BE1002296A5 - Derives peptidiques. - Google Patents

Derives peptidiques. Download PDF

Info

Publication number
BE1002296A5
BE1002296A5 BE8901294A BE8901294A BE1002296A5 BE 1002296 A5 BE1002296 A5 BE 1002296A5 BE 8901294 A BE8901294 A BE 8901294A BE 8901294 A BE8901294 A BE 8901294A BE 1002296 A5 BE1002296 A5 BE 1002296A5
Authority
BE
Belgium
Prior art keywords
somatostatin
receptors
peptide derivatives
amino group
detectable element
Prior art date
Application number
BE8901294A
Other languages
English (en)
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1002296A5 publication Critical patent/BE1002296A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BE8901294A 1988-12-05 1989-12-05 Derives peptidiques. BE1002296A5 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
BE1002296A5 true BE1002296A5 (fr) 1990-11-20

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8901294A BE1002296A5 (fr) 1988-12-05 1989-12-05 Derives peptidiques.

Country Status (24)

Country Link
JP (2) JP2726320B2 (ko)
KR (1) KR0156541B1 (ko)
AT (1) AT403476B (ko)
AU (1) AU633859B2 (ko)
BE (1) BE1002296A5 (ko)
CA (1) CA2004532C (ko)
CH (1) CH678329A5 (ko)
DE (1) DE3991505B4 (ko)
DK (1) DK175338B1 (ko)
ES (1) ES2023533A6 (ko)
FI (1) FI102540B (ko)
FR (1) FR2639947B1 (ko)
GB (1) GB2225579B (ko)
HK (1) HK189995A (ko)
HU (2) HUT53375A (ko)
IE (1) IE62091B1 (ko)
IL (1) IL92534A (ko)
LU (1) LU87633A1 (ko)
MY (1) MY106120A (ko)
NL (1) NL194828C (ko)
PT (1) PT92487B (ko)
SA (1) SA96160495B1 (ko)
SE (1) SE508799C2 (ko)
WO (1) WO1990006949A2 (ko)

Families Citing this family (51)

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AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
WO1992013554A1 (en) * 1991-02-08 1992-08-20 Biomeasure, Inc. Method of treating benign and malignant proliferative skin disease
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
WO1992021383A1 (en) * 1991-06-03 1992-12-10 Mallinckrodt Medical, Inc. Radiolabelled somatostatin derivatives, their preparation and use
ES2150916T3 (es) * 1991-08-29 2000-12-16 Mallinckrodt Medical Inc Utilizacion del acido gentisico o del alcohol gentisilico para estabilizar peptidos y proteinas radiomarcados.
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
DE69231586T2 (de) * 1992-01-03 2001-07-19 Rhomed Inc Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
CA2129033A1 (en) * 1992-02-05 1993-08-19 Leon Lyle Radiolabelled peptide compounds
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
EP0636032A1 (en) * 1992-03-25 1995-02-01 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
SK2094A3 (en) * 1993-01-12 1995-01-12 Sandoz Ag Somatostatine polypeptides, method of their preparing and using
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
EP0683676A4 (en) * 1993-02-02 1998-09-30 Neorx Corp BIODISTRIBUTION DIRECTED FROM SMALL MOLECULES.
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
EP0720621B1 (en) * 1993-06-23 2001-02-07 Diatide, Inc. Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A (fi) * 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalkoholi-peptidijohdannaiset
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
WO2002085418A2 (en) 2001-04-23 2002-10-31 Mallinckrodt Inc. Tc and re labeler radioactive glycosylated octreotide derivatives
WO2005018682A2 (en) 2003-08-20 2005-03-03 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
EP2474328A3 (en) * 2003-09-17 2012-07-18 Board Of Regents, The University Of Texas System Mechanism-based targeted pancreatic beta cell imaging and therapy
EP2067786A1 (en) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Novel non selective analogs of somatostatin
WO2014081655A1 (en) 2012-11-21 2014-05-30 Serene Oncology, Llc Tin-1 17m comprising somatostatin receptor binding compounds

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (en) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (en) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
EP0247866A1 (en) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Coupling agents for radiolabeling proteins
EP0248506A1 (en) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Metal ion labeling of carrier molecules
WO1989004666A1 (en) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Treatment of cancer with somatostatin and analogs thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
CH679045A5 (ko) * 1987-06-29 1991-12-13 Sandoz Ag
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150844A2 (en) * 1984-01-30 1985-08-07 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
EP0233619A1 (en) * 1986-02-14 1987-08-26 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
EP0248506A1 (en) * 1986-03-05 1987-12-09 Mallinckrodt, Inc. (a Delaware corporation) Metal ion labeling of carrier molecules
EP0247866A1 (en) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Coupling agents for radiolabeling proteins
WO1989004666A1 (en) * 1987-11-18 1989-06-01 The Administrators Of The Tulane Educational Fund Treatment of cancer with somatostatin and analogs thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIFE SCIENCES, vol. 43, no. 5, 1988, Pergamon Press plc, US; J.E. TAYLOR et al.: "High affinity binding of [125l-Tyr 11Üsomatostatin-14 to human small cell lung carcinoma (NCI-H69)", pages 421-427 *

Also Published As

Publication number Publication date
HUT53375A (en) 1990-10-28
FI102540B1 (fi) 1998-12-31
MY106120A (en) 1995-03-31
HU896359D0 (en) 1990-02-28
SE8904087L (sv) 1991-06-05
PT92487A (pt) 1990-06-29
HU211468A9 (en) 1995-11-28
AU4587189A (en) 1990-06-14
PT92487B (pt) 1996-01-31
AU633859B2 (en) 1993-02-11
ATA901789A (de) 1997-07-15
AT403476B (de) 1998-02-25
IE62091B1 (en) 1994-12-14
SE8904087D0 (sv) 1989-12-04
DE3991505B4 (de) 2006-04-20
WO1990006949A2 (en) 1990-06-28
NL194828C (nl) 2003-04-03
JP3686503B2 (ja) 2005-08-24
NL194828B (nl) 2002-12-02
JPH1095737A (ja) 1998-04-14
CH678329A5 (ko) 1991-08-30
KR0156541B1 (ko) 1998-10-15
FR2639947A1 (fr) 1990-06-08
DK175338B1 (da) 2004-08-30
SA96160495B1 (ar) 2006-08-23
WO1990006949A3 (en) 1990-07-26
IL92534A (en) 1994-06-24
KR900009697A (ko) 1990-07-05
GB2225579B (en) 1993-03-17
LU87633A1 (fr) 1991-09-18
ES2023533A6 (es) 1992-01-16
JP2726320B2 (ja) 1998-03-11
CA2004532A1 (en) 1990-06-05
CA2004532C (en) 2000-02-22
SE508799C2 (sv) 1998-11-09
FI895809A0 (fi) 1989-12-04
GB2225579A (en) 1990-06-06
NL8902981A (nl) 1990-07-02
DK612689D0 (da) 1989-12-05
FI102540B (fi) 1998-12-31
HK189995A (en) 1995-12-29
GB8927255D0 (en) 1990-01-31
FR2639947B1 (fr) 1995-04-21
DK612689A (da) 1990-06-06
JPH02184698A (ja) 1990-07-19
IE893866L (en) 1990-06-05

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20091205