BR9711002A - Análogos ao hormÈnio da paratireóide para o tratamento da osteoporose - Google Patents
Análogos ao hormÈnio da paratireóide para o tratamento da osteoporoseInfo
- Publication number
- BR9711002A BR9711002A BR9711002-7A BR9711002A BR9711002A BR 9711002 A BR9711002 A BR 9711002A BR 9711002 A BR9711002 A BR 9711002A BR 9711002 A BR9711002 A BR 9711002A
- Authority
- BR
- Brazil
- Prior art keywords
- analogues
- lys
- parathyroid hormone
- activities
- rat
- Prior art date
Links
- 208000001132 Osteoporosis Diseases 0.000 title 1
- 102000003982 Parathyroid hormone Human genes 0.000 title 1
- 108090000445 Parathyroid hormone Proteins 0.000 title 1
- 239000000199 parathyroid hormone Substances 0.000 title 1
- 229960001319 parathyroid hormone Drugs 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 3
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 230000001077 hypotensive effect Effects 0.000 abstract 2
- 101001135770 Homo sapiens Parathyroid hormone Proteins 0.000 abstract 1
- 101001135995 Homo sapiens Probable peptidyl-tRNA hydrolase Proteins 0.000 abstract 1
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 1
- 102000030621 adenylate cyclase Human genes 0.000 abstract 1
- 108060000200 adenylate cyclase Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 102000058004 human PTH Human genes 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- 230000002188 osteogenic effect Effects 0.000 abstract 1
- 201000008968 osteosarcoma Diseases 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000011552 rat model Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Measurement Of Radiation (AREA)
- Display Devices Of Pinball Game Machines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"ANáLOGOS AO HORMÈNIO DA PARA TIREóIDE PARA O TRATAMENTO DA OSTEOPOROSE". São descritos nesta invenção os quais aumentam as atividades de rastauração dos ossos e aumentam a biodisponibilidade. Os peptídeos descritos são derivados do hPTH-(1 -31) os quais são ciclizados por exemplo, pelo formação de Lactans entre ambos Glu^ 22^ e Lys^ 26^ ou Lys^ 26^ e Asp^ 20^. Ainda, Lys^ 27^ natural pode ser substituído por um Leu ou outro resíduo hidrofóbico, tal como lle, norleucina, Met, Val, Ala, Trp, ou Phe. Tipicamente, estes análogos tiveram desenvolvidas habilidadespara estimilar ciclizado adenylyl em células de rato com osteosarcoma, e mostra aumento de atividades na restauração de ossos, usando o modelo de rato ovariectomizado. Os análogos também demonstram aumento de atividades e biodisponibilidades, como demonstrado pelos efeitos hipotensivo nos ratos. Um ensaio que relaciona a atividade hipotensivo com a atividade osteogênica é também descrito.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/691.647 | 1996-08-02 | ||
| US08/691,647 US5955425A (en) | 1996-08-02 | 1996-08-02 | Parathyroid hormone analogues for the treatment of osteoporosis |
| US4056097P | 1997-03-14 | 1997-03-14 | |
| US60/040.560 | 1997-03-14 | ||
| PCT/CA1997/000547 WO1998005683A1 (en) | 1996-08-02 | 1997-08-01 | Parathyroid hormone analogues for the treatment of osteoporosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9711002A true BR9711002A (pt) | 2002-01-15 |
| BR9711002B1 BR9711002B1 (pt) | 2011-09-06 |
Family
ID=26717175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9711002-7A BR9711002B1 (pt) | 1996-08-02 | 1997-08-01 | análogo do hormÈnio da paratireóide para o tratamento de osteoporose. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0915911B1 (pt) |
| JP (3) | JP4122061B2 (pt) |
| KR (1) | KR100500859B1 (pt) |
| CN (1) | CN1176947C (pt) |
| AT (1) | ATE253078T1 (pt) |
| AU (1) | AU723728B2 (pt) |
| BG (1) | BG103128A (pt) |
| BR (1) | BR9711002B1 (pt) |
| CA (1) | CA2261564C (pt) |
| CZ (1) | CZ34799A3 (pt) |
| DE (1) | DE69725850T2 (pt) |
| DK (1) | DK0915911T3 (pt) |
| EE (1) | EE9900039A (pt) |
| ES (1) | ES2207740T3 (pt) |
| FI (1) | FI990126A (pt) |
| GE (1) | GEP20033095B (pt) |
| IS (1) | IS4962A (pt) |
| LV (1) | LV12293B (pt) |
| NZ (1) | NZ333809A (pt) |
| PT (1) | PT915911E (pt) |
| RU (1) | RU2203286C2 (pt) |
| SI (1) | SI9720057A (pt) |
| SK (1) | SK287397B6 (pt) |
| WO (1) | WO1998005683A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL132901A0 (en) * | 1997-05-14 | 2001-03-19 | Aventis Pharm Prod Inc | Peptide parathyroid hormone analogs |
| WO2000023594A1 (en) * | 1998-10-22 | 2000-04-27 | The General Hospital Corporation | BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP) |
| WO2000031266A1 (en) * | 1998-11-25 | 2000-06-02 | The General Hospital Corporation | Human parathyroid hormone modifications, preparation and use |
| DK1141237T3 (da) | 1998-12-31 | 2006-02-13 | Gen Hospital Corp | PTH-receptor og screeningsassay der anvender denne |
| WO2001008699A1 (en) * | 1999-07-28 | 2001-02-08 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclastogenesis |
| US6316410B1 (en) * | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| AU2002339843B2 (en) | 2001-07-23 | 2007-12-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| US7015195B2 (en) | 2002-01-10 | 2006-03-21 | Osteotrophin, Llc | Treatment of bone disorders with skeletal anabolic drugs |
| AU2002359391A1 (en) * | 2002-11-01 | 2004-07-29 | Amgen, Inc. | Modulators of receptors for parathyrois hormone and parathyroid hormone-related protein |
| US8088734B2 (en) * | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
| WO2007130113A2 (en) * | 2005-09-06 | 2007-11-15 | Zelos Therapeutics, Inc. | Parathyroid hormone analogues and methods of use |
| CA2659846A1 (en) * | 2006-07-31 | 2008-02-07 | Zelos Therapeutics, Inc. | Parathyroid hormone analogues and methods of use |
| ATE469173T1 (de) | 2006-10-13 | 2010-06-15 | Lilly Co Eli | Pegyliertes pth als pth-rezeptormodulatoren und ihre verwendung |
| EP2187902B1 (en) | 2007-08-01 | 2013-04-17 | The General Hospital Corporation | Screening methods using g-protein coupled receptors and related compositions |
| WO2011143406A2 (en) * | 2010-05-13 | 2011-11-17 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
| CN105440126B (zh) * | 2015-12-31 | 2019-10-25 | 南京工业大学 | 治疗骨质疏松的α-螺旋多肽及其制备方法与应用 |
| EP3655104A4 (en) | 2017-07-15 | 2021-03-17 | The Regents of the University of California | OSTEOADSORPTIVE FLUOROGENIC SUBSTRATE FROM CATHEPSIN K FOR IMAGING OSTEOCLAST ACTIVITY AND MIGRATION |
| BR112021003442A2 (pt) | 2018-09-26 | 2021-05-18 | Borealis Ag | composição de copolímero de propileno com excelentes propriedades mecânicas e ópticas |
| JP7342310B2 (ja) | 2019-05-28 | 2023-09-12 | 国立大学法人東北大学 | 電源装置、超伝導装置、超伝導デバイス、及び超伝導デバイスの製造方法 |
| CN113549144A (zh) * | 2021-06-30 | 2021-10-26 | 华南理工大学 | 一种特立帕肽hPTH(1-34)的生产和纯化方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5317010A (en) * | 1991-10-10 | 1994-05-31 | Peter K. T. Pang | Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment |
| US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| US5556940A (en) * | 1994-06-20 | 1996-09-17 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
-
1997
- 1997-08-01 KR KR10-1999-7000903A patent/KR100500859B1/ko not_active IP Right Cessation
- 1997-08-01 AU AU36905/97A patent/AU723728B2/en not_active Ceased
- 1997-08-01 JP JP50741398A patent/JP4122061B2/ja not_active Expired - Fee Related
- 1997-08-01 EP EP97933603A patent/EP0915911B1/en not_active Expired - Lifetime
- 1997-08-01 RU RU99104132/14A patent/RU2203286C2/ru not_active IP Right Cessation
- 1997-08-01 NZ NZ333809A patent/NZ333809A/xx not_active IP Right Cessation
- 1997-08-01 ES ES97933603T patent/ES2207740T3/es not_active Expired - Lifetime
- 1997-08-01 AT AT97933603T patent/ATE253078T1/de active
- 1997-08-01 CZ CZ99347A patent/CZ34799A3/cs unknown
- 1997-08-01 PT PT97933603T patent/PT915911E/pt unknown
- 1997-08-01 GE GEAP19974655A patent/GEP20033095B/en unknown
- 1997-08-01 SK SK132-99A patent/SK287397B6/sk not_active IP Right Cessation
- 1997-08-01 SI SI9720057A patent/SI9720057A/sl not_active IP Right Cessation
- 1997-08-01 BR BRPI9711002-7A patent/BR9711002B1/pt not_active IP Right Cessation
- 1997-08-01 DE DE69725850T patent/DE69725850T2/de not_active Expired - Lifetime
- 1997-08-01 EE EEP199900039A patent/EE9900039A/xx unknown
- 1997-08-01 CN CNB971981612A patent/CN1176947C/zh not_active Expired - Fee Related
- 1997-08-01 CA CA002261564A patent/CA2261564C/en not_active Expired - Fee Related
- 1997-08-01 DK DK97933603T patent/DK0915911T3/da active
- 1997-08-01 WO PCT/CA1997/000547 patent/WO1998005683A1/en active IP Right Grant
-
1999
- 1999-01-22 FI FI990126A patent/FI990126A/fi unknown
- 1999-01-28 BG BG103128A patent/BG103128A/xx unknown
- 1999-01-29 IS IS4962A patent/IS4962A/is unknown
- 1999-02-01 LV LVP-99-15A patent/LV12293B/en unknown
-
2007
- 2007-05-01 JP JP2007121289A patent/JP4224111B2/ja not_active Expired - Fee Related
-
2008
- 2008-09-25 JP JP2008246839A patent/JP2009057386A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: PARA QUE A PETICAO NO 429/RS DE 20/02/2002 SEJA ACEITA, APRESENTE A PETICAO DE DESARQUIVAMENTO DO PEDIDO, BEM COMO A RETRIBUICAO RELATIVA AO CUMPRIMENTO DE EXIGENCIA. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/09/2011, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE AS 16A, 17A E 18A ANUIDADES. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |