JPS5573682A - 1-carba-1-penem-3-carboxylic acid derivative and its preparation - Google Patents

1-carba-1-penem-3-carboxylic acid derivative and its preparation

Info

Publication number
JPS5573682A
JPS5573682A JP14846278A JP14846278A JPS5573682A JP S5573682 A JPS5573682 A JP S5573682A JP 14846278 A JP14846278 A JP 14846278A JP 14846278 A JP14846278 A JP 14846278A JP S5573682 A JPS5573682 A JP S5573682A
Authority
JP
Japan
Prior art keywords
formula
compound shown
reacted
carboxyl
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14846278A
Other languages
Japanese (ja)
Inventor
Koichi Hirai
Yuji Iwano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP14846278A priority Critical patent/JPS5573682A/en
Publication of JPS5573682A publication Critical patent/JPS5573682A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NEW MATERIAL:A compound shown by the formula I (R1 is H or alkyl; R2 is H, ester residue, or salt-forming group together with carboxyl; X is carboxyl, substituted thio, substituted sulfonyl, etc.), its ester and its salt at the carboxyl group respectively.
EXAMPLE: 2-Formyl-1-carba-1-penem-3,3-dicarboxylic acid dimethyl ester.
USE: A synthetic intermediate of carbapenem compound having high antimicrobial action. Having an effect in the use together with other β-lactam antibiotic.
PROCESS: A diformyl compound shown by the formula II (R3 is ester residue) undergoes ring formation to give a compound shown by the formula I. The compound shwon by the formula II (X is carboxyl related group) usable as a starting material is obtained as follows. A compound shown by the formula III is reacted with oxomalonic diester, submitted to halogenation, and reacted with a tertiary phosphine to give a compound shown by the formula IV, which is reacted with a compound shown by the formula V and reacted with an oxidizing agent to give the starting material.
COPYRIGHT: (C)1980,JPO&Japio
JP14846278A 1978-11-30 1978-11-30 1-carba-1-penem-3-carboxylic acid derivative and its preparation Pending JPS5573682A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14846278A JPS5573682A (en) 1978-11-30 1978-11-30 1-carba-1-penem-3-carboxylic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14846278A JPS5573682A (en) 1978-11-30 1978-11-30 1-carba-1-penem-3-carboxylic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5573682A true JPS5573682A (en) 1980-06-03

Family

ID=15453286

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14846278A Pending JPS5573682A (en) 1978-11-30 1978-11-30 1-carba-1-penem-3-carboxylic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5573682A (en)

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