AU732392B2 - Ret ligand (retL) for stimulating neural and renal growth - Google Patents
Ret ligand (retL) for stimulating neural and renal growth Download PDFInfo
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- AU732392B2 AU732392B2 AU34729/97A AU3472997A AU732392B2 AU 732392 B2 AU732392 B2 AU 732392B2 AU 34729/97 A AU34729/97 A AU 34729/97A AU 3472997 A AU3472997 A AU 3472997A AU 732392 B2 AU732392 B2 AU 732392B2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
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| US1742796P | 1996-05-08 | 1996-05-08 | |
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| US60/021859 | 1996-07-16 | ||
| US4353397P | 1997-04-11 | 1997-04-11 | |
| US60/043533 | 1997-04-11 | ||
| PCT/US1997/007726 WO1997044356A2 (en) | 1996-05-08 | 1997-05-07 | RET LIGAND (RetL) FOR STIMULATING NEURAL AND RENAL GROWTH |
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| TR (2) | TR200103297T2 (enExample) |
| WO (1) | WO1997044356A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6696259B1 (en) | 1995-11-13 | 2004-02-24 | Licentia Ltd. | Assays using glial cell line-derived neurotrophic factor receptors |
| EP0846764A3 (en) * | 1996-11-27 | 1998-09-30 | Smithkline Beecham Plc | Glial cell line-derived neurotrophic factor alpha receptor family |
| CA2273845A1 (en) * | 1996-12-06 | 1998-06-11 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US6372453B1 (en) | 1997-02-18 | 2002-04-16 | Genetech, Inc. | Neurturin receptor |
| US6025157A (en) | 1997-02-18 | 2000-02-15 | Genentech, Inc. | Neurturin receptor |
| JP4086324B2 (ja) * | 1997-02-18 | 2008-05-14 | ジェネンテク，インコーポレイテッド | ニュールツリン受容体 |
| US6777196B2 (en) | 1997-02-18 | 2004-08-17 | Genentech, Inc. | Neurturin receptor |
| CA2291705A1 (en) * | 1997-04-17 | 1998-10-22 | Washington University | Receptors for tgf-.beta.-related neurotrophic factors |
| AU7583898A (en) * | 1997-05-20 | 1998-12-11 | Human Genome Sciences, Inc. | Gdnf receptors |
| EP1007072A4 (en) * | 1997-05-22 | 2002-06-26 | Cephalon Inc | RECEPTORS NEUROTROPHER FACTORS FROM A GLIA CELL LINE |
| AU7165998A (en) * | 1997-05-30 | 1998-12-30 | Amgen, Inc. | Neurotrophic factor receptors |
| DK1064376T3 (da) * | 1998-03-23 | 2006-07-24 | Genentech Inc | GFR-alpha3 og dets anvendelser |
| US7026138B1 (en) | 1998-03-23 | 2006-04-11 | Genentech, Inc. | Polynucleotides encoding GFRα3 |
| US20020055467A1 (en) | 1998-07-06 | 2002-05-09 | Johansen Teit E. | Novel neurotrophic factors |
| US6593133B1 (en) | 1998-07-06 | 2003-07-15 | Nsgene A/S | Neurotrophic factors |
| AU7103900A (en) * | 1999-09-01 | 2001-03-26 | Biogen, Inc. | Ret ligand 5 (retl5) compositions and uses thereof |
| EP2301960A3 (en) | 2003-01-31 | 2011-08-03 | Biogen Idec MA Inc. | Polymer conjugates of mutated neublastin |
| ES2628418T3 (es) | 2010-05-20 | 2017-08-02 | Array Biopharma, Inc. | Compuestos macrocíclicos como inhibidores de la TRK cinasa |
| US10023855B2 (en) | 2011-10-31 | 2018-07-17 | Macrogen, Inc. | Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker |
| JPWO2014017491A1 (ja) * | 2012-07-26 | 2016-07-11 | 国立研究開発法人国立がん研究センター | Ｃｅｐ５５遺伝子とｒｅｔ遺伝子との融合遺伝子 |
| CA2910553A1 (en) | 2013-04-30 | 2014-11-06 | Universite De Montreal | Novel biomarkers for acute myeloid leukemia |
| RS61485B1 (sr) | 2015-07-16 | 2021-03-31 | Array Biopharma Inc | Supstituisana pirazolo [1,5-a] piridinska jedinjenja kao inhibitori ret kinaze |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| EP3571203B1 (en) | 2017-01-18 | 2023-06-07 | Array BioPharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| JP2022500383A (ja) | 2018-09-10 | 2022-01-04 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての縮合複素環式化合物 |
