BE1008323A3 - Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules. - Google Patents

Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules. Download PDF

Info

Publication number
BE1008323A3
BE1008323A3 BE9400480A BE9400480A BE1008323A3 BE 1008323 A3 BE1008323 A3 BE 1008323A3 BE 9400480 A BE9400480 A BE 9400480A BE 9400480 A BE9400480 A BE 9400480A BE 1008323 A3 BE1008323 A3 BE 1008323A3
Authority
BE
Belgium
Prior art keywords
biocompatible polymer
particles
support phase
stirring
active principle
Prior art date
Application number
BE9400480A
Other languages
English (en)
French (fr)
Inventor
Jean-Marc Ruiz
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of BE1008323A3 publication Critical patent/BE1008323A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
BE9400480A 1993-05-15 1994-05-09 Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules. BE1008323A3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939310030A GB9310030D0 (en) 1993-05-15 1993-05-15 Dry processed particles and process for the preparation of the same

Publications (1)

Publication Number Publication Date
BE1008323A3 true BE1008323A3 (fr) 1996-04-02

Family

ID=10735537

Family Applications (1)

Application Number Title Priority Date Filing Date
BE9400480A BE1008323A3 (fr) 1993-05-15 1994-05-09 Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules.

Country Status (35)

Country Link
JP (1) JP3139913B2 (nl)
KR (1) KR100341261B1 (nl)
CN (1) CN1050534C (nl)
AT (1) AT406017B (nl)
AU (1) AU685094B2 (nl)
BE (1) BE1008323A3 (nl)
BR (1) BR9401968A (nl)
CA (1) CA2123481C (nl)
CH (1) CH688572A5 (nl)
DE (1) DE4416812C2 (nl)
DK (1) DK171454B1 (nl)
DZ (1) DZ1779A1 (nl)
ES (1) ES2097083B1 (nl)
FI (1) FI112915B (nl)
FR (1) FR2705232B1 (nl)
GB (2) GB9310030D0 (nl)
GR (1) GR1002034B (nl)
HK (1) HK1002831A1 (nl)
HU (1) HU220617B1 (nl)
IE (1) IE940392A1 (nl)
IN (1) IN182330B (nl)
IT (1) IT1269508B (nl)
LU (1) LU88482A1 (nl)
MA (1) MA23194A1 (nl)
NL (1) NL9400795A (nl)
NO (1) NO307403B1 (nl)
NZ (1) NZ260520A (nl)
OA (1) OA09939A (nl)
PL (1) PL175780B1 (nl)
PT (1) PT101518B (nl)
RU (1) RU2125869C1 (nl)
SE (1) SE519004C2 (nl)
SG (1) SG46631A1 (nl)
TN (1) TNSN94046A1 (nl)
ZA (1) ZA943316B (nl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69435055T2 (de) * 1993-01-06 2008-12-04 IPSEN Manufacturing Ireland Ltd., Blanchardstown Bioabbaubare Polyester zur Herstellung ionischer molekularer Konjugate mit bioaktiven Polypeptiden
DK0678018T3 (da) * 1993-01-06 2003-04-28 Kinerton Ltd Ion molekylærkonjugater af bionedbrydelige polyestere og bioaktive polypeptider
DE19604744A1 (de) 1996-02-09 1997-08-14 Henkel Kgaa Technische Di-/Triglyceridgemische
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
DE19617137C1 (de) * 1996-04-29 1997-02-27 Henkel Kgaa Verwendung von Copolymerestern für die Herstellung von Mikrosphären
US5858531A (en) * 1996-10-24 1999-01-12 Bio Syntech Method for preparation of polymer microparticles free of organic solvent traces
US6867181B1 (en) 1997-06-02 2005-03-15 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
ES2491866T3 (es) 1999-11-15 2014-09-08 Piramal Healthcare (Canada) Limited Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH
KR100558119B1 (ko) 2000-06-16 2006-03-10 가부시키가이샤 닛폰 쇼쿠바이 가교 중합체, 그것의 제조 방법 및 용도
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2070153A1 (nl) * 1969-10-23 1971-09-10 Du Pont
DE3916020A1 (de) * 1989-05-17 1990-11-22 Burkhard Wichert Retardierende mikropartikel aus bioabbaubaren polyestern
GB2246514A (en) * 1990-08-01 1992-02-05 Scras Sustained release particles preparation
WO1992021326A1 (en) * 1991-05-27 1992-12-10 Medinvent Method of producing reproducible particles

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CH672887A5 (nl) * 1987-10-14 1990-01-15 Debiopharm Sa
WO1989003678A1 (en) * 1987-10-30 1989-05-05 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
KR0168849B1 (ko) * 1990-04-12 1999-01-15 요시또시 가즈오 피목 조성물 및 그의 제조방법
JP3116311B2 (ja) * 1990-06-13 2000-12-11 エーザイ株式会社 マイクロスフィアの製法
GB9016885D0 (en) * 1990-08-01 1990-09-12 Scras Sustained release pharmaceutical compositions
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
CA2055522A1 (en) * 1990-12-12 1992-06-13 Masako Andoh Microspheres for ophthalmic use
GB9203689D0 (en) * 1992-02-20 1992-04-08 Euro Celtique Sa Pharmaceutical composition
JPH07507768A (ja) * 1992-03-12 1995-08-31 アルカーメス　コントロールド　セラピューティクス，インコーポレイテッド Ａｃｔｈ含有マイクロスフェアの制御放出
SE9200858L (sv) * 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
EP0644771B2 (en) * 1992-06-11 2006-12-06 Alkermes Controlled Therapeutics, Inc. Erythropoietin drug delivery system
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
JP2651320B2 (ja) * 1992-07-16 1997-09-10 田辺製薬株式会社 徐放性マイクロスフェア製剤の製造方法
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
GB2273874A (en) * 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2070153A1 (nl) * 1969-10-23 1971-09-10 Du Pont
DE3916020A1 (de) * 1989-05-17 1990-11-22 Burkhard Wichert Retardierende mikropartikel aus bioabbaubaren polyestern
GB2246514A (en) * 1990-08-01 1992-02-05 Scras Sustained release particles preparation
WO1992021326A1 (en) * 1991-05-27 1992-12-10 Medinvent Method of producing reproducible particles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MATHIOWITZ E. ET AL: "POLYANHYDRIDE MICROSPHERES AS DRUG CARRIERS . I. HOT-MELT ENCAPSULATION", J. OF CONTROLLED RELEASE, vol. 5, 1987, AMSTERDAM, pages 13 - 22 *
WICHERT B. ET AL: "A NEW METHOD FOR THE PREPARATION OF DRUG CONTAINING POLYLACTIC ACID MICROPARTICLES WITHOUT USING ORGANIC SOLVENTS", J. OF CONTROLLED RELEASE, vol. 14, no. 3, December 1990 (1990-12-01), AMSTERDAM, pages 269 - 283, XP000165640 *

