BA98299A - Postupak za pripremanje azabiciklo hinolon karboksilne kiseline - Google Patents

Postupak za pripremanje azabiciklo hinolon karboksilne kiseline

Info

Publication number
BA98299A
BA98299A BA980299A BA980299A BA98299A BA 98299 A BA98299 A BA 98299A BA 980299 A BA980299 A BA 980299A BA 980299 A BA980299 A BA 980299A BA 98299 A BA98299 A BA 98299A
Authority
BA
Bosnia and Herzegovina
Prior art keywords
azabicycloquinolone
preparation
carboxylic acid
alkyl
methyl
Prior art date
Application number
BA980299A
Other languages
Bosnian (bs)
English (en)
Inventor
Katherine Elizabeth Brighty
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from YU156890A external-priority patent/YU47935B/sh
Application filed by Pfizer filed Critical Pfizer
Publication of BA98299A publication Critical patent/BA98299A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
BA980299A 1989-08-16 1998-03-30 Postupak za pripremanje azabiciklo hinolon karboksilne kiseline BA98299A (bs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1989/003489 WO1991002526A1 (en) 1989-08-16 1989-08-16 Azabicyclo quinolone carboxylic acids
YU156890A YU47935B (sh) 1989-08-16 1990-08-15 Azabiciklo hinolon karboksilne kiseline

Publications (1)

Publication Number Publication Date
BA98299A true BA98299A (bs) 2001-09-14

Family

ID=22215165

Family Applications (1)

Application Number Title Priority Date Filing Date
BA980299A BA98299A (bs) 1989-08-16 1998-03-30 Postupak za pripremanje azabiciklo hinolon karboksilne kiseline

Country Status (30)

Country Link
EP (1) EP0413455B1 (no)
JP (2) JPH072734B2 (no)
KR (1) KR930004844B1 (no)
CN (1) CN1025192C (no)
AT (1) ATE124040T1 (no)
AU (1) AU623801B2 (no)
BA (1) BA98299A (no)
CA (2) CA2127561C (no)
CY (2) CY1969A (no)
CZ (1) CZ281127B6 (no)
DD (1) DD298399A5 (no)
DE (3) DE69020262T2 (no)
DK (1) DK0413455T3 (no)
EG (1) EG19251A (no)
ES (1) ES2074131T4 (no)
FI (2) FI108228B (no)
GR (1) GR3017072T3 (no)
HK (1) HK1000207A1 (no)
HU (2) HU219403B (no)
IE (1) IE66202B1 (no)
IL (1) IL95331A (no)
LU (2) LU90311I2 (no)
NL (2) NL980033I2 (no)
NO (1) NO300214B1 (no)
NZ (1) NZ234920A (no)
PL (1) PL166381B1 (no)
PT (1) PT94998B (no)
RU (1) RU2049777C1 (no)
WO (1) WO1991002526A1 (no)
ZA (1) ZA906450B (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
JPH0678335B2 (ja) * 1991-06-19 1994-10-05 ファイザー・インコーポレーテッド アザスピロキノロン化合物、その製法および抗菌組成物
US5256791A (en) * 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5591766A (en) * 1993-12-03 1997-01-07 Cheil Foods & Chemicals, Inc. Solid oral formulations of pyridone carboxylic acids
DK0812838T3 (da) * 1994-02-04 2002-08-19 Dainippon Pharmaceutical Co Pyridoncarboxylsyrederivater substitueret med bicyclisk aminogruppe, estere og salte deraf og bicyclisk amin som mellemprodukt
ATE239720T1 (de) * 1995-02-02 2003-05-15 Daiichi Seiyaku Co Heterozyklische verbindungen
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
ATE240312T1 (de) * 1995-02-07 2003-05-15 Daiichi Seiyaku Co Heterocyclische spiroderivate
ES2117426T3 (es) * 1995-06-06 1998-08-01 Pfizer Forma cristalina de la sal anhidra compuesta de los acidos 7-((1a,5a,6a)-6-amino-3-azabiciclo(3.1.0.)hex-3-il)-6-fluoro-1-(2,4-difluorofenil)-1,4-dihidro-4-oxo-1,8-naftiridina-3-carboxilico y metanosulfonico.
ATE221544T1 (de) * 1995-06-15 2002-08-15 Pfizer Verfahren zur herstellung von derivaten der ein peptid enthaltenden azabizylo-naphtyridin- carbonsäure
WO1997029102A1 (fr) * 1996-02-09 1997-08-14 Toyama Chemical Co., Ltd. Derives de l'acide quinolonecarboxylique et leurs sels
AP788A (en) * 1996-08-26 1999-12-03 Pfizer Novel crystal form of anhydrous 7-(1a, 5a, 6a)-6-Amino-3-Azabicyclo(3.1.0) hex-3-YI)-6-Fluoro-1-(2,4- Difluorophenyl)-1,4-Dihydro-4-Oxo-1, 8-Naphthyridine-3-Carboxylic Acid, Methanesulfonic acid salt.
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
CN1103769C (zh) * 1996-10-25 2003-03-26 第一制药株式会社 三环胺衍生物
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
DE19733439A1 (de) * 1997-08-02 1999-02-04 Bayer Ag Neue 6-endo-Amino-3-azabicyclo(3.1.0)hexande, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von Chinolon- und Naphthyridincarbonsäure-Derviaten mit verbesserten Eigenschaften
HUP0100051A3 (en) 1997-09-15 2002-08-28 Procter & Gamble Antimicrobial quinolones, their compositions and uses
PA8464701A1 (es) * 1998-01-16 2000-09-29 Pfizer Prod Inc Procedimiento e intermedios para preparar naftiridonas
US6184380B1 (en) * 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
US7019142B2 (en) 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
EP2275141A1 (en) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Tastemasked pharmaceutical compositions
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
PL363301A1 (en) 2000-12-14 2004-11-15 The Procter & Gamble Company Antimicrobial 2-pyridones, their compositions and uses
WO2002048138A1 (en) 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial quinolones
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
CN1668585A (zh) 2002-07-08 2005-09-14 兰贝克赛实验室有限公司 用作蝇蕈碱受体拮抗剂的3,6－二取代氮杂双环[3.1.0]己烷衍生物
US7288562B2 (en) 2002-08-23 2007-10-30 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
AU2003214520A1 (en) 2003-04-09 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003214535B2 (en) 2003-04-10 2009-09-03 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089900A1 (en) 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
EP1670759A1 (en) * 2003-09-18 2006-06-21 Ranbaxy Laboratories Limited PROCESS FOR THE PREPARATION OF (1a, 5a, 6a)-6-AMINOME THYL-3-BENZYL-3-AZABICYCLO 3.1.0 HEXANE
KR101084521B1 (ko) 2006-03-28 2011-11-18 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
MX2008012328A (es) 2006-03-28 2008-10-09 Procter & Gamble Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil- piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinc arboxilico.
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
WO2012042539A2 (en) 2010-09-28 2012-04-05 Panacea Biotec Ltd Novel bicyclic compounds
WO2020073031A1 (en) * 2018-10-05 2020-04-09 New York University Fused bicyclic heterocycles as thereapeutic agents
CN112442084B (zh) * 2020-12-03 2022-09-09 国药集团致君（深圳）制药有限公司 一种抗菌药中间体的制备方法
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0676400B2 (ja) * 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
US4973091A (en) * 1989-09-20 1990-11-27 Truth Incorporated Sliding patio door dual point latch and lock

Also Published As

Publication number Publication date
PL286484A1 (en) 1991-05-20
PT94998A (pt) 1991-04-18
CY99010I2 (en) 2010-07-28
CA2023217A1 (en) 1991-02-17
IE902950A1 (en) 1991-02-27
EP0413455A2 (en) 1991-02-20
CZ402790A3 (en) 1996-04-17
HK1000207A1 (en) 1998-02-06
JPH072734B2 (ja) 1995-01-18
IL95331A0 (en) 1991-06-30
ATE124040T1 (de) 1995-07-15
KR910004572A (ko) 1991-03-28
CA2127561A1 (en) 1991-02-17
RU2049777C1 (ru) 1995-12-10
LU90311I2 (fr) 1999-01-25
AU6104290A (en) 1991-02-21
NO920599D0 (no) 1992-02-14
EG19251A (en) 1994-09-29
NL980032I1 (nl) 1999-02-01
ES2074131T4 (es) 1996-05-01
CN1049501A (zh) 1991-02-27
FI964520A0 (fi) 1996-11-11
EP0413455A3 (en) 1991-10-09
EP0413455B1 (en) 1995-06-21
FI108228B (fi) 2001-12-14
HU211681A9 (en) 1995-12-28
HU219403B (hu) 2001-04-28
DE19875052I2 (de) 2009-05-28
FI103879B (fi) 1999-10-15
CZ281127B6 (cs) 1996-06-12
LU90310I2 (fr) 1999-01-25
DK0413455T3 (da) 1995-08-14
IE66202B1 (en) 1995-12-13
AU623801B2 (en) 1992-05-21
CN1025192C (zh) 1994-06-29
DD298399A5 (de) 1992-02-20
IL95331A (en) 1995-07-31
WO1991002526A1 (en) 1991-03-07
CY1969A (en) 1997-09-05
NL980033I1 (nl) 1999-02-01
PT94998B (pt) 1997-05-28
JPH0819099B2 (ja) 1996-02-28
NL980032I2 (nl) 1999-05-03
ES2074131T3 (es) 1995-09-01
DE19875050I2 (de) 2009-05-28
JPH07149758A (ja) 1995-06-13
PL166381B1 (pl) 1995-05-31
JPH0386875A (ja) 1991-04-11
FI103879B1 (fi) 1999-10-15
NL980033I2 (nl) 1999-05-03
DE69020262T2 (de) 1995-10-26
NO300214B1 (no) 1997-04-28
NO920599L (no) 1992-04-14
FI964520A (fi) 1996-11-11
CA2127561C (en) 1998-07-28
FI920632A0 (fi) 1992-02-14
CA2023217C (en) 1996-12-10
ZA906450B (en) 1992-03-25
GR3017072T3 (en) 1995-11-30
DE69020262D1 (de) 1995-07-27
NZ234920A (en) 1992-06-25
KR930004844B1 (ko) 1993-06-09

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