MA25391A1 - Inhibiteurs d'alcenyl et alcynyl metalloproteases. - Google Patents
Inhibiteurs d'alcenyl et alcynyl metalloproteases.Info
- Publication number
- MA25391A1 MA25391A1 MA26310A MA26310A MA25391A1 MA 25391 A1 MA25391 A1 MA 25391A1 MA 26310 A MA26310 A MA 26310A MA 26310 A MA26310 A MA 26310A MA 25391 A1 MA25391 A1 MA 25391A1
- Authority
- MA
- Morocco
- Prior art keywords
- alcynyl
- alcenyl
- metalloproteases inhibitors
- metalloproteases
- inhibitors
- Prior art date
Links
- 102000005741 Metalloproteases Human genes 0.000 title 1
- 108010006035 Metalloproteases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US12264499P | 1999-03-03 | 1999-03-03 |
Publications (1)
Publication Number | Publication Date |
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MA25391A1 true MA25391A1 (fr) | 2002-04-01 |
Family
ID=22403942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MA26310A MA25391A1 (fr) | 1999-03-03 | 2001-09-03 | Inhibiteurs d'alcenyl et alcynyl metalloproteases. |
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US (1) | US6197770B1 (fr) |
EP (1) | EP1165501A1 (fr) |
JP (1) | JP2002538136A (fr) |
KR (1) | KR20010102486A (fr) |
CN (1) | CN1349498A (fr) |
AU (1) | AU764051B2 (fr) |
BR (1) | BR0008716A (fr) |
CA (1) | CA2364878A1 (fr) |
CO (1) | CO5150219A1 (fr) |
CZ (1) | CZ20013176A3 (fr) |
HK (1) | HK1044754A1 (fr) |
HU (1) | HUP0202199A2 (fr) |
IL (1) | IL145089A0 (fr) |
MA (1) | MA25391A1 (fr) |
MX (1) | MXPA01008855A (fr) |
NO (1) | NO20014242L (fr) |
NZ (1) | NZ513831A (fr) |
PE (1) | PE20001565A1 (fr) |
PL (1) | PL350340A1 (fr) |
RU (1) | RU2001126721A (fr) |
SK (1) | SK12452001A3 (fr) |
TR (1) | TR200102523T2 (fr) |
WO (1) | WO2000051975A1 (fr) |
ZA (1) | ZA200106967B (fr) |
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US7108982B1 (en) * | 1999-02-19 | 2006-09-19 | University Of Iowa Research Foundation | Diagnostics and the therapeutics for macular degeneration |
US20030149997A1 (en) * | 1999-02-19 | 2003-08-07 | Hageman Gregory S. | Diagnostics and therapeutics for arterial wall disruptive disorders |
US6696456B1 (en) | 1999-10-14 | 2004-02-24 | The Procter & Gamble Company | Beta disubstituted metalloprotease inhibitors |
KR20020038951A (ko) * | 1999-10-14 | 2002-05-24 | 데이비드 엠 모이어 | 베타 이치환된 메탈로프로테아제 저해제 |
US6897237B2 (en) | 2000-04-28 | 2005-05-24 | Shionogi & Co. Ltd. | MMP-12 inhibitors |
CA2423885A1 (fr) * | 2000-09-29 | 2003-03-27 | Shionogi & Co., Ltd. | Derives de thiazole et d'oxazole |
CA2423933A1 (fr) * | 2000-10-17 | 2002-04-25 | Applied Research Systems Ars Holding N.V. | Derives de sulfanilide actifs du point de vue pharmaceutique |
AU2003221160A1 (en) * | 2002-03-27 | 2003-10-08 | Shionogi And Co., Ltd. | Decomposition inhibitor for extracellular matrix of cartilage |
AR040126A1 (es) | 2002-05-29 | 2005-03-16 | Glaxo Group Ltd | Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento |
BR0311767A (pt) | 2002-06-11 | 2005-03-08 | Wyeth Corp | Compostos inibidores de sulfonamida substituìda da produção de beta amilóide, suas composições e usos |
