ATE423138T1 - Verfahren zur extraktion und isolierung von insulin aus recombinanten quellen - Google Patents
Verfahren zur extraktion und isolierung von insulin aus recombinanten quellenInfo
- Publication number
- ATE423138T1 ATE423138T1 AT03769848T AT03769848T ATE423138T1 AT E423138 T1 ATE423138 T1 AT E423138T1 AT 03769848 T AT03769848 T AT 03769848T AT 03769848 T AT03769848 T AT 03769848T AT E423138 T1 ATE423138 T1 AT E423138T1
- Authority
- AT
- Austria
- Prior art keywords
- isolation
- insulin
- extraction
- recombinant sources
- bound forms
- Prior art date
Links
- 102000004877 Insulin Human genes 0.000 title abstract 4
- 108090001061 Insulin Proteins 0.000 title abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 238000002955 isolation Methods 0.000 title abstract 3
- 238000000605 extraction Methods 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000005352 clarification Methods 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43105002P | 2002-12-05 | 2002-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE423138T1 true ATE423138T1 (de) | 2009-03-15 |
Family
ID=32469590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03769848T ATE423138T1 (de) | 2002-12-05 | 2003-11-14 | Verfahren zur extraktion und isolierung von insulin aus recombinanten quellen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7608583B2 (de) |
| EP (1) | EP1575967B1 (de) |
| AT (1) | ATE423138T1 (de) |
| AU (1) | AU2003278550A1 (de) |
| DE (1) | DE60326271D1 (de) |
| WO (1) | WO2004050672A2 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2603752C2 (ru) | 2011-02-01 | 2016-11-27 | Ново Нордиск А/С | Очистка инсулина |
| US8506797B2 (en) * | 2011-04-10 | 2013-08-13 | Therapeutic Proteins International, LLC | Downstream bioprocessing device |
| US10155799B2 (en) | 2014-07-21 | 2018-12-18 | Merck Sharp & Dohme Corp. | Chromatography process for purification of insulin and insulin analogs |
| US10799564B1 (en) | 2019-05-06 | 2020-10-13 | Baxter International Inc. | Insulin premix formulation and product, methods of preparing same, and methods of using same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744327A (en) * | 1990-02-20 | 1998-04-28 | Board Of Regents, The University Of Texas System | Methods for producing insulin in response to non-glucose secretagogues |
| DE19652713C2 (de) * | 1996-12-18 | 2001-11-22 | Aventis Pharma Gmbh | Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher |
| KR100253916B1 (ko) * | 1997-12-29 | 2000-05-01 | 김충환 | 사람 인슐린 전구체의 제조방법 |
| DE19838097A1 (de) * | 1998-08-24 | 2000-03-02 | Hoechst Marion Roussel De Gmbh | Verfahren zur chromatographischen Reinigung von Insulinen |
| AR025646A1 (es) * | 2000-09-13 | 2002-12-04 | Beta Lab Sa | Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa. |
-
2003
- 2003-11-14 US US10/523,999 patent/US7608583B2/en not_active Expired - Fee Related
- 2003-11-14 DE DE60326271T patent/DE60326271D1/de not_active Expired - Lifetime
- 2003-11-14 AU AU2003278550A patent/AU2003278550A1/en not_active Abandoned
- 2003-11-14 AT AT03769848T patent/ATE423138T1/de not_active IP Right Cessation
- 2003-11-14 WO PCT/IB2003/005197 patent/WO2004050672A2/en not_active Application Discontinuation
- 2003-11-14 EP EP03769848A patent/EP1575967B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004050672A3 (en) | 2006-03-02 |
| AU2003278550A8 (en) | 2004-06-23 |
| EP1575967A4 (de) | 2007-05-30 |
| DE60326271D1 (de) | 2009-04-02 |
| AU2003278550A1 (en) | 2004-06-23 |
| EP1575967A2 (de) | 2005-09-21 |
| US7608583B2 (en) | 2009-10-27 |
| EP1575967B1 (de) | 2009-02-18 |
| WO2004050672A2 (en) | 2004-06-17 |
| US20060167221A1 (en) | 2006-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |