ATE327510T1 - Verwendung von 13c-nmr zum nachweis von bindungen - Google Patents

Verwendung von 13c-nmr zum nachweis von bindungen

Info

Publication number
ATE327510T1
ATE327510T1 AT00918228T AT00918228T ATE327510T1 AT E327510 T1 ATE327510 T1 AT E327510T1 AT 00918228 T AT00918228 T AT 00918228T AT 00918228 T AT00918228 T AT 00918228T AT E327510 T1 ATE327510 T1 AT E327510T1
Authority
AT
Austria
Prior art keywords
nmr
bonds
detecting
detecting bonds
Prior art date
Application number
AT00918228T
Other languages
English (en)
Inventor
Stephen W Fesik
Philip J Hajduk
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE327510T1 publication Critical patent/ATE327510T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027—Cleaning the internal surfaces; Removal of blockages
    • B08B9/04—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes
    • B08B9/053—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved along the pipes by a fluid, e.g. by fluid pressure or by suction
    • B08B9/055—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved along the pipes by a fluid, e.g. by fluid pressure or by suction the cleaning devices conforming to, or being conformable to, substantially the same cross-section of the pipes, e.g. pigs or moles
    • B08B9/0553—Cylindrically shaped pigs
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH DRILLING; MINING
    • E21B—EARTH DRILLING, e.g. DEEP DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B37/00—Methods or apparatus for cleaning boreholes or wells
    • E21B37/02—Scrapers specially adapted therefor
    • E21B37/04—Scrapers specially adapted therefor operated by fluid pressure, e.g. free-piston scrapers
    • E21B37/045—Free-piston scrapers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4633—Sequences for multi-dimensional NMR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
AT00918228T 1999-04-09 2000-03-21 Verwendung von 13c-nmr zum nachweis von bindungen ATE327510T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/288,924 US20010004528A1 (en) 1995-11-14 1999-04-09 Use of 13c nuclear magnetic resonance to detect binding to target molecules

Publications (1)

Publication Number Publication Date
ATE327510T1 true ATE327510T1 (de) 2006-06-15

Family

ID=23109248

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00918228T ATE327510T1 (de) 1999-04-09 2000-03-21 Verwendung von 13c-nmr zum nachweis von bindungen

Country Status (18)

Country Link
US (2) US20010004528A1 (de)
EP (1) EP1169648B1 (de)
JP (1) JP4723094B2 (de)
AR (1) AR024540A1 (de)
AT (1) ATE327510T1 (de)
AU (1) AU776165B2 (de)
CA (1) CA2365385C (de)
CO (1) CO5241342A1 (de)
CY (1) CY1107474T1 (de)
DE (1) DE60028196T2 (de)
DK (1) DK1169648T3 (de)
ES (1) ES2264930T3 (de)
HK (1) HK1044817B (de)
IL (1) IL145135A (de)
MX (1) MXPA01010180A (de)
PT (1) PT1169648E (de)
TW (1) TWI223710B (de)
WO (1) WO2000062074A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10139465A1 (de) * 2001-08-10 2003-02-20 Bayer Cropscience Ag Selektive Herbizide auf Basis von substituierten, cayclischen Ketoenolen und Safenern
DE10160177A1 (de) * 2001-12-07 2003-06-26 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden die an ein drug target binden mittels 1H,1H-Kernresonanzspektroskopie
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
DE10221158A1 (de) * 2002-05-13 2004-02-19 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden, die an ein drug target binden, mittels heteronuklearer Kernresonanzspektroskopie
KR100901309B1 (ko) * 2002-06-15 2009-06-09 크리스탈지노믹스(주) 단백질의 활성 부위에 결합하는 화합물을 선별하는 방법
US20040132102A1 (en) * 2002-10-29 2004-07-08 Maurizio Pellecchia Use of selective labeling to detect and characterize molecular interactions by nuclear magnetic resonance spectroscopy
NO20025738D0 (no) 2002-11-29 2002-11-29 Amersham Health As Metode
WO2006082963A1 (ja) * 2005-02-07 2006-08-10 Mitsubishi Chemical Corporation 標的分子とリガンドあるいはリガンド候補化合物との結合検出方法
US9182406B2 (en) * 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
EP3237906B8 (de) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Befestigung von proteinen an schnittstellen zur verwendung in nicht-linearer optischer detektion

