BE901139A - Derives 2,6-disubstitues du naphtalene, leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique. - Google Patents

Derives 2,6-disubstitues du naphtalene, leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique.

Info

Publication number
BE901139A
BE901139A BE0/214062A BE214062A BE901139A BE 901139 A BE901139 A BE 901139A BE 0/214062 A BE0/214062 A BE 0/214062A BE 214062 A BE214062 A BE 214062A BE 901139 A BE901139 A BE 901139A
Authority
BE
Belgium
Prior art keywords
alkyl
derivatives
disubstitued
naphthalene
pharmaceutical
Prior art date
Application number
BE0/214062A
Other languages
English (en)
Inventor
B Shroot
J Eustache
M Bouclier
Original Assignee
Galderma Rech Dermatologique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Rech Dermatologique filed Critical Galderma Rech Dermatologique
Publication of BE901139A publication Critical patent/BE901139A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/34—Monohydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/546—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/49—Polycyclic acids containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/17—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Abstract

Nouveaux dérivés 2,6-disubstitués du naphtalène de formule générale (I), dans laquelle n = 1 ou 2, R1 à R4 = H; ou CH3; R5 = -(R7CH)m-R6, -C =N, -CO-R8 ou un groupe 2-oxazolinyle; m = O ou 1; R6 = H, alkyle ou OR9 et R9 = H, alkyle, ou-CO-R10 = alkyle ou aryle; R6 pouvant aussi représenter - Nr'(r''), lorsque m = 1, r' et r'' = H, alkyle, mono- ou poly-hydroxyalkyle, aryle ou hétéroycle (ensemble), R7 = H ou alkyle et R8 = H ou alkyle, leurs sels et acétals. Les dérivés sont utilisé dans le traitement topique des affections dermatologiques liées à un désordre de kératinisation ou pour certaines affections rhumatismales l'origine psoriasique.
BE0/214062A 1983-11-28 1984-11-27 Derives 2,6-disubstitues du naphtalene, leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique. BE901139A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8318917A FR2555571B1 (fr) 1983-11-28 1983-11-28 Derives du naphtalene, leur procede de preparation et leur application dans le domaine therapeutique

Publications (1)

Publication Number Publication Date
BE901139A true BE901139A (fr) 1985-05-28

Family

ID=9294579

Family Applications (2)

Application Number Title Priority Date Filing Date
BE0/214063A BE901140A (fr) 1983-11-28 1984-11-27 Derives poly-substitues du naphtalene, leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetique.
BE0/214062A BE901139A (fr) 1983-11-28 1984-11-27 Derives 2,6-disubstitues du naphtalene, leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE0/214063A BE901140A (fr) 1983-11-28 1984-11-27 Derives poly-substitues du naphtalene, leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetique.

Country Status (12)

