ES2491866T3 - Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH - Google Patents

Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH Download PDF

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Publication number
ES2491866T3
ES2491866T3 ES00975711.3T ES00975711T ES2491866T3 ES 2491866 T3 ES2491866 T3 ES 2491866T3 ES 00975711 T ES00975711 T ES 00975711T ES 2491866 T3 ES2491866 T3 ES 2491866T3
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Prior art keywords
hydroxyethyl
sulfonate
piperazine
bis
hydroxymethyl
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Expired - Lifetime
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ES00975711.3T
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Abdellatif Chenite
Cyril Chaput
Dong Wang
Amine Selmani
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Piramal Healthcare Canada Ltd
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Piramal Healthcare Canada Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)

Abstract

Una composición líquida autogelificante, que permite la formación de geles biopoliméricos controlados por la temperatura y dependientes del pH a una temperatura entre 30 y 80°C, caracterizada porque comprende: a) un medio ácido basado en agua, y b) 0,1 a 10% en peso de un biopolímero soluble en ácidos que gelifica por acción del pH seleccionado de colágeno y un biopolímero quitosano catiónico que porta grupos amino, y c) 0,1 a 10% en peso de una molécula soluble en agua, capaz de capturar protones en disolución acuosa dando de este modo lugar a un aumento del pH, seleccionada del grupo que consiste en: - sales de sodio, magnesio o hierro de N-[carbamoilmetil]-2-aminoetano-sulfonato (ACES), N,Nbis[ 2-hidroxietil]-2-aminoetano-sulfonato (BES), 3-[N,N-bis(2-hidroxietil)amino]-2-hidroxipropano sulfonato (DIPSO), N-[2-hidroxietil]piperazina-N'-3-propano-sulfonato (EPPS), N-[2- hidroxietil]piperazina-N'-4-butano-sulfonato (HEPBS), N-[2-hidroxietil]piperazina-N'-2-etanosulfonato (HEPES), N-[2-hidroxietil]piperazina-N'-2-hidroxipropano-sulfonato (HEPSO), 2-[Nmorfolino] etano-sulfonato (MES), 4-[N-morfolino]butano-sulfonato (MOBS), 3-[Nmorfolino] propano-sulfonato (MOPS), 3-[N-morfolino]-2-hidroxipropano-sulfonato (MOPSO), piperazina-N',N'-bis[2-etanosulfonato] (PIPES), piperazina-N,N'-bis[2-hidroxipropanosulfonato] (POPSO), 3-[N-tris(hidroximetil)metilamino]-2-hidroxipropano-sulfonato (TAPSO), o Ntris[ hidroximetil]metil-2-aminoetano-sulfonato (TES), o mezclas de los mismos; - N,N-bis[hidroxietil]glicina (BICINE), bis[2-hidroxietil]iminotris-[hidroximetil]metano (BIS-TRIS), glicil-glicina (GLY-GLY), trietanolamina (TEA), N-tris[hidroximetil]metilglicina (TRICINE), tris[hidroximetil]aminometano (TRIZMA), o mezclas de los mismos; - un residuo aminoácido seleccionado del grupo que consiste en histidina, arginina, lisina, asparagina, y glutamina o una mezcla de los mismos, residuo aminoácido que opcionalmente está modificado con un radical acetilo, t-butilo, bencilo, benzoilo, etilo, formilo, o metilo; - una secuencia de aminoácidos que incluye alanina, histidina, arginina, lisina, ácido aspártico, glutamina, glicina, hidroxiprolina, isoleucina, leucina, norleucina, fenilalanina, prolina, serina, treonina, tirosina, o valina, donde dicha composición líquida tiene un pH final que varía de 5,8 a 7,4.

Description

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Claims (1)

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ES00975711.3T 1999-11-15 2000-11-10 Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH Expired - Lifetime ES2491866T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16564199P 1999-11-15 1999-11-15
US165641P 1999-11-15
PCT/CA2000/001341 WO2001036000A1 (en) 1999-11-15 2000-11-10 Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution

Publications (1)

Publication Number Publication Date
ES2491866T3 true ES2491866T3 (es) 2014-09-08

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ES00975711.3T Expired - Lifetime ES2491866T3 (es) 1999-11-15 2000-11-10 Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH