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000500565A (ja) * 1995-10-19 2000-01-18 スミスクライン・ビーチャム・コーポレイション コンビナトリアルケミストリーにて用いるための２元的コード化方法
US5698401A (en) * 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
JP3300366B2 (ja) * 1995-11-14 2002-07-08 アボツト・ラボラトリーズ 標的生体分子に対するリガンドを設計するための核磁気共鳴の使用

Also Published As

Publication number Publication date
JP4723094B2 (ja) 2011-07-13
WO2000062074A1 (en) 2000-10-19
CY1107474T1 (el) 2012-12-19
JP2004510952A (ja) 2004-04-08
HK1044817A1 (en) 2002-11-01
CA2365385C (en) 2009-11-03
PT1169648E (pt) 2006-09-29
AR024540A1 (es) 2002-10-16
EP1169648B1 (de) 2006-05-24
US20010004528A1 (en) 2001-06-21
CO5241342A1 (es) 2003-01-31
WO2000062074A8 (en) 2003-10-23
ES2264930T3 (es) 2007-02-01
DE60028196T2 (de) 2007-03-29
MXPA01010180A (es) 2002-10-23
CA2365385A1 (en) 2000-10-19
TWI223710B (en) 2004-11-11
IL145135A (en) 2007-06-17
AU3907700A (en) 2000-11-14
DK1169648T3 (da) 2006-09-11
US20020037529A1 (en) 2002-03-28
DE60028196D1 (de) 2006-06-29
HK1044817B (zh) 2006-12-22
IL145135A0 (en) 2002-06-30
EP1169648A1 (de) 2002-01-09
AU776165B2 (en) 2004-08-26

Similar Documents

Publication Publication Date Title
DE60027711D1 (de) Verbesserte vorrichtung zum nachweis von myokardischämie
DE60044907D1 (de) Verfahren zum bestimmen von glykoproteinen
DE69929895D1 (de) Prüfvorrichtung
ATE305461T1 (de) Olefinische trans-glukokinase-aktivatoren
NO20014944L (no) Prosessering for soniske bölgeformer
DE60019547D1 (de) Biosensor
DE60018541D1 (de) Biosensor
FR2794459B1 (fr) Polyalcoxyamines issues de nitroxydes beta-substitues
DE60124301D1 (de) Dünnschichtelektroden zum feststellen von herzdepolarisationsignalen
DE60044114D1 (de) Wegwerfartikel zum Aufnehmen von Urin für den Mann
DE60041315D1 (de) Wegwerfartikel zum Aufnehmen von Urin für den Mann
NO20015949L (no) Mono- og disubstituerte 3-propyl-gamma-amino-smörsyrer
DE69909611D1 (de) Reagenz zum nachweis von singulett-sauerstoff
DE69930175D1 (de) Kohlenwasserstoffsensor
NO20014242D0 (no) Alkenyl- og alkynyl-inneholdende metalloprotease inhibitorer
ATE327510T1 (de) Verwendung von 13c-nmr zum nachweis von bindungen
DE69918484D1 (de) Gerät zum Abtasten der zentrischen Relation der Mandibel
DE69935436D1 (de) Verfahren zum nachweis von mikroorganismen
DE60001644T2 (de) Verfarhung zum bestimmung flüssigen konzentration
ATA8172000A (de) Induktiver sensor zum erfassen von metallteilen
DE50006887D1 (de) Klammer zum auswuchten
DE69908679D1 (de) Verfahren zum Weitern
DE60026023D1 (de) Verfahren zum immunologischen bestimmen von pivka-ii
DE60030066D1 (de) Prüfgerät
DE60037785D1 (de) Wellenformentzerrer

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1169648

Country of ref document: EP