| CA3222177A1 (en) * | 2021-06-03 | 2022-12-08 | Fundacao D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud | Neuro-mesenchyme units control ilc2 and obesity via a brain-adipose circuit |
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| US5169637A (en) | 1983-03-24 | 1992-12-08 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| CA1237671A (en) | 1983-08-01 | 1988-06-07 | Michael W. Fountain | Enhancement of pharmaceutical activity |
| US4762915A (en) | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4956288A (en) | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
| US5185154A (en) | 1989-02-02 | 1993-02-09 | Liposome Technology, Inc. | Method for instant preparation of a drug containing large unilamellar vesicles |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| JP3021800B2 (ja) | 1990-07-24 | 2000-03-15 | セイコーエプソン株式会社 | 半導体装置及びその製造方法 |
| US5219990A (en) | 1991-01-28 | 1993-06-15 | Biogen, Inc. | Papillomavirus e2 trans-activation repressors |
| FR2693107B1 (fr) | 1992-07-01 | 1994-09-23 | Chauvin Laboratoire | Moyens pour la prévention de la cataracte secondaire. |
| AU1404395A (en) * | 1993-12-13 | 1995-07-03 | Biogen, Inc. | Anti-mullerian hormone receptor polypeptides and antibodies thereto |
| WO1997018240A1 (en) * | 1995-11-13 | 1997-05-22 | Carlos Ibanez | Glial cell line-derived neurotrophic factor receptors |
| JP4301347B2 (ja) * | 1996-03-14 | 2009-07-22 | ジェネンテク， インコーポレイテッド | Ｇｄｎｆおよびｇｄｎｆ受容体の用途 |
| US6455277B1 (en) * | 1996-04-22 | 2002-09-24 | Amgen Inc. | Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides |
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- 1997-05-07 SK SK1524-98A patent/SK286115B6/sk not_active IP Right Cessation
- 1997-05-07 TR TR2001/03297T patent/TR200103297T2/xx unknown
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- 1997-05-07 EP EP97930981A patent/EP0914339B1/en not_active Expired - Lifetime
- 1997-05-07 AT AT97930981T patent/ATE335003T1/de not_active IP Right Cessation
- 1997-05-07 CN CNB971954666A patent/CN1163509C/zh not_active Expired - Fee Related
- 1997-05-07 TR TR1998/02252T patent/TR199802252T2/xx unknown
- 1997-05-07 EA EA199800990A patent/EA002544B1/ru not_active IP Right Cessation
- 1997-05-07 ES ES97930981T patent/ES2270465T3/es not_active Expired - Lifetime
- 1997-05-07 BR BR9710665A patent/BR9710665A/pt not_active Application Discontinuation
- 1997-05-07 CN CNA2004100629039A patent/CN1624126A/zh active Pending
- 1997-05-07 CZ CZ0361598A patent/CZ296516B6/cs not_active IP Right Cessation
- 1997-05-07 KR KR1020067002921A patent/KR20060024843A/ko not_active Ceased
- 1997-05-07 WO PCT/US1997/007726 patent/WO1997044356A2/en not_active Ceased
- 1997-05-07 RO RO98-01550A patent/RO120343B1/ro unknown
- 1997-05-07 EP EP06013826A patent/EP1757617A1/en not_active Withdrawn
- 1997-05-07 IL IL126918A patent/IL126918A/en not_active IP Right Cessation
- 1997-05-07 DE DE69736428T patent/DE69736428T2/de not_active Expired - Fee Related
- 1997-05-07 EE EE9800377A patent/EE9800377A/xx unknown
- 1997-05-07 PT PT97930981T patent/PT914339E/pt unknown
- 1997-05-07 NZ NZ332706A patent/NZ332706A/en unknown
- 1997-05-07 AU AU34729/97A patent/AU732392B2/en not_active Ceased
- 1997-05-07 DK DK97930981T patent/DK0914339T3/da active
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1998
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- 1998-12-01 BG BG102973A patent/BG64907B1/bg unknown
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2006
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