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US (1) US8920842B2 (es)
EP (1) EP1229940B1 (es)
AU (1) AU1375301A (es)
CA (2) CA2427938C (es)
DK (1) DK1229940T3 (es)
ES (1) ES2491866T3 (es)
WO (1) WO2001036000A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1375301A (en) 1999-11-15 2001-05-30 Bio Syntech Canada Inc Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
ATE247495T1 (de) 1999-12-09 2003-09-15 Biosyntech Canada Inc Mineral-polymer hybrid-zusammensetzung
US20030158302A1 (en) 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
JP5089006B2 (ja) 2000-06-29 2012-12-05 ピラマル ヘルスケア （カナダ） リミテッド 軟骨および他の組織の修復および再生のための組成物および方法
WO2002040072A2 (en) * 2000-11-15 2002-05-23 Bio Syntech Canada Inc. Filler composition for soft tissue augmentation and reconstructive surgery
DE60125973D1 (de) * 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
US6989373B2 (en) * 2000-11-15 2006-01-24 Bio Syntech Canada Inc. Method for restoring a fat-pad
US7202091B2 (en) 2001-04-11 2007-04-10 Inlight Solutions, Inc. Optically similar reference samples
AU2003287812A1 (en) * 2002-12-03 2004-06-23 Bio Syntech Canada Inc. Method for treating a tumor using a thermo-gelling chitosan composition
GB2408937A (en) * 2003-12-09 2005-06-15 Johnson & Johnson Medical Ltd pH dependent medicinal compositions
GB0403938D0 (en) * 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution
US20090149421A1 (en) * 2005-11-04 2009-06-11 Bio Syntech Canada Inc. Gel formation of polyelectrolyte aqueous solutions by thermally induced changes in ionization state
DE602005016030D1 (de) 2005-12-23 2009-09-24 Medidom Lab Duroplastische neutralisierte chitosan-zusammensetzung zur bildung eines hydrogels, lyophilisats, und herstellungsverfahren dafür
ES3010268T3 (en) 2009-03-10 2025-04-01 Allergan Pharmaceuticals Int Ltd Injectable biomaterials
US8506972B2 (en) 2010-08-27 2013-08-13 Oligo Medic Inc Highly biocompatible dual thermogelling chitosan/glucosamine salt compositions
PL2609149T3 (pl) * 2010-08-27 2016-04-29 Oligo Medic Inc Wysoce biokompatybilne podwójne termożelujące kompozycje chitozan/sól glukozaminy
US10377647B2 (en) * 2010-12-15 2019-08-13 Queen's University at Kingson Systems and methods for use of water with switchable ionic strength
US9546235B2 (en) 2011-12-19 2017-01-17 The University Of Sydney Peptide-hydrogel composite
US9688741B2 (en) 2012-10-23 2017-06-27 Elastagen Pty Ltd Elastic hydrogel
EP3449955B1 (en) 2012-12-10 2020-12-02 Allergan Pharmaceuticals International Limited Scalable three-dimensional elastic construct manufacturing
ES2965893T3 (es) 2013-08-13 2024-04-17 Allergan Pharmaceuticals Int Ltd Regeneración de tejido dañado con tropoelastina
JP6952348B2 (ja) 2015-07-24 2021-10-20 トリンプ アイピー ピーティーワイ リミテッド 殺菌性ポリマー及びポリマーと細胞との複合体ならびにそれらの合成
MX374683B (es) 2015-11-03 2025-03-04 Zoetis Services Llc Compuestos polimericos sol-gel y sus usos.
US9655842B1 (en) 2015-12-04 2017-05-23 Covidien Lp Injectable non-aqueous compositions and methods of treating vascular disease
UY37687A (es) 2017-04-20 2018-11-30 Zoetis Services Llc Composiciones veterinarias para uso en tratamiento de mastitis y métodos asociados
CN111629766A (zh) 2017-12-01 2020-09-04 硕腾服务有限责任公司 水凝胶组合物及其用途
CN109957150A (zh) * 2017-12-25 2019-07-02 成都昕才医药科技有限公司 一种温敏水凝胶前体的制备方法
CN109957115A (zh) * 2017-12-25 2019-07-02 成都昕才医药科技有限公司 一种温敏水凝胶
CN109957116A (zh) * 2017-12-25 2019-07-02 成都昕才医药科技有限公司 一种反复相变的凝胶材料
CN108853599B (zh) * 2018-07-27 2021-03-05 王宇清 一种富氧温敏型水凝胶及其制备方法
CN110388199B (zh) * 2019-06-18 2021-06-01 中国石油天然气股份有限公司 一种碳酸盐岩储层大排量复合酸压改造方法
CN111603441B (zh) * 2020-07-01 2022-11-25 瑞希(重庆)生物科技有限公司 一种两亲性聚氨基酸共聚物/泊洛沙姆温敏凝胶及其制备方法
CN114349983A (zh) * 2022-01-10 2022-04-15 深圳市勇粒生物科技有限公司 一种抗炎杀菌氨基酸水凝胶及其制备方法与应用

Family Cites Families (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976574A (en) * 1956-07-31 1961-03-28 Union Carbide Corp Chemical process and product
US3266906A (en) * 1962-12-13 1966-08-16 Kelco Co Algin gel and gelatin composition having high bloom strength and process
US3586654A (en) * 1969-04-15 1971-06-22 Nat Distillers Chem Corp Process for the preparation of polymer powders of controlled particle shape,size and size distribution and product
US3755558A (en) * 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
IT1021282B (it) * 1973-10-11 1978-01-30 Basf Ag Processo per la preparazione di dispersioni di poliesterimidi
US4060081A (en) 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4185618A (en) * 1976-01-05 1980-01-29 Population Research, Inc. Promotion of fibrous tissue growth in fallopian tubes for female sterilization
US4097935A (en) * 1976-07-21 1978-07-04 Sterling Drug Inc. Hydroxylapatite ceramic
US4195175A (en) * 1978-01-03 1980-03-25 Johnson Edwin L Process for the manufacture of chitosan
US4337760A (en) * 1978-10-13 1982-07-06 Adolf Schwimmer Method for the treatment of tumors with β-glucuronidase activity dependent pharmaceuticals
JPS5943041B2 (ja) * 1979-02-16 1984-10-19 大日精化工業株式会社 尿素基を有する糖誘導体およびその製造方法
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4254207A (en) * 1979-12-26 1981-03-03 Hercules Incorporated Process for producing spherical particles or crystalline polymers
US4933105A (en) * 1980-06-13 1990-06-12 Sandoz Pharm. Corp. Process for preparation of microspheres
DE3026762C2 (de) * 1980-07-15 1985-04-25 Akzo Gmbh, 5600 Wuppertal Verfahren zum Herstellen von porösem, pulverförmigem Polypropylen und Verwendung der Verfahrensprodukte
US4394373A (en) * 1981-04-06 1983-07-19 Malette William Graham Method of achieving hemostasis
US4532134A (en) * 1981-04-06 1985-07-30 Malette William Graham Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound
US4424346A (en) * 1981-06-04 1984-01-03 Canadian Patents And Development Ltd. Derivatives of chitins, chitosans and other polysaccharides
SE441009B (sv) * 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
US4605623A (en) * 1982-11-08 1986-08-12 Malette William Graham Method of altering growth and development and suppressing contamination microorganisms in cell or tissue culture
US4474769A (en) 1983-05-13 1984-10-02 Pfanstiehl Laboratories, Inc. Chitosan as a contraceptive
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4659700A (en) * 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
US4722948A (en) * 1984-03-16 1988-02-02 Dynatech Corporation Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone
US4731081A (en) * 1984-09-11 1988-03-15 Mentor Corporation Rupture-resistant prosthesis with creasable shell and method of forming same
US4902792A (en) * 1985-04-19 1990-02-20 Kanebo Ltd. Fine cellulose particles and process for production thereof
US4678470A (en) * 1985-05-29 1987-07-07 American Hospital Supply Corporation Bone-grafting material
US4895724A (en) * 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
JPS624702A (ja) * 1985-06-28 1987-01-10 Lion Corp 水溶性アシル化キトサンの製造方法
US6005161A (en) 1986-01-28 1999-12-21 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US4877775A (en) 1986-06-16 1989-10-31 E. I. Du Pont De Nemours And Company Polymeric aminosaccharides as antihypercholesterolemic agents
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US5989579A (en) * 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
US5736372A (en) * 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
JPH01104305A (ja) * 1987-10-15 1989-04-21 Tadashi Uragami 液体分離用膜
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
DE3869850D1 (de) 1987-07-10 1992-05-14 Asahi Optical Co Ltd Zusammensetzung zur herstellung eines haertbaren kalziumphosphatartigen materials und verfahren zur produktion eines derartigen materials.
US6610669B1 (en) 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
GB8803697D0 (en) * 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells
JPH0228112A (ja) * 1988-04-21 1990-01-30 Kaken Pharmaceut Co Ltd 点眼用眼圧調整剤
US4956350A (en) 1988-08-18 1990-09-11 Minnesota Mining And Manufacturing Company Wound filling compositions
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US4911926A (en) * 1988-11-16 1990-03-27 Mediventures Inc. Method and composition for reducing postsurgical adhesions
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5073202A (en) 1989-03-09 1991-12-17 Micro Vesicular Systems, Inc. Method of using a biodegradable superabsorbing sponge
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
WO1991001720A1 (en) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
JPH0678372B2 (ja) * 1990-06-19 1994-10-05 信越化学工業株式会社 重合体スケール付着防止用溶液および重合体スケールの付着防止方法
GB2246514B (en) 1990-08-01 1993-12-15 Scras Sustained release pharmaceutical compositions and the preparation of particles for use therein
US5071644A (en) 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
US5226326A (en) * 1991-05-31 1993-07-13 Environmental Stress Screening Corp. Vibration chamber
EP0606219A1 (en) * 1991-06-24 1994-07-20 Carrington Laboratories, Inc. Wound cleanser
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
GB2261672A (en) 1991-11-18 1993-05-26 Michael Braden The use of biomaterials for tissue repair
IL100096A (en) * 1991-11-20 1996-03-31 Univ Ramot Method for entrapment of active materials in chitosan
US5658593A (en) * 1992-01-16 1997-08-19 Coletica Injectable compositions containing collagen microcapsules
US5306305A (en) * 1992-01-31 1994-04-26 Etex Corporation Methods of coating implants with bony structure
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US5708152A (en) 1992-03-27 1998-01-13 Ciba Specialty Chemicals Corporation N-substituted chitosan derivatives in a process for their preparation
FR2692147B1 (fr) 1992-06-15 1995-02-24 Centre Nat Rech Scient Microsphères en polymère biorésorbable exemptes de tensioactif, leur préparation et leur application comme médicament.
US5266326A (en) 1992-06-30 1993-11-30 Pfizer Hospital Products Group, Inc. In situ modification of alginate
US5871985A (en) * 1992-09-28 1999-02-16 Brown University Research Foundation Particulate non cross-linked chitosan core matrices for encapsulated cells
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
GB9310030D0 (en) 1993-05-15 1993-06-30 Scras Dry processed particles and process for the preparation of the same
US5368051A (en) 1993-06-30 1994-11-29 Dunn; Allan R. Method of regenerating articular cartilage
CA2130295A1 (en) 1993-08-26 1995-02-27 Richard A. Berg Ionically crosslinked glycosaminoglycan gels for soft tissue augmentation and drug delivery
US5531716A (en) 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US6743783B1 (en) * 1993-12-01 2004-06-01 Marine Polymer Technologies, Inc. Pharmaceutical compositions comprising poly-β-1→4-N-acetylglucosamine
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
US6251137B1 (en) 1994-03-23 2001-06-26 Mcghan Medical Corporation Synthetic triglyceride filler material for surgically implanted prostheses
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
DE69531638T2 (de) * 1994-06-06 2004-06-17 Osiris Therapeutics, Inc. Biomatrix für geweberegenaration
US5837235A (en) 1994-07-08 1998-11-17 Sulzer Medizinaltechnik Ag Process for regenerating bone and cartilage
AU3274895A (en) 1994-07-18 1996-02-16 Gel Sciences, Inc. Novel polymer gel networks and methods of use
SE9402528D0 (sv) * 1994-07-19 1994-07-19 Astra Ab Hårdvävnadsstimulerande med el
SE9402531L (sv) * 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
US5510102A (en) * 1995-01-23 1996-04-23 The Regents Of The University Of California Plasma and polymer containing surgical hemostatic adhesives
US5749874A (en) * 1995-02-07 1998-05-12 Matrix Biotechnologies, Inc. Cartilage repair unit and method of assembling same
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US5906934A (en) * 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
NL9500580A (nl) 1995-03-27 1996-11-01 Hollandse Signaalapparaten Bv Phased array antenne voorzien van een calibratienetwerk.
US5620706A (en) * 1995-04-10 1997-04-15 Universite De Sherbrooke Polyionic insoluble hydrogels comprising xanthan and chitosan
US5676976A (en) 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
AU723740B2 (en) 1995-06-06 2000-09-07 Howmedica Inc. Biocompatible hydroxyapatite formulations and uses therefor
US5655546A (en) * 1995-06-07 1997-08-12 Halpern; Alan A. Method for cartilage repair
EP0830381A4 (en) 1995-06-09 2000-11-22 William N Drohan CHITINE HYDROGELS, PRODUCTION METHOD AND USE
JP3881707B2 (ja) * 1995-07-20 2007-02-14 学校法人松本歯科大学 骨形成促進剤の製造方法及び骨形成促進剤を用いた骨形成組成物の製造方法
US5900238A (en) * 1995-07-27 1999-05-04 Immunex Corporation Vaccine delivery system
TW389694B (en) * 1995-08-17 2000-05-11 Novartis Ag Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics
US5944754A (en) 1995-11-09 1999-08-31 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
ES2238077T3 (es) * 1995-11-16 2005-08-16 Case Western Reserve University Induccion condrogenica in vitro de celulas madre mesenquimatosas humanas.
JPH09143093A (ja) 1995-11-17 1997-06-03 Hoechst Japan Ltd 軟骨・骨誘導性修復用材料
JP4193917B2 (ja) * 1995-12-18 2008-12-10 アンジオデバイス インターナショナル ゲーエムベーハー 架橋ポリマー組成物およびその使用方法
US6200606B1 (en) * 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
WO1997033562A1 (en) * 1996-03-13 1997-09-18 Laboratoires Merck Sharp & Dohme-Chibret Snc Ophthalmological composition of the type which undergoes liquid-gel phase transition
CA2251129A1 (en) 1996-05-03 1997-11-13 Innogenetics N.V. New medicaments containing gelatin cross-linked with oxidized polysaccharides
IL118376A0 (en) * 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
US5830503A (en) 1996-06-21 1998-11-03 Andrx Pharmaceuticals, Inc. Enteric coated diltiazem once-a-day formulation
US6060534A (en) * 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6649192B2 (en) 1996-07-29 2003-11-18 Universidade De Santiago De Compostela Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms
US5964807A (en) 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US7320962B2 (en) * 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US6706690B2 (en) * 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
AU4941297A (en) 1996-11-15 1998-06-10 Dumex-Alpharma A/S A method for promoting tissue repair
JPH10158188A (ja) * 1996-11-29 1998-06-16 Senju Pharmaceut Co Ltd 角膜治療用組成物
US5866415A (en) * 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
WO1999004720A1 (en) 1997-07-11 1999-02-04 Reprogenesis Inc. Repair of intervertebral disks
CA2212300A1 (en) * 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
US6110209A (en) 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
US20020068048A1 (en) * 1997-09-05 2002-06-06 Patrick A. Dreyfus Method for the treatment or diagnosis of human pathologies with disseminated or difficult to access cells or tissues
US6417247B1 (en) * 1997-10-14 2002-07-09 Beth L. Armstrong Polymer/ceramic composites
CA2219399A1 (en) 1997-10-24 1999-04-24 Bio Syntech Ltd. Bulk formation of monolithic polysaccharide-based hydrogels
EP1030676B1 (en) 1997-10-30 2005-09-14 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
US6482223B1 (en) 1997-12-16 2002-11-19 Closys Corporation Clotting cascade initiating apparatus and methods of use
US7019192B2 (en) 1998-02-27 2006-03-28 Musculoskeletal Transplant Foundation Composition for filling bone defects
JP2002507437A (ja) 1998-02-27 2002-03-12 バイオエラスチックス・リサーチ・リミテッド 組織の増強及び回復のための注射可能インプラント
US7045141B2 (en) * 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US6911212B2 (en) * 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
DE19810965A1 (de) 1998-03-13 1999-09-16 Aventis Res & Tech Gmbh & Co Nanopartikel, Verfahren zu ihrer Herstellung und ihre Verwendung
US6179872B1 (en) * 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
WO1999047186A1 (en) 1998-03-18 1999-09-23 University Of Pittsburgh Chitosan-based composite materials containing glycosaminoglycan for cartilage repair
US20030147860A1 (en) 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
DE19817698A1 (de) 1998-04-22 1999-10-28 Jan Zoellner Verwendung einer autopolymerisierenden Zusammensetzung auf Organosiloxanbasis
JP3686335B2 (ja) 1998-07-13 2005-08-24 ユニヴァースティ オブ サザーン カリフォルニア 骨および軟骨成長と修復を促進する方法
JP2002535378A (ja) 1999-02-01 2002-10-22 ジェネティックス・インスチチュート・インコーポレーテッド 関節軟骨の治癒および修復のための方法および組成物
EP1161201A4 (en) 1999-02-16 2006-07-19 Zimmer Orthobiologics Inc DEVICE AND METHOD FOR REGENERATING AND RESTORING CARTILAGE DEFECTS
US6436143B1 (en) 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
CA2377435A1 (en) * 1999-06-29 2001-01-04 J. Alexander Marchosky Compositions and methods for forming and strengthening bone
US6429013B1 (en) 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
AU1375301A (en) 1999-11-15 2001-05-30 Bio Syntech Canada Inc Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
US20030158302A1 (en) 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
ATE247495T1 (de) 1999-12-09 2003-09-15 Biosyntech Canada Inc Mineral-polymer hybrid-zusammensetzung
US20050244393A1 (en) 1999-12-22 2005-11-03 Henogen S.A. Sealant or tissue generating product
JP5089006B2 (ja) 2000-06-29 2012-12-05 ピラマル ヘルスケア （カナダ） リミテッド 軟骨および他の組織の修復および再生のための組成物および方法
US6866866B1 (en) * 2000-11-03 2005-03-15 Andrx Labs, Llc Controlled release metformin compositions
US20040047892A1 (en) * 2000-11-15 2004-03-11 Desrosiers Eric Andre Filler composition for soft tissue augmentation and reconstructive surgery
DE60125973D1 (de) * 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
US6756363B1 (en) * 2000-11-17 2004-06-29 Wound Healing Of Oklahoma, Inc. Solutions and films of glycated chitosan
US20060263401A1 (en) 2001-07-13 2006-11-23 Flow Focusing, Inc. Formulation and Method for Preventing Infection
US7459307B2 (en) 2001-08-14 2008-12-02 Medipost Co., Ltd Composition for treatment of articular cartilage damage
US6632468B2 (en) * 2001-08-16 2003-10-14 Kerry Inc. Controlled-viscosity food flavoring system
US8740973B2 (en) 2001-10-26 2014-06-03 Icon Medical Corp. Polymer biodegradable medical device
US7098194B2 (en) 2001-11-15 2006-08-29 Biosyntech Canada, Inc. Composition and method to homogeneously modify or cross-link chitosan under neutral conditions
PT1455802E (pt) * 2001-12-14 2008-11-03 Dnp Canada Inc Oligossacáridos de quitosano e suas utilizações
TWI245634B (en) * 2001-12-28 2005-12-21 Ind Tech Res Inst Preparation of a biodegradable thermal-sensitive gel system
US7514249B2 (en) 2002-04-18 2009-04-07 The University Of Florida Research Foundation, Inc. Biomimetic organic/inorganic composites
US20060204544A1 (en) 2002-05-20 2006-09-14 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
KR20050038008A (ko) * 2002-07-31 2005-04-25 알자 코포레이션 주사용 저장형 조성물 및 이의 용도
NZ537953A (en) * 2002-07-31 2007-02-23 Alza Corp Injectable multimodal polymer depot compositions and uses thereof
WO2004028578A1 (en) * 2002-09-30 2004-04-08 Regen Biotech, Inc. Composition for stimulating bone-formation and bone consolidation
EP1581181B1 (en) * 2002-11-06 2008-12-24 ALZA Corporation Controlled release depot formulations
GB0302738D0 (en) 2003-02-06 2003-03-12 Advanced Biopolymers As Composition
US7217294B2 (en) * 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
GB0403938D0 (en) 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution
US20060004189A1 (en) * 2004-07-02 2006-01-05 James Gandy Compositions for treating wounds and processes for their preparation
US20060062768A1 (en) * 2004-09-23 2006-03-23 Olexander Hnojewyj Biocompatible hydrogel compositions
ITRM20040539A1 (it) * 2004-11-02 2005-02-02 Mavi Sud S R L Preparati a base di chitina o suoi derivati per uso cosmetico o medico.
WO2007127795A2 (en) 2006-04-25 2007-11-08 Bumgardner Joel D Chitosan/nanocrystalline hydroxyapatite composite microsphere-based scaffolds
CA2672936A1 (en) 2006-11-30 2008-06-05 Bio Syntech Canada Inc. Method for in situ solidification of blood-polymer compositions for regenerative medicine and cartilage repair applications
US8153612B2 (en) * 2006-12-11 2012-04-10 Chi2Gel Ltd. Injectable chitosan mixtures forming hydrogels
US7776840B2 (en) 2007-02-21 2010-08-17 Cutanea Life Sciences, Inc. Methods of use of biomaterial and injectable implant containing biomaterial

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