cell-associated ca 125/o772p and methods of use thereof
EP1708745A4 (en) ANTIBODIES FOR ONCOGEN STRAINS OF HPV AND METHODS OF USE
CY1108046T1 (el) Μεθοδος για τον καθορισμο προπροϊνσουλινης
DK0912738T3 (da) Antigen-bindende-fragmenter der specifikt detekterer cancerceller, nukleotider der koder fragmenterne og anvendelse deraf til profylakse og detektion af cancere
ATE294164T1 (de) Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening
TR200002257T2 (tr) Nükleer reseptör ligandları ve ligand bağlanma domainleri.
UA41476C2 (uk) Пристрій для високочутливої магнітної детекції аналітів (варіанти)
DE69723111D1 (de) Nachweis biospezifischer fluoreszenz durch zwei-photonen-anregung
ATE178053T1 (de) N2s2-chelatoren des hydrazino-typs
DE69434384D1 (de) Metalkomplexbildner
ATE441110T1 (de) In-vivo detektion von biomolekülekonzentrationen mittels fluoreszenzmarker
DE69831229D1 (de) Schnelle bestimmung des verhältnisses von biologischen molekülen
DE50205750D1 (de) Liganden für den nachweis von prionen
PL364358A1 (en) Receptor in the edb fibronectin domain (ii)
DK1224486T3 (da) Anvendelse af dobbeltkvantum-1H-NMR-spektroskopi til identifikation af ligander, der interagerer med malbiomolekyler
NO20025738D0 (no) Metode
ATE419861T1 (de) Peptide mit homing für lymphgefässtumor und ihre verwendung
DE59709109D1 (de) Monoklonale antikörper gegen einen komplex aus humanem act und einer serinprotease

Legal Events

Date Code Title Description
FB Suspension of granting procedure