AU723268B2 - Improved solid-phase peptide synthesis and agent for use in such synthesis - Google Patents
Improved solid-phase peptide synthesis and agent for use in such synthesis Download PDFInfo
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- AU723268B2 AU723268B2 AU41993/97A AU4199397A AU723268B2 AU 723268 B2 AU723268 B2 AU 723268B2 AU 41993/97 A AU41993/97 A AU 41993/97A AU 4199397 A AU4199397 A AU 4199397A AU 723268 B2 AU723268 B2 AU 723268B2
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- Australia
- Prior art keywords
- acid
- sequence
- process according
- peptide
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007790 solid phase Substances 0.000 title claims abstract description 25
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- C—CHEMISTRY; METALLURGY
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- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Prostheses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK971/96 | 1996-09-09 | ||
| DK97196 | 1996-09-09 | ||
| PCT/DK1997/000375 WO1998011125A1 (en) | 1996-09-09 | 1997-09-09 | Improved solid-phase peptide synthesis and agent for use in such synthesis |
Publications (2)
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| AU4199397A AU4199397A (en) | 1998-04-02 |
| AU723268B2 true AU723268B2 (en) | 2000-08-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU41993/97A Ceased AU723268B2 (en) | 1996-09-09 | 1997-09-09 | Improved solid-phase peptide synthesis and agent for use in such synthesis |
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|---|---|
| US (1) | US7348404B2 (enExample) |
| EP (1) | EP0929567B1 (enExample) |
| JP (1) | JP4405594B2 (enExample) |
| AT (1) | ATE290014T1 (enExample) |
| AU (1) | AU723268B2 (enExample) |
| CA (1) | CA2265900C (enExample) |
| CZ (1) | CZ295838B6 (enExample) |
| DE (1) | DE69732640T2 (enExample) |
| DK (1) | DK0929567T3 (enExample) |
| ES (1) | ES2239364T3 (enExample) |
| HU (1) | HU230354B1 (enExample) |
| IL (1) | IL128829A (enExample) |
| PT (1) | PT929567E (enExample) |
| WO (1) | WO1998011125A1 (enExample) |
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| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| US7550425B2 (en) | 2000-06-16 | 2009-06-23 | Zealand Pharma A/S | Diuretic peptide conjugates |
| WO2006045503A1 (en) | 2004-10-19 | 2006-05-04 | Lonza Ag | Method for solid phase peptide synthesis |
| AU2006242998B2 (en) | 2005-05-04 | 2012-03-22 | Zealand Pharma A/S | Glucagon-like-peptide-2 (GLP-2) analogues |
| GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| JPWO2007060860A1 (ja) * | 2005-11-22 | 2009-05-07 | 学校法人日本大学 | ピロールイミダゾールポリアミドの固相自動合成 |
| CN101336229B (zh) | 2005-12-23 | 2012-06-13 | 西兰岛药物有限公司 | 改性的拟赖氨酸化合物 |
| EP1991560B1 (en) * | 2006-02-20 | 2018-04-04 | Ewha University-Industry Collaboration Foundation | Peptide having cell membrane penetrating activity |
| CA2647867C (en) * | 2006-03-29 | 2015-11-03 | Otsuka Chemical Co., Ltd. | Method for production of peptide thioester compound |
| EP2051995B1 (en) | 2006-11-08 | 2017-02-08 | Zealand Pharma A/S | Selective glucagon-like-peptide-2 (glp-2) analogues |
| EP2158214B1 (en) | 2007-06-15 | 2011-08-17 | Zealand Pharma A/S | Glucagon analogues |
| JP5635530B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| DK2370461T3 (da) | 2008-12-15 | 2013-12-16 | Zealand Pharma As | Glucagonanaloger |
| BRPI0823377A2 (pt) | 2008-12-15 | 2016-09-27 | Zealand Pharma As | análogos de glucagon |
| MA32970B1 (fr) | 2008-12-15 | 2012-01-02 | Zealand Pharma As | Analogues du glucagon |
| JP6054742B2 (ja) | 2009-07-13 | 2016-12-27 | ジーランド ファーマ アクティーゼルスカブ | アシル化グルカゴン類似体 |
| JP5969461B2 (ja) | 2010-04-27 | 2016-08-17 | ジーランド ファーマ アクティーゼルスカブ | Ｇｌｐ−１受容体作動薬とガストリンとのペプチド複合体及びその使用 |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| US9169310B2 (en) | 2010-06-24 | 2015-10-27 | Zealand Pharma A/S | Glucagon analogues |
