DK1224486T3 - Anvendelse af dobbeltkvantum-1H-NMR-spektroskopi til identifikation af ligander, der interagerer med malbiomolekyler - Google Patents

Anvendelse af dobbeltkvantum-1H-NMR-spektroskopi til identifikation af ligander, der interagerer med malbiomolekyler

Info

Publication number
DK1224486T3
DK1224486T3 DK00972833T DK00972833T DK1224486T3 DK 1224486 T3 DK1224486 T3 DK 1224486T3 DK 00972833 T DK00972833 T DK 00972833T DK 00972833 T DK00972833 T DK 00972833T DK 1224486 T3 DK1224486 T3 DK 1224486T3
Authority
DK
Denmark
Prior art keywords
malbio
molecules
quantum
double
nmr spectroscopy
Prior art date
Application number
DK00972833T
Other languages
English (en)
Inventor
Claudio Dalvit
Carlo Battistini
Paolo Caccia
Patrizia Giordano
Paolo Pevarello
Michael Sundstrom
Marco Tato'
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Application granted granted Critical
Publication of DK1224486T3 publication Critical patent/DK1224486T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4633—Sequences for multi-dimensional NMR

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Signal Processing (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
  • Spectrometry And Color Measurement (AREA)
DK00972833T 1999-10-29 2000-10-19 Anvendelse af dobbeltkvantum-1H-NMR-spektroskopi til identifikation af ligander, der interagerer med malbiomolekyler DK1224486T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9925677.8A GB9925677D0 (en) 1999-10-29 1999-10-29 Use of double-quantum 1H-NMR spectroscopy for the identification of ligands interacting with target biomolecules

Publications (1)

Publication Number Publication Date
DK1224486T3 true DK1224486T3 (da) 2006-02-13

Family

ID=10863638

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00972833T DK1224486T3 (da) 1999-10-29 2000-10-19 Anvendelse af dobbeltkvantum-1H-NMR-spektroskopi til identifikation af ligander, der interagerer med malbiomolekyler

Country Status (11)

Country Link
EP (1) EP1224486B1 (da)
JP (1) JP2003513290A (da)
AT (1) ATE314660T1 (da)
AU (1) AU780921B2 (da)
CA (1) CA2388216A1 (da)
CY (1) CY1105315T1 (da)
DE (1) DE60025246T2 (da)
DK (1) DK1224486T3 (da)
ES (1) ES2254245T3 (da)
GB (1) GB9925677D0 (da)
WO (1) WO2001033243A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20013387A (no) * 2001-07-09 2002-12-16 Leiv Eiriksson Nyfotek As Fremgangsmåte for måling av ulike bestanddeler i organisk og biologisk materiale
JP2005529328A (ja) * 2002-06-05 2005-09-29 ファーマシア アンド アップジョン カンパニー 競合的結合１ｈｎｍｒ実験を用いたリガンドの同定方法
KR100901309B1 (ko) * 2002-06-15 2009-06-09 크리스탈지노믹스(주) 단백질의 활성 부위에 결합하는 화합물을 선별하는 방법
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
GB0308586D0 (en) * 2003-04-14 2003-05-21 Amersham Health R & D Ab Method and arrangements in NMR spectroscopy
EP2994143A4 (en) 2013-05-08 2017-02-01 Board of Regents, The University of Texas System Stat6 inhibitors
CN104181186B (zh) * 2014-09-03 2016-08-24 山西大学 一种黄芪注射液1h-nmr指纹图谱的构建方法
CN105823788B (zh) * 2016-05-12 2017-10-17 山西大学 山西老陈醋1h‑nmr指纹图谱的构建方法和应用
CN107102021A (zh) * 2017-05-03 2017-08-29 山西广誉远国药有限公司 一种海马1h‑nmr指纹图谱的构建方法和用途
CN114624276B (zh) * 2022-03-14 2023-03-24 中国科学院精密测量科学与技术创新研究院 氢检测半整数四极核高分辨固体nmr异核相关谱方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69613146T3 (de) * 1995-11-14 2007-06-14 Abbott Laboratories, Abbott Park Verwendung von kernspinresonanz zur bestimmung von liganden für zielbiomoleküle
US5891643A (en) * 1995-11-14 1999-04-06 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
US5698401A (en) * 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
DE19649359C1 (de) * 1996-11-28 1998-02-12 Thomas Prof Dr Peters Verfahren zum Nachweis biologisch aktiver Substanzen in Substanzbibliotheken

Also Published As

Publication number Publication date
CY1105315T1 (el) 2010-03-03
WO2001033243A1 (en) 2001-05-10
EP1224486A1 (en) 2002-07-24
GB9925677D0 (en) 1999-12-29
AU780921B2 (en) 2005-04-28
ATE314660T1 (de) 2006-01-15
ES2254245T3 (es) 2006-06-16
DE60025246D1 (de) 2006-02-02
JP2003513290A (ja) 2003-04-08
AU1142601A (en) 2001-05-14
DE60025246T2 (de) 2006-09-07
EP1224486B1 (en) 2005-12-28
CA2388216A1 (en) 2001-05-10

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