NO20014242D0 - Alkenyl- og alkynyl-inneholdende metalloprotease inhibitorer - Google Patents
Alkenyl- og alkynyl-inneholdende metalloprotease inhibitorerInfo
- Publication number
- NO20014242D0 NO20014242D0 NO20014242A NO20014242A NO20014242D0 NO 20014242 D0 NO20014242 D0 NO 20014242D0 NO 20014242 A NO20014242 A NO 20014242A NO 20014242 A NO20014242 A NO 20014242A NO 20014242 D0 NO20014242 D0 NO 20014242D0
- Authority
- NO
- Norway
- Prior art keywords
- alkynyl
- alkenyl
- metalloprotease inhibitors
- containing metalloprotease
- inhibitors
- Prior art date
Links
- 125000000304 alkynyl group Chemical group 0.000 title 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US12264499P | 1999-03-03 | 1999-03-03 | |
PCT/US2000/005162 WO2000051975A1 (en) | 1999-03-03 | 2000-03-01 | Alkenyl- and alkynyl-containing metalloprotease inhibitors |
Publications (2)
Publication Number | Publication Date |
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NO20014242D0 true NO20014242D0 (no) | 2001-08-31 |
NO20014242L NO20014242L (no) | 2001-09-27 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20014242A NO20014242L (no) | 1999-03-03 | 2001-08-31 | Alkenyl- og alkynyl-inneholdende metalloprotease inhibitorer |
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US (1) | US6197770B1 (no) |
EP (1) | EP1165501A1 (no) |
JP (1) | JP2002538136A (no) |
KR (1) | KR20010102486A (no) |
CN (1) | CN1349498A (no) |
AU (1) | AU764051B2 (no) |
BR (1) | BR0008716A (no) |
CA (1) | CA2364878A1 (no) |
CO (1) | CO5150219A1 (no) |
CZ (1) | CZ20013176A3 (no) |
HK (1) | HK1044754A1 (no) |
HU (1) | HUP0202199A2 (no) |
IL (1) | IL145089A0 (no) |
MA (1) | MA25391A1 (no) |
MX (1) | MXPA01008855A (no) |
NO (1) | NO20014242L (no) |
NZ (1) | NZ513831A (no) |
PE (1) | PE20001565A1 (no) |
PL (1) | PL350340A1 (no) |
RU (1) | RU2001126721A (no) |
SK (1) | SK12452001A3 (no) |
TR (1) | TR200102523T2 (no) |
WO (1) | WO2000051975A1 (no) |
ZA (1) | ZA200106967B (no) |
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US20030149997A1 (en) * | 1999-02-19 | 2003-08-07 | Hageman Gregory S. | Diagnostics and therapeutics for arterial wall disruptive disorders |
US7108982B1 (en) * | 1999-02-19 | 2006-09-19 | University Of Iowa Research Foundation | Diagnostics and the therapeutics for macular degeneration |
SK5082002A3 (en) * | 1999-10-14 | 2002-10-08 | Procter & Gamble | Beta disubstituted metalloprotease inhibitors |
US6696456B1 (en) | 1999-10-14 | 2004-02-24 | The Procter & Gamble Company | Beta disubstituted metalloprotease inhibitors |
WO2001083431A1 (fr) * | 2000-04-28 | 2001-11-08 | Shionogi & Co., Ltd. | Inhibiteurs de mmp-12 |
CA2423885A1 (en) * | 2000-09-29 | 2003-03-27 | Shionogi & Co., Ltd. | Thiazole and oxazole derivatives |
AU1401902A (en) | 2000-10-17 | 2002-04-29 | Applied Research Systems | Pharmaceutically active sulfanilide derivatives |
US20050227994A1 (en) * | 2002-03-27 | 2005-10-13 | Shionogi & Co., Ltd. | Decomposition inhibitor for extracellular matrix of cartilage |
MY133587A (en) | 2002-05-29 | 2007-11-30 | Glaxo Group Ltd | Aromatic sulfones and their medical use |
KR20050010882A (ko) * | 2002-06-11 | 2005-01-28 | 와이어쓰 | 베타 아밀로이드 생산의 치환 페닐술폰아미드 저해제 |
US20050107306A1 (en) * | 2003-05-16 | 2005-05-19 | Barr Philip J. | Treatment of respiratory disease associated with matrix metalloproteases by inhalation of synthetic matrix metalloprotease inhibitors |