Country Link
US (4) US4581380A (fr)
JP (2) JPS60155140A (fr)
AT (2) AT395583B (fr)
AU (2) AU573652B2 (fr)
BE (2) BE901140A (fr)
CA (2) CA1247132A (fr)
CH (2) CH662559A5 (fr)
DE (2) DE3443231C2 (fr)
FR (1) FR2555571B1 (fr)
GB (2) GB2150564B (fr)
IT (2) IT1177330B (fr)
NL (2) NL193819C (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492373A1 (fr) * 1980-10-21 1982-04-23 Cird Adducts de dihydroxy-1,8 anthrone-9 et leur utilisation en medecine humaine ou veterinaire et en cosmetique
FR2555571B1 (fr) * 1983-11-28 1986-11-28 Interna Rech Dermatolo Centre Derives du naphtalene, leur procede de preparation et leur application dans le domaine therapeutique
DE3434946A1 (de) * 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen Diarylacetylene, ihre herstellung und verwendung
LU85562A1 (fr) * 1984-10-01 1986-06-11 Oreal Nouveaux derives 1-substitutes du methoxy-4 trimethyl-2, 3, 6 benzene,leur procede de preparation et compositions medicamenteuse et cosmetique les contenant
FR2573755B1 (fr) * 1984-11-27 1988-04-22 Cird Derives polysubstitues du naphtalene, leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique
LU85849A1 (fr) * 1985-04-11 1986-11-05 Cird Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques
FR2601359B1 (fr) * 1986-07-09 1988-10-28 Cird Nouveaux derives bicycliques naphtaleniques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique.
IL80270A0 (en) * 1985-10-11 1987-01-30 Cird Naphthalene derivatives,their preparation and pharmaceutical compositions containing them
DE3602473A1 (de) * 1986-01-28 1987-07-30 Basf Ag Vinylphenolderivate, ihre herstellung und verwendung
US4795629A (en) * 1987-07-06 1989-01-03 Chesebrough-Pond's Inc. Crosslinking of hair thiols using cystamine
KR0139216B1 (ko) * 1988-04-11 1998-05-01 제임스 엠. 캐내지 레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르
MY105521A (en) * 1989-04-17 1994-10-31 Healthpoint Ltd Moisturizing vehicle for topical application of vitamin a acid.
FR2670482A1 (fr) * 1990-12-14 1992-06-19 Atochem Derives des acides naphtyloxy benzouiques et naphtouiques leur procede de synthese.
DE4329379C1 (de) * 1993-09-01 1995-02-16 Beiersdorf Ag Gegen unreine Haut und milde Formen der Akne wirksame Zubereitungen mit einem Gehalt an Wollwachssäuren
FR2767525B1 (fr) 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
US6608212B1 (en) * 2002-06-04 2003-08-19 Pfizer, Inc. Process for preparing vinylaromatic compounds
US20040259744A1 (en) * 2003-12-19 2004-12-23 Meidong Yang Skin and hair cleansers containing sulfur
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2931661B1 (fr) 2008-05-30 2010-07-30 Galderma Res & Dev Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide.
ES2466695T3 (es) 2008-10-30 2014-06-11 Biogen Idec Ma Inc. Análogos de esfingosina 1-fosfato de arilo bicíclico
US8349849B2 (en) * 2008-10-30 2013-01-08 Biogen Idec Ma Inc. Heterobicyclic sphingosine 1-phosphate analogs
US9181191B2 (en) 2008-10-30 2015-11-10 Biogen Ma Inc. Heterobicyclic sphingosine 1-phosphate analogs
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
PT2672823T (pt) 2011-02-07 2016-11-21 Biogen Ma Inc Agentes que modulam s1p
EP3152190A4 (fr) 2014-06-04 2018-03-28 Haro Pharmaceutical Inc. Composés bi-polycycliques de 18 à 20 éléments
JP6298022B2 (ja) 2015-08-05 2018-03-20 信越化学工業株式会社 高分子化合物、ポジ型レジスト組成物、積層体、及びレジストパターン形成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499751A (en) * 1966-07-05 1970-03-10 Givaudan Corp Method and composition for controlling weeds with acylated tetrahydronaphthalene
US4326055A (en) * 1977-12-22 1982-04-20 Hoffmann-La Roche Inc. Stilbene derivatives
DK159967C (da) * 1977-12-22 1991-06-03 Hoffmann La Roche Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater
US4454341A (en) * 1983-03-03 1984-06-12 Sri International Naphthyl or tetrahydronaphthyl-substituted naphthoic acid and derivatives
FR2555571B1 (fr) * 1983-11-28 1986-11-28 Interna Rech Dermatolo Centre Derives du naphtalene, leur procede de preparation et leur application dans le domaine therapeutique

Also Published As

Publication number Publication date
NL193819B (nl) 2000-08-01
US5041639A (en) 1991-08-20
DE3443230A1 (de) 1985-06-05
IT8423748A1 (it) 1986-05-27
GB8429901D0 (en) 1985-01-03
GB2150563A (en) 1985-07-03
US4886907A (en) 1989-12-12
IT1209603B (it) 1989-08-30
JPH0678275B2 (ja) 1994-10-05
AU3593484A (en) 1985-06-06
CA1247123A (fr) 1988-12-20
NL8403608A (nl) 1985-06-17
DE3443230C2 (de) 1994-11-24
AT394362B (de) 1992-03-25
AU573652B2 (en) 1988-06-16
DE3443231A1 (de) 1985-06-05
NL193819C (nl) 2000-12-04
JPH0583528B2 (fr) 1993-11-26
US4666941A (en) 1987-05-19
GB2150564B (en) 1987-05-13
GB2150564A (en) 1985-07-03
AU3593584A (en) 1985-06-06
NL8403607A (nl) 1985-06-17
NL193855B (nl) 2000-09-01
US4581380A (en) 1986-04-08
IT1177330B (it) 1987-08-26
NL193855C (nl) 2001-01-03
GB2150563B (en) 1987-04-15
CA1247132A (fr) 1988-12-20
IT8423747A0 (it) 1984-11-27
JPS60155141A (ja) 1985-08-15
CH662559A5 (fr) 1987-10-15
IT8423748A0 (it) 1984-11-27
FR2555571A1 (fr) 1985-05-31
BE901140A (fr) 1985-05-28
DE3443231C2 (de) 1994-04-07
AT395583B (de) 1993-01-25
AU582556B2 (en) 1989-04-06
GB8429900D0 (en) 1985-01-03
JPS60155140A (ja) 1985-08-15
ATA376184A (de) 1992-06-15
ATA376284A (de) 1991-09-15
FR2555571B1 (fr) 1986-11-28
CH663952A5 (fr) 1988-01-29

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Legal Events

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RE Patent lapsed

Owner name: *CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUE

Effective date: 20021130