IE46100L - Clavulanic acid derivatives - Google Patents
Clavulanic acid derivativesInfo
- Publication number
- IE46100L IE46100L IE772448A IE244877A IE46100L IE 46100 L IE46100 L IE 46100L IE 772448 A IE772448 A IE 772448A IE 244877 A IE244877 A IE 244877A IE 46100 L IE46100 L IE 46100L
- Authority
- IE
- Ireland
- Prior art keywords
- clavulanic acid
- acid derivatives
- esters
- formula
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Esters of compounds of the formula I, in which X and R<1> to R<3> have the meanings given in Claim 1, are obtained by reacting an ester of clavulanic acid with a compound of the formula V, in which Y is a readily displaceable radical. The corresponding free carboxylic acids, or their salts, are obtained by cleaving the esters by hydrolysis or hydrogenolysis. The compounds increase the antibacterial effect of penicillins and cephalosporins. They can be used in synergistic drug preparations. <IMAGE>
[GB1595176A]
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE2947/81A IE46101B1 (en) | 1976-12-03 | 1977-12-02 | Clavulanic acid ethers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB50444/76A GB1595176A (en) | 1976-12-03 | 1976-12-03 | Clavulanic acid ethers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE46100L true IE46100L (en) | 1978-06-03 |
| IE46100B1 IE46100B1 (en) | 1983-02-23 |
Family
ID=10455915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2448/77A IE46100B1 (en) | 1976-12-03 | 1977-12-02 | Clavulanic acid ethers |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5392796A (en) |
| AU (1) | AU515916B2 (en) |
| BE (1) | BE861325A (en) |
| CH (1) | CH637395A5 (en) |
| DE (1) | DE2752701A1 (en) |
| DK (1) | DK540177A (en) |
| FR (2) | FR2372837A1 (en) |
| GB (1) | GB1595176A (en) |
| IE (1) | IE46100B1 (en) |
| NL (1) | NL7713220A (en) |
| SE (1) | SE7713710L (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2004541B (en) * | 1977-09-16 | 1982-05-12 | Beecham Group Ltd | Ethers of clavulanic acid a process for their preparation and pharmaceutical compositions containing them |
| EP0002370B1 (en) * | 1977-12-02 | 1983-05-11 | Beecham Group Plc | A process for the preparation of ether derivatives of clavulanic acid |
| EP0080284A1 (en) * | 1981-11-25 | 1983-06-01 | Beecham Group Plc | Derivatives of clavulanic acid, processes for their preparation and their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE44295B1 (en) * | 1975-10-13 | 1981-10-07 | Beecham Group Ltd | Clavulanic acid derivatives |
| GB1573503A (en) * | 1975-12-17 | 1980-08-28 | Glaxo Lab Ltd | Clavulanic acid derivatives |
-
1976
- 1976-12-03 GB GB50444/76A patent/GB1595176A/en not_active Expired
-
1977
- 1977-11-25 DE DE19772752701 patent/DE2752701A1/en not_active Withdrawn
- 1977-11-29 BE BE183035A patent/BE861325A/en not_active IP Right Cessation
- 1977-11-30 FR FR7736053A patent/FR2372837A1/en active Granted
- 1977-11-30 NL NL7713220A patent/NL7713220A/en not_active Application Discontinuation
- 1977-12-02 CH CH1479277A patent/CH637395A5/en not_active IP Right Cessation
- 1977-12-02 JP JP14560177A patent/JPS5392796A/en active Pending
- 1977-12-02 DK DK540177A patent/DK540177A/en not_active Application Discontinuation
- 1977-12-02 IE IE2448/77A patent/IE46100B1/en unknown
- 1977-12-02 SE SE7713710A patent/SE7713710L/en unknown
- 1977-12-02 AU AU31189/77A patent/AU515916B2/en not_active Expired
-
1979
- 1979-01-30 FR FR7902279A patent/FR2411194A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2411194B1 (en) | 1982-02-26 |
| IE46100B1 (en) | 1983-02-23 |
| DE2752701A1 (en) | 1978-06-08 |
| FR2372837B1 (en) | 1980-07-25 |
| DK540177A (en) | 1978-06-04 |
| JPS5392796A (en) | 1978-08-15 |
| FR2411194A1 (en) | 1979-07-06 |
| CH637395A5 (en) | 1983-07-29 |
| FR2372837A1 (en) | 1978-06-30 |
| AU515916B2 (en) | 1981-05-07 |
| SE7713710L (en) | 1978-06-04 |
| GB1595176A (en) | 1981-08-12 |
| AU3118977A (en) | 1979-06-07 |
| BE861325A (en) | 1978-05-29 |
| NL7713220A (en) | 1978-06-06 |
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