DK1107988T3 - Fremgangsmåde til kromatografisk oprensning af insulin - Google Patents

Fremgangsmåde til kromatografisk oprensning af insulin

Info

Publication number
DK1107988T3
DK1107988T3 DK99944373T DK99944373T DK1107988T3 DK 1107988 T3 DK1107988 T3 DK 1107988T3 DK 99944373 T DK99944373 T DK 99944373T DK 99944373 T DK99944373 T DK 99944373T DK 1107988 T3 DK1107988 T3 DK 1107988T3
Authority
DK
Denmark
Prior art keywords
chromatographic purification
insulin
insulins
pressure
water
Prior art date
Application number
DK99944373T
Other languages
English (en)
Inventor
Werner Sievers
Richard Bicker
Dieter Desch
Eysmondt Joerg Von
Reinhold Keller
Frank Richard
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of DK1107988T3 publication Critical patent/DK1107988T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
DK99944373T 1998-08-24 1999-08-11 Fremgangsmåde til kromatografisk oprensning af insulin DK1107988T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19838097A DE19838097A1 (de) 1998-08-24 1998-08-24 Verfahren zur chromatographischen Reinigung von Insulinen
PCT/EP1999/005887 WO2000011030A2 (de) 1998-08-24 1999-08-11 Verfahren zur chromatographischen reinigung von insulinen

Publications (1)

Publication Number Publication Date
DK1107988T3 true DK1107988T3 (da) 2008-04-21

Family

ID=7878335

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99944373T DK1107988T3 (da) 1998-08-24 1999-08-11 Fremgangsmåde til kromatografisk oprensning af insulin

Country Status (23)

Country Link
US (1) US6710167B1 (da)
EP (1) EP1107988B1 (da)
JP (1) JP2002523732A (da)
KR (1) KR100703578B1 (da)
CN (1) CN1198843C (da)
AT (1) ATE380827T1 (da)
AU (1) AU756105B2 (da)
BR (1) BR9913092A (da)
CA (1) CA2341355C (da)
CY (1) CY1107877T1 (da)
CZ (1) CZ300604B6 (da)
DE (2) DE19838097A1 (da)
DK (1) DK1107988T3 (da)
ES (1) ES2296407T3 (da)
HK (1) HK1039130B (da)
HU (1) HU227753B1 (da)
ID (1) ID29517A (da)
PL (1) PL201880B1 (da)
PT (1) PT1107988E (da)
RU (1) RU2222546C2 (da)
TR (1) TR200100634T2 (da)
WO (1) WO2000011030A2 (da)
ZA (1) ZA200101096B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19838097A1 (de) * 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
DE60326271D1 (de) * 2002-12-05 2009-04-02 Wockhardt Ltd Verfahren zur extraktion und isolierung von insulin aus recombinanten quellen
US6921703B2 (en) * 2003-05-13 2005-07-26 Texas Instruments Incorporated System and method for mitigating oxide growth in a gate dielectric
EP1589045B1 (en) * 2004-04-20 2007-03-14 Rohm And Haas Company Polymeric adsorbent, and method of preparation and use
WO2005115303A1 (en) * 2004-05-24 2005-12-08 Wockhardt Limited Purification of insulin-like material by reverse phase chromatography
DE102004051807B4 (de) * 2004-10-25 2008-10-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung von hydrophobiertem Kieselgel als selektives Sorbens zur Entfernung von organischen Siliziumverbindungen
CN100368804C (zh) * 2006-01-24 2008-02-13 李振国 测定注射剂中高分子量物质含量的方法
CA2766571A1 (en) * 2009-07-09 2011-02-24 Biocon Limited A preparative non-linear gradient based chromatographic method and purified products thereof
EP3091562B1 (en) * 2010-12-28 2019-01-30 Quest Diagnostics Investments LLC Quantitation of insulin by mass spectrometry
RU2453331C1 (ru) * 2011-06-29 2012-06-20 Общество с ограниченной ответственностью "Завод Медсинтез" Способ получения высокоочищенного кристаллического инсулина любого происхождения
PL2748181T3 (pl) 2011-09-30 2016-08-31 Ge Healthcare Bioprocess R&D Ab Sposób oczyszczania rozszczepionej proinsuliny
EP2931301B2 (en) * 2012-12-17 2021-09-15 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
CN103275210B (zh) * 2013-06-25 2015-02-25 珠海联邦制药股份有限公司 脂肪酸单酰化胰岛素的色谱纯化方法
US10407483B2 (en) 2014-03-14 2019-09-10 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
US10155799B2 (en) 2014-07-21 2018-12-18 Merck Sharp & Dohme Corp. Chromatography process for purification of insulin and insulin analogs
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
RU2736358C2 (ru) * 2015-12-09 2020-11-16 Общество С Ограниченной Ответственностью "Синбио" Способ очистки полисиалированного инсулина человека

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285024A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Process of purifying insulin
NZ199391A (en) 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US4616078A (en) * 1985-04-08 1986-10-07 Eli Lilly And Company Process for purifying proinsulin-like materials
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE4028120C2 (de) 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
ATE150032T1 (de) * 1991-12-18 1997-03-15 Hoechst Ag Verfahren zur gewinnung von insulinhaltigen lösungen
EP0600372B1 (de) 1992-12-02 1997-02-05 Hoechst Aktiengesellschaft Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
DE4405179A1 (de) 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
ES2218622T3 (es) 1996-07-26 2004-11-16 Aventis Pharma Deutschland Gmbh Derivados de insulina con actividad de union al zinc incrementada.
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19838097A1 (de) * 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen

Also Published As

Publication number Publication date
HK1039130A1 (en) 2002-04-12
EP1107988A2 (de) 2001-06-20
ZA200101096B (en) 2002-06-26
JP2002523732A (ja) 2002-07-30
CA2341355C (en) 2009-04-07
HK1039130B (zh) 2006-05-12
TR200100634T2 (tr) 2001-07-23
EP1107988B1 (de) 2007-12-12
HUP0103325A2 (hu) 2001-12-28
ATE380827T1 (de) 2007-12-15
AU5733199A (en) 2000-03-14
HUP0103325A3 (en) 2003-09-29
CN1313866A (zh) 2001-09-19
DE19838097A1 (de) 2000-03-02
CY1107877T1 (el) 2013-06-19
CN1198843C (zh) 2005-04-27
CA2341355A1 (en) 2000-03-02
US6710167B1 (en) 2004-03-23
PT1107988E (pt) 2008-01-16
KR20010072914A (ko) 2001-07-31
KR100703578B1 (ko) 2007-04-05
ID29517A (id) 2001-09-06
DE59914580D1 (de) 2008-01-24
ES2296407T3 (es) 2008-04-16
PL346865A1 (en) 2002-03-11
CZ300604B6 (cs) 2009-06-24
PL201880B1 (pl) 2009-05-29
BR9913092A (pt) 2001-10-30
RU2222546C2 (ru) 2004-01-27
CZ2001646A3 (cs) 2001-09-12
HU227753B1 (en) 2012-02-28
WO2000011030A2 (de) 2000-03-02
WO2000011030A3 (de) 2000-06-02
AU756105B2 (en) 2003-01-02

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