MA25391A1 - Inhibiteurs d'alcenyl et alcynyl metalloproteases. - Google Patents
Inhibiteurs d'alcenyl et alcynyl metalloproteases.Info
- Publication number
- MA25391A1 MA25391A1 MA26310A MA26310A MA25391A1 MA 25391 A1 MA25391 A1 MA 25391A1 MA 26310 A MA26310 A MA 26310A MA 26310 A MA26310 A MA 26310A MA 25391 A1 MA25391 A1 MA 25391A1
- Authority
- MA
- Morocco
- Prior art keywords
- alcynyl
- alcenyl
- metalloproteases inhibitors
- metalloproteases
- inhibitors
- Prior art date
Links
- 102000005741 Metalloproteases Human genes 0.000 title 1
- 108010006035 Metalloproteases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Orthopedic Medicine & Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US12264499P | 1999-03-03 | 1999-03-03 |
Publications (1)
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MA25391A1 true MA25391A1 (fr) | 2002-04-01 |
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Family Applications (1)
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MA26310A MA25391A1 (fr) | 1999-03-03 | 2001-09-03 | Inhibiteurs d'alcenyl et alcynyl metalloproteases. |
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US (1) | US6197770B1 (fr) |
EP (1) | EP1165501A1 (fr) |
JP (1) | JP2002538136A (fr) |
KR (1) | KR20010102486A (fr) |
CN (1) | CN1349498A (fr) |
AU (1) | AU764051B2 (fr) |
BR (1) | BR0008716A (fr) |
CA (1) | CA2364878A1 (fr) |
CO (1) | CO5150219A1 (fr) |
CZ (1) | CZ20013176A3 (fr) |
HK (1) | HK1044754A1 (fr) |
HU (1) | HUP0202199A2 (fr) |
IL (1) | IL145089A0 (fr) |
MA (1) | MA25391A1 (fr) |
MX (1) | MXPA01008855A (fr) |
NO (1) | NO20014242L (fr) |
NZ (1) | NZ513831A (fr) |
PE (1) | PE20001565A1 (fr) |
PL (1) | PL350340A1 (fr) |
RU (1) | RU2001126721A (fr) |
SK (1) | SK12452001A3 (fr) |
TR (1) | TR200102523T2 (fr) |
WO (1) | WO2000051975A1 (fr) |
ZA (1) | ZA200106967B (fr) |
Families Citing this family (20)
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US20030149997A1 (en) * | 1999-02-19 | 2003-08-07 | Hageman Gregory S. | Diagnostics and therapeutics for arterial wall disruptive disorders |
US7108982B1 (en) * | 1999-02-19 | 2006-09-19 | University Of Iowa Research Foundation | Diagnostics and the therapeutics for macular degeneration |
BR0014759A (pt) * | 1999-10-14 | 2002-07-02 | Procter & Gamble | Inibidores de metaloprotease beta dissubstituìdos |
US6696456B1 (en) * | 1999-10-14 | 2004-02-24 | The Procter & Gamble Company | Beta disubstituted metalloprotease inhibitors |
AU4882101A (en) | 2000-04-28 | 2001-11-12 | Shionogi & Co., Ltd. | Mmp-12 inhibitors |
JPWO2002028844A1 (ja) * | 2000-09-29 | 2004-02-12 | 塩野義製薬株式会社 | チアゾールおよびオキサゾール誘導体 |
DE60141849D1 (de) | 2000-10-17 | 2010-05-27 | Merck Serono Sa Coinsins | Pharmazeutisch aktive sulfonamid-derivate |
WO2003080042A1 (fr) * | 2002-03-27 | 2003-10-02 | Shionogi & Co., Ltd. | Inhibiteur de decomposition pour matrice extracellulaire de cartilage |
TWI281914B (en) | 2002-05-29 | 2007-06-01 | Glaxo Group Ltd | Compounds |
NZ536665A (en) * | 2002-06-11 | 2006-11-30 | Wyeth Corp | Use of substituted phenylsulfonamide as inhibitors of beta amyloid production |
EP1624866A2 (fr) * | 2003-05-16 | 2006-02-15 | Arriva Pharmaceuticals, Inc. | Traitement de maladies respiratoires induites par les metalloproteases matricielles par inhalation d'inhibiteurs de synthese des metalloproteases matricielles |
RU2005141571A (ru) * | 2003-07-02 | 2007-07-10 | Янссен Фармацевтика Н.В. (Be) | Модуляторы рецептора сск-1 |
US20050020565A1 (en) * | 2003-07-02 | 2005-01-27 | Jones Todd K. | CCK-1 receptor modulators |
US20080119513A1 (en) * | 2004-09-06 | 2008-05-22 | Fumihiko Watanabe | Sulfonamide Derivative Selectively Inhibiting Mmp-13 |
US7576222B2 (en) * | 2004-12-28 | 2009-08-18 | Wyeth | Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase |
CN101906134A (zh) * | 2005-01-13 | 2010-12-08 | 卧龙岗大学 | 肽化合物 |
US20070275944A1 (en) * | 2006-04-05 | 2007-11-29 | The Board Of Trustees Operating Michigan State University | Antioxidants and methods of their use |