AU2004240629B2 (en) * | 2003-05-16 | 2010-02-25 | Arriva Pharmaceuticals, Inc. | Treatment of respiratory disease by inhalation of synthetic matrix metalloprotease inhibitors |
US20050020565A1 (en) * | 2003-07-02 | 2005-01-27 | Jones Todd K. | CCK-1 receptor modulators |
BRPI0412269A (pt) * | 2003-07-02 | 2006-09-05 | Janssen Pharmaceutica Nv | moduladores de receptor de cck-1 |
US20080119513A1 (en) * | 2004-09-06 | 2008-05-22 | Fumihiko Watanabe | Sulfonamide Derivative Selectively Inhibiting Mmp-13 |
US7576222B2 (en) * | 2004-12-28 | 2009-08-18 | Wyeth | Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase |
CN102584940B (zh) * | 2005-01-13 | 2014-12-31 | 卧龙岗大学 | 肽化合物 |
US20070275944A1 (en) * | 2006-04-05 | 2007-11-29 | The Board Of Trustees Operating Michigan State University | Antioxidants and methods of their use |
EP2681209B1 (fr) * | 2011-03-02 | 2018-05-09 | Aquilus Pharmaceuticals, Inc | Composés et méthodes de traitement de la douleur et d'autres troubles |
JP6118808B2 (ja) | 2011-10-31 | 2017-04-19 | ザ メソジスト ホスピタル リサーチ インスティテュート | ヒトグリオームを治療するためのmao標的化/探索部分を含む化合物 |
WO2015107139A1 (fr) | 2014-01-17 | 2015-07-23 | Proyecto De Biomedicina Cima, S.L. | Composés destinés à être utilisés en tant qu'agents anti-fibrinolytiques |
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2000
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- 2000-03-01 JP JP2000602203A patent/JP2002538136A/ja not_active Withdrawn
- 2000-03-01 SK SK1245-2001A patent/SK12452001A3/sk unknown
- 2000-03-01 RU RU2001126721/04A patent/RU2001126721A/ru unknown
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- 2000-03-01 HU HU0202199A patent/HUP0202199A2/hu unknown
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- 2000-03-01 CA CA002364878A patent/CA2364878A1/fr not_active Abandoned
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- 2001-09-03 MA MA26310A patent/MA25391A1/fr unknown
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2002
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Also Published As
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KR20010102486A (ko) | 2001-11-15 |
US6197770B1 (en) | 2001-03-06 |
CZ20013176A3 (cs) | 2002-04-17 |
HK1044754A1 (zh) | 2002-11-01 |
WO2000051975A1 (fr) | 2000-09-08 |
NZ513831A (en) | 2001-09-28 |
NO20014242L (no) | 2001-09-27 |
BR0008716A (pt) | 2002-09-24 |
CA2364878A1 (fr) | 2000-09-08 |
AU764051B2 (en) | 2003-08-07 |
NO20014242D0 (no) | 2001-08-31 |
JP2002538136A (ja) | 2002-11-12 |
ZA200106967B (en) | 2002-03-13 |
MXPA01008855A (es) | 2002-07-02 |
RU2001126721A (ru) | 2004-02-20 |
TR200102523T2 (tr) | 2002-02-21 |
CN1349498A (zh) | 2002-05-15 |
EP1165501A1 (fr) | 2002-01-02 |
HUP0202199A2 (en) | 2002-10-28 |
SK12452001A3 (sk) | 2002-04-04 |
PE20001565A1 (es) | 2001-02-02 |
PL350340A1 (en) | 2002-12-02 |
IL145089A0 (en) | 2002-06-30 |
CO5150219A1 (es) | 2002-04-29 |
AU3386000A (en) | 2000-09-21 |
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