RU2203286C2 - Аналоги паратиреоидного гормона для лечения остеопороза - Google Patents

Аналоги паратиреоидного гормона для лечения остеопороза Download PDF

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Publication number
RU2203286C2
RU2203286C2 RU99104132/14A RU99104132A RU2203286C2 RU 2203286 C2 RU2203286 C2 RU 2203286C2 RU 99104132/14 A RU99104132/14 A RU 99104132/14A RU 99104132 A RU99104132 A RU 99104132A RU 2203286 C2 RU2203286 C2 RU 2203286C2
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RU
Russia
Prior art keywords
lys
leu
seq
hpth
analogue
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RU99104132/14A
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English (en)
Russian (ru)
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RU99104132A (ru
Inventor
Жан Рене БАРБЬЕ
Пол МОРЛИ
Витолд НЬЮДЖИБАУЭР
Вирджиния РОСС
Джеймс УИТФИЛД
Гордон Э. УИЛЛИК
Original Assignee
Нэшнл Рисерч Каунсил ов Кэнэда
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Priority claimed from US08/691,647 external-priority patent/US5955425A/en
Application filed by Нэшнл Рисерч Каунсил ов Кэнэда filed Critical Нэшнл Рисерч Каунсил ов Кэнэда
Publication of RU99104132A publication Critical patent/RU99104132A/ru
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Publication of RU2203286C2 publication Critical patent/RU2203286C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement Of Radiation (AREA)
RU99104132/14A 1996-08-02 1997-08-01 Аналоги паратиреоидного гормона для лечения остеопороза RU2203286C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/691,647 US5955425A (en) 1996-08-02 1996-08-02 Parathyroid hormone analogues for the treatment of osteoporosis
US08/691,647 1996-08-02
US4056097P 1997-03-14 1997-03-14
US60/040,560 1997-03-14

Publications (2)

Publication Number Publication Date
RU99104132A RU99104132A (ru) 2001-02-20
RU2203286C2 true RU2203286C2 (ru) 2003-04-27

Family

ID=26717175

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99104132/14A RU2203286C2 (ru) 1996-08-02 1997-08-01 Аналоги паратиреоидного гормона для лечения остеопороза

Country Status (24)

Country Link
EP (1) EP0915911B1 (enExample)
JP (3) JP4122061B2 (enExample)
KR (1) KR100500859B1 (enExample)
CN (1) CN1176947C (enExample)
AT (1) ATE253078T1 (enExample)
AU (1) AU723728B2 (enExample)
BG (1) BG103128A (enExample)
BR (1) BR9711002B1 (enExample)
CA (1) CA2261564C (enExample)
CZ (1) CZ34799A3 (enExample)
DE (1) DE69725850T2 (enExample)
DK (1) DK0915911T3 (enExample)
EE (1) EE9900039A (enExample)
ES (1) ES2207740T3 (enExample)
FI (1) FI990126A7 (enExample)
GE (1) GEP20033095B (enExample)
IS (1) IS4962A (enExample)
LV (1) LV12293B (enExample)
NZ (1) NZ333809A (enExample)
PT (1) PT915911E (enExample)
RU (1) RU2203286C2 (enExample)
SI (1) SI9720057A (enExample)
SK (1) SK287397B6 (enExample)
WO (1) WO1998005683A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2604809C2 (ru) * 2010-05-13 2016-12-10 Дзе Дженерал Хоспитал Корпорейшн Аналоги паратиреоидного гормона и их применение

