PT1107988E - Processo para a purificação cromatográfica de insulinas - Google Patents

Processo para a purificação cromatográfica de insulinas Download PDF

Info

Publication number
PT1107988E
PT1107988E PT99944373T PT99944373T PT1107988E PT 1107988 E PT1107988 E PT 1107988E PT 99944373 T PT99944373 T PT 99944373T PT 99944373 T PT99944373 T PT 99944373T PT 1107988 E PT1107988 E PT 1107988E
Authority
PT
Portugal
Prior art keywords
insulins
chromatographically purifying
chromatographically
purifying
pressure
Prior art date
Application number
PT99944373T
Other languages
English (en)
Inventor
Reinhold Keller
Werner Sievers
Richard Bicker
Dieter Desch
Joerg Von Eysmondt
Frank Richard
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PT1107988E publication Critical patent/PT1107988E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
PT99944373T 1998-08-24 1999-08-11 Processo para a purificação cromatográfica de insulinas PT1107988E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19838097A DE19838097A1 (de) 1998-08-24 1998-08-24 Verfahren zur chromatographischen Reinigung von Insulinen

Publications (1)

Publication Number Publication Date
PT1107988E true PT1107988E (pt) 2008-01-16

Family

ID=7878335

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99944373T PT1107988E (pt) 1998-08-24 1999-08-11 Processo para a purificação cromatográfica de insulinas

Country Status (23)

Country Link
US (1) US6710167B1 (pt)
EP (1) EP1107988B1 (pt)
JP (1) JP2002523732A (pt)
KR (1) KR100703578B1 (pt)
CN (1) CN1198843C (pt)
AT (1) ATE380827T1 (pt)
AU (1) AU756105B2 (pt)
BR (1) BR9913092A (pt)
CA (1) CA2341355C (pt)
CY (1) CY1107877T1 (pt)
CZ (1) CZ300604B6 (pt)
DE (2) DE19838097A1 (pt)
DK (1) DK1107988T3 (pt)
ES (1) ES2296407T3 (pt)
HK (1) HK1039130B (pt)
HU (1) HU227753B1 (pt)
ID (1) ID29517A (pt)
PL (1) PL201880B1 (pt)
PT (1) PT1107988E (pt)
RU (1) RU2222546C2 (pt)
TR (1) TR200100634T2 (pt)
WO (1) WO2000011030A2 (pt)
ZA (1) ZA200101096B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19838097A1 (de) * 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
AU2003278550A1 (en) * 2002-12-05 2004-06-23 Edupuganti B. Raju Process for the extraction and isolation of insulin from recombinant sources
US6921703B2 (en) * 2003-05-13 2005-07-26 Texas Instruments Incorporated System and method for mitigating oxide growth in a gate dielectric
EP1589045B1 (en) * 2004-04-20 2007-03-14 Rohm And Haas Company Polymeric adsorbent, and method of preparation and use
WO2005115303A1 (en) * 2004-05-24 2005-12-08 Wockhardt Limited Purification of insulin-like material by reverse phase chromatography
DE102004051807B4 (de) * 2004-10-25 2008-10-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung von hydrophobiertem Kieselgel als selektives Sorbens zur Entfernung von organischen Siliziumverbindungen
CN100368804C (zh) * 2006-01-24 2008-02-13 李振国 测定注射剂中高分子量物质含量的方法
JP2012532862A (ja) * 2009-07-09 2012-12-20 バイオコン リミティド 調製用非線形勾配に基づくクロマトグラフィー法及びその精製産物
EP2659501B1 (en) * 2010-12-28 2017-09-06 Quest Diagnostics Investments Incorporated Quantitation of insulin by mass spectrometry
RU2453331C1 (ru) * 2011-06-29 2012-06-20 Общество с ограниченной ответственностью "Завод Медсинтез" Способ получения высокоочищенного кристаллического инсулина любого происхождения
PL2748181T3 (pl) 2011-09-30 2016-08-31 Ge Healthcare Bioprocess R&D Ab Sposób oczyszczania rozszczepionej proinsuliny
WO2014099577A1 (en) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
CN103275210B (zh) * 2013-06-25 2015-02-25 珠海联邦制药股份有限公司 脂肪酸单酰化胰岛素的色谱纯化方法
WO2015138548A1 (en) 2014-03-14 2015-09-17 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
US10155799B2 (en) 2014-07-21 2018-12-18 Merck Sharp & Dohme Corp. Chromatography process for purification of insulin and insulin analogs
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
RU2736358C2 (ru) * 2015-12-09 2020-11-16 Общество С Ограниченной Ответственностью "Синбио" Способ очистки полисиалированного инсулина человека

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285024A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Process of purifying insulin
NZ199391A (en) 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US4616078A (en) * 1985-04-08 1986-10-07 Eli Lilly And Company Process for purifying proinsulin-like materials
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE4028120C2 (de) 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
DE59208181D1 (de) * 1991-12-18 1997-04-17 Hoechst Ag Verfahren zur Gewinnung von insulinhaltigen Lösungen
DK0600372T3 (da) 1992-12-02 1997-08-11 Hoechst Ag Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer.
DE4405179A1 (de) 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
DK0821006T3 (da) 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulinderivater med öget zinkbinding
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19838097A1 (de) * 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen

Also Published As

Publication number Publication date
HK1039130A1 (en) 2002-04-12
EP1107988A2 (de) 2001-06-20
ATE380827T1 (de) 2007-12-15
CA2341355A1 (en) 2000-03-02
HUP0103325A2 (hu) 2001-12-28
DE59914580D1 (de) 2008-01-24
ID29517A (id) 2001-09-06
CY1107877T1 (el) 2013-06-19
JP2002523732A (ja) 2002-07-30
CZ2001646A3 (cs) 2001-09-12
AU5733199A (en) 2000-03-14
RU2222546C2 (ru) 2004-01-27
HU227753B1 (en) 2012-02-28
TR200100634T2 (tr) 2001-07-23
DE19838097A1 (de) 2000-03-02
CZ300604B6 (cs) 2009-06-24
PL346865A1 (en) 2002-03-11
DK1107988T3 (da) 2008-04-21
KR100703578B1 (ko) 2007-04-05
CN1198843C (zh) 2005-04-27
US6710167B1 (en) 2004-03-23
ZA200101096B (en) 2002-06-26
PL201880B1 (pl) 2009-05-29
EP1107988B1 (de) 2007-12-12
AU756105B2 (en) 2003-01-02
WO2000011030A2 (de) 2000-03-02
ES2296407T3 (es) 2008-04-16
HUP0103325A3 (en) 2003-09-29
HK1039130B (zh) 2006-05-12
CA2341355C (en) 2009-04-07
WO2000011030A3 (de) 2000-06-02
BR9913092A (pt) 2001-10-30
KR20010072914A (ko) 2001-07-31
CN1313866A (zh) 2001-09-19

Similar Documents

Publication Publication Date Title
HK1039130A1 (en) Method for chromatographically purifying insulins
EP1081492A4 (en) FILLING FOR CHROMATOGRAPHY HAVING A NEW CHARACTERISTIC AND METHOD FOR ISOLATING A SUBSTANCE USING THE SAME
AU6043598A (en) Method of displacement chromatography
HK1013806A1 (en) Antibody purification
GB2437442A (en) Improved process for purification of 6 acetyl 4,1',6' trichlorogalactosucrose and 4,1',6' trichlorogalactosucrose by chromatography on silanized silica gel
EP1017725A4 (en) METHOD, BASED ON AFFINITY CROSS-BINDING, THE INTERACTION OF BIOLOGICALLY ACTIVE PEPTIDES WITH ANTIBODIES
AU6080698A (en) Method for purifying factor viii/vwf complex by cation-exchange chromatography
WO2002018929A3 (en) Chromatography and other adsorptions using modified carbon adsorbents
NO941866D0 (no) Fremgangsmåte for fastgjöring av gjenstander, spesielt skjell, til understöttelsesmateriale
AU7062198A (en) Purification of peptides and oligonucleotides by sample displacement chromatography process and apparatus
GB9622515D0 (en) Seal for chromatography column
PT1025126E (pt) Purificacao de moleculas
AU4500296A (en) Chromatographic purification of vancomycin hydrochloride by the use of preparative hplc
BR9710386A (pt) Composto processo de prepara-Æo do composto e processo de transforma-Æo do composto
WO2002030542A3 (en) Purification of substance by reaction affinity chromatography
PT920447E (pt) Processo para a purificacao de ciclosporinas
AUPN756496A0 (en) Isolation of fibrinogen by affinity chromatography
ATE208223T1 (de) Umkehrphasenchromatographieverfahren
AU4734097A (en) Method for discovering novel anthelmintic compounds
AU5311098A (en) Indane or dihydroindole derivatives
AU2003232936A1 (en) Polyvinyl ethers
MX9705158A (es) Anticuerpos monoclonales anti-tpo.
AU1360197A (en) Isolation of fibrinogen by affinity chromatography
KR900013072A (ko) 친화성 크로마토그래피법에 의한 소형 전기가오리의 효소인 아세틸콜린에스테라제의 정제방법
MX9605277A (es) Procedimiento para obtener carboxilatos croman.