JPS5573682A - 1-carba-1-penem-3-carboxylic acid derivative and its preparation - Google Patents
1-carba-1-penem-3-carboxylic acid derivative and its preparationInfo
- Publication number
- JPS5573682A JPS5573682A JP14846278A JP14846278A JPS5573682A JP S5573682 A JPS5573682 A JP S5573682A JP 14846278 A JP14846278 A JP 14846278A JP 14846278 A JP14846278 A JP 14846278A JP S5573682 A JPS5573682 A JP S5573682A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- reacted
- carboxyl
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
NEW MATERIAL:A compound shown by the formula I (R1 is H or alkyl; R2 is H, ester residue, or salt-forming group together with carboxyl; X is carboxyl, substituted thio, substituted sulfonyl, etc.), its ester and its salt at the carboxyl group respectively.
EXAMPLE: 2-Formyl-1-carba-1-penem-3,3-dicarboxylic acid dimethyl ester.
USE: A synthetic intermediate of carbapenem compound having high antimicrobial action. Having an effect in the use together with other β-lactam antibiotic.
PROCESS: A diformyl compound shown by the formula II (R3 is ester residue) undergoes ring formation to give a compound shown by the formula I. The compound shwon by the formula II (X is carboxyl related group) usable as a starting material is obtained as follows. A compound shown by the formula III is reacted with oxomalonic diester, submitted to halogenation, and reacted with a tertiary phosphine to give a compound shown by the formula IV, which is reacted with a compound shown by the formula V and reacted with an oxidizing agent to give the starting material.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14846278A JPS5573682A (en) | 1978-11-30 | 1978-11-30 | 1-carba-1-penem-3-carboxylic acid derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14846278A JPS5573682A (en) | 1978-11-30 | 1978-11-30 | 1-carba-1-penem-3-carboxylic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5573682A true JPS5573682A (en) | 1980-06-03 |
Family
ID=15453286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14846278A Pending JPS5573682A (en) | 1978-11-30 | 1978-11-30 | 1-carba-1-penem-3-carboxylic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5573682A (en) |
-
1978
- 1978-11-30 JP JP14846278A patent/JPS5573682A/en active Pending
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