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1261281A (zh) * 1997-05-14 2000-07-26 罗纳·布朗克罗尔药制品有限公司 肽甲状旁腺激素类似物
JP4486256B2 (ja) 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
AU1633200A (en) 1998-11-25 2000-06-13 General Hospital Corporation, The Human parathyroid hormone modifications, preparation and use
WO2000040698A1 (en) 1998-12-31 2000-07-13 The General Hospital Corporation Pth receptor and screening assay utilizing the same
JP2003505514A (ja) * 1999-07-28 2003-02-12 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア 破骨細胞生成を阻害する方法
US6316410B1 (en) * 1999-09-22 2001-11-13 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
AU2002339843B2 (en) 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
JP4959917B2 (ja) * 2001-08-17 2012-06-27 ノバルティス アーゲー 副甲状腺ホルモンフラグメント用経口送達剤としての５−ｃｎａｃ
MXPA04006728A (es) 2002-01-10 2005-08-19 Osteotrophin Llc Tratamiento de desordenes oseos con medicamentos anabolicos esqueleticos.
EP1567178A4 (en) * 2002-11-01 2009-07-15 Amgen Inc MODULATORS OF RECEPTORS FOR NEUTRAL THERAPY HORMONE AND SIDE-HORSE HORMONE-RELATED PROTEINS
CN100508957C (zh) * 2003-01-21 2009-07-08 尤尼金实验室股份有限公司 肽经口输递的改进
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
WO2007130113A2 (en) * 2005-09-06 2007-11-15 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
EP2056862A2 (en) * 2006-07-31 2009-05-13 Zelos Therapeutics, Inc. Parathyroid hormone analogues and uses thereof
KR101108354B1 (ko) 2006-10-13 2012-01-25 일라이 릴리 앤드 캄파니 Ｐｔｈ 수용체 조절제로서의 페길화된 ｐｔｈ 및 그의 용도
CA2694667C (en) 2007-08-01 2018-10-30 The General Hospital Corporation Screening methods using g-protein coupled receptors and related compositions
CN105440126B (zh) * 2015-12-31 2019-10-25 南京工业大学 治疗骨质疏松的α-螺旋多肽及其制备方法与应用
WO2019018238A1 (en) 2017-07-15 2019-01-24 The Regents Of The University Of California CATHEPSIN K OSTEOADSORBENT FLUOROGEN SUBSTRATE FOR THE IMAGING OF OSTEOCLAST ACTIVITY AND MIGRATION
WO2020064190A1 (en) 2018-09-26 2020-04-02 Borealis Ag Propylene copolymer composition with excellent optical and mechanical properties
CN113549144A (zh) * 2021-06-30 2021-10-26 华南理工大学 一种特立帕肽hPTH(1-34)的生产和纯化方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317010A (en) * 1991-10-10 1994-05-31 Peter K. T. Pang Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
US5393869A (en) * 1990-09-28 1995-02-28 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
US5556940A (en) * 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5393869A (en) * 1990-09-28 1995-02-28 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
US5317010A (en) * 1991-10-10 1994-05-31 Peter K. T. Pang Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5556940A (en) * 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2604809C2 (ru) * 2010-05-13 2016-12-10 Дзе Дженерал Хоспитал Корпорейшн Аналоги паратиреоидного гормона и их применение

Also Published As

Publication number Publication date
CN1231676A (zh) 1999-10-13
JP4122061B2 (ja) 2008-07-23
CA2261564C (en) 2007-10-30
ATE253078T1 (de) 2003-11-15
SK13299A3 (en) 1999-10-08
KR20000029783A (ko) 2000-05-25
JP2007254480A (ja) 2007-10-04
SK287397B6 (sk) 2010-08-09
AU723728B2 (en) 2000-09-07
DE69725850T2 (de) 2004-08-19
SI9720057A (sl) 1999-12-31
FI990126A0 (fi) 1999-01-22
DE69725850D1 (de) 2003-12-04
AU3690597A (en) 1998-02-25
BR9711002A (pt) 2002-01-15
CZ34799A3 (cs) 1999-07-14
GEP20033095B (en) 2003-10-27
KR100500859B1 (ko) 2005-07-14
NZ333809A (en) 2000-07-28
CA2261564A1 (en) 1998-02-12
CN1176947C (zh) 2004-11-24
DK0915911T3 (da) 2004-03-08
BG103128A (bg) 2000-05-31
EP0915911A1 (en) 1999-05-19
LV12293B (en) 2000-11-20
JP2001500845A (ja) 2001-01-23
FI990126L (fi) 1999-03-31
FI990126A7 (fi) 1999-03-31
JP2009057386A (ja) 2009-03-19
PT915911E (pt) 2004-03-31
EE9900039A (et) 1999-08-16
LV12293A (lv) 1999-06-20
IS4962A (is) 1999-01-29
WO1998005683A1 (en) 1998-02-12
BR9711002B1 (pt) 2011-09-06
JP4224111B2 (ja) 2009-02-12
ES2207740T3 (es) 2004-06-01
EP0915911B1 (en) 2003-10-29

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Effective date: 20120802