DK1169648T3 - Anvendelse af 13C-NMR til påvisning af bindinger - Google Patents

Anvendelse af 13C-NMR til påvisning af bindinger

Info

Publication number
DK1169648T3
DK1169648T3 DK00918228T DK00918228T DK1169648T3 DK 1169648 T3 DK1169648 T3 DK 1169648T3 DK 00918228 T DK00918228 T DK 00918228T DK 00918228 T DK00918228 T DK 00918228T DK 1169648 T3 DK1169648 T3 DK 1169648T3
Authority
DK
Denmark
Prior art keywords
nmr
bonds
detection
Prior art date
Application number
DK00918228T
Other languages
English (en)
Inventor
Stephen W Fesik
Philip J Hajduk
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK1169648T3 publication Critical patent/DK1169648T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027—Cleaning the internal surfaces; Removal of blockages
    • B08B9/04—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes
    • B08B9/053—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved along the pipes by a fluid, e.g. by fluid pressure or by suction
    • B08B9/055—Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved along the pipes by a fluid, e.g. by fluid pressure or by suction the cleaning devices conforming to, or being conformable to, substantially the same cross-section of the pipes, e.g. pigs or moles
    • B08B9/0553—Cylindrically shaped pigs
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B37/00—Methods or apparatus for cleaning boreholes or wells
    • E21B37/02—Scrapers specially adapted therefor
    • E21B37/04—Scrapers specially adapted therefor operated by fluid pressure, e.g. free-piston scrapers
    • E21B37/045—Free-piston scrapers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4633—Sequences for multi-dimensional NMR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mining & Mineral Resources (AREA)
  • Fluid Mechanics (AREA)
  • Geology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Environmental & Geological Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK00918228T 1999-04-09 2000-03-21 Anvendelse af 13C-NMR til påvisning af bindinger DK1169648T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/288,924 US20010004528A1 (en) 1995-11-14 1999-04-09 Use of 13c nuclear magnetic resonance to detect binding to target molecules

Publications (1)

Publication Number Publication Date
DK1169648T3 true DK1169648T3 (da) 2006-09-11

Family

ID=23109248

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00918228T DK1169648T3 (da) 1999-04-09 2000-03-21 Anvendelse af 13C-NMR til påvisning af bindinger

Country Status (18)

Country Link
US (2) US20010004528A1 (da)
EP (1) EP1169648B1 (da)
JP (1) JP4723094B2 (da)
AR (1) AR024540A1 (da)
AT (1) ATE327510T1 (da)
AU (1) AU776165B2 (da)
CA (1) CA2365385C (da)
CO (1) CO5241342A1 (da)
CY (1) CY1107474T1 (da)
DE (1) DE60028196T2 (da)
DK (1) DK1169648T3 (da)
ES (1) ES2264930T3 (da)
HK (1) HK1044817B (da)
IL (1) IL145135A (da)
MX (1) MXPA01010180A (da)
PT (1) PT1169648E (da)
TW (1) TWI223710B (da)
WO (1) WO2000062074A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10139465A1 (de) * 2001-08-10 2003-02-20 Bayer Cropscience Ag Selektive Herbizide auf Basis von substituierten, cayclischen Ketoenolen und Safenern
DE10160177A1 (de) * 2001-12-07 2003-06-26 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden die an ein drug target binden mittels 1H,1H-Kernresonanzspektroskopie
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
DE10221158A1 (de) * 2002-05-13 2004-02-19 Novaspin Biotech Gmbh Verfahren zur Auffindung von Liganden, die an ein drug target binden, mittels heteronuklearer Kernresonanzspektroskopie
KR100901309B1 (ko) * 2002-06-15 2009-06-09 크리스탈지노믹스(주) 단백질의 활성 부위에 결합하는 화합물을 선별하는 방법
US20040132102A1 (en) * 2002-10-29 2004-07-08 Maurizio Pellecchia Use of selective labeling to detect and characterize molecular interactions by nuclear magnetic resonance spectroscopy
NO20025738D0 (no) 2002-11-29 2002-11-29 Amersham Health As Metode
WO2006082963A1 (ja) * 2005-02-07 2006-08-10 Mitsubishi Chemical Corporation 標的分子とリガンドあるいはリガンド候補化合物との結合検出方法
US9182406B2 (en) * 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
CA2831136A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
EP3237906B8 (en) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014814A1 (en) * 1995-10-19 1997-04-24 Smithkline Beecham Corporation A binary coding method for use in combinatorial chemistry
US5698401A (en) * 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
EP0870197B2 (en) * 1995-11-14 2006-11-08 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules

Also Published As

Publication number Publication date
EP1169648B1 (en) 2006-05-24
DE60028196T2 (de) 2007-03-29
CA2365385C (en) 2009-11-03
HK1044817A1 (en) 2002-11-01
JP4723094B2 (ja) 2011-07-13
CO5241342A1 (es) 2003-01-31
ATE327510T1 (de) 2006-06-15
DE60028196D1 (de) 2006-06-29
WO2000062074A8 (en) 2003-10-23
ES2264930T3 (es) 2007-02-01
IL145135A0 (en) 2002-06-30
WO2000062074A1 (en) 2000-10-19
CY1107474T1 (el) 2012-12-19
PT1169648E (pt) 2006-09-29
TWI223710B (en) 2004-11-11
AU776165B2 (en) 2004-08-26
IL145135A (en) 2007-06-17
US20020037529A1 (en) 2002-03-28
US20010004528A1 (en) 2001-06-21
JP2004510952A (ja) 2004-04-08
HK1044817B (zh) 2006-12-22
MXPA01010180A (es) 2002-10-23
EP1169648A1 (en) 2002-01-09
CA2365385A1 (en) 2000-10-19
AR024540A1 (es) 2002-10-16
AU3907700A (en) 2000-11-14

Similar Documents

Publication Publication Date Title
PT1242364E (pt) Derivados de adamantano
IS6103A (is) Adamantan afleiður
PT1207825E (pt) Instrumento microcirurgico
DE50002558D1 (de) Rückspülfiltervorrichtung
FI990170A0 (fi) Maksunosoitus
IT1316831B1 (it) Dispositivo per il collegamento di due parti costruttive
DK1169648T3 (da) Anvendelse af 13C-NMR til påvisning af bindinger
DK1177189T3 (da) Pymetrozinsolvater
DK1022396T3 (da) Bruserkombination
DE69822315D1 (de) Atomsonde
DE60037638D1 (de) Zeitmessgerät
DE60014306D1 (de) Tintenstrahlaufzeichnungselement
DE69919457D1 (de) Messtaster
DE69900351D1 (de) Prüfkopfanordnung
FI982378A0 (fi) Järjestely kohteen tutkimiseen
DE60030066D1 (de) Prüfgerät
DE60018655D1 (de) Prüfvorrichtung
DE29900461U1 (de) Flechtwerk
NO20006721L (no) Stender
DE29903856U1 (de) Sondenanordnung
DE29903652U1 (de) Befestigungsvorrichtung
DE29905095U1 (de) Duschvorrichtung
DE29903650U1 (de) Befestigungsvorrichtung
DE29907809U1 (de) Befestigungsvorrichtung
DE50008855D1 (de) Einrichtung zur entlastung der halswirbelsäule