| PH12013501495A1 (en) | 2011-01-20 | 2013-09-16 | Zealand Pharma As | Combination of acylated glucagon analogues with insulin analogues |
| CN104144704B (zh) | 2011-11-03 | 2018-03-23 | 西兰制药公司 | Glp‑1受体激动剂肽胃泌素缀合物 |
| SG11201403377QA (en) | 2011-12-23 | 2014-07-30 | Zealand Pharma As | Glucagon analogues |
| WO2013098408A1 (en) | 2011-12-30 | 2013-07-04 | Zealand Pharma A/S | Glucagon and cck receptor agonist peptide conjugates |
| TW201336864A (zh) | 2012-02-03 | 2013-09-16 | Zealand Pharma As | 胃飢餓素（ｇｈｒｅｌｉｎ）類似物 |
| EP2844670B1 (en) | 2012-05-03 | 2017-12-06 | Zealand Pharma A/S | Glucagon-like-peptide-2 (glp-2) analogues |
| JP6228187B2 (ja) | 2012-05-03 | 2017-11-08 | ジーランド ファーマ アクティーゼルスカブ | Ｇｉｐ−ｇｌｐ−１デュアルアゴニスト化合物及び方法 |
| MX356957B (es) | 2012-07-23 | 2018-06-20 | Zealand Pharma As | Analogos del glucagon. |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| CN105051067B (zh) | 2013-03-12 | 2020-04-17 | 分子模板公司 | 用于引起细胞内化的cd20结合免疫毒素及其使用方法 |
| US9169287B2 (en) | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| US9695214B2 (en) | 2013-03-15 | 2017-07-04 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| DK2976325T3 (en) | 2013-03-21 | 2017-06-06 | Sanofi Aventis Deutschland | SYNTHESIS OF PEPTIDE PRODUCTS CONTAINING CYCLIC IMID |
| AU2014234400B2 (en) | 2013-03-21 | 2017-11-16 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
| CA2926314C (en) | 2013-10-17 | 2023-08-29 | Zealand Pharma A/S | Acylated glucagon analogues |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| CN105829339B (zh) | 2013-11-06 | 2021-03-12 | 西兰制药公司 | 胰高血糖素-glp-1-gip三重激动剂化合物 |
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| JPS5116666A (enExample) * | 1974-07-30 | 1976-02-10 | Shionogi Seiyaku Kk | |
| US5021550A (en) * | 1986-10-07 | 1991-06-04 | Thomas Jefferson University | Method for preventing deletion sequences in solid phase synthesis |
| JP2807287B2 (ja) * | 1989-10-13 | 1998-10-08 | 株式会社医学生物学研究所 | ペプチドおよびその用途 |
| EP0719334A1 (en) * | 1993-09-14 | 1996-07-03 | Genentech, Inc. | Pharmaceutical compositions containing ecotin and homologs thereof |
| US7176282B1 (en) * | 1996-09-09 | 2007-02-13 | Zealand Pharma A/S | Solid-phase peptide synthesis and agent for use in such synthesis |
| IL138214A0 (en) * | 1998-03-09 | 2001-10-31 | Zealand Pharmaceuticals As | Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
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1997
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- 1997-09-09 DK DK97939974T patent/DK0929567T3/da active
- 1997-09-09 EP EP97939974A patent/EP0929567B1/en not_active Expired - Lifetime
- 1997-09-09 DE DE69732640T patent/DE69732640T2/de not_active Expired - Lifetime
- 1997-09-09 PT PT97939974T patent/PT929567E/pt unknown
- 1997-09-09 AT AT97939974T patent/ATE290014T1/de active
- 1997-09-09 JP JP51316698A patent/JP4405594B2/ja not_active Expired - Fee Related
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- 1997-09-09 AU AU41993/97A patent/AU723268B2/en not_active Ceased
- 1997-09-09 WO PCT/DK1997/000375 patent/WO1998011125A1/en not_active Ceased
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| CA2265900A1 (en) | 1998-03-19 |
| HU230354B1 (hu) | 2016-02-29 |
| IL128829A (en) | 2005-08-31 |
| CZ295838B6 (cs) | 2005-11-16 |
| HUP0102900A3 (en) | 2002-02-28 |
| CZ80399A3 (cs) | 1999-08-11 |
| ES2239364T3 (es) | 2005-09-16 |
| JP4405594B2 (ja) | 2010-01-27 |
| WO1998011125A1 (en) | 1998-03-19 |
| JP2001500134A (ja) | 2001-01-09 |
| US20070004905A1 (en) | 2007-01-04 |
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| US7348404B2 (en) | 2008-03-25 |
| HUP0102900A2 (hu) | 2002-01-28 |
| PT929567E (pt) | 2005-07-29 |
| CA2265900C (en) | 2007-07-31 |
| AU4199397A (en) | 1998-04-02 |
| IL128829A0 (en) | 2000-01-31 |
| DE69732640T2 (de) | 2006-01-12 |
| DE69732640D1 (de) | 2005-04-07 |
| EP0929567B1 (en) | 2005-03-02 |
| ATE290014T1 (de) | 2005-03-15 |
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