US20050020565A1 (en) * | 2003-07-02 | 2005-01-27 | Jones Todd K. | CCK-1 receptor modulators |
EP1641762A2 (en) * | 2003-07-02 | 2006-04-05 | Janssen Pharmaceutica N.V. | Cck-1 receptor modulators |
US20080119513A1 (en) * | 2004-09-06 | 2008-05-22 | Fumihiko Watanabe | Sulfonamide Derivative Selectively Inhibiting Mmp-13 |
US7576222B2 (en) | 2004-12-28 | 2009-08-18 | Wyeth | Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase |
AP2616A (en) * | 2005-01-13 | 2013-03-18 | Univ Wollongong | Peptidic compounds |
US20070275944A1 (en) * | 2006-04-05 | 2007-11-29 | The Board Of Trustees Operating Michigan State University | Antioxidants and methods of their use |
EP2681209B1 (en) * | 2011-03-02 | 2018-05-09 | Aquilus Pharmaceuticals, Inc | Compounds and methods for the treatment of pain and other disorders |
EP3815685A3 (en) | 2011-10-31 | 2021-10-13 | The Methodist Hospital Research Institute | Compound comprising a mao targeting/seeker moiety for treating human gliomas |
WO2015107139A1 (en) | 2014-01-17 | 2015-07-23 | Proyecto De Biomedicina Cima, S.L. | Compounds for use as antifibrinolytic agents |
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2000
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- 2000-03-01 CA CA002364878A patent/CA2364878A1/en not_active Abandoned
- 2000-03-01 US US09/517,080 patent/US6197770B1/en not_active Expired - Fee Related
- 2000-03-01 HU HU0202199A patent/HUP0202199A2/hu unknown
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- 2000-03-01 EP EP00912064A patent/EP1165501A1/en not_active Withdrawn
- 2000-03-01 NZ NZ513831A patent/NZ513831A/en unknown
- 2000-03-01 RU RU2001126721/04A patent/RU2001126721A/ru unknown
- 2000-03-01 BR BR0008716-5A patent/BR0008716A/pt not_active IP Right Cessation
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- 2000-03-01 SK SK1245-2001A patent/SK12452001A3/sk unknown
- 2000-03-01 MX MXPA01008855A patent/MXPA01008855A/es unknown
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- 2000-03-01 AU AU33860/00A patent/AU764051B2/en not_active Ceased
- 2000-03-01 WO PCT/US2000/005162 patent/WO2000051975A1/en not_active Application Discontinuation
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- 2000-03-03 CO CO00015564A patent/CO5150219A1/es unknown
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2001
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2002
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CA2364878A1 (en) | 2000-09-08 |
IL145089A0 (en) | 2002-06-30 |
CZ20013176A3 (cs) | 2002-04-17 |
RU2001126721A (ru) | 2004-02-20 |
AU764051B2 (en) | 2003-08-07 |
AU3386000A (en) | 2000-09-21 |
WO2000051975A1 (en) | 2000-09-08 |
BR0008716A (pt) | 2002-09-24 |
PE20001565A1 (es) | 2001-02-02 |
KR20010102486A (ko) | 2001-11-15 |
CN1349498A (zh) | 2002-05-15 |
ZA200106967B (en) | 2002-03-13 |
PL350340A1 (en) | 2002-12-02 |
NO20014242L (no) | 2001-09-27 |
HUP0202199A2 (en) | 2002-10-28 |
EP1165501A1 (en) | 2002-01-02 |
JP2002538136A (ja) | 2002-11-12 |
SK12452001A3 (sk) | 2002-04-04 |
NZ513831A (en) | 2001-09-28 |
HK1044754A1 (zh) | 2002-11-01 |
MA25391A1 (fr) | 2002-04-01 |
TR200102523T2 (tr) | 2002-02-21 |
MXPA01008855A (es) | 2002-07-02 |
CO5150219A1 (es) | 2002-04-29 |
US6197770B1 (en) | 2001-03-06 |
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