TR200100634T2 - İnsülinlerin kromatografik olarak arındırılmasına yönelik yöntem. - Google Patents

İnsülinlerin kromatografik olarak arındırılmasına yönelik yöntem.

Info

Publication number
TR200100634T2
TR200100634T2 TR2001/00634T TR200100634T TR200100634T2 TR 200100634 T2 TR200100634 T2 TR 200100634T2 TR 2001/00634 T TR2001/00634 T TR 2001/00634T TR 200100634 T TR200100634 T TR 200100634T TR 200100634 T2 TR200100634 T2 TR 200100634T2
Authority
TR
Turkey
Prior art keywords
chromatographic purification
insulins
insulin
buffer
mixed
Prior art date
Application number
TR2001/00634T
Other languages
English (en)
Inventor
Sievers Werner
Bicker Richard
Desch Dieter
Von Eysmondt J�Rg
Keller Reinhold
Richard Frank
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200100634T2 publication Critical patent/TR200100634T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Bu bulus insülinlerin kromatografik olarak arindirilmasina iliskin iyilestirilmis olan bir yöntemle ilgilidir; söz konusu yöntemin ayirt edici özelligi sabit safha olarak basinca dayanikli organik bir polimer kromatografi malzemesinin kullanilmasi, sabit olmayan safhanin su ile karistirilabilen organik bir çözücü madde ile en az bir tampon maddesini içeriyor olmasi ve pH degerinin 7 ila 11 arasinda olmasidir.
TR2001/00634T 1998-08-24 1999-08-11 İnsülinlerin kromatografik olarak arındırılmasına yönelik yöntem. TR200100634T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19838097A DE19838097A1 (de) 1998-08-24 1998-08-24 Verfahren zur chromatographischen Reinigung von Insulinen

Publications (1)

Publication Number Publication Date
TR200100634T2 true TR200100634T2 (tr) 2001-07-23

Family

ID=7878335

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00634T TR200100634T2 (tr) 1998-08-24 1999-08-11 İnsülinlerin kromatografik olarak arındırılmasına yönelik yöntem.

Country Status (23)

Country Link
US (1) US6710167B1 (tr)
EP (1) EP1107988B1 (tr)
JP (1) JP2002523732A (tr)
KR (1) KR100703578B1 (tr)
CN (1) CN1198843C (tr)
AT (1) ATE380827T1 (tr)
AU (1) AU756105B2 (tr)
BR (1) BR9913092A (tr)
CA (1) CA2341355C (tr)
CY (1) CY1107877T1 (tr)
CZ (1) CZ300604B6 (tr)
DE (2) DE19838097A1 (tr)
DK (1) DK1107988T3 (tr)
ES (1) ES2296407T3 (tr)
HK (1) HK1039130B (tr)
HU (1) HU227753B1 (tr)
ID (1) ID29517A (tr)
PL (1) PL201880B1 (tr)
PT (1) PT1107988E (tr)
RU (1) RU2222546C2 (tr)
TR (1) TR200100634T2 (tr)
WO (1) WO2000011030A2 (tr)
ZA (1) ZA200101096B (tr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19838097A1 (de) * 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
ATE423138T1 (de) * 2002-12-05 2009-03-15 Wockhardt Ltd Verfahren zur extraktion und isolierung von insulin aus recombinanten quellen
US6921703B2 (en) * 2003-05-13 2005-07-26 Texas Instruments Incorporated System and method for mitigating oxide growth in a gate dielectric
DK1589045T3 (da) * 2004-04-20 2007-07-23 Rohm & Haas Polymeradsorbent og fremgangsmåde til fremstilling og anvendelse heraf
EP1758540A4 (en) * 2004-05-24 2007-06-20 Wockhardt Ltd PURIFICATION OF INSULIN-LIKE MATERIAL BY REVERSE-PHASE CHROMATOGRAPHY
DE102004051807B4 (de) * 2004-10-25 2008-10-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung von hydrophobiertem Kieselgel als selektives Sorbens zur Entfernung von organischen Siliziumverbindungen
CN100368804C (zh) * 2006-01-24 2008-02-13 李振国 测定注射剂中高分子量物质含量的方法
RU2489441C1 (ru) * 2009-07-09 2013-08-10 Биокон Лимитед Препаративный хроматографический способ на основе нелинейного градиента и продукты, очищенные этим способом
US10436803B2 (en) * 2010-12-28 2019-10-08 Quest Diagnostics Investments Incorporated Quantitation of insulin by tandem mass spectrometry of insulin B chain
RU2453331C1 (ru) * 2011-06-29 2012-06-20 Общество с ограниченной ответственностью "Завод Медсинтез" Способ получения высокоочищенного кристаллического инсулина любого происхождения
WO2013048330A1 (en) * 2011-09-30 2013-04-04 Ge Healthcare Bio-Sciences Ab Method for purification of cleaved pro-insulin
US10421795B2 (en) * 2012-12-17 2019-09-24 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
CN103275210B (zh) * 2013-06-25 2015-02-25 珠海联邦制药股份有限公司 脂肪酸单酰化胰岛素的色谱纯化方法
EP3116531B1 (en) 2014-03-14 2021-10-20 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
US10155799B2 (en) 2014-07-21 2018-12-18 Merck Sharp & Dohme Corp. Chromatography process for purification of insulin and insulin analogs
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
RU2736358C2 (ru) * 2015-12-09 2020-11-16 Общество С Ограниченной Ответственностью "Синбио" Способ очистки полисиалированного инсулина человека

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285024A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Process of purifying insulin
NZ199391A (en) 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US4616078A (en) * 1985-04-08 1986-10-07 Eli Lilly And Company Process for purifying proinsulin-like materials
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE4028120C2 (de) 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
SG44748A1 (en) * 1991-12-18 1997-12-19 Hoechst Ag Process for obtaining insulin-containing solutions
DK0600372T3 (da) 1992-12-02 1997-08-11 Hoechst Ag Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer.
DE4405179A1 (de) 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
ES2218622T3 (es) 1996-07-26 2004-11-16 Aventis Pharma Deutschland Gmbh Derivados de insulina con actividad de union al zinc incrementada.
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19838097A1 (de) * 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen

Also Published As

Publication number Publication date
CN1198843C (zh) 2005-04-27
DE59914580D1 (de) 2008-01-24
CZ300604B6 (cs) 2009-06-24
HUP0103325A2 (hu) 2001-12-28
CN1313866A (zh) 2001-09-19
ZA200101096B (en) 2002-06-26
BR9913092A (pt) 2001-10-30
RU2222546C2 (ru) 2004-01-27
DE19838097A1 (de) 2000-03-02
US6710167B1 (en) 2004-03-23
HK1039130A1 (en) 2002-04-12
KR100703578B1 (ko) 2007-04-05
CY1107877T1 (el) 2013-06-19
PL201880B1 (pl) 2009-05-29
CA2341355A1 (en) 2000-03-02
HU227753B1 (en) 2012-02-28
DK1107988T3 (da) 2008-04-21
EP1107988A2 (de) 2001-06-20
HUP0103325A3 (en) 2003-09-29
CZ2001646A3 (cs) 2001-09-12
ATE380827T1 (de) 2007-12-15
WO2000011030A2 (de) 2000-03-02
KR20010072914A (ko) 2001-07-31
ES2296407T3 (es) 2008-04-16
CA2341355C (en) 2009-04-07
JP2002523732A (ja) 2002-07-30
EP1107988B1 (de) 2007-12-12
PL346865A1 (en) 2002-03-11
HK1039130B (zh) 2006-05-12
AU756105B2 (en) 2003-01-02
AU5733199A (en) 2000-03-14
PT1107988E (pt) 2008-01-16
WO2000011030A3 (de) 2000-06-02
ID29517A (id) 2001-09-06

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