CA2828831C (fr) * | 2011-03-02 | 2019-05-07 | Aquilus Pharmaceuticals, Inc. | Composes et methodes de traitement de la douleur et d'autres troubles |
AU2012376221A1 (en) | 2011-10-31 | 2014-06-19 | David S. Baskin | Compound comprising a MAO targeting/ seeker moiety for treating human gliomas |
WO2015107139A1 (fr) | 2014-01-17 | 2015-07-23 | Proyecto De Biomedicina Cima, S.L. | Composés destinés à être utilisés en tant qu'agents anti-fibrinolytiques |
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JPH10204054A (ja) * | 1997-01-21 | 1998-08-04 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
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AU747280B2 (en) | 1997-04-01 | 2002-05-09 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
EP0877019B1 (fr) * | 1997-05-09 | 2001-12-12 | Hoechst Aktiengesellschaft | Acides diaminocarboxyliques substitués |
AU7294098A (en) * | 1997-05-09 | 1998-11-27 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
WO1999006340A2 (fr) * | 1997-07-31 | 1999-02-11 | The Procter & Gamble Company | Inhibiteurs de metalloprotease acycliques |
RU2208609C2 (ru) * | 1998-02-04 | 2003-07-20 | Новартис Аг | Сульфониламинопроизводные, которые ингибируют разлагающие матрикс металлопротеиназы |
JPH11246527A (ja) * | 1998-03-02 | 1999-09-14 | Shionogi & Co Ltd | Mmp−8阻害剤 |
CA2327290A1 (fr) * | 1998-04-03 | 1999-10-14 | Sankyo Company Limited | Derives de sulfonamide |
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2000
- 2000-03-01 EP EP00912064A patent/EP1165501A1/fr not_active Withdrawn
- 2000-03-01 CZ CZ20013176A patent/CZ20013176A3/cs unknown
- 2000-03-01 SK SK1245-2001A patent/SK12452001A3/sk unknown
- 2000-03-01 TR TR2001/02523T patent/TR200102523T2/xx unknown
- 2000-03-01 NZ NZ513831A patent/NZ513831A/en unknown
- 2000-03-01 WO PCT/US2000/005162 patent/WO2000051975A1/fr not_active Application Discontinuation
- 2000-03-01 KR KR1020017011236A patent/KR20010102486A/ko not_active Application Discontinuation
- 2000-03-01 AU AU33860/00A patent/AU764051B2/en not_active Ceased
- 2000-03-01 US US09/517,080 patent/US6197770B1/en not_active Expired - Fee Related
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- 2000-03-01 IL IL14508900A patent/IL145089A0/xx unknown
- 2000-03-01 JP JP2000602203A patent/JP2002538136A/ja not_active Withdrawn
- 2000-03-01 MX MXPA01008855A patent/MXPA01008855A/es unknown
- 2000-03-01 BR BR0008716-5A patent/BR0008716A/pt not_active IP Right Cessation
- 2000-03-01 PL PL00350340A patent/PL350340A1/xx not_active Application Discontinuation
- 2000-03-01 CA CA002364878A patent/CA2364878A1/fr not_active Abandoned
- 2000-03-01 CN CN00806919A patent/CN1349498A/zh active Pending
- 2000-03-03 CO CO00015564A patent/CO5150219A1/es unknown
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2001
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- 2001-09-03 MA MA26310A patent/MA25391A1/fr unknown
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2002
- 2002-06-24 HK HK02104689.6A patent/HK1044754A1/zh unknown
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AU3386000A (en) | 2000-09-21 |
HK1044754A1 (zh) | 2002-11-01 |
NO20014242L (no) | 2001-09-27 |
EP1165501A1 (fr) | 2002-01-02 |
CA2364878A1 (fr) | 2000-09-08 |
CZ20013176A3 (cs) | 2002-04-17 |
KR20010102486A (ko) | 2001-11-15 |
RU2001126721A (ru) | 2004-02-20 |
US6197770B1 (en) | 2001-03-06 |
ZA200106967B (en) | 2002-03-13 |
IL145089A0 (en) | 2002-06-30 |
SK12452001A3 (sk) | 2002-04-04 |
AU764051B2 (en) | 2003-08-07 |
PE20001565A1 (es) | 2001-02-02 |
TR200102523T2 (tr) | 2002-02-21 |
BR0008716A (pt) | 2002-09-24 |
NZ513831A (en) | 2001-09-28 |
CN1349498A (zh) | 2002-05-15 |
JP2002538136A (ja) | 2002-11-12 |
PL350340A1 (en) | 2002-12-02 |
NO20014242D0 (no) | 2001-08-31 |
WO2000051975A1 (fr) | 2000-09-08 |
MXPA01008855A (es) | 2002-07-02 |
HUP0202199A2 (en) | 2002-10-28 |
CO5150219A1 (es) | 2002-04-29 |
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