BG103128A - Аналози на паратироидния хормон за лечение на остеопороза - Google Patents
Аналози на паратироидния хормон за лечение на остеопорозаInfo
- Publication number
- BG103128A BG103128A BG103128A BG10312899A BG103128A BG 103128 A BG103128 A BG 103128A BG 103128 A BG103128 A BG 103128A BG 10312899 A BG10312899 A BG 10312899A BG 103128 A BG103128 A BG 103128A
- Authority
- BG
- Bulgaria
- Prior art keywords
- analogues
- activity
- lys26
- paratiroid
- osteoporosis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Measurement Of Radiation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/691,647 US5955425A (en) | 1996-08-02 | 1996-08-02 | Parathyroid hormone analogues for the treatment of osteoporosis |
| US4056097P | 1997-03-14 | 1997-03-14 | |
| PCT/CA1997/000547 WO1998005683A1 (en) | 1996-08-02 | 1997-08-01 | Parathyroid hormone analogues for the treatment of osteoporosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG103128A true BG103128A (bg) | 2000-05-31 |
Family
ID=26717175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103128A BG103128A (bg) | 1996-08-02 | 1999-01-28 | Аналози на паратироидния хормон за лечение на остеопороза |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0915911B1 (enExample) |
| JP (3) | JP4122061B2 (enExample) |
| KR (1) | KR100500859B1 (enExample) |
| CN (1) | CN1176947C (enExample) |
| AT (1) | ATE253078T1 (enExample) |
| AU (1) | AU723728B2 (enExample) |
| BG (1) | BG103128A (enExample) |
| BR (1) | BR9711002B1 (enExample) |
| CA (1) | CA2261564C (enExample) |
| CZ (1) | CZ34799A3 (enExample) |
| DE (1) | DE69725850T2 (enExample) |
| DK (1) | DK0915911T3 (enExample) |
| EE (1) | EE9900039A (enExample) |
| ES (1) | ES2207740T3 (enExample) |
| FI (1) | FI990126A7 (enExample) |
| GE (1) | GEP20033095B (enExample) |
| IS (1) | IS4962A (enExample) |
| LV (1) | LV12293B (enExample) |
| NZ (1) | NZ333809A (enExample) |
| PT (1) | PT915911E (enExample) |
| RU (1) | RU2203286C2 (enExample) |
| SI (1) | SI9720057A (enExample) |
| SK (1) | SK287397B6 (enExample) |
| WO (1) | WO1998005683A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1261281A (zh) * | 1997-05-14 | 2000-07-26 | 罗纳·布朗克罗尔药制品有限公司 | 肽甲状旁腺激素类似物 |
| JP4486256B2 (ja) | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 |
| AU1633200A (en) | 1998-11-25 | 2000-06-13 | General Hospital Corporation, The | Human parathyroid hormone modifications, preparation and use |
| WO2000040698A1 (en) | 1998-12-31 | 2000-07-13 | The General Hospital Corporation | Pth receptor and screening assay utilizing the same |
| JP2003505514A (ja) * | 1999-07-28 | 2003-02-12 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア | 破骨細胞生成を阻害する方法 |
| US6316410B1 (en) * | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| AU2002339843B2 (en) | 2001-07-23 | 2007-12-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| JP4959917B2 (ja) * | 2001-08-17 | 2012-06-27 | ノバルティス アーゲー | 副甲状腺ホルモンフラグメント用経口送達剤としての５−ｃｎａｃ |
| MXPA04006728A (es) | 2002-01-10 | 2005-08-19 | Osteotrophin Llc | Tratamiento de desordenes oseos con medicamentos anabolicos esqueleticos. |
| EP1567178A4 (en) * | 2002-11-01 | 2009-07-15 | Amgen Inc | MODULATORS OF RECEPTORS FOR NEUTRAL THERAPY HORMONE AND SIDE-HORSE HORMONE-RELATED PROTEINS |
| CN100508957C (zh) * | 2003-01-21 | 2009-07-08 | 尤尼金实验室股份有限公司 | 肽经口输递的改进 |
| US8088734B2 (en) * | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
| WO2007130113A2 (en) * | 2005-09-06 | 2007-11-15 | Zelos Therapeutics, Inc. | Parathyroid hormone analogues and methods of use |
| EP2056862A2 (en) * | 2006-07-31 | 2009-05-13 | Zelos Therapeutics, Inc. | Parathyroid hormone analogues and uses thereof |
| KR101108354B1 (ko) | 2006-10-13 | 2012-01-25 | 일라이 릴리 앤드 캄파니 | Ｐｔｈ 수용체 조절제로서의 페길화된 ｐｔｈ 및 그의 용도 |
| CA2694667C (en) | 2007-08-01 | 2018-10-30 | The General Hospital Corporation | Screening methods using g-protein coupled receptors and related compositions |
| RU2604809C2 (ru) * | 2010-05-13 | 2016-12-10 | Дзе Дженерал Хоспитал Корпорейшн | Аналоги паратиреоидного гормона и их применение |
| CN105440126B (zh) * | 2015-12-31 | 2019-10-25 | 南京工业大学 | 治疗骨质疏松的α-螺旋多肽及其制备方法与应用 |
| WO2019018238A1 (en) | 2017-07-15 | 2019-01-24 | The Regents Of The University Of California | CATHEPSIN K OSTEOADSORBENT FLUOROGEN SUBSTRATE FOR THE IMAGING OF OSTEOCLAST ACTIVITY AND MIGRATION |
| WO2020064190A1 (en) | 2018-09-26 | 2020-04-02 | Borealis Ag | Propylene copolymer composition with excellent optical and mechanical properties |
| CN113549144A (zh) * | 2021-06-30 | 2021-10-26 | 华南理工大学 | 一种特立帕肽hPTH(1-34)的生产和纯化方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0532696A (ja) * | 1990-09-28 | 1993-02-09 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| US5317010A (en) * | 1991-10-10 | 1994-05-31 | Peter K. T. Pang | Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment |
| US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| US5556940A (en) * | 1994-06-20 | 1996-09-17 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
-
1997
- 1997-08-01 EE EEP199900039A patent/EE9900039A/xx unknown
- 1997-08-01 RU RU99104132/14A patent/RU2203286C2/ru not_active IP Right Cessation
- 1997-08-01 JP JP50741398A patent/JP4122061B2/ja not_active Expired - Fee Related
- 1997-08-01 AU AU36905/97A patent/AU723728B2/en not_active Ceased
- 1997-08-01 ES ES97933603T patent/ES2207740T3/es not_active Expired - Lifetime
- 1997-08-01 AT AT97933603T patent/ATE253078T1/de active
- 1997-08-01 CN CNB971981612A patent/CN1176947C/zh not_active Expired - Fee Related
- 1997-08-01 CA CA002261564A patent/CA2261564C/en not_active Expired - Fee Related
- 1997-08-01 KR KR10-1999-7000903A patent/KR100500859B1/ko not_active Expired - Fee Related
- 1997-08-01 SI SI9720057A patent/SI9720057A/sl not_active IP Right Cessation
- 1997-08-01 SK SK132-99A patent/SK287397B6/sk not_active IP Right Cessation
- 1997-08-01 WO PCT/CA1997/000547 patent/WO1998005683A1/en not_active Ceased
- 1997-08-01 GE GEAP19974655A patent/GEP20033095B/en unknown
- 1997-08-01 PT PT97933603T patent/PT915911E/pt unknown
- 1997-08-01 BR BRPI9711002-7A patent/BR9711002B1/pt not_active IP Right Cessation
- 1997-08-01 EP EP97933603A patent/EP0915911B1/en not_active Expired - Lifetime
- 1997-08-01 DE DE69725850T patent/DE69725850T2/de not_active Expired - Lifetime
- 1997-08-01 CZ CZ99347A patent/CZ34799A3/cs unknown
- 1997-08-01 NZ NZ333809A patent/NZ333809A/xx not_active IP Right Cessation
- 1997-08-01 DK DK97933603T patent/DK0915911T3/da active
- 1997-08-01 FI FI990126A patent/FI990126A7/fi unknown
-
1999
- 1999-01-28 BG BG103128A patent/BG103128A/xx unknown
- 1999-01-29 IS IS4962A patent/IS4962A/is unknown
- 1999-02-01 LV LVP-99-15A patent/LV12293B/en unknown
-
2007
- 2007-05-01 JP JP2007121289A patent/JP4224111B2/ja not_active Expired - Fee Related
-
2008
- 2008-09-25 JP JP2008246839A patent/JP2009057386A/ja active Pending
Also Published As
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