Also Published As

Publication number Publication date
PL175780B1 (pl) 1999-02-26
IT1269508B (it) 1997-04-01
LU88482A1 (fr) 1994-12-01
FR2705232A1 (fr) 1994-11-25
IN182330B (nl) 1999-03-20
CN1104557A (zh) 1995-07-05
AU685094B2 (en) 1998-01-15
GB2277915B (en) 1997-10-29
AT406017B (de) 2000-01-25
HU9401412D0 (en) 1994-08-29
ATA98794A (de) 1999-06-15
GR1002034B (en) 1995-10-31
CA2123481A1 (en) 1994-11-16
JPH072652A (ja) 1995-01-06
IE940392A1 (en) 1994-11-16
PT101518B (pt) 2000-12-29
AU6308494A (en) 1994-11-17
KR100341261B1 (ko) 2002-09-27
HU220617B1 (hu) 2002-03-28
DK171454B1 (da) 1996-11-04
DZ1779A1 (fr) 2002-02-17
HUT67599A (en) 1995-04-28
NO941810D0 (no) 1994-05-13
SG46631A1 (en) 1998-02-20
NO941810L (no) 1994-11-16
NZ260520A (en) 1994-12-22
CA2123481C (en) 2005-01-11
FR2705232B1 (fr) 1995-08-25
SE9401557L (sv) 1994-11-16
DE4416812C2 (de) 2003-02-06
GB9310030D0 (en) 1993-06-30
NL9400795A (nl) 1994-12-01
SE9401557D0 (sv) 1994-05-05
ES2097083B1 (es) 1997-12-01
TNSN94046A1 (fr) 1995-04-25
SE519004C2 (sv) 2002-12-17
CN1050534C (zh) 2000-03-22
ZA943316B (en) 1995-01-16
BR9401968A (pt) 1994-12-13
DK54994A (da) 1994-11-16
ITMI940931A1 (it) 1995-11-11
JP3139913B2 (ja) 2001-03-05
FI942222A (fi) 1994-11-16
OA09939A (fr) 1994-11-15
NO307403B1 (no) 2000-04-03
GB2277915A (en) 1994-11-16
MA23194A1 (fr) 1994-12-31
HK1002831A1 (en) 1998-09-18
FI942222A0 (fi) 1994-05-13
RU2125869C1 (ru) 1999-02-10
PT101518A (pt) 1995-03-01
DE4416812A1 (de) 1994-11-17
FI112915B (fi) 2004-02-13
CH688572A5 (fr) 1997-11-28
ITMI940931A0 (it) 1994-05-11
ES2097083A1 (es) 1997-03-16
GB9409565D0 (en) 1994-07-06

Similar Documents

Publication Publication Date Title
EP0608207B1 (fr) Compositions pharmaceutiques contenant des nanocapsules
EP0585151B1 (fr) Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues
BE1008323A3 (fr) Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules.
BE1006143A3 (fr) Sels de peptides avec des polyesters carboxytermines.
EP1450766B1 (fr) Microspheres biodegradables a liberation prolongee et leur procede de preparation
EP0804173B1 (fr) Microspheres biodegradables a liberation controlee et leur procede de preparation
EP0646001B1 (fr) Microspheres en polymere bioresorbable, exemptes de tensioactif, leur preparation et leur application comme medicament
LU87982A1 (fr) Procede de preparation de compositions a liberation prolongee et compositions ainsi obtenues
FR2810885A1 (fr) Microparticule a liberation soutenue et procede de fabrication
FR2484281A1 (fr) Procede de preparation de microspheres comportant un noyau solide et une matiere polymere
FR2491351A1 (fr) Procede de microcapsulation
FR2694894A1 (fr) Utilisation d'une réaction de transacylation entre un polysaccharide estérifié et une substance polyaminée ou polyhydroxylée pour la fabrication de microparticules, procédé et composition.
EP1082104A1 (fr) Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant
WO1994021371A1 (fr) Procede de preparation de particules renfermant un ingredient actif par extrusion et lyophilisation
CH654207A5 (fr) Procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic.
EP3697527A1 (fr) Procédé de préparation de capsules sensibles au ph ou au rayonnement uv et capsules obtenues
KR101831417B1 (ko) 자발적 공극 폐쇄 기능성을 갖는 고분자 미립구 및 이의 제조방법
KR102383448B1 (ko) 락트산 또는 글리콜산을 포함하는 미립구형 서방출 제제 및 그의 제조방법
FR2756736A1 (fr) Compositions pharmaceutiques contenant des derives de n-sulfonyl indoline
EP1830811A2 (fr) Procede de preparation d'une composition pharmaceutique solide a liberation prolongee et controlee par traitement sous hautes pressions
EP0542855B1 (fr) Microcapsules a paroi mixte d'atelocollagene et de polyholosides coagulee par un cation bivalent
FR2797784A1 (fr) Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore
FR2702375A1 (fr) Microcapsules à libération progressive, leur procédé de préparation et compositions pharmaceutiques ou vétérinaires les contenant.
EP0900564A1 (fr) Comprimé antiseptique vaginal à action prolongée
EP1683568A1 (fr) Procédé de coacervation amélioré pour la préparation de microcapsules de principe actif hydrophobe isolées filtrables et redispersables dans l'eau

Legal Events

Date Code Title Description
RE Patent lapsed

Effective date: 20100531