AU756105B2 - Method for chromatographically purifying insulins - Google Patents

Method for chromatographically purifying insulins Download PDF

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Publication number
AU756105B2
AU756105B2 AU57331/99A AU5733199A AU756105B2 AU 756105 B2 AU756105 B2 AU 756105B2 AU 57331/99 A AU57331/99 A AU 57331/99A AU 5733199 A AU5733199 A AU 5733199A AU 756105 B2 AU756105 B2 AU 756105B2
Authority
AU
Australia
Prior art keywords
procedure
pressure
insulin
water
chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU57331/99A
Other languages
English (en)
Other versions
AU5733199A (en
Inventor
Richard Bicker
Dieter Desch
Reinhold Keller
Frank Richard
Werner Sievers
Jorg Von Eysmondt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Publication of AU5733199A publication Critical patent/AU5733199A/en
Application granted granted Critical
Publication of AU756105B2 publication Critical patent/AU756105B2/en
Assigned to SANOFI-AVENTIS DEUTSCHLAND GMBH reassignment SANOFI-AVENTIS DEUTSCHLAND GMBH Request to Amend Deed and Register Assignors: AVENTIS PHARMA DEUTSCHLAND GMBH
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
AU57331/99A 1998-08-24 1999-08-11 Method for chromatographically purifying insulins Expired AU756105B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19838097 1998-08-24
DE19838097A DE19838097A1 (de) 1998-08-24 1998-08-24 Verfahren zur chromatographischen Reinigung von Insulinen
PCT/EP1999/005887 WO2000011030A2 (de) 1998-08-24 1999-08-11 Verfahren zur chromatographischen reinigung von insulinen

Publications (2)

Publication Number Publication Date
AU5733199A AU5733199A (en) 2000-03-14
AU756105B2 true AU756105B2 (en) 2003-01-02

Family

ID=7878335

Family Applications (1)

Application Number Title Priority Date Filing Date
AU57331/99A Expired AU756105B2 (en) 1998-08-24 1999-08-11 Method for chromatographically purifying insulins

Country Status (23)

Country Link
US (1) US6710167B1 (zh)
EP (1) EP1107988B1 (zh)
JP (1) JP2002523732A (zh)
KR (1) KR100703578B1 (zh)
CN (1) CN1198843C (zh)
AT (1) ATE380827T1 (zh)
AU (1) AU756105B2 (zh)
BR (1) BR9913092A (zh)
CA (1) CA2341355C (zh)
CY (1) CY1107877T1 (zh)
CZ (1) CZ300604B6 (zh)
DE (2) DE19838097A1 (zh)
DK (1) DK1107988T3 (zh)
ES (1) ES2296407T3 (zh)
HK (1) HK1039130B (zh)
HU (1) HU227753B1 (zh)
ID (1) ID29517A (zh)
PL (1) PL201880B1 (zh)
PT (1) PT1107988E (zh)
RU (1) RU2222546C2 (zh)
TR (1) TR200100634T2 (zh)
WO (1) WO2000011030A2 (zh)
ZA (1) ZA200101096B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19838097A1 (de) * 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
US7608583B2 (en) * 2002-12-05 2009-10-27 Wockhardt Limited Process for the extraction and isolation of insulin from recombinant sources
US6921703B2 (en) * 2003-05-13 2005-07-26 Texas Instruments Incorporated System and method for mitigating oxide growth in a gate dielectric
ATE356837T1 (de) * 2004-04-20 2007-04-15 Rohm & Haas Polymerabsorbens, und herstellungsverfahren und verwendung
US20080108787A1 (en) * 2004-05-24 2008-05-08 Maharaj K Sahib Purification of Insulin-Like Material by Reverse Phase Chromatography
DE102004051807B4 (de) * 2004-10-25 2008-10-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung von hydrophobiertem Kieselgel als selektives Sorbens zur Entfernung von organischen Siliziumverbindungen
CN100368804C (zh) * 2006-01-24 2008-02-13 李振国 测定注射剂中高分子量物质含量的方法
RU2489441C1 (ru) * 2009-07-09 2013-08-10 Биокон Лимитед Препаративный хроматографический способ на основе нелинейного градиента и продукты, очищенные этим способом
CN107064330B (zh) * 2010-12-28 2022-02-25 探索诊断投资公司 通过质谱法定量胰岛素
RU2453331C1 (ru) * 2011-06-29 2012-06-20 Общество с ограниченной ответственностью "Завод Медсинтез" Способ получения высокоочищенного кристаллического инсулина любого происхождения
CN103827136B (zh) * 2011-09-30 2016-07-06 通用电气健康护理生物科学股份公司 纯化裂解的胰岛素原的方法
EP2931301B2 (en) 2012-12-17 2021-09-15 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
CN103275210B (zh) * 2013-06-25 2015-02-25 珠海联邦制药股份有限公司 脂肪酸单酰化胰岛素的色谱纯化方法
WO2015138548A1 (en) 2014-03-14 2015-09-17 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
US10155799B2 (en) 2014-07-21 2018-12-18 Merck Sharp & Dohme Corp. Chromatography process for purification of insulin and insulin analogs
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
RU2736358C2 (ru) * 2015-12-09 2020-11-16 Общество С Ограниченной Ответственностью "Синбио" Способ очистки полисиалированного инсулина человека

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285024A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Process of purifying insulin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199391A (en) 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US4616078A (en) * 1985-04-08 1986-10-07 Eli Lilly And Company Process for purifying proinsulin-like materials
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE4028120C2 (de) 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
DK0547544T3 (da) * 1991-12-18 1997-09-08 Hoechst Ag Fremgangsmåde til fremstilling af insulinholdige opløsninger.
DE59305396D1 (de) 1992-12-02 1997-03-20 Hoechst Ag Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
DE4405179A1 (de) 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
EP0821006B1 (de) 1996-07-26 2004-04-21 Aventis Pharma Deutschland GmbH Insulinderivate mit erhöhter Zinkbindung
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19838097A1 (de) * 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285024A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Process of purifying insulin

Also Published As

Publication number Publication date
JP2002523732A (ja) 2002-07-30
EP1107988A2 (de) 2001-06-20
CN1313866A (zh) 2001-09-19
WO2000011030A3 (de) 2000-06-02
CZ300604B6 (cs) 2009-06-24
CN1198843C (zh) 2005-04-27
HK1039130A1 (en) 2002-04-12
HUP0103325A2 (hu) 2001-12-28
ES2296407T3 (es) 2008-04-16
RU2222546C2 (ru) 2004-01-27
AU5733199A (en) 2000-03-14
PL201880B1 (pl) 2009-05-29
DE19838097A1 (de) 2000-03-02
TR200100634T2 (tr) 2001-07-23
CA2341355C (en) 2009-04-07
BR9913092A (pt) 2001-10-30
HK1039130B (zh) 2006-05-12
PL346865A1 (en) 2002-03-11
ATE380827T1 (de) 2007-12-15
HU227753B1 (en) 2012-02-28
WO2000011030A2 (de) 2000-03-02
CY1107877T1 (el) 2013-06-19
CA2341355A1 (en) 2000-03-02
KR20010072914A (ko) 2001-07-31
PT1107988E (pt) 2008-01-16
HUP0103325A3 (en) 2003-09-29
ZA200101096B (en) 2002-06-26
EP1107988B1 (de) 2007-12-12
KR100703578B1 (ko) 2007-04-05
DK1107988T3 (da) 2008-04-21
CZ2001646A3 (cs) 2001-09-12
DE59914580D1 (de) 2008-01-24
ID29517A (id) 2001-09-06
US6710167B1 (en) 2004-03-23

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired