AU770397B2 - 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders - Google Patents

4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders Download PDF

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Publication number
AU770397B2
AU770397B2 AU24328/00A AU2432800A AU770397B2 AU 770397 B2 AU770397 B2 AU 770397B2 AU 24328/00 A AU24328/00 A AU 24328/00A AU 2432800 A AU2432800 A AU 2432800A AU 770397 B2 AU770397 B2 AU 770397B2
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AU
Australia
Prior art keywords
formula
compound
trans
6alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU24328/00A
Other languages
English (en)
Other versions
AU2432800A (en
Inventor
Jean-Paul Rene Marie Andre Bosmans
Michel Anna Jozef De Cleyn
Henricus Jacobus Maria Gijsen
Ann Louise Gabrielle Meulemans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of AU2432800A publication Critical patent/AU2432800A/en
Application granted granted Critical
Publication of AU770397B2 publication Critical patent/AU770397B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU24328/00A 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders Ceased AU770397B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22
EP98204411 1998-12-22
PCT/EP1999/010064 WO2000037461A1 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Publications (2)

Publication Number Publication Date
AU2432800A AU2432800A (en) 2000-07-12
AU770397B2 true AU770397B2 (en) 2004-02-19

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
AU24328/00A Ceased AU770397B2 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Country Status (34)

Country Link
US (2) US6544997B1 (hu)
EP (1) EP1140915B1 (hu)
JP (1) JP4615725B2 (hu)
KR (1) KR100633680B1 (hu)
CN (1) CN1150190C (hu)
AR (1) AR024240A1 (hu)
AT (1) ATE297917T1 (hu)
AU (1) AU770397B2 (hu)
BG (1) BG64953B1 (hu)
BR (1) BR9916491A (hu)
CA (1) CA2355857C (hu)
CZ (1) CZ300851B6 (hu)
DE (1) DE69925865T2 (hu)
DK (1) DK1140915T3 (hu)
EA (1) EA003608B1 (hu)
EE (1) EE200100335A (hu)
ES (1) ES2245131T3 (hu)
HK (1) HK1039114B (hu)
HR (1) HRP20010445A2 (hu)
HU (1) HUP0104838A3 (hu)
ID (1) ID28953A (hu)
IL (1) IL143858A (hu)
MY (1) MY121852A (hu)
NO (1) NO321324B1 (hu)
NZ (1) NZ512871A (hu)
PL (1) PL197409B1 (hu)
PT (1) PT1140915E (hu)
SI (1) SI1140915T1 (hu)
SK (1) SK285829B6 (hu)
TR (1) TR200101962T2 (hu)
TW (1) TW570920B (hu)
UA (1) UA71591C2 (hu)
WO (1) WO2000037461A1 (hu)
ZA (1) ZA200105135B (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004024143A1 (ja) * 2002-09-12 2004-03-25 Nagase Chemtex Corporation 医薬組成物
ATE486865T1 (de) 2003-06-19 2010-11-15 Janssen Pharmaceutica Nv Hydroxycarbonylphenyl substituierte 4- (aminomethyl)-piperidinbenzamide als 5ht4- antagonisten
DE602004009069T2 (de) * 2003-06-19 2008-06-19 Janssen Pharmaceutica N.V. 4-(aminomethyl)-piperidinbenzamide als 5ht4-antagonisten
CA2526079C (en) 2003-06-19 2012-01-10 Janssen Pharmaceutica N.V. Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
EA008514B1 (ru) * 2003-06-19 2007-06-29 Янссен Фармацевтика Н.В. Гетероциклические замещенные 4-(аминометил)пиперидин бензамиды в качестве 5-нт-антагонистов
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
RS20060145A (en) 2003-09-03 2008-06-05 Pfizer Inc., Benzimidazolone compounds having 5-ht4 receptor agonistic activity
EP1689742B1 (en) * 2003-11-24 2010-03-17 Pfizer, Inc. Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
WO2005123718A2 (en) 2004-06-15 2005-12-29 Pfizer Japan Inc. Benzimidazolone carboxylic acid derivatives
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
DE602005014566D1 (de) * 2004-11-05 2009-07-02 Theravance Inc Chinolinon-carboxamid-verbindungen
WO2006052640A1 (en) * 2004-11-05 2006-05-18 Theravance, Inc. 5-ht4 receptor agonist compounds
RU2404179C2 (ru) * 2004-12-22 2010-11-20 Тереванс, Инк. Индазол-карбоксамидные соединения
AU2006218603A1 (en) * 2005-03-02 2006-09-08 Theravance, Inc. Quinolinone compounds as 5-HT4 receptor agonists
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
EP2961403A4 (en) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd HETEROCYCLIC INHIBITORS OF SODIUM CHANNEL
US20180305334A1 (en) * 2015-10-14 2018-10-25 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
BR112022000429A2 (pt) 2019-07-11 2022-03-29 Praxis Prec Medicines Inc Formulações de moduladores do canal de cálcio tipo t e métodos de uso dos mesmos

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005038A1 (en) * 1991-09-12 1993-03-18 Smithkline Beecham Plc 5-ht4 receptor antagonists
WO1993016072A1 (en) * 1992-02-06 1993-08-19 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
NZ243993A (en) 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
JP2525552B2 (ja) * 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途
GB9219163D0 (en) 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
AU5150393A (en) 1992-10-13 1994-05-09 Smithkline Beecham Plc Heterocyclic -esters or -amides used as 5-ht4 receptor antagonists
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
NZ257545A (en) 1992-11-05 1997-01-29 Smithkline Beecham Plc Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
ES2103675B1 (es) * 1995-01-10 1998-07-01 Almirall Lab Nuevas piperidinas sustituidas.
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
ATE250931T1 (de) * 1996-02-15 2003-10-15 Janssen Pharmaceutica Nv Verwendung von 5-ht4 antagonisten zur überwindung der gastrointestinalen beschädigung, die durch inhibitoren der serotonin-wiederaufnahme hervorgerufen werden
TW445263B (en) * 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
TW548103B (en) * 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
DE69935600T2 (de) * 1998-09-10 2007-12-06 F. Hoffmann-La Roche Ag Dihydrobenzodioxincarbonsäureamid- und ketonderivate als 5-ht4-rezeptorantagonisten
DE10217868A1 (de) * 2002-04-22 2003-10-30 Jomed N V Ballon-Katheter

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005038A1 (en) * 1991-09-12 1993-03-18 Smithkline Beecham Plc 5-ht4 receptor antagonists
WO1993016072A1 (en) * 1992-02-06 1993-08-19 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists

Also Published As

Publication number Publication date
DE69925865D1 (de) 2005-07-21
CZ300851B6 (cs) 2009-08-26
BG105571A (en) 2002-01-31
SK8592001A3 (en) 2002-02-05
SK285829B6 (sk) 2007-09-06
ES2245131T3 (es) 2005-12-16
PL197409B1 (pl) 2008-03-31
JP4615725B2 (ja) 2011-01-19
TW570920B (en) 2004-01-11
HRP20010445A2 (en) 2002-06-30
DK1140915T3 (da) 2005-10-10
AR024240A1 (es) 2002-09-25
IL143858A (en) 2005-03-20
MY121852A (en) 2006-02-28
CA2355857A1 (en) 2000-06-29
KR20010080293A (ko) 2001-08-22
NO20012858D0 (no) 2001-06-08
SI1140915T1 (sl) 2005-12-31
BR9916491A (pt) 2001-09-04
IL143858A0 (en) 2002-04-21
ZA200105135B (en) 2002-06-21
HUP0104838A3 (en) 2003-05-28
ATE297917T1 (de) 2005-07-15
EE200100335A (et) 2002-08-15
EA003608B1 (ru) 2003-06-26
EA200100710A1 (ru) 2001-12-24
KR100633680B1 (ko) 2006-10-11
HK1039114A1 (en) 2002-04-12
BG64953B1 (bg) 2006-10-31
ID28953A (id) 2001-07-19
CN1331690A (zh) 2002-01-16
AU2432800A (en) 2000-07-12
NO20012858L (no) 2001-06-08
JP2002533337A (ja) 2002-10-08
CZ20012117A3 (cs) 2001-10-17
CA2355857C (en) 2008-10-28
PL348417A1 (en) 2002-05-20
EP1140915B1 (en) 2005-06-15
NZ512871A (en) 2002-11-26
CN1150190C (zh) 2004-05-19
PT1140915E (pt) 2005-11-30
HK1039114B (zh) 2005-08-19
US6544997B1 (en) 2003-04-08
US20030181456A1 (en) 2003-09-25
EP1140915A1 (en) 2001-10-10
US7205410B2 (en) 2007-04-17
UA71591C2 (en) 2004-12-15
NO321324B1 (no) 2006-04-24
DE69925865T2 (de) 2006-05-11
TR200101962T2 (tr) 2002-04-22
WO2000037461A1 (en) 2000-06-29
HUP0104838A2 (hu) 2002